CR20190481A - Composiciones de anticuerpo optimizados para el tratamiento de trastornos oculares - Google Patents
Composiciones de anticuerpo optimizados para el tratamiento de trastornos ocularesInfo
- Publication number
- CR20190481A CR20190481A CR20190481A CR20190481A CR20190481A CR 20190481 A CR20190481 A CR 20190481A CR 20190481 A CR20190481 A CR 20190481A CR 20190481 A CR20190481 A CR 20190481A CR 20190481 A CR20190481 A CR 20190481A
- Authority
- CR
- Costa Rica
- Prior art keywords
- treatment
- ocular disorders
- antibody compositions
- optimized antibody
- polymers
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
La presente invención provee conjugados de anticuerpo que incluyen anticuerpos (por ejemplo, anticuerpos anti-VEGF) unidos de forma covalente a polímeros (por ejemplo, polímeros de ácido hialurónico (HA)), anticuerpos modificados con cisteína, composiciones farmacéuticas de estos y 5 sus usos, por ejemplo, para el tratamiento de trastornos asociados a angiogénesis patológica (por ejemplo, trastornos oculares).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762475163P | 2017-03-22 | 2017-03-22 | |
PCT/US2018/023812 WO2018175752A1 (en) | 2017-03-22 | 2018-03-22 | Optimized antibody compositions for treatment of ocular disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
CR20190481A true CR20190481A (es) | 2020-01-06 |
Family
ID=61837830
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR20190481A CR20190481A (es) | 2017-03-22 | 2018-03-22 | Composiciones de anticuerpo optimizados para el tratamiento de trastornos oculares |
Country Status (18)
Country | Link |
---|---|
US (2) | US11111291B2 (es) |
EP (1) | EP3600442A1 (es) |
JP (2) | JP7227151B2 (es) |
KR (1) | KR20190138636A (es) |
AR (1) | AR111249A1 (es) |
AU (1) | AU2018237359A1 (es) |
BR (1) | BR112019019706A2 (es) |
CA (1) | CA3056248A1 (es) |
CL (1) | CL2019002658A1 (es) |
CO (1) | CO2019011582A2 (es) |
CR (1) | CR20190481A (es) |
IL (1) | IL269378A (es) |
MA (1) | MA49279A (es) |
MX (1) | MX2019011141A (es) |
PE (1) | PE20191758A1 (es) |
PH (1) | PH12019502149A1 (es) |
SG (1) | SG11201908650PA (es) |
WO (1) | WO2018175752A1 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2009228217A1 (en) | 2008-03-28 | 2009-10-01 | The Regents Of The University Of California | Polypeptide-polymer conjugates and methods of use thereof |
US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
WO2017100470A1 (en) | 2015-12-09 | 2017-06-15 | The Regents Of The University Of California | Methods of treating an ocular disease or disorder |
AU2016381964B2 (en) | 2015-12-30 | 2024-02-15 | Kodiak Sciences Inc. | Antibodies and conjugates thereof |
AU2020326243A1 (en) * | 2019-08-06 | 2022-02-17 | F. Hoffmann-La Roche Ag | Personalized treatment of ophthalmologic diseases |
BR112022003282A2 (pt) * | 2019-08-23 | 2022-05-24 | Igm Biosciences Inc | Glicovariantes de igm |
WO2021072265A1 (en) * | 2019-10-10 | 2021-04-15 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
WO2021231866A2 (en) * | 2020-05-15 | 2021-11-18 | The Regents Of The University Of Michigan | Carbon nanotubes and complexes thereof for treating and detecting ocular tumors |
US20230242633A1 (en) * | 2020-07-07 | 2023-08-03 | Kanaph Therapeutics Inc. | Fusion protein including complement pathway inhibitor and angiogenesis inhibitor and use thereof |
CN114106190A (zh) | 2020-08-31 | 2022-03-01 | 普米斯生物技术(珠海)有限公司 | 一种抗vegf/pd-l1双特异性抗体及其用途 |
EP4147709A1 (en) * | 2021-09-14 | 2023-03-15 | The Provost, Fellows, Foundation Scholars, and The Other Members of Board, of The College of The Holy and Undivided Trinity of Queen Elizabeth | A composition comprising il-36 and/or il-18 for use in treating ocular disorders |
KR20230105972A (ko) * | 2022-01-05 | 2023-07-12 | 주식회사 카나프테라퓨틱스 | 혈관신생 억제제가 결합된 항-C3b 항체 또는 항-C5 항체 및 이의 용도 |
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- 2018-03-22 KR KR1020197027884A patent/KR20190138636A/ko not_active Application Discontinuation
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- 2018-03-22 SG SG11201908650P patent/SG11201908650PA/en unknown
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MX2019011141A (es) | 2019-11-05 |
US11891437B2 (en) | 2024-02-06 |
CO2019011582A2 (es) | 2019-10-31 |
PH12019502149A1 (en) | 2020-06-29 |
JP2020514376A (ja) | 2020-05-21 |
EP3600442A1 (en) | 2020-02-05 |
AU2018237359A1 (en) | 2019-10-10 |
US20210363231A1 (en) | 2021-11-25 |
WO2018175752A8 (en) | 2018-11-15 |
IL269378A (en) | 2019-11-28 |
WO2018175752A1 (en) | 2018-09-27 |
RU2019132064A3 (es) | 2021-07-26 |
MA49279A (fr) | 2020-02-05 |
TW201838649A (zh) | 2018-11-01 |
CL2019002658A1 (es) | 2019-12-27 |
US11111291B2 (en) | 2021-09-07 |
JP2023065424A (ja) | 2023-05-12 |
CA3056248A1 (en) | 2018-09-27 |
KR20190138636A (ko) | 2019-12-13 |
US20200002411A1 (en) | 2020-01-02 |
PE20191758A1 (es) | 2019-12-12 |
JP7227151B2 (ja) | 2023-02-21 |
AR111249A1 (es) | 2019-06-19 |
RU2019132064A (ru) | 2021-04-22 |
BR112019019706A2 (pt) | 2020-04-28 |
SG11201908650PA (en) | 2019-10-30 |
CN110612124A (zh) | 2019-12-24 |
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