CR20130649A - Liberación modificada de 4-metil-3-[[4-(3-piridinil)-2-pirimidinil]-amino]-n-[5-(4-metil-1h-imidazol-1-il)-3-(trifluoro-metil)-fenil]-benzamida solubilizada utilizando ácidos orgánicos - Google Patents
Liberación modificada de 4-metil-3-[[4-(3-piridinil)-2-pirimidinil]-amino]-n-[5-(4-metil-1h-imidazol-1-il)-3-(trifluoro-metil)-fenil]-benzamida solubilizada utilizando ácidos orgánicosInfo
- Publication number
- CR20130649A CR20130649A CR20130649A CR20130649A CR20130649A CR 20130649 A CR20130649 A CR 20130649A CR 20130649 A CR20130649 A CR 20130649A CR 20130649 A CR20130649 A CR 20130649A CR 20130649 A CR20130649 A CR 20130649A
- Authority
- CR
- Costa Rica
- Prior art keywords
- methyl
- organic acids
- banzamide
- metil
- penyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Se inventaron composiciones farmacéuticas solubles denilotinib, o de una sal farmacéuticamente aceptable del mismo,utilizando uno o más ácidos orgánicos que funcionan como un agente solubilizante, que aumentan la biodisponibilidad del nilotinib, y que suprimen el efecto del alimento asociado con ciertas composiciones de nilotinib.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161496913P | 2011-06-14 | 2011-06-14 | |
US201161541306P | 2011-09-30 | 2011-09-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
CR20130649A true CR20130649A (es) | 2014-02-04 |
Family
ID=46317545
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR20130649A CR20130649A (es) | 2011-06-14 | 2013-12-12 | Liberación modificada de 4-metil-3-[[4-(3-piridinil)-2-pirimidinil]-amino]-n-[5-(4-metil-1h-imidazol-1-il)-3-(trifluoro-metil)-fenil]-benzamida solubilizada utilizando ácidos orgánicos |
Country Status (20)
Country | Link |
---|---|
US (1) | US20150273070A1 (es) |
EP (1) | EP2721024A1 (es) |
JP (1) | JP2014517040A (es) |
KR (1) | KR20140036225A (es) |
CN (1) | CN103608342A (es) |
AP (1) | AP2013007233A0 (es) |
AR (1) | AR086913A1 (es) |
BR (1) | BR112013032122A2 (es) |
CA (1) | CA2838741A1 (es) |
CL (1) | CL2013003576A1 (es) |
CO (1) | CO6801777A2 (es) |
CR (1) | CR20130649A (es) |
EA (1) | EA201490014A1 (es) |
GT (1) | GT201300309A (es) |
IL (1) | IL229395A0 (es) |
MX (1) | MX2013014788A (es) |
PE (1) | PE20141318A1 (es) |
SG (1) | SG194756A1 (es) |
TW (1) | TW201311246A (es) |
WO (1) | WO2012174082A1 (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2742940B1 (en) | 2012-12-13 | 2017-07-26 | IP Gesellschaft für Management mbH | Fumarate salt of (R)-3-(6-(4-methylphenyl)-pyridin-3-yloxy)-l-aza-bicyclo-[2.2.2]octane for adminstration once daily, twice daily or thrice daily |
KR101633292B1 (ko) * | 2014-02-25 | 2016-06-24 | 동아에스티 주식회사 | 용법이 개선된 엔테카비어를 함유하는 약학적 조성물 |
WO2015130083A1 (ko) * | 2014-02-25 | 2015-09-03 | 동아에스티 주식회사 | 용법이 개선된 엔테카비어를 함유하는 약학적 조성물 |
MX2017004770A (es) | 2014-10-16 | 2017-07-26 | Apotex Inc | Formas solidas del clorhidrato de nilotinib. |
WO2017158625A1 (en) | 2016-03-17 | 2017-09-21 | Sun Pharmaceutical Industries Ltd. | Pharmaceutical composition of nilotinib |
