CR20230170A - ANTICUERPOS ANTI-TREM2 Y MÉTODOS PARA UTILIZARLOS (divisional 2019-0485) - Google Patents
ANTICUERPOS ANTI-TREM2 Y MÉTODOS PARA UTILIZARLOS (divisional 2019-0485)Info
- Publication number
- CR20230170A CR20230170A CR20230170A CR20230170A CR20230170A CR 20230170 A CR20230170 A CR 20230170A CR 20230170 A CR20230170 A CR 20230170A CR 20230170 A CR20230170 A CR 20230170A CR 20230170 A CR20230170 A CR 20230170A
- Authority
- CR
- Costa Rica
- Prior art keywords
- trem2
- methods
- trem2 antibodies
- antibodies
- compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
La presente descripción hace referencia, en líneas generales, a composiciones que incluyen anticuerpos, por ejemplo, anticuerpos monoclonales, quiméricos, humanizados, fragmentos de anticuerpos, etc., que se unen específicamente a uno o más epítopos de una proteína CD33, por ejemplo, CD33 humana o CD33 de mamífero y tienen características funcionales mejoradas y/o potenciadas, y al uso de dichas composiciones para prevenir, reducir el riesgo y tratar a un individuo que lo necesite.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762541019P | 2017-08-03 | 2017-08-03 | |
US201862636095P | 2018-02-27 | 2018-02-27 | |
PCT/US2018/045068 WO2019028292A1 (en) | 2017-08-03 | 2018-08-02 | ANTI-TREM2 ANTIBODIES AND METHODS OF USE |
Publications (1)
Publication Number | Publication Date |
---|---|
CR20230170A true CR20230170A (es) | 2023-05-31 |
Family
ID=63364160
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR20190485A CR20190485A (es) | 2017-08-03 | 2018-08-02 | Anticuerpos anti-trem2 y métodos para utilizarlos |
CR20230170A CR20230170A (es) | 2017-08-03 | 2018-08-02 | ANTICUERPOS ANTI-TREM2 Y MÉTODOS PARA UTILIZARLOS (divisional 2019-0485) |
CR20230169A CR20230169A (es) | 2017-08-03 | 2018-08-02 | ANTICUERPOS ANTI-TREM2 Y MÉTODOS PARA UTILIZARLOS (divisional 2019-0485) |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR20190485A CR20190485A (es) | 2017-08-03 | 2018-08-02 | Anticuerpos anti-trem2 y métodos para utilizarlos |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR20230169A CR20230169A (es) | 2017-08-03 | 2018-08-02 | ANTICUERPOS ANTI-TREM2 Y MÉTODOS PARA UTILIZARLOS (divisional 2019-0485) |
Country Status (30)
Country | Link |
---|---|
US (3) | US10676525B2 (es) |
EP (2) | EP4248996A3 (es) |
JP (2) | JP2020533948A (es) |
KR (1) | KR20200033794A (es) |
CN (1) | CN110621696A (es) |
AU (1) | AU2018311055A1 (es) |
BR (1) | BR112019022752A2 (es) |
CA (1) | CA3061755A1 (es) |
CL (2) | CL2019003093A1 (es) |
CO (1) | CO2019012210A2 (es) |
CR (3) | CR20190485A (es) |
DK (1) | DK3601358T3 (es) |
EC (1) | ECSP19078429A (es) |
ES (1) | ES2952982T3 (es) |
FI (1) | FI3601358T3 (es) |
HR (1) | HRP20230675T1 (es) |
HU (1) | HUE062436T2 (es) |
LT (1) | LT3601358T (es) |
MD (1) | MD3601358T2 (es) |
MX (1) | MX2019012868A (es) |
NZ (1) | NZ758301A (es) |
PE (1) | PE20200148A1 (es) |
PH (1) | PH12019502459A1 (es) |
PL (1) | PL3601358T3 (es) |
PT (1) | PT3601358T (es) |
RS (1) | RS64419B1 (es) |
SI (1) | SI3601358T1 (es) |
TW (2) | TWI811229B (es) |
WO (1) | WO2019028292A1 (es) |
ZA (2) | ZA201906730B (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6669749B2 (ja) | 2014-08-08 | 2020-03-18 | アレクトル エルエルシー | 抗trem2抗体及びその使用方法 |
