EA200970461A1 - ЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ 3-ИЗОБУТИЛ-9,10-ДИМЕТОКСИ-1,3,4,6,7,11b-ГЕКСАГИДРО-2Н-ПИРИДО[2,1-a]ИЗОХИНОЛИН-2-ОЛА И СВЯЗАННЫЕ С НИМИ СПОСОБЫ - Google Patents

ЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ 3-ИЗОБУТИЛ-9,10-ДИМЕТОКСИ-1,3,4,6,7,11b-ГЕКСАГИДРО-2Н-ПИРИДО[2,1-a]ИЗОХИНОЛИН-2-ОЛА И СВЯЗАННЫЕ С НИМИ СПОСОБЫ

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Publication number
EA200970461A1
EA200970461A1 EA200970461A EA200970461A EA200970461A1 EA 200970461 A1 EA200970461 A1 EA 200970461A1 EA 200970461 A EA200970461 A EA 200970461A EA 200970461 A EA200970461 A EA 200970461A EA 200970461 A1 EA200970461 A1 EA 200970461A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyrido
hexahydro
isobutyl
izohinolin
dimetoxi
Prior art date
Application number
EA200970461A
Other languages
English (en)
Other versions
EA018378B1 (ru
Inventor
Кайл У. Гано
Original Assignee
Ньюрокрайн Байосайенсиз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39110526&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200970461(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ньюрокрайн Байосайенсиз, Инк. filed Critical Ньюрокрайн Байосайенсиз, Инк.
Publication of EA200970461A1 publication Critical patent/EA200970461A1/ru
Publication of EA018378B1 publication Critical patent/EA018378B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Рассматриваются замещенные 3-изобутил-9,10-диметокси-1,3,4,6,7,11b-гексагидро-2Н-пиридо[2,1-а]изохинолин-2-ола, которые являются ингибиторами везикулярного моноаминного переносчика 2 (VMAT2). Соединения данного изобретения имеют структуру (I)в которой Rявляется таким, как определено здесь, включая его стереоизомеры и фармацевтически приемлемые соли и сольваты. Также рассматриваются композиции, содержащие соединение данного изобретения в комбинации с фармацевтически приемлемым носителем, а также способы, относящиеся к применению в субъекте, нуждающемся в этом.
EA200970461A 2006-11-08 2007-11-08 ЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ 3-ИЗОБУТИЛ-9,10-ДИМЕТОКСИ-1,3,4,6,7,11b-ГЕКСАГИДРО-2Н-ПИРИДО[2,1-a]ИЗОХИНОЛИН-2-ОЛА И СВЯЗАННЫЕ С НИМИ СПОСОБЫ EA018378B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86494406P 2006-11-08 2006-11-08
PCT/US2007/084176 WO2008058261A1 (en) 2006-11-08 2007-11-08 Substituted 3-isobutyl-9, 10-dimethoxy-1,3,4,6,7,11b-hexahydro-2h-pyrido[2,1-a] isoquinolin-2-ol compounds and methods relating thereto

Publications (2)

Publication Number Publication Date
EA200970461A1 true EA200970461A1 (ru) 2009-12-30
EA018378B1 EA018378B1 (ru) 2013-07-30

Family

ID=39110526

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200970461A EA018378B1 (ru) 2006-11-08 2007-11-08 ЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ 3-ИЗОБУТИЛ-9,10-ДИМЕТОКСИ-1,3,4,6,7,11b-ГЕКСАГИДРО-2Н-ПИРИДО[2,1-a]ИЗОХИНОЛИН-2-ОЛА И СВЯЗАННЫЕ С НИМИ СПОСОБЫ

Country Status (16)

Country Link
US (2) US8039627B2 (ru)
EP (1) EP2081929B1 (ru)
JP (1) JP5290185B2 (ru)
KR (1) KR101500766B1 (ru)
CN (1) CN101553487B (ru)
AU (1) AU2007317242B2 (ru)
BR (1) BRPI0718247B1 (ru)
CA (1) CA2668689C (ru)
DK (1) DK2081929T3 (ru)
EA (1) EA018378B1 (ru)
ES (1) ES2402220T3 (ru)
IL (1) IL198250A0 (ru)
MX (1) MX2009004910A (ru)
PL (1) PL2081929T3 (ru)
PT (1) PT2081929E (ru)
WO (1) WO2008058261A1 (ru)

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EP2081929B1 (en) 2013-01-09
EP2081929A1 (en) 2009-07-29
PL2081929T3 (pl) 2013-06-28
US8357697B2 (en) 2013-01-22
US20120077839A1 (en) 2012-03-29
KR101500766B1 (ko) 2015-03-16
BRPI0718247B1 (pt) 2021-09-21
JP2010509366A (ja) 2010-03-25
CA2668689A1 (en) 2008-05-15
KR20090079257A (ko) 2009-07-21
ES2402220T3 (es) 2013-04-29
CA2668689C (en) 2015-12-29
US20080167337A1 (en) 2008-07-10
US8039627B2 (en) 2011-10-18
CN101553487A (zh) 2009-10-07
ES2402220T8 (es) 2021-12-23
CN101553487B (zh) 2012-06-13
EA018378B1 (ru) 2013-07-30
AU2007317242A1 (en) 2008-05-15
PT2081929E (pt) 2013-04-15
MX2009004910A (es) 2009-07-24
JP5290185B2 (ja) 2013-09-18
DK2081929T3 (da) 2013-04-15
WO2008058261A1 (en) 2008-05-15
AU2007317242B2 (en) 2013-08-01
BRPI0718247A2 (pt) 2014-01-07
IL198250A0 (en) 2009-12-24

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