CU20150168A7 - 4-(5-(4-clorofenil)-2-(2-ciclopropilacetil)-1,4-dimetil-1h-pirrol-3-il)bencenosulfonamida como modulador de nachr alfa 7 - Google Patents

4-(5-(4-clorofenil)-2-(2-ciclopropilacetil)-1,4-dimetil-1h-pirrol-3-il)bencenosulfonamida como modulador de nachr alfa 7

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Publication number
CU20150168A7
CU20150168A7 CUP2015000168A CU20150168A CU20150168A7 CU 20150168 A7 CU20150168 A7 CU 20150168A7 CU P2015000168 A CUP2015000168 A CU P2015000168A CU 20150168 A CU20150168 A CU 20150168A CU 20150168 A7 CU20150168 A7 CU 20150168A7
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CU
Cuba
Prior art keywords
chlorophenyl
dimethyl
nachr
modulator
cyclopropilacetile
Prior art date
Application number
CUP2015000168A
Other languages
English (en)
Inventor
Neelima Sinha
Navnath Popat Karche
Ajay Ramchandra Tilekar
Venkata P Palle
Rajender Kumar Kamboj
Original Assignee
Lupin Ltd
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50981599&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CU20150168(A7) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lupin Ltd filed Critical Lupin Ltd
Publication of CU20150168A7 publication Critical patent/CU20150168A7/es

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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/333—Radicals substituted by oxygen or sulfur atoms

Abstract

Se describe un compuesto modulador del receptor nAChR alfa 7, 4-(5-(4-clorofenil)-2-(2-ciclopropilacetil)-1, 4-dimetil-1H-pirrol-3-il) bencenosulfonamida, su forma tautomérica, sus sales farmacéuticas aceptables, composiciones farmacéuticas que comprenden el compuesto o una sal de este, para el tratamiento de varias enfermedades, trastornos o afecciones, por ejemplo, enfermedad de Alzheimer, deterioro cognitivo leve, demencia senil, demencia vascular, demencia de la enfermedad de Parkinson y trastorno por déficit de atención.
CUP2015000168A 2013-06-03 2015-12-03 4-(5-(4-clorofenil)-2-(2-ciclopropilacetil)-1,4-dimetil-1h-pirrol-3-il)bencenosulfonamida como modulador de nachr alfa 7 CU20150168A7 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1937MU2013 2013-06-03
PCT/IB2014/061891 WO2014195848A1 (en) 2013-06-03 2014-06-02 4-(5-(4-chlorophenyl)-2-(2-cyclopropylacetyl)-1,4-dimethyl-1h-pyrrol-3-yl)benzenesulfonamide as alpha 7 nachr modulator

Publications (1)

Publication Number Publication Date
CU20150168A7 true CU20150168A7 (es) 2016-06-29

Family

ID=50981599

Family Applications (1)

Application Number Title Priority Date Filing Date
CUP2015000168A CU20150168A7 (es) 2013-06-03 2015-12-03 4-(5-(4-clorofenil)-2-(2-ciclopropilacetil)-1,4-dimetil-1h-pirrol-3-il)bencenosulfonamida como modulador de nachr alfa 7

Country Status (22)

Country Link
US (1) US9447037B2 (es)
EP (1) EP3004054A1 (es)
JP (1) JP2016520642A (es)
CN (1) CN105263905A (es)
AP (1) AP2015008884A0 (es)
AR (1) AR096462A1 (es)
AU (1) AU2014276436B2 (es)
BR (1) BR112015030171A2 (es)
CA (1) CA2912841A1 (es)
CL (1) CL2015003515A1 (es)
CR (1) CR20150646A (es)
CU (1) CU20150168A7 (es)
EA (1) EA201592247A1 (es)
IL (1) IL242837A0 (es)
MA (1) MA38697A1 (es)
MX (1) MX2015016539A (es)
PE (1) PE20160009A1 (es)
PH (1) PH12015502676A1 (es)
SG (1) SG11201509442RA (es)
TW (1) TW201446243A (es)
WO (1) WO2014195848A1 (es)
ZA (1) ZA201600021B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2764660T3 (es) 2014-12-16 2020-06-04 Axovant Sciences Gmbh Compuestos de amida de quinuclidina sustituida geminal como agonistas de receptores alfa-7 nicotínicos de acetilcolina
AU2016274694A1 (en) 2015-06-10 2018-01-18 Axovant Sciences Gmbh Aminobenzisoxazole compounds as agonists of A7-nicotinic acetylcholine receptors
WO2017027600A1 (en) 2015-08-12 2017-02-16 Forum Pharmaceuticals, Inc. GEMINAL SUBSTITUTED AMINOBENZISOXAZOLE COMPOUNDS AS AGONISTS OF α7-NICOTINIC ACETYLCHOLINE RECEPTORS
US9840481B2 (en) 2016-03-22 2017-12-12 Merck Sharp & Dohme Corp. Allosteric modulators of nicotinic acetylcholine receptors
US11382875B2 (en) * 2017-04-07 2022-07-12 Lundquist Institute For Biomedical Innovation At Harbor-Ucla Medical Center Methods and compositions for modulating β-amyloid/α7-nAChR interactions