CN106999585A (zh) | 2014-09-28 | 2017-08-01 | 加利福尼亚大学董事会 | 对刺激性和非刺激性骨髓细胞的调节 |
JOP20190248A1 (ar) | 2017-04-21 | 2019-10-20 | Amgen Inc | بروتينات ربط مولد ضد trem2 واستخداماته |
ES2952982T3 (es) | 2017-08-03 | 2023-11-07 | Alector Llc | Anticuerpos anti-TREM2 y métodos de uso de los mismos |
EP3723803A4 (en) | 2017-12-12 | 2021-09-15 | Pionyr Immunotherapeutics, Inc. | ANTI-TREM2 ANTIBODIES AND RELATED METHODS |
EP3887401A2 (en) | 2018-11-26 | 2021-10-06 | Denali Therapeutics Inc. | Methods for treating dysregulated lipid metabolism |
EA202192294A1 (ru) | 2019-02-20 | 2021-12-24 | Денали Терапьютикс Инк. | Антитела к trem2 и способы их применения |
IL293018A (en) | 2019-11-22 | 2022-07-01 | Lilly Co Eli | trem2 antibodies and their uses |
CN115003699A (zh) | 2019-12-05 | 2022-09-02 | 艾利妥 | 抗trem2抗体的使用方法 |
WO2021146256A1 (en) | 2020-01-13 | 2021-07-22 | Denali Therapeutics Inc. | Anti-trem2 antibodies and methods of use thereof |
KR20220131246A (ko) | 2020-01-13 | 2022-09-27 | 데날리 테라퓨틱스 인크. | 항-trem2 항체 및 이의 사용 방법 |
WO2021173565A1 (en) | 2020-02-24 | 2021-09-02 | Alector Llc | Methods of use of anti-trem2 antibodies |
CA3172451A1 (en) | 2020-04-03 | 2021-10-07 | Robert Paul | Methods of use of anti-trem2 antibodies |
BR112023023777A2 (pt) | 2021-05-14 | 2024-01-30 | Genentech Inc | Anticorpos isolados, composição farmacêutica, ácido nucleico isolado, vetor isolado, célula hospedeira isolada, método para produzir um anticorpo, método para tratar uma condição associada à perda de função de trem2, método para reduzir os níveis de strem2 e uso de um anticorpo |
WO2023114499A1 (en) | 2021-12-17 | 2023-06-22 | Denali Therapeutics Inc. | Polypeptide engineering, libraries, and engineered cd98 heavy chain and transferrin receptor binding polypeptides |
WO2023164516A1 (en) | 2022-02-23 | 2023-08-31 | Alector Llc | Methods of use of anti-trem2 antibodies |
WO2023192288A1 (en) | 2022-03-28 | 2023-10-05 | Denali Therapeutics Inc. | Monovalent anti-trem2 binding molecules and methods of use thereof |
WO2023192282A1 (en) | 2022-03-28 | 2023-10-05 | Denali Therapeutics Inc. | Methods for treating brain glucose hypometabolism |
WO2024040195A1 (en) | 2022-08-17 | 2024-02-22 | Capstan Therapeutics, Inc. | Conditioning for in vivo immune cell engineering |
WO2024052343A1 (en) | 2022-09-06 | 2024-03-14 | Institut National de la Santé et de la Recherche Médicale | Trem-2 agonists for the treatment of marfan syndrome |
Family Cites Families (118)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4657760A (en) | 1979-03-20 | 1987-04-14 | Ortho Pharmaceutical Corporation | Methods and compositions using monoclonal antibody to human T cells |
DK187280A (da) | 1980-04-30 | 1981-10-31 | Novo Industri As | Ruhedsreducerende middel til et fuldvaskemiddel fuldvaskemiddel og fuldvaskemetode |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US5206344A (en) | 1985-06-26 | 1993-04-27 | Cetus Oncology Corporation | Interleukin-2 muteins and polymer conjugation thereof |
GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
US5225212A (en) | 1989-10-20 | 1993-07-06 | Liposome Technology, Inc. | Microreservoir liposome composition and method |