FI3436461T3 (fi) | 2016-03-28 | 2024-01-16 | Incyte Corp | Pyrrolotriatsiiniyhdisteitä tam-inhibiittoreina |
US10449195B2 (en) | 2016-03-29 | 2019-10-22 | Shenzhen Pharmacin Co., Ltd. | Pharmaceutical formulation of palbociclib and a preparation method thereof |
WO2019018570A1 (en) * | 2017-07-19 | 2019-01-24 | Ignyta, Inc. | PHARMACEUTICAL COMPOSITIONS CONTAINING ENTRECTINIB |
CZ2017821A3 (cs) | 2017-12-20 | 2019-07-03 | Zentiva, K.S. | Léková forma obsahující krystalický nilotinib |
TWI770624B (zh) | 2018-06-15 | 2022-07-11 | 漢達生技醫藥股份有限公司 | 尼洛替尼十二烷基硫酸鹽在製備用於治療慢性骨髓性白血病之劑型的用途 |
US11241438B2 (en) | 2018-06-29 | 2022-02-08 | Incyte Corporation | Formulations of an AXL/MER inhibitor |
WO2020101597A2 (en) * | 2018-08-27 | 2020-05-22 | Arven Ilac Sanayi Ve Ticaret Anonim Sirketi | Capsule compositions comprising tyrosine-kinase inhibitors |
CN113573712A (zh) * | 2019-02-18 | 2021-10-29 | 斯莱班克制药有限责任公司 | 尼洛替尼的药物组合物 |
JP7378279B2 (ja) * | 2019-11-18 | 2023-11-13 | 日本化薬株式会社 | ニロチニブを有効成分とする医薬錠剤及びその製造方法 |
AU2021212258A1 (en) | 2020-01-31 | 2022-09-29 | Nanocopoeia, Llc | Amorphous nilotinib microparticles and uses thereof |
EP4142699A1 (en) * | 2020-04-30 | 2023-03-08 | Nanocopoeia LLC | Orally disintegrating tablet comprising amorphous solid dispersion of nilotinib |
JP7489849B2 (ja) | 2020-07-20 | 2024-05-24 | 日本化薬株式会社 | ニロチニブ錠剤 |
EP4185273A1 (en) * | 2020-07-24 | 2023-05-31 | Lonza Bend Inc. | Spray drying of supersaturated solutions of api with acetic acid |
CN114306245A (zh) | 2020-09-29 | 2022-04-12 | 深圳市药欣生物科技有限公司 | 无定形固体分散体的药物组合物及其制备方法 |
CA3193829A1 (en) * | 2020-09-29 | 2022-04-07 | Shenzhen Pharmacin Co., Ltd. | Pharmaceutical compositions |
MX2023015480A (es) | 2021-06-19 | 2024-01-19 | Helm Ag | Composicion granulada que comprende nilotinib. |
EP4122452A1 (en) * | 2021-07-23 | 2023-01-25 | KRKA, d.d., Novo mesto | Pharmaceutical composition comprising nilotinib and method of manufacturing the same |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE424815T1 (de) * | 2001-12-03 | 2009-03-15 | Dor Biopharma Inc | Stabilisierte umkehr-mizellen-zusammensetzungen und ihre verwendung |
SA06270147B1 (ar) * | 2005-06-09 | 2009-12-22 | نوفارتيس ايه جي | عملية لتخليق 5-(مثيل–1h–إيميدازول–1-يل )–3-(ثلاثي فلـورو مثيل)–بنزامـين |
ES2356257T3 (es) * | 2005-06-09 | 2011-04-06 | Novartis Ag | Proceso para la síntesis del 5-(metil-1h-imidazol-1-il)-3-(trifluorometil)-bencenoamina. |
CN101228151B (zh) * | 2005-07-20 | 2013-01-09 | 诺瓦提斯公司 | 4-甲基-n-[3-(4-甲基-咪唑-1-基)-5-三氟甲基-苯基]-3-(4-吡啶-3-基-嘧啶-2-基氨基)-苯甲酰胺的盐 |
GT200600316A (es) | 2005-07-20 | 2007-04-02 | Sales de 4-metilo-n-(3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo)-3-(4-piridina-3-ilo-pirimidina-2-iloamino)- benzamida. | |
CN101228150B (zh) * | 2005-07-20 | 2014-10-15 | 诺华股份有限公司 | 4-甲基-n-[3-(4-甲基-咪唑-1-基)-5-三氟甲基-苯基]-3-(4-吡啶-3-基-嘧啶-2-基氨基)-苯甲酰胺的晶形 |
GT200600315A (es) * | 2005-07-20 | 2007-03-19 | Formas cristalinas de 4-metilo-n-[3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo]-3-(4-pyridina-3-ilo-pirimidina-2-iloamino)-benzamida | |
