CU20200051A7 - Componentes heterocíclicos bicíclicos sustituidos como inhibidores de prmt5 - Google Patents
Componentes heterocíclicos bicíclicos sustituidos como inhibidores de prmt5Info
- Publication number
- CU20200051A7 CU20200051A7 CU2020000051A CU20200051A CU20200051A7 CU 20200051 A7 CU20200051 A7 CU 20200051A7 CU 2020000051 A CU2020000051 A CU 2020000051A CU 20200051 A CU20200051 A CU 20200051A CU 20200051 A7 CU20200051 A7 CU 20200051A7
- Authority
- CU
- Cuba
- Prior art keywords
- bicyclic heterocyclic
- prmt5 inhibitors
- components replaced
- heterocyclic components
- replaced
- Prior art date
Links
- 102100034607 Protein arginine N-methyltransferase 5 Human genes 0.000 title 1
- 101710084427 Protein arginine N-methyltransferase 5 Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Abstract
<p>La invención se refiere a compuestos heterocíclicos bicíclicos sustituidos de fórmula (I), a sales farmacéuticamente aceptables de los mismos y a composiciones farmacéuticas que comprenden al menos un compuesto de fórmula (I).</p>
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN201721044886 | 2017-12-13 | ||
IN201821024634 | 2018-07-02 | ||
IN201821040029 | 2018-10-23 | ||
PCT/IB2018/060015 WO2019116302A1 (en) | 2017-12-13 | 2018-12-13 | Substituted bicyclic heterocyclic compounds as prmt5 inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
CU20200051A7 true CU20200051A7 (es) | 2021-03-11 |
CU24621B1 CU24621B1 (es) | 2022-09-08 |
Family
ID=65036860
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CU2020000051A CU24621B1 (es) | 2017-12-13 | 2018-12-13 | Componentes heterocíclicos bicíclicos sustituidos como inhibidores de prmt5 |
Country Status (28)
Country | Link |
---|---|
US (2) | US11459330B2 (es) |
EP (1) | EP3724190B1 (es) |
JP (1) | JP7282778B2 (es) |
KR (1) | KR20200098598A (es) |
CN (1) | CN111712498B (es) |
AU (1) | AU2018385664B2 (es) |
BR (1) | BR112020011746A2 (es) |
CA (1) | CA3085259A1 (es) |
CL (1) | CL2020001576A1 (es) |
CR (1) | CR20200263A (es) |
CU (1) | CU24621B1 (es) |
DK (1) | DK3724190T3 (es) |
ES (1) | ES2927860T3 (es) |
GE (1) | GEP20227359B (es) |
HR (1) | HRP20221207T1 (es) |
HU (1) | HUE059945T2 (es) |
IL (1) | IL274936B2 (es) |
LT (1) | LT3724190T (es) |
MX (1) | MX2020006181A (es) |
PE (1) | PE20211444A1 (es) |
PH (1) | PH12020550881A1 (es) |
PL (1) | PL3724190T3 (es) |
PT (1) | PT3724190T (es) |
RS (1) | RS63623B1 (es) |
SG (1) | SG11202004934QA (es) |
UA (1) | UA126349C2 (es) |
WO (1) | WO2019116302A1 (es) |
ZA (1) | ZA202003528B (es) |
Families Citing this family (14)
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WO2020243178A1 (en) * | 2019-05-30 | 2020-12-03 | Angex Pharmaceutical, Inc. | Heterocyclic compounds as prmt5 inhibitors |
US11077101B1 (en) | 2018-07-18 | 2021-08-03 | Tango Therapeutics, Inc. | Compounds and methods of use |
MX2021003819A (es) | 2018-10-05 | 2021-06-23 | Vertex Pharma | Moduladores de alfa-1 antitripsina. |
CA3134613A1 (en) | 2019-04-02 | 2020-10-08 | Aligos Therapeutics, Inc. | Compounds targeting prmt5 |
US11884672B2 (en) | 2019-05-14 | 2024-01-30 | Vertex Pharmaceuticals Incorporated | Modulators of alpha-1 antitrypsin |
