CO6341569A2 - Vacuna de vesicula de membrana externa nativa multivalente del meningococo, metodo para su fabricacion y uso. - Google Patents
Vacuna de vesicula de membrana externa nativa multivalente del meningococo, metodo para su fabricacion y uso.Info
- Publication number
- CO6341569A2 CO6341569A2 CO10164103A CO10164103A CO6341569A2 CO 6341569 A2 CO6341569 A2 CO 6341569A2 CO 10164103 A CO10164103 A CO 10164103A CO 10164103 A CO10164103 A CO 10164103A CO 6341569 A2 CO6341569 A2 CO 6341569A2
- Authority
- CO
- Colombia
- Prior art keywords
- vaccine
- multivally
- meningococo
- vesicula
- manufacturing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/36—Adaptation or attenuation of cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
1.- Una vacuna que comprende vesículas nativas de la membrana externa (NOMV) obtenida de por lo menos dos cepas del meningococo que hayan sido genéticamente modificadas para proporcionar una amplia base de protección, en donde las vesículas nativas de la membrana externa (NOMV) incluyen tres diferentes juegos de antígenos basados en PorA, LOS y las proteínas conservadas de membranas externas; en donde las cepas genéticamente modificadas han sido modificadas para proporcionar seguridad mejorada con base en la inactivación de los genes lpxLl synX, y IgtA; y donde al menos una de las cepas genéticamente modificadas expresa al menos dos proteínas diferentes de subtipo PorA o de subtipo de epítope.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5746208P | 2008-05-30 | 2008-05-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6341569A2 true CO6341569A2 (es) | 2011-11-21 |
Family
ID=41444870
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO10164103A CO6341569A2 (es) | 2008-05-30 | 2010-12-29 | Vacuna de vesicula de membrana externa nativa multivalente del meningococo, metodo para su fabricacion y uso. |
Country Status (19)
Country | Link |
---|---|
US (2) | US9387239B2 (es) |
EP (1) | EP2296699A4 (es) |
JP (2) | JP5723768B2 (es) |
KR (1) | KR20110053314A (es) |
CN (1) | CN102105166A (es) |
AU (1) | AU2009262893B2 (es) |
BR (1) | BRPI0913268A2 (es) |
CA (1) | CA2726465A1 (es) |
CO (1) | CO6341569A2 (es) |
CR (1) | CR11812A (es) |
DO (1) | DOP2010000364A (es) |
EC (1) | ECSP10010723A (es) |
IL (1) | IL209660A0 (es) |
MX (1) | MX2010012999A (es) |
NZ (1) | NZ589812A (es) |
RU (1) | RU2477145C2 (es) |
UA (1) | UA99659C2 (es) |
WO (1) | WO2009158142A1 (es) |
ZA (1) | ZA201008548B (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2563677T3 (es) | 1999-05-19 | 2016-03-15 | Glaxosmithkline Biologicals Sa | Composiciones de combinaciones de Neisseria |
GB9928196D0 (en) | 1999-11-29 | 2000-01-26 | Chiron Spa | Combinations of B, C and other antigens |
MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
GB0316560D0 (en) | 2003-07-15 | 2003-08-20 | Chiron Srl | Vesicle filtration |
GB0424092D0 (en) | 2004-10-29 | 2004-12-01 | Chiron Srl | Immunogenic bacterial vesicles with outer membrane proteins |
CN102869378A (zh) * | 2010-03-10 | 2013-01-09 | 葛兰素史密丝克莱恩生物有限公司 | 免疫原性组合物 |
PL3246044T5 (pl) | 2010-08-23 | 2024-06-17 | Wyeth Llc | Stabilne preparaty antygenów rLP2086 Neisseria meningitidis |
MY166172A (en) | 2010-09-10 | 2018-06-07 | Wyeth Llc | Non-lipidated variants of neisseria meningitidis orf2086 antigens |
ES2759484T3 (es) * | 2010-09-10 | 2020-05-11 | Glaxosmithkline Biologicals Sa | Meningococo que sobreexpresa NadA y/o NHBA y vesículas de la membrana externa derivadas del mismo |
GB201015132D0 (en) * | 2010-09-10 | 2010-10-27 | Univ Bristol | Vaccine composition |
EP2750702A4 (en) * | 2011-08-31 | 2015-03-04 | Childrens Hosp & Res Ct Oak | MANIPULATED SEQUENCES FOR THE EXPRESSION OF ANTIGENS IN NEISSERIA AND METHOD OF USE THEREOF |
ES2654613T3 (es) | 2012-02-02 | 2018-02-14 | Glaxosmithkline Biologicals Sa | Promotores para una expresión aumentada de proteínas en meningococos |
ES2750366T3 (es) | 2012-03-08 | 2020-03-25 | Glaxosmithkline Biologicals Sa | Ensayo de potencia in vitro para vacunas meningocócicas basadas en proteína |
