MX2022001260A - Anticuerpos anti-ms4a4a y metodos de uso de los mismos. - Google Patents

Anticuerpos anti-ms4a4a y metodos de uso de los mismos.

Info

Publication number
MX2022001260A
MX2022001260A MX2022001260A MX2022001260A MX2022001260A MX 2022001260 A MX2022001260 A MX 2022001260A MX 2022001260 A MX2022001260 A MX 2022001260A MX 2022001260 A MX2022001260 A MX 2022001260A MX 2022001260 A MX2022001260 A MX 2022001260A
Authority
MX
Mexico
Prior art keywords
ms4a4a
antibodies
methods
compositions
mammalian
Prior art date
Application number
MX2022001260A
Other languages
English (en)
Inventor
Jeonghoon Sun
Arnon Rosenthal
Hua Long
Herve Rhinn
Wei-Hsien Ho
Muhammad A Alhawagri
Philip Ling Kong
Karpagam Srinivasan
Ananya Mitra
Daniel P Bermingham
Klaus-Dieter Heger
Santiago Viveros Salazar
Francesca Cignarella
Ilaria Tassi
Tina Schwabe
Angie Grace Yee
Original Assignee
Alector Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alector Llc filed Critical Alector Llc
Publication of MX2022001260A publication Critical patent/MX2022001260A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

La presente invención está dirigida en general a composiciones que comprenden anticuerpos, tales como por ejemplo, anticuerpos monoclonales, anticuerpos humanizados y fragmentos de anticuerpos, que se ligan específicamente a un polipéptido MS4A4A, por ejemplo, un MS4A4A de mamífero o un MS4A4A humano, y al uso de dichas composiciones para la prevención, la reducción del riesgo o el tratamiento de un individuo que las necesita.
MX2022001260A 2019-07-31 2020-07-30 Anticuerpos anti-ms4a4a y metodos de uso de los mismos. MX2022001260A (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201962881187P 2019-07-31 2019-07-31
US201962892467P 2019-08-27 2019-08-27
US201962947449P 2019-12-12 2019-12-12
US202062960606P 2020-01-13 2020-01-13
US202063057142P 2020-07-27 2020-07-27
PCT/US2020/044335 WO2021022083A2 (en) 2019-07-31 2020-07-30 Anti-ms4a4a antibodies and methods of use thereof

Publications (1)

Publication Number Publication Date
MX2022001260A true MX2022001260A (es) 2022-04-18

Family

ID=72139691

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022001260A MX2022001260A (es) 2019-07-31 2020-07-30 Anticuerpos anti-ms4a4a y metodos de uso de los mismos.

Country Status (17)

Country Link
US (2) US11667699B2 (es)
EP (1) EP4003519A2 (es)
JP (1) JP2022542964A (es)
KR (1) KR20220058540A (es)
CN (1) CN114341181A (es)
AU (1) AU2020321969A1 (es)
BR (1) BR112022001733A2 (es)
CA (1) CA3145885A1 (es)
CL (1) CL2022000230A1 (es)
CO (1) CO2022000832A2 (es)
CR (1) CR20220078A (es)
EC (1) ECSP22015044A (es)
IL (1) IL289952A (es)
MX (1) MX2022001260A (es)
PE (1) PE20220487A1 (es)
TW (1) TW202120547A (es)
WO (1) WO2021022083A2 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111971301A (zh) 2018-01-31 2020-11-20 艾莱克特有限责任公司 抗ms4a4a抗体及其使用方法
US11667699B2 (en) 2019-07-31 2023-06-06 Alector Llc Anti-MS4A4A antibodies and methods of use thereof
TW202405020A (zh) * 2022-07-29 2024-02-01 美商阿列克特有限責任公司 轉鐵蛋白受體抗原結合域及其用途
WO2024026447A1 (en) * 2022-07-29 2024-02-01 Alector Llc Anti-gpnmb antibodies and methods of use thereof
WO2024086796A1 (en) 2022-10-20 2024-04-25 Alector Llc Anti-ms4a4a antibodies with amyloid-beta therapies

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Also Published As

Publication number Publication date
KR20220058540A (ko) 2022-05-09
WO2021022083A2 (en) 2021-02-04
PE20220487A1 (es) 2022-04-04
CO2022000832A2 (es) 2022-04-29
US20210079074A1 (en) 2021-03-18
WO2021022083A3 (en) 2021-03-11
EP4003519A2 (en) 2022-06-01
CA3145885A1 (en) 2021-02-04
CN114341181A (zh) 2022-04-12
CL2022000230A1 (es) 2022-10-07
JP2022542964A (ja) 2022-10-07
BR112022001733A2 (pt) 2022-06-28
US11667699B2 (en) 2023-06-06
ECSP22015044A (es) 2022-03-31
AU2020321969A1 (en) 2022-03-17
CR20220078A (es) 2022-06-24
US20240076362A1 (en) 2024-03-07
IL289952A (en) 2022-03-01
TW202120547A (zh) 2021-06-01

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