RS64972B1 (sr) * | 2019-06-10 | 2024-01-31 | Lupin Ltd | Inhibitori prmt5 |
CN114599361A (zh) * | 2019-10-22 | 2022-06-07 | 印度鲁宾有限公司 | Prmt5抑制剂的药物组合物 |
JP2022553376A (ja) * | 2019-10-25 | 2022-12-22 | アクセント・セラピューティクス・インコーポレイテッド | Mettl3モジュレーター |
WO2021111322A1 (en) | 2019-12-03 | 2021-06-10 | Lupin Limited | Substituted nucleoside analogs as prmt5 inhibitors |
WO2021202480A1 (en) * | 2020-04-01 | 2021-10-07 | Aligos Therapeutics, Inc. | Compounds targeting prmt5 |
WO2021203028A1 (en) * | 2020-04-03 | 2021-10-07 | Vertex Pharmaceuticals Incorporated | 7- or 8-hydroxy-isoquinoline and 7- or 8-hydroxy-quinoline derivatives as alpha-1 -antitrypsin modulators for treating alpha-1 -antitrypsin deficiency (aatd) |
WO2022026892A1 (en) | 2020-07-31 | 2022-02-03 | Tango Therapeutics, Inc. | Piperidin-1- yl-n-pyrydi ne-3-yl-2-oxoacet am ide derivatives useful for the treatment of mtap-deficient and/or mt a-accumulating cancers |
AU2022210517A1 (en) | 2021-01-19 | 2023-07-27 | Lupin Limited | Pharmaceutical combinations of sos1 inhibitors for treating and/or preventing cancer |
CN113234079B (zh) * | 2021-04-30 | 2022-02-01 | 上海湃隆生物科技有限公司 | 用作prmt5抑制剂的核苷类似物 |
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AU2003251431A1 (en) | 2002-07-22 | 2004-02-09 | Cambridge University Technical Services Ltd. | Synthesis of discodermolide |
WO2005016878A2 (en) | 2003-08-13 | 2005-02-24 | Isis Pharmaceuticals, Inc. | METHODS FOR THE PREPARATION OF 5-FLUORO-PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS |
WO2006091905A1 (en) | 2005-02-25 | 2006-08-31 | Gilead Sciences, Inc. | Bicyclo (3.1.0) hexane derivatives as antiviral compounds |
US20080045521A1 (en) | 2006-06-09 | 2008-02-21 | Astrazeneca Ab | Phenylalanine derivatives |
US8299256B2 (en) | 2007-03-08 | 2012-10-30 | Janssen Pharmaceutica Nv | Quinolinone derivatives as PARP and TANK inhibitors |
FR2926556B1 (fr) | 2008-01-22 | 2010-02-19 | Sanofi Aventis | Derives de carboxamides n-azabicycliques, leur preparation et leur application en therapeutique |
CN102369204A (zh) | 2008-09-26 | 2012-03-07 | 新加坡科技研究局 | 3-脱氮瓶菌素衍生物 |
US9044432B2 (en) | 2009-12-22 | 2015-06-02 | Ohio State Innovation Foundation | Compositions and methods for cancer detection and treatment |
GB0922332D0 (en) | 2009-12-22 | 2010-02-03 | Isis Innovation | Method of treatment and screening method |
KR101789129B1 (ko) | 2010-06-30 | 2017-11-20 | 후지필름 가부시키가이샤 | 신규 니코틴아미드 유도체 또는 그 염 |
WO2012037108A1 (en) | 2010-09-13 | 2012-03-22 | Glaxosmithkline Llc | Aminoquinoline derivatives as antiviral agents |
WO2012123298A1 (en) | 2011-03-11 | 2012-09-20 | F. Hoffmann-La Roche Ag | Antiviral compounds |
WO2013028447A1 (en) | 2011-08-19 | 2013-02-28 | Glaxosmithkline Llc | Fatty acid synthase inhibitors |
JP6182593B2 (ja) * | 2012-04-20 | 2017-08-16 | アドヴィーナス セラピューティクス リミテッド | 置換ヘテロ二環化合物、組成物及び医薬並びにそれらの用途 |
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JP6437452B2 (ja) | 2013-01-14 | 2018-12-12 | インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation | Pimキナーゼ阻害剤として有用な二環式芳香族カルボキサミド化合物 |
GB201302927D0 (en) | 2013-02-20 | 2013-04-03 | Cancer Therapeutics Crc Pty Ltd | Compounds |
