CO6660445A2 - Compuestos heterocíclicos agonistas del receptor ip - Google Patents

Compuestos heterocíclicos agonistas del receptor ip

Info

Publication number
CO6660445A2
CO6660445A2 CO13005895A CO13005895A CO6660445A2 CO 6660445 A2 CO6660445 A2 CO 6660445A2 CO 13005895 A CO13005895 A CO 13005895A CO 13005895 A CO13005895 A CO 13005895A CO 6660445 A2 CO6660445 A2 CO 6660445A2
Authority
CO
Colombia
Prior art keywords
receptor agonist
heterocyclic compounds
receptor
derivatives
agonist heterocyclic
Prior art date
Application number
CO13005895A
Other languages
English (en)
Inventor
Steven John Charlot
Catherine Leblanc
Stephen Carl Mckeown
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CO6660445A2 publication Critical patent/CO6660445A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

La presente invención proporciona derivados heterocíclicos que activan el receptor IP. La activación de la senda de señalización del receptor IP es útil para tratar muchas formas de hipertensión arterial pulmonar (PAH), fibrosis pulmonar, y para ejercer efectos benéficos sobre las condiciones fibróticas de diferentes órganos en modelos animales y en los pacientes. También se abarcan las composiciones farmacéuticas que comprenden estos derivados.
CO13005895A 2010-07-14 2013-01-14 Compuestos heterocíclicos agonistas del receptor ip CO6660445A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36413510P 2010-07-14 2010-07-14

Publications (1)

Publication Number Publication Date
CO6660445A2 true CO6660445A2 (es) 2013-04-30

Family

ID=44628483

Family Applications (1)

Application Number Title Priority Date Filing Date
CO13005895A CO6660445A2 (es) 2010-07-14 2013-01-14 Compuestos heterocíclicos agonistas del receptor ip

Country Status (34)

Country Link
US (2) US8754085B2 (es)
EP (1) EP2593452B1 (es)
JP (1) JP5781159B2 (es)
KR (1) KR101491938B1 (es)
CN (1) CN103097385B (es)
AU (1) AU2011278279C1 (es)
BR (1) BR112013000946B1 (es)
CA (1) CA2804744C (es)
CL (1) CL2013000104A1 (es)
CO (1) CO6660445A2 (es)
CR (1) CR20130012A (es)
CU (1) CU24147B1 (es)
CY (1) CY1118819T1 (es)
DK (1) DK2593452T3 (es)
EA (1) EA022046B1 (es)
EC (1) ECSP13012385A (es)
ES (1) ES2622519T3 (es)
GT (1) GT201300018A (es)
HR (1) HRP20170617T1 (es)
HU (1) HUE031710T2 (es)
IL (1) IL224164A (es)
LT (1) LT2593452T (es)
MA (1) MA34373B1 (es)
MX (1) MX2013000537A (es)
MY (1) MY156795A (es)
NZ (1) NZ605528A (es)
PE (1) PE20130404A1 (es)
PL (1) PL2593452T3 (es)
PT (1) PT2593452T (es)
RS (1) RS55856B1 (es)
SG (1) SG186989A1 (es)
SI (1) SI2593452T1 (es)
UA (1) UA109786C2 (es)
WO (1) WO2012007539A1 (es)

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Also Published As

Publication number Publication date
CU20130009A7 (es) 2013-04-19
CY1118819T1 (el) 2018-01-10
SI2593452T1 (sl) 2017-06-30
DK2593452T3 (en) 2017-04-24
AU2011278279B2 (en) 2014-08-07
CN103097385B (zh) 2016-08-03
EP2593452A1 (en) 2013-05-22
HRP20170617T1 (hr) 2017-06-30
CA2804744A1 (en) 2012-01-19
HUE031710T2 (en) 2017-07-28
JP5781159B2 (ja) 2015-09-16
KR20130038924A (ko) 2013-04-18
US20130102611A1 (en) 2013-04-25
MA34373B1 (fr) 2013-07-03
EA201300118A1 (ru) 2013-06-28
NZ605528A (en) 2015-02-27
BR112013000946A2 (pt) 2016-05-17
SG186989A1 (en) 2013-02-28
US20140243346A1 (en) 2014-08-28
PT2593452T (pt) 2017-04-24
US9132127B2 (en) 2015-09-15
US8754085B2 (en) 2014-06-17
WO2012007539A9 (en) 2012-11-01
ES2622519T3 (es) 2017-07-06
MY156795A (en) 2016-03-31
EP2593452B1 (en) 2017-01-18
CR20130012A (es) 2013-02-19
LT2593452T (lt) 2017-04-10
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JP2013531025A (ja) 2013-08-01
IL224164A (en) 2016-08-31
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KR101491938B1 (ko) 2015-02-10
CL2013000104A1 (es) 2013-05-17
BR112013000946B1 (pt) 2020-09-08
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EA022046B1 (ru) 2015-10-30
CA2804744C (en) 2019-05-28
GT201300018A (es) 2015-11-24
CN103097385A (zh) 2013-05-08
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CU24147B1 (es) 2016-02-29

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