US5959177A (en) | 1989-10-27 | 1999-09-28 | The Scripps Research Institute | Transgenic plants expressing assembled secretory antibodies |
DE69120146T2 (de) | 1990-01-12 | 1996-12-12 | Cell Genesys Inc | Erzeugung xenogener antikörper |
US6075181A (en) | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
ES2246502T3 (es) | 1990-08-29 | 2006-02-16 | Genpharm International, Inc. | Animales no humanos transgenicos capaces de producir anticuerpos heterologos. |
US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
US5571894A (en) | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
US7018809B1 (en) | 1991-09-19 | 2006-03-28 | Genentech, Inc. | Expression of functional antibody fragments |
ES2136092T3 (es) | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
US5587458A (en) | 1991-10-07 | 1996-12-24 | Aronex Pharmaceuticals, Inc. | Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof |
WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
JPH07501451A (ja) | 1991-11-25 | 1995-02-16 | エンゾン・インコーポレイテッド | 多価抗原結合タンパク質 |
AU675929B2 (en) | 1992-02-06 | 1997-02-27 | Curis, Inc. | Biosynthetic binding protein for cancer marker |
US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
ATE149570T1 (de) | 1992-08-17 | 1997-03-15 | Genentech Inc | Bispezifische immunoadhesine |
US5789199A (en) | 1994-11-03 | 1998-08-04 | Genentech, Inc. | Process for bacterial production of polypeptides |
US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
US5840523A (en) | 1995-03-01 | 1998-11-24 | Genetech, Inc. | Methods and compositions for secretion of heterologous polypeptides |
US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
US5739277A (en) | 1995-04-14 | 1998-04-14 | Genentech Inc. | Altered polypeptides with increased half-life |
ES2304786T3 (es) | 1995-04-27 | 2008-10-16 | Amgen Fremont Inc. | Anticuerpos anti-il-8 humanos, derivados a partir de xenoratones inmunizados. |
EP0823941A4 (en) | 1995-04-28 | 2001-09-19 | Abgenix Inc | HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES |
AU7378096A (en) | 1995-09-28 | 1997-04-17 | Alexion Pharmaceuticals, Inc. | Porcine cell interaction proteins |
DE19544393A1 (de) | 1995-11-15 | 1997-05-22 | Hoechst Schering Agrevo Gmbh | Synergistische herbizide Mischungen |
DK1500329T3 (da) | 1996-12-03 | 2012-07-09 | Amgen Fremont Inc | Humane antistoffer, der specifikt binder TNF-alfa |
US6040498A (en) | 1998-08-11 | 2000-03-21 | North Caroline State University | Genetically engineered duckweed |
ATE531812T1 (de) | 1997-12-05 | 2011-11-15 | Scripps Research Inst | Humanisierung von nager-antikörpern |
GB9809951D0 (en) | 1998-05-08 | 1998-07-08 | Univ Cambridge Tech | Binding molecules |
CA2331386A1 (en) | 1998-06-26 | 2000-01-06 | Incyte Pharmaceuticals, Inc. | Human signal peptide-containing proteins |
AU782626B2 (en) | 1999-10-04 | 2005-08-18 | Medicago Inc. | Method for regulating transcription of foreign genes |
US7125978B1 (en) | 1999-10-04 | 2006-10-24 | Medicago Inc. | Promoter for regulating expression of foreign genes |
US6849425B1 (en) * | 1999-10-14 | 2005-02-01 | Ixsys, Inc. | Methods of optimizing antibody variable region binding affinity |
ES2528794T3 (es) | 2000-04-11 | 2015-02-12 | Genentech, Inc. | Anticuerpos multivalentes y usos de los mismos |