JP6510485B2 (ja) | 2013-03-15 | 2019-05-08 | オハイオ・ステイト・イノベーション・ファウンデーション | Prmt5インヒビターおよびそれらの使用方法 |
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CA2943882A1 (en) | 2014-05-22 | 2015-11-26 | F. Hoffmann-La Roche Ag | Indolin-2-one and 1,3-dihydro-pyrrolo[3,2-c]pyridin-2-one derivatives |
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EA032017B1 (ru) | 2014-06-25 | 2019-03-29 | Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед | Кристаллические соли (s)-6-((1-ацетилпиперидин-4-ил)амино)-n-(3-(3,4-дигидроизохинолин-2(1h)-ил)-2-гидроксипропил)пиримидин-4-карбоксамида |
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TWI791251B (zh) * | 2015-08-26 | 2023-02-01 | 比利時商健生藥品公司 | 使用作為prmt5抑制劑之新穎經6-6雙環芳香環取代之核苷類似物 |
JP7015059B2 (ja) | 2015-11-16 | 2022-02-15 | アラクセス ファーマ エルエルシー | 置換複素環式基を含む2-置換キナゾリン化合物およびその使用方法 |
EA201990851A1 (ru) * | 2017-02-24 | 2019-09-30 | Янссен Фармацевтика Нв | Новые аналоги карбануклеозида, замещенные моноциклической и бициклической кольцевой системой, для применения в качестве ингибиторов prmt5 |
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2018
- 2018-12-13 PE PE2020000761A patent/PE20211444A1/es unknown
- 2018-12-13 DK DK18836520.9T patent/DK3724190T3/da active
- 2018-12-13 BR BR112020011746-3A patent/BR112020011746A2/pt unknown
- 2018-12-13 UA UAA202004140A patent/UA126349C2/uk unknown
- 2018-12-13 PT PT188365209T patent/PT3724190T/pt unknown
- 2018-12-13 GE GEAP201815385A patent/GEP20227359B/en unknown
- 2018-12-13 CU CU2020000051A patent/CU24621B1/es unknown
- 2018-12-13 AU AU2018385664A patent/AU2018385664B2/en active Active
- 2018-12-13 EP EP18836520.9A patent/EP3724190B1/en active Active
- 2018-12-13 LT LTEPPCT/IB2018/060015T patent/LT3724190T/lt unknown
- 2018-12-13 CA CA3085259A patent/CA3085259A1/en active Pending
- 2018-12-13 SG SG11202004934QA patent/SG11202004934QA/en unknown
- 2018-12-13 ES ES18836520T patent/ES2927860T3/es active Active
- 2018-12-13 IL IL274936A patent/IL274936B2/en unknown
- 2018-12-13 JP JP2020532614A patent/JP7282778B2/ja active Active
- 2018-12-13 RS RS20220931A patent/RS63623B1/sr unknown
- 2018-12-13 US US16/772,959 patent/US11459330B2/en active Active
- 2018-12-13 KR KR1020207019844A patent/KR20200098598A/ko not_active Application Discontinuation
- 2018-12-13 WO PCT/IB2018/060015 patent/WO2019116302A1/en unknown
- 2018-12-13 PL PL18836520.9T patent/PL3724190T3/pl unknown
- 2018-12-13 HU HUE18836520A patent/HUE059945T2/hu unknown
- 2018-12-13 CN CN201880089329.6A patent/CN111712498B/zh active Active
- 2018-12-13 MX MX2020006181A patent/MX2020006181A/es unknown
- 2018-12-13 CR CR20200263A patent/CR20200263A/es unknown
- 2018-12-13 HR HRP20221207TT patent/HRP20221207T1/hr unknown
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2020
- 2020-06-06 PH PH12020550881A patent/PH12020550881A1/en unknown
- 2020-06-11 CL CL2020001576A patent/CL2020001576A1/es unknown
- 2020-06-12 ZA ZA2020/03528A patent/ZA202003528B/en unknown
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2022
- 2022-05-06 US US17/738,370 patent/US11952380B2/en active Active
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