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US5019369A (en) 1984-10-22 1991-05-28 Vestar, Inc. Method of targeting tumors in humans
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
CA2561639A1 (en) 2004-03-29 2005-10-06 Neurosearch A/S Novel urea derivatives and their medical use
US20060142349A1 (en) 2004-12-23 2006-06-29 Pfizer Inc Methods of modulating the activities of alpha-7 nicotinic acetylcholine receptor
ATE481407T1 (de) 2005-02-16 2010-10-15 Neurosearch As Neue diazabicyclische arylderivate und medizinische verwendung dafür
EA015034B1 (ru) 2005-09-13 2011-04-29 Янссен Фармацевтика Н.В. 2-анилин-4-арилзамещенные тиазольные производные
DE602007004307D1 (de) 2006-02-16 2010-03-04 Neurosearch As Enantiomerenreine chinuclidinyloxy-pyridazine und ihre verwendung als nikotin-acetylcholin-rezeptorliganden
JO3019B1 (ar) 2006-04-19 2016-09-05 Janssen Pharmaceutica Nv ثلاثي مستبدل 4،2،1-ثلاثي زولات
WO2008002956A2 (en) 2006-06-27 2008-01-03 Abbott Laboratories Thiazoline and oxazoline derivatives and their methods of use
MX2008016338A (es) 2006-06-27 2009-01-16 Abbott Lab Derivados de pirrol y sus metodos de uso.
JP2010535738A (ja) 2007-08-08 2010-11-25 ノイロサーチ アクティーゼルスカブ ニコチン性アセチルコリン受容体の調節物質として有用な新規１，２，３−トリアゾール誘導体
WO2009043780A1 (en) 2007-10-04 2009-04-09 F. Hoffmann-La Roche Ag Tetrazole-substituted aryl amide derivatives and uses thereof
MX2010003155A (es) 2007-10-04 2010-04-01 Hoffmann La Roche Derivados de ciclopropil aril amida y uso de los mismos.
JO2784B1 (en) 2007-10-18 2014-03-15 شركة جانسين فارماسوتيكا ان. في 5,3,1 - Triazole substitute derivative
AU2009226988B2 (en) 2008-03-19 2013-05-23 Janssen Pharmaceutica Nv Trisubstituted 1, 2, 4 -triazoles as nicotinic acetylcholine receptor modulators
US7786171B2 (en) 2008-04-04 2010-08-31 Abbott Laboratories Amide derivatives as positive allosteric modulators and methods of use thereof
US8377941B2 (en) 2008-04-17 2013-02-19 Proximagen Limited Indoles as modulators of nicotinic acetylcholine receptor subtype alpha-7
JP5486591B2 (ja) 2008-05-09 2014-05-07 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ アセチルコリン受容体モジュレーターとしての三置換ピラゾール
EP2387575B1 (en) 2009-01-15 2013-09-04 Anvyl, LLC Alpha7 nicotinic acetylcholine receptor allosteric modulators, their derivatives and uses thereof
US20120071469A1 (en) 2009-05-14 2012-03-22 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.1]octane derivatives useful as nicotinic acetylcholine receptor modulators
JO3250B1 (ar) 2009-09-22 2018-09-16 Novartis Ag إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7
JO3078B1 (ar) 2009-11-27 2017-03-15 Janssen Pharmaceutica Nv مورفولينوثيازولات بصفتها منظمات الوستيرية نوع الفا 7 موجبة
AU2012213086B2 (en) 2011-02-03 2016-05-05 Lupin Limited Pyrrole derivatives used as modulators of alpha7 nAChR
RS55433B1 (sr) * 2011-02-23 2017-04-28 Lupin Ltd Derivati heteroarila kao modulatori nachr alfa7
EP2691368A1 (en) 2011-03-31 2014-02-05 Lupin Limited Pyrrole derivatives as nicotinic acetylcholine receptor modulators for use in the treatment of neurodegenerative disorders such as alzheimer's and parkinson's disease
WO2013005153A1 (en) * 2011-07-05 2013-01-10 Lupin Limited Biaryl derivatives as nachr modulators
CA2866015A1 (en) 2012-03-06 2013-09-12 Lupin Limited Thiazole derivatives as alpha 7 nachr modulators
EP2945936A1 (en) 2012-11-12 2015-11-25 Lupin Limited Thiazole derivatives as alpha 7 nachr modulators
EP2945941B1 (en) 2013-01-16 2016-12-07 Lupin Limited Pyrrole derivatives as alpha 7 nachr modulators
US9617210B2 (en) 2013-03-13 2017-04-11 Lupin Limited Pyrrole derivatives as alpha 7 NACHR modulators

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Publication number Publication date
BR112015030171A2 (pt) 2017-07-25
IL242837A0 (en) 2016-02-01
CR20150646A (es) 2016-04-07
EA201592247A1 (ru) 2016-04-29
JP2016520642A (ja) 2016-07-14
CA2912841A1 (en) 2014-12-11
AU2014276436A1 (en) 2015-12-17
MA38697A1 (fr) 2017-03-31
MX2015016539A (es) 2016-04-15
EP3004054A1 (en) 2016-04-13
AR096462A1 (es) 2015-12-30
SG11201509442RA (en) 2015-12-30
WO2014195848A1 (en) 2014-12-11
AU2014276436B2 (en) 2017-03-02
CN105263905A (zh) 2016-01-20
PE20160009A1 (es) 2016-02-14
PH12015502676A1 (en) 2016-03-07
US9447037B2 (en) 2016-09-20
CL2015003515A1 (es) 2016-07-01
US20160107990A1 (en) 2016-04-21
TW201446243A (zh) 2014-12-16
AP2015008884A0 (en) 2015-11-30
ZA201600021B (en) 2017-05-31

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