CA2342376C (en) | 2001-03-20 | 2013-11-12 | Marco Colonna | A receptor trem (triggering receptor expressed on myeloid cells) and uses thereof |
US20090081199A1 (en) | 2001-03-20 | 2009-03-26 | Bioxell S.P.A. | Novel receptor trem (triggering receptor expressed on myeloid cells) and uses thereof |
US8231878B2 (en) | 2001-03-20 | 2012-07-31 | Cosmo Research & Development S.P.A. | Receptor trem (triggering receptor expressed on myeloid cells) and uses thereof |
US8981061B2 (en) | 2001-03-20 | 2015-03-17 | Novo Nordisk A/S | Receptor TREM (triggering receptor expressed on myeloid cells) and uses thereof |
EP2316485A1 (en) | 2001-10-12 | 2011-05-04 | Schering Corporation | Use of bispecific antibodies to regulate immune responses |
US7556926B2 (en) | 2002-05-24 | 2009-07-07 | Takeda Pharmaceuticals Company Ltd. | Methods for screening insulin-sensitizing agents |
JP2004073182A (ja) | 2002-05-24 | 2004-03-11 | Takeda Chem Ind Ltd | インスリン抵抗性改善剤 |
US20040119010A1 (en) | 2002-11-01 | 2004-06-24 | The Regents Of The University Of Colorado | Quantitative analysis of protein isoforms using matrix-assisted laser desorption/ionization time of flight mass spectrometry |
WO2004041170A2 (en) | 2002-11-01 | 2004-05-21 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
AU2003303384A1 (en) | 2002-12-23 | 2004-07-22 | Schering Corporation | Uses of mammalian cytokine; related reagents |
WO2004074506A2 (en) | 2003-02-13 | 2004-09-02 | Mergen Ltd | Polynucleotide sequences and corresponding encoded polypeptides of particular secreted and membrane-bound proteins overexpressed in certain cancers |
JP2008526205A (ja) | 2004-12-31 | 2008-07-24 | ジェネンテック・インコーポレーテッド | Br3に結合するポリペプチド及びその使用 |
US7700099B2 (en) | 2005-02-14 | 2010-04-20 | Merck & Co., Inc. | Non-immunostimulatory antibody and compositions containing the same |
US8101345B1 (en) | 2005-03-25 | 2012-01-24 | Isis Pharmaceuticals, Inc. | Proinflammatory nucleic acids |
US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
EP4316465A3 (en) | 2006-03-15 | 2024-04-24 | Alexion Pharmaceuticals, Inc. | Treatment of paroxysmal nocturnal hemoglobinuria patients by an inhibitor of complement |
DE202006007499U1 (de) | 2006-05-11 | 2007-01-11 | Osaka University | Verwendung einer Zusammensetzung, die Plexin-A1-DAP12-Interaktion inhibiert, zur Behandlung von Entzündungs-, Autoimmun- oder Knochenresorptionserkrankungen |
JP2009539413A (ja) | 2006-06-12 | 2009-11-19 | トゥルビオン・ファーマシューティカルズ・インコーポレーテッド | エフェクター機能を有する単鎖多価結合タンパク質 |
US8093360B2 (en) * | 2006-09-28 | 2012-01-10 | Elusys Therapeutics, Inc. | Antibodies that bind B. anthracis exotoxin, formulations thereof, and methods of use |
US7673853B2 (en) | 2006-10-12 | 2010-03-09 | Cordell Eldred Ebeling | Fencing section with adjustable fencing members |
UY30776A1 (es) | 2006-12-21 | 2008-07-03 | Medarex Inc | Anticuerpos cd44 |
CA2675583A1 (en) * | 2007-01-16 | 2008-07-24 | Wyeth | Inflammation treatment, detection and monitoring via trem-1 |
EP2193146B1 (en) | 2007-09-14 | 2016-05-25 | Adimab, LLC | Rationally designed, synthetic antibody libraries and uses therefor |
US8877688B2 (en) | 2007-09-14 | 2014-11-04 | Adimab, Llc | Rationally designed, synthetic antibody libraries and uses therefor |