NZ628449A (en) | 2012-03-09 | 2016-04-29 | Pfizer | Neisseria meningitidis compositions and methods thereof |
SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
KR101452830B1 (ko) * | 2012-04-06 | 2014-10-21 | 아이진 주식회사 | 두 가지 항암물질을 동시에 제공하는 대장균 균주 |
RU2662970C2 (ru) | 2012-09-18 | 2018-07-31 | Новартис Аг | Везикулы наружной мембраны |
ES2685894T3 (es) | 2013-03-08 | 2018-10-15 | Pfizer Inc. | Polipéptidos de fusión inmunogénicos |
KR101905278B1 (ko) | 2013-09-08 | 2018-10-08 | 화이자 인코포레이티드 | 나이세리아 메닌지티디스 조성물 및 그의 방법 |
EP3270959A1 (en) | 2015-02-19 | 2018-01-24 | Pfizer Inc | Neisseria meningitidis compositions and methods thereof |
EP3263695A1 (en) * | 2016-06-29 | 2018-01-03 | GlaxoSmithKline Biologicals SA | Immunogenic compositions |
EP3544637B1 (en) * | 2016-11-25 | 2020-11-11 | GlaxoSmithKline Biologicals S.A. | Native omv-antigen conjugates and use thereof |
SG11201906519RA (en) | 2017-01-31 | 2019-08-27 | Pfizer | Neisseria meningitidis compositions and methods thereof |
CN107961369B (zh) * | 2017-03-22 | 2020-08-11 | 武汉博沃生物科技有限公司 | 多价脑膜炎球菌缀合疫苗及其制备方法 |
CN113151354B (zh) * | 2021-03-22 | 2022-03-08 | 中国农业科学院兰州兽医研究所 | 一种用于条件性敲除目的基因的载体及条件性敲除目的基因的方法 |
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US4601903A (en) * | 1985-05-01 | 1986-07-22 | The United States Of America As Represented By The Department Of Health And Human Services | Vaccine against Neisseria meningitidis Group B serotype 2 invasive disease |
US4727136A (en) * | 1985-10-01 | 1988-02-23 | Canadian Patents And Development Ltd. | Modified meningococcal group B polysaccharide for conjugate vaccine |
ES2070312T5 (es) | 1988-12-19 | 2003-05-16 | American Cyanamid Co | Vacuna de proteina de membrana exterior meningococica de clase 1. |
US7118757B1 (en) * | 1988-12-19 | 2006-10-10 | Wyeth Holdings Corporation | Meningococcal class 1 outer-membrane protein vaccine |
DE4023721A1 (de) | 1990-07-26 | 1992-01-30 | Boehringer Mannheim Gmbh | Verfahren zur herstellung von vakzinen und ihre verwendung |
US5552146A (en) | 1991-08-15 | 1996-09-03 | Board Of Regents, The University Of Texas System | Methods and compositions relating to useful antigens of Moraxella catarrhalis |
NL9201716A (nl) * | 1992-10-02 | 1994-05-02 | Nederlanden Staat | Buitenmembraanvesikel dat voorzien is van een groep polypeptiden welke ten minste de immuunwerking van aan membraan gebonden buitenmembraaneiwitten (OMP's) hebben, werkwijze ter bereiding ervan alsmede een vaccin dat een dergelijk buitenmembraanvesikel omvat. |
US7112332B1 (en) * | 1992-10-08 | 2006-09-26 | The United States Of America As Represented By The Secretary Of The Army | Oral or intranasal vaccines using hydrophobic complexes having proteosomes and lipopolysaccharides |
DE69423383T2 (de) * | 1993-05-13 | 2000-08-24 | American Cyanamid Co | Herstellung und Verwendungen von LOS-verminderten Aussenmembran-Proteinen von Gram-negativen Kokken |
US5961970A (en) * | 1993-10-29 | 1999-10-05 | Pharmos Corporation | Submicron emulsions as vaccine adjuvants |
US6476201B1 (en) * | 1995-09-18 | 2002-11-05 | Id Biomedical Corporation Of Quebec | Methods for the production of non-covalently complexed and multivalent proteosome sub-unit vaccines |
US6558677B2 (en) * | 1996-10-15 | 2003-05-06 | Wendell D. Zollinger | Vaccine against gram negative bacteria |
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GB9918319D0 (en) * | 1999-08-03 | 1999-10-06 | Smithkline Beecham Biolog | Vaccine composition |
DE60142772D1 (de) * | 2000-01-17 | 2010-09-23 | Novartis Vaccines & Diagnostic | Membranvesikel (omv) impfstoff, der n. meningitidis serogruppe b membranproteine enthält |
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GB0024200D0 (en) * | 2000-10-03 | 2000-11-15 | Smithkline Beecham Sa | Component vaccine |
GB0103169D0 (en) * | 2001-02-08 | 2001-03-28 | Smithkline Beecham Biolog | Vaccine composition |
US20030072764A1 (en) * | 2001-04-05 | 2003-04-17 | O'hagan Derek | Mucosal boosting following parenteral priming |