CN104721168A (zh) * | 2006-08-25 | 2015-06-24 | 贝林格尔·英格海姆国际有限公司 | 控制释放***及其制造方法 |
EP1923053A1 (en) * | 2006-09-27 | 2008-05-21 | Novartis AG | Pharmaceutical compositions comprising nilotinib or its salt |
CA2667720A1 (en) * | 2006-11-09 | 2008-05-15 | Abbott Gmbh & Co. Kg. | Pharmaceutical dosage form for oral administration of tyrosine kinase inhibitor |
GB0716591D0 (en) * | 2007-08-24 | 2007-10-03 | Vereniging Het Nl Kanker I | Composition |
US20100016590A1 (en) * | 2008-07-17 | 2010-01-21 | Teva Pharmaceutical Industries Ltd. | Nilotinib intermediates and preparation thereof |
PL2262793T3 (pl) * | 2008-11-05 | 2013-01-31 | Teva Pharma | Formy krystaliczne nilotynibu HCL |
EP2571863B1 (en) * | 2010-06-21 | 2015-09-23 | Teva Pharmaceutical Industries Ltd. | Nilotinib salts and crystalline forms thereof |
-
2012
- 2012-06-12 AR ARP120102086A patent/AR086913A1/es unknown
- 2012-06-13 CN CN201280029595.2A patent/CN103608342A/zh active Pending
- 2012-06-13 JP JP2014515941A patent/JP2014517040A/ja active Pending
- 2012-06-13 US US14/126,219 patent/US20150273070A1/en not_active Abandoned
- 2012-06-13 SG SG2013081344A patent/SG194756A1/en unknown
- 2012-06-13 BR BR112013032122A patent/BR112013032122A2/pt not_active IP Right Cessation
- 2012-06-13 PE PE2013002815A patent/PE20141318A1/es not_active Application Discontinuation
- 2012-06-13 MX MX2013014788A patent/MX2013014788A/es not_active Application Discontinuation
- 2012-06-13 AP AP2013007233A patent/AP2013007233A0/xx unknown
- 2012-06-13 EA EA201490014A patent/EA201490014A1/ru unknown
- 2012-06-13 CA CA2838741A patent/CA2838741A1/en not_active Abandoned
- 2012-06-13 WO PCT/US2012/042205 patent/WO2012174082A1/en active Application Filing
- 2012-06-13 KR KR1020137032874A patent/KR20140036225A/ko not_active Application Discontinuation
- 2012-06-13 EP EP12728015.4A patent/EP2721024A1/en not_active Withdrawn
- 2012-06-13 TW TW101121210A patent/TW201311246A/zh unknown
-
2013
- 2013-11-11 IL IL229395A patent/IL229395A0/en unknown
- 2013-11-14 CO CO13268350A patent/CO6801777A2/es not_active Application Discontinuation
- 2013-12-12 GT GT201300309A patent/GT201300309A/es unknown
- 2013-12-12 CR CR20130649A patent/CR20130649A/es unknown
- 2013-12-13 CL CL2013003576A patent/CL2013003576A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
WO2012174082A1 (en) | 2012-12-20 |
CN103608342A (zh) | 2014-02-26 |
EP2721024A1 (en) | 2014-04-23 |
TW201311246A (zh) | 2013-03-16 |
KR20140036225A (ko) | 2014-03-25 |
JP2014517040A (ja) | 2014-07-17 |
EA201490014A1 (ru) | 2014-04-30 |
MX2013014788A (es) | 2014-07-28 |
IL229395A0 (en) | 2014-01-30 |
GT201300309A (es) | 2015-02-19 |
CA2838741A1 (en) | 2012-12-20 |
CL2013003576A1 (es) | 2014-07-11 |
SG194756A1 (en) | 2013-12-30 |
CO6801777A2 (es) | 2013-11-29 |
PE20141318A1 (es) | 2014-10-13 |
US20150273070A1 (en) | 2015-10-01 |
AP2013007233A0 (en) | 2013-11-30 |
BR112013032122A2 (pt) | 2016-12-13 |
AR086913A1 (es) | 2014-01-29 |
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