US20100203047A1 (en) | 2007-10-05 | 2010-08-12 | University Of Maryland, Baltimore | Novel Compositions And Methods For Stimulating Erythropoiesis In A Mammal |
KR100960684B1 (ko) | 2008-02-22 | 2010-05-31 | 전남대학교산학협력단 | Ga733-2 발현 억제제로서의 trem-2 유전자, 및 이를포함하는 형질전환 동물 및 이의 사용방법 |
EP2186928A1 (en) | 2008-11-14 | 2010-05-19 | Enthone, Inc. | Method for the post-treatment of metal layers |
FR2945538B1 (fr) | 2009-05-12 | 2014-12-26 | Sanofi Aventis | Anticorps humanises specifiques de la forme protofibrillaire du peptide beta-amyloide. |
US8513185B2 (en) | 2009-10-13 | 2013-08-20 | Alexander B. Sigalov | Inhibition of TREM receptor signaling with peptide variants |
EP2507381A4 (en) | 2009-12-04 | 2016-07-20 | Hoffmann La Roche | PLURISPECIFIC ANTIBODIES, ANTIBODY ANALOGUES, COMPOSITIONS AND METHODS |
TWI653333B (zh) * | 2010-04-01 | 2019-03-11 | 安進研究(慕尼黑)有限責任公司 | 跨物種專一性之PSMAxCD3雙專一性單鏈抗體 |
EP4219805A1 (en) | 2010-07-16 | 2023-08-02 | Adimab, LLC | Antibody libraries |
UA112062C2 (uk) | 2010-10-04 | 2016-07-25 | Бьорінгер Інгельхайм Інтернаціональ Гмбх | Cd33-зв'язувальний агент |
UY33826A (es) | 2010-12-22 | 2012-07-31 | Abbott Lab | Proteínas de unión con dominios trivariables y sus usos |
UY33827A (es) | 2010-12-22 | 2012-07-31 | Abbott Lab | Proteínas de unión a media-inmunoglobulina y sus usos |
TWI559929B (en) * | 2011-09-01 | 2016-12-01 | Sanofi Aventis Deutschland | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
US20130309223A1 (en) | 2012-05-18 | 2013-11-21 | Seattle Genetics, Inc. | CD33 Antibodies And Use Of Same To Treat Cancer |
WO2014074942A1 (en) | 2012-11-08 | 2014-05-15 | Illumina, Inc. | Risk variants of alzheimer's disease |
CA2825821A1 (en) | 2013-08-28 | 2015-02-28 | Chiesi Farmaceutici S.P.A. | 1-phenylalkanecarboxylic acid derivatives for the treatment of alzheimer's disease and multiple sclerosis |
WO2015037000A1 (en) | 2013-09-11 | 2015-03-19 | Compugen Ltd | Vstm5 polypeptides and uses thereof as a drug for treatment of cancer, infectious diseases and immune related diseases |
US20170218091A1 (en) | 2014-07-03 | 2017-08-03 | Abbvie Inc. | Monovalent binding proteins |
JP6669749B2 (ja) * | 2014-08-08 | 2020-03-18 | アレクトル エルエルシー | 抗trem2抗体及びその使用方法 |
MA40764A (fr) | 2014-09-26 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Agent thérapeutique induisant une cytotoxicité |
CN106999585A (zh) * | 2014-09-28 | 2017-08-01 | 加利福尼亚大学董事会 | 对刺激性和非刺激性骨髓细胞的调节 |
WO2016064895A1 (en) * | 2014-10-20 | 2016-04-28 | The Brigham And Women's Hospital, Inc. | Targeting apolipoprotein e (apoe) in neurologic disease |
CN107709364A (zh) | 2015-04-07 | 2018-02-16 | 豪夫迈·罗氏有限公司 | 具有激动剂活性的抗原结合复合体及使用方法 |
WO2016187339A1 (en) | 2015-05-18 | 2016-11-24 | Synaptec Development Llc | GALANTAMINE CLEARANCE OF AMYLOIDß |
WO2017011342A1 (en) | 2015-07-10 | 2017-01-19 | Abbvie Inc. | Igm-or-ige-modified binding proteins and uses thereof |
WO2017058866A1 (en) | 2015-09-28 | 2017-04-06 | Precision Immune, Inc. | Anti-trem2 antibodies and uses thereof |
CN117069841A (zh) * | 2015-10-06 | 2023-11-17 | 艾利妥 | 抗trem2抗体及其使用方法 |
KR102415925B1 (ko) * | 2016-01-11 | 2022-07-04 | 삼성디스플레이 주식회사 | 표시장치 |
WO2017147509A1 (en) | 2016-02-25 | 2017-08-31 | Marco Colonna | Compositions comprising trem2 and methods of use thereof |