GB0130123D0 (en) * | 2001-12-17 | 2002-02-06 | Microbiological Res Agency | Outer membrane vesicle vaccine and its preparation |
EP1374892A1 (en) * | 2002-06-28 | 2004-01-02 | Braun, Jan Matthias, Dr. | Medicament for the treatment of diseases due to infection by Neisseria Meningitidis |
PT1524993E (pt) * | 2002-08-02 | 2013-06-12 | Glaxosmithkline Biolog Sa | Composições de vacina de neisseria compreendendo uma combinação de antigénios |
CU23377A1 (es) | 2003-11-04 | 2009-05-28 | Ct De Ingenieria Genetica Y Biotecnologia | Metodo para la incorporacion de antigenos en vesiculas de membrana externa de bacterias y formulaciones resultantes |
EP1706481A2 (en) * | 2003-12-23 | 2006-10-04 | GlaxoSmithKline Biologicals S.A. | Vaccine |
SI1748791T1 (sl) * | 2004-05-11 | 2010-07-30 | Staat Der Nederlanden - Minister Van Vws | Neisseria meningitidis IgtB LOS kot adjuvans |
US7537766B2 (en) * | 2004-08-30 | 2009-05-26 | Wyeth | Neisseria meningitidis inner core lipo-oligosaccharide epitopes, multivalent conjugates thereof and immunogenic compositions thereof |
GB0419627D0 (en) | 2004-09-03 | 2004-10-06 | Chiron Srl | Immunogenic bacterial vesicles with outer membrane proteins |
EP2682126B1 (en) * | 2005-01-27 | 2016-11-23 | Children's Hospital & Research Center at Oakland | GNA1870-based vesicle vaccines for broad spectrum protection against diseases caused by Neisseria meningitidis |
ES2337309T5 (es) | 2006-06-12 | 2013-07-30 | Glaxosmithkline Biologicals S.A. | Vacuna |
-
2009
- 2009-06-01 CA CA2726465A patent/CA2726465A1/en not_active Abandoned
- 2009-06-01 WO PCT/US2009/045818 patent/WO2009158142A1/en active Application Filing
- 2009-06-01 CN CN200980125861XA patent/CN102105166A/zh active Pending
- 2009-06-01 KR KR1020107029750A patent/KR20110053314A/ko not_active Application Discontinuation
- 2009-06-01 MX MX2010012999A patent/MX2010012999A/es unknown
- 2009-06-01 JP JP2011511892A patent/JP5723768B2/ja not_active Expired - Fee Related
- 2009-06-01 AU AU2009262893A patent/AU2009262893B2/en not_active Ceased
- 2009-06-01 US US12/995,268 patent/US9387239B2/en not_active Expired - Fee Related
- 2009-06-01 RU RU2010153658/15A patent/RU2477145C2/ru not_active IP Right Cessation
- 2009-06-01 EP EP09770677.4A patent/EP2296699A4/en not_active Withdrawn
- 2009-06-01 BR BRPI0913268A patent/BRPI0913268A2/pt not_active IP Right Cessation
- 2009-06-01 UA UAA201015812A patent/UA99659C2/uk unknown
- 2009-06-01 NZ NZ589812A patent/NZ589812A/xx not_active IP Right Cessation
-
2010
- 2010-11-25 CR CR11812A patent/CR11812A/es unknown
- 2010-11-26 DO DO2010000364A patent/DOP2010000364A/es unknown
- 2010-11-29 ZA ZA2010/08548A patent/ZA201008548B/en unknown
- 2010-11-30 IL IL209660A patent/IL209660A0/en unknown
- 2010-12-27 EC EC2010010723A patent/ECSP10010723A/es unknown
- 2010-12-29 CO CO10164103A patent/CO6341569A2/es not_active Application Discontinuation
-
2014
- 2014-12-11 JP JP2014250805A patent/JP2015061870A/ja not_active Withdrawn
-
2016
- 2016-07-12 US US15/208,067 patent/US20170100471A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2009262893A9 (en) | 2015-05-21 |
NZ589812A (en) | 2012-08-31 |
UA99659C2 (uk) | 2012-09-10 |
US9387239B2 (en) | 2016-07-12 |
RU2010153658A (ru) | 2012-08-10 |
JP5723768B2 (ja) | 2015-05-27 |
JP2011521976A (ja) | 2011-07-28 |
CA2726465A1 (en) | 2009-12-30 |
RU2477145C2 (ru) | 2013-03-10 |
KR20110053314A (ko) | 2011-05-20 |
EP2296699A4 (en) | 2013-11-13 |
EP2296699A1 (en) | 2011-03-23 |
MX2010012999A (es) | 2012-03-07 |
IL209660A0 (en) | 2011-02-28 |
BRPI0913268A2 (pt) | 2016-03-15 |
JP2015061870A (ja) | 2015-04-02 |
AU2009262893B2 (en) | 2015-05-21 |
CN102105166A (zh) | 2011-06-22 |
ECSP10010723A (es) | 2011-05-31 |
AU2009262893A1 (en) | 2009-12-30 |
WO2009158142A1 (en) | 2009-12-30 |
ZA201008548B (en) | 2012-06-27 |
US20170100471A1 (en) | 2017-04-13 |
DOP2010000364A (es) | 2011-07-15 |
CR11812A (es) | 2011-07-06 |
US20110182942A1 (en) | 2011-07-28 |
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