EA201991196A1 - Претерпевшие самосборку диблок-сополимеры, состоящие из pegmema и несущих лекарственное средство полимерных сегментов - Google Patents

Претерпевшие самосборку диблок-сополимеры, состоящие из pegmema и несущих лекарственное средство полимерных сегментов

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Publication number
EA201991196A1
EA201991196A1 EA201991196A EA201991196A EA201991196A1 EA 201991196 A1 EA201991196 A1 EA 201991196A1 EA 201991196 A EA201991196 A EA 201991196A EA 201991196 A EA201991196 A EA 201991196A EA 201991196 A1 EA201991196 A1 EA 201991196A1
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EA
Eurasian Patent Office
Prior art keywords
diblo
pegmema
assembled
self
copolymers consisting
Prior art date
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EA201991196A
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English (en)
Inventor
Рана Саньял
Амитав Саньял
Садик Кага
Original Assignee
Рс Арастирма Эгитим Данисманлик Иладж Санайи Тиджарет Аноним Сиркети
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Publication of EA201991196A1 publication Critical patent/EA201991196A1/ru

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    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
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    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
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    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F293/00—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
    • C08F293/005—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule using free radical "living" or "controlled" polymerisation, e.g. using a complexing agent
    • C—CHEMISTRY; METALLURGY
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    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
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    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
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    • C08F220/28—Esters containing oxygen in addition to the carboxy oxygen containing no aromatic rings in the alcohol moiety
    • C08F220/285—Esters containing oxygen in addition to the carboxy oxygen containing no aromatic rings in the alcohol moiety and containing a polyether chain in the alcohol moiety
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    • C—CHEMISTRY; METALLURGY
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    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2438/00—Living radical polymerisation
    • C08F2438/03—Use of a di- or tri-thiocarbonylthio compound, e.g. di- or tri-thioester, di- or tri-thiocarbamate, or a xanthate as chain transfer agent, e.g . Reversible Addition Fragmentation chain Transfer [RAFT] or Macromolecular Design via Interchange of Xanthates [MADIX]

Abstract

Данное изобретение относится к конъюгатам полимер-лекарственное средство согласно формуле I и их применению для лечения заболеваний, таких как рак.
EA201991196A 2016-11-16 2017-11-16 Претерпевшие самосборку диблок-сополимеры, состоящие из pegmema и несущих лекарственное средство полимерных сегментов EA201991196A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1619372.4A GB2556055B (en) 2016-11-16 2016-11-16 Self-assembled diblock copolymers composed of pegmema and drug bearing polymeric segments
PCT/IB2017/057155 WO2018092048A1 (en) 2016-11-16 2017-11-16 Self-assembled diblock copolymers composed of pegmema and drug bearing polymeric segments

Publications (1)

Publication Number Publication Date
EA201991196A1 true EA201991196A1 (ru) 2020-02-12

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US (1) US20240108736A1 (ru)
EP (2) EP4242240A3 (ru)
JP (2) JP7208136B2 (ru)
KR (2) KR20230159714A (ru)
CN (2) CN117883590A (ru)
AU (2) AU2017362067B2 (ru)
BR (1) BR112019009656A2 (ru)
CA (1) CA3043577A1 (ru)
DK (1) DK3541427T3 (ru)
EA (1) EA201991196A1 (ru)
ES (1) ES2941790T3 (ru)
FI (1) FI3541427T3 (ru)
GB (1) GB2556055B (ru)
HR (1) HRP20230349T1 (ru)
HU (1) HUE061518T2 (ru)
IL (1) IL266593B (ru)
MX (2) MX2019005657A (ru)
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CN110124050B (zh) * 2019-05-24 2022-05-24 西南大学 基于共价自组装策略的电荷翻转型聚合物载体的制备方法
CN110208498A (zh) * 2019-07-17 2019-09-06 吉林大学 一种基于水分动态机理的土壤给水度原位测试方法
TR201911542A2 (tr) * 2019-07-30 2021-02-22 Bogazici Ueniversitesi Anti̇kor-poli̇mer konjugatlari
CN111116928B (zh) * 2019-10-28 2021-11-12 西北工业大学 一种以双药物分子为基元的超分子超支化聚合物及制备方法
WO2021233549A1 (en) * 2020-05-21 2021-11-25 Rs Arastirma Egitim Danismanlik Ilac Sanayi Ticaret Anonim Sirketi Cleavable polymer drug conjugates for viral diseases
WO2023086949A1 (en) * 2021-11-12 2023-05-19 Northwestern University Inflammation stimuli responsive peptide brush polymers

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WO2000064946A2 (en) 1999-04-28 2000-11-02 Board Of Regents, The University Of Texas System Compositions and methods for cancer treatment by selectively inhibiting vegf
US20030215395A1 (en) 2002-05-14 2003-11-20 Lei Yu Controllably degradable polymeric biomolecule or drug carrier and method of synthesizing said carrier
EP2210616A1 (en) * 2009-01-21 2010-07-28 Centre National de la Recherche Scientifique Multifunctional stealth nanoparticles for biomedical use
WO2014152451A2 (en) * 2013-03-14 2014-09-25 University Of Rochester Compositions and methods for controlled localized delivery of bone forming therapeutic agents
CN106029059A (zh) * 2013-10-07 2016-10-12 康涅狄格大学 用于药品递送的自组装刷状嵌段共聚物-纳米颗粒
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HRP20230349T1 (hr) 2023-06-09
IL266593A (en) 2019-07-31
JP7208136B2 (ja) 2023-01-18
JP7467548B2 (ja) 2024-04-15
GB2556055B (en) 2022-03-23
JP2022169715A (ja) 2022-11-09
BR112019009656A2 (pt) 2019-09-17
AU2017362067A1 (en) 2019-06-06
EP4242240A2 (en) 2023-09-13
WO2018092048A1 (en) 2018-05-24
FI3541427T3 (fi) 2023-04-21
KR20230159714A (ko) 2023-11-21
EP4242240A3 (en) 2023-11-22
DK3541427T3 (da) 2023-04-03
AU2023248123A1 (en) 2023-11-02
GB2556055A (en) 2018-05-23
PL3541427T3 (pl) 2023-05-08
AU2017362067B2 (en) 2023-07-20
MX2023004647A (es) 2023-05-18
CA3043577A1 (en) 2018-05-24
US20240108736A1 (en) 2024-04-04
KR20190084975A (ko) 2019-07-17
EP3541427B1 (en) 2023-01-11
IL266593B (en) 2022-02-01
ES2941790T3 (es) 2023-05-25
MX2019005657A (es) 2019-07-04
EP3541427A1 (en) 2019-09-25
PT3541427T (pt) 2023-04-17
HUE061518T2 (hu) 2023-07-28
CN109982719A (zh) 2019-07-05
JP2019535710A (ja) 2019-12-12
CN117883590A (zh) 2024-04-16
CN109982719B (zh) 2024-02-02

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