WO2018015573A2 (en) | 2016-07-22 | 2018-01-25 | Deutsches Zentrum Für Neurodegenerative Erkrankungen E.V. (Dzne) | Trem2 cleavage modulators and uses thereof |
CN109843916B (zh) | 2016-08-12 | 2023-10-31 | 詹森生物科技公司 | 具有增强的激动活性的Fc工程化抗TNFR超家族成员抗体及其使用方法 |
EP3570883A2 (en) | 2017-01-17 | 2019-11-27 | Yeda Research and Development Co. Ltd | Methods of treating neurodegenerative diseases by inducing disease-associated microglia (dam) cells |
CA3049791A1 (en) | 2017-01-27 | 2018-08-02 | Silverback Therapeutics, Inc. | Tumor targeting conjugates and methods of use thereof |
US10457717B2 (en) | 2017-02-17 | 2019-10-29 | Denali Therapeutics Inc. | Engineered polypeptides |
JOP20190248A1 (ar) * | 2017-04-21 | 2019-10-20 | Amgen Inc | بروتينات ربط مولد ضد trem2 واستخداماته |
US20190008812A1 (en) | 2017-07-07 | 2019-01-10 | Washington University | Methods for treating microglial dysfunction |
KR20200032722A (ko) | 2017-07-27 | 2020-03-26 | 노파르티스 아게 | 부분절단효소 내성 trem2 변이체 |
ES2952982T3 (es) | 2017-08-03 | 2023-11-07 | Alector Llc | Anticuerpos anti-TREM2 y métodos de uso de los mismos |
CN117700548A (zh) | 2017-08-03 | 2024-03-15 | 艾利妥 | 抗cd33抗体及其使用方法 |
CA3075285A1 (en) | 2017-09-14 | 2019-03-21 | Denali Therapeutics Inc. | Anti-trem2 antibodies and methods of use thereof |
AU2018346105C1 (en) | 2017-10-03 | 2023-10-12 | Prevail Therapeutics, Inc. | Gene therapies for lysosomal disorders |
US20210186917A1 (en) | 2017-10-17 | 2021-06-24 | The Translational Genomics Research Institute | Trem2 agonists for the stimulation of microglia and methods of identification |
EP3723803A4 (en) | 2017-12-12 | 2021-09-15 | Pionyr Immunotherapeutics, Inc. | ANTI-TREM2 ANTIBODIES AND RELATED METHODS |
AU2019222760A1 (en) | 2018-02-14 | 2020-09-10 | Yale University | Compositions for modulation of a TREM or TREML protein and methods of use |
CA3172451A1 (en) * | 2020-04-03 | 2021-10-07 | Robert Paul | Methods of use of anti-trem2 antibodies |
BR112023023777A2 (pt) * | 2021-05-14 | 2024-01-30 | Genentech Inc | Anticorpos isolados, composição farmacêutica, ácido nucleico isolado, vetor isolado, célula hospedeira isolada, método para produzir um anticorpo, método para tratar uma condição associada à perda de função de trem2, método para reduzir os níveis de strem2 e uso de um anticorpo |
-
2018
- 2018-08-02 ES ES18759461T patent/ES2952982T3/es active Active
- 2018-08-02 BR BR112019022752A patent/BR112019022752A2/pt unknown
- 2018-08-02 CR CR20190485A patent/CR20190485A/es unknown
- 2018-08-02 CA CA3061755A patent/CA3061755A1/en active Pending
- 2018-08-02 CR CR20230170A patent/CR20230170A/es unknown
- 2018-08-02 JP JP2019559017A patent/JP2020533948A/ja active Pending
- 2018-08-02 WO PCT/US2018/045068 patent/WO2019028292A1/en active Application Filing
- 2018-08-02 LT LTEPPCT/US2018/045068T patent/LT3601358T/lt unknown
- 2018-08-02 FI FIEP18759461.9T patent/FI3601358T3/fi active
- 2018-08-02 RS RS20230644A patent/RS64419B1/sr unknown
- 2018-08-02 EP EP23166216.4A patent/EP4248996A3/en active Pending
- 2018-08-02 HR HRP20230675TT patent/HRP20230675T1/hr unknown
- 2018-08-02 TW TW107126810A patent/TWI811229B/zh active
- 2018-08-02 CR CR20230169A patent/CR20230169A/es unknown
- 2018-08-02 SI SI201830958T patent/SI3601358T1/sl unknown
- 2018-08-02 EP EP18759461.9A patent/EP3601358B1/en active Active
- 2018-08-02 MD MDE20200147T patent/MD3601358T2/ro unknown
- 2018-08-02 AU AU2018311055A patent/AU2018311055A1/en active Pending
- 2018-08-02 NZ NZ758301A patent/NZ758301A/en unknown
- 2018-08-02 HU HUE18759461A patent/HUE062436T2/hu unknown
- 2018-08-02 MX MX2019012868A patent/MX2019012868A/es unknown
- 2018-08-02 PL PL18759461.9T patent/PL3601358T3/pl unknown
- 2018-08-02 TW TW112126799A patent/TW202342547A/zh unknown
- 2018-08-02 PT PT187594619T patent/PT3601358T/pt unknown
- 2018-08-02 DK DK18759461.9T patent/DK3601358T3/da active
- 2018-08-02 PE PE2019002183A patent/PE20200148A1/es unknown
- 2018-08-02 KR KR1020197031793A patent/KR20200033794A/ko not_active Application Discontinuation
- 2018-08-02 CN CN201880027792.8A patent/CN110621696A/zh active Pending
- 2018-08-03 US US16/054,680 patent/US10676525B2/en active Active
-
2019
- 2019-10-11 ZA ZA2019/06730A patent/ZA201906730B/en unknown
- 2019-10-28 CL CL2019003093A patent/CL2019003093A1/es unknown
- 2019-10-30 CO CONC2019/0012210A patent/CO2019012210A2/es unknown
- 2019-10-30 PH PH12019502459A patent/PH12019502459A1/en unknown
- 2019-10-31 EC ECSENADI201978429A patent/ECSP19078429A/es unknown
-
2020
- 2020-03-30 US US16/835,140 patent/US11634489B2/en active Active
- 2020-07-28 CL CL2020001974A patent/CL2020001974A1/es unknown
-
2022
- 2022-10-10 ZA ZA2022/11057A patent/ZA202211057B/en unknown
- 2022-11-22 JP JP2022186859A patent/JP2023029882A/ja active Pending
-
2023
- 2023-02-24 US US18/174,499 patent/US20230312712A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA202211057B (en) | Anti-trem2 antibodies and methods of use thereof | |
CR20200566A (es) | Anticuerpos anti-sirpa y metodos de utilización de los mismos | |
MX2017012802A (es) | Anticuerpos antisortilina y métodos para su uso. | |
WO2017062672A3 (en) | Anti-trem2 antibodies and methods of use thereof | |
WO2017075432A3 (en) | Anti-siglec-9 antibodies and methods of use thereof | |
WO2017152102A3 (en) | Anti-trem1 antibodies and methods of use thereof | |
PH12019502463A1 (en) | Anti-cd33 antibodies and methods of use thereof | |
WO2016201388A3 (en) | Anti-cd33 antibodies and methods of use thereof | |
WO2016201389A3 (en) | Anti-cd33 antibodies and methods of use thereof | |
CR20210057A (es) | Anticuerpos anti-sortilina y métodos para su uso | |
MX2023000334A (es) | Anticuerpos anti-trem2 y metodos de uso de los mismos. | |
MX2020013324A (es) | Anticuerpos anti proteína reguladora de señales beta 1 (sirp-beta1) y métodos de uso de los mismos. | |
CR20210155A (es) | Anticuerpos anti-cd33 y métodos para usarlos | |
MX2022007231A (es) | Anticuerpos anti-mertk y metodos de uso de los mismos. | |
MX2021000933A (es) | Anticuerpos anti-siglec-5 y métodos para su uso. | |
MX2022001260A (es) | Anticuerpos anti-ms4a4a y metodos de uso de los mismos. | |
MX2021015212A (es) | Anticuerpos antisortilina para uso en terapia. | |
MX2019009498A (es) | Anticuerpos mimeticos de fgf21 y usos de los mismos. | |
MX2020013172A (es) | Anticuerpos anti-siglec-7 y sus metodos de uso. | |
MX2015009819A (es) | Anticuerpo humano especifico a metapneumovirus humano, o fragmento de union al antigeno del mismo. | |
EA201992324A1 (ru) | Анти-trem2 антитела и способы их применения |