CO5261549A1 - PIRIDO [2,3-d] PIRIMIDIN-2,7-DIAMINAS INHIBIDORES DE CINASAS - Google Patents

PIRIDO [2,3-d] PIRIMIDIN-2,7-DIAMINAS INHIBIDORES DE CINASAS

Info

Publication number
CO5261549A1
CO5261549A1 CO01005268A CO01005268A CO5261549A1 CO 5261549 A1 CO5261549 A1 CO 5261549A1 CO 01005268 A CO01005268 A CO 01005268A CO 01005268 A CO01005268 A CO 01005268A CO 5261549 A1 CO5261549 A1 CO 5261549A1
Authority
CO
Colombia
Prior art keywords
substituted
unsubstituted lower
compounds
group
unsubstituted
Prior art date
Application number
CO01005268A
Other languages
English (en)
Inventor
Richard John Booth
Ellen Myra Dobrusin
Prasad Venkata Nagendra J Vara
Dennis Joseph Mcnamara
Peter Laurence Toogood
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of CO5261549A1 publication Critical patent/CO5261549A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Abstract

Se describen compuestos de fórmula: <EMI FILE="01005268_1" ID="1" IMF=JPEG >en la cual : R2, R7. R13, R14 y R15 son, independientemente, hidrógeno o alquilo inferior sustituido o sin sustituir, alquenilo inferior sustituido o sin sustituir, alquinilo inferior sustituido o sin sustituir, o bien -(CH2)nR12 sustituido o sin sustituir; R5 es halógeno, ciano, nitro, -R9, -NR9R10, o bien -OR9; R6 es halógeno, ciano, nitro, -R9, -NR9R10, -OR9, -C02R9, -COR9, -CONR9R10, NR9COR10, alquenilo inferior sustituido o sin sustituir, o alquinilo inferior sustituido o sin sustituir; R8 es -CO2R13, -COR13, -CINR13R14, -CSNR13R14, -C(NR13)NR14R15, -SO3R13, -SO2R13, -SO2NR13R14, -PO3R13R14, POR13R14, -PO(NR13R14)2; R9 Y R10 son, independientemente, hidrógeno o alquilo inferior sustituido o sin sustituir; R11 es un grupo heteroarilo o un grupo heterocíclico; R12 es un grupo cicloalquilo, un grupo heterociclico, un grupo arilo, o un grupo heteroarilo; y n vale 0, 1, 2 ó 3. Estos compuestos y sus composiciones farmacéuticas son útiles para tratar trastornos proliferativos celulares, tales como cáncer y restenosis. Estos compuestos son potentes inhibidores de cdks y de cinasas mediadas por factor de crecimiento.
CO01005268A 2000-01-25 2001-01-24 PIRIDO [2,3-d] PIRIMIDIN-2,7-DIAMINAS INHIBIDORES DE CINASAS CO5261549A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17826100P 2000-01-25 2000-01-25

Publications (1)

Publication Number Publication Date
CO5261549A1 true CO5261549A1 (es) 2003-03-31

Family

ID=22651853

Family Applications (1)

Application Number Title Priority Date Filing Date
CO01005268A CO5261549A1 (es) 2000-01-25 2001-01-24 PIRIDO [2,3-d] PIRIMIDIN-2,7-DIAMINAS INHIBIDORES DE CINASAS

Country Status (34)

Country Link
EP (1) EP1254137A1 (es)
JP (1) JP4047010B2 (es)
KR (1) KR20020065939A (es)
CN (1) CN1395578A (es)
AP (1) AP2002002586A0 (es)
AR (1) AR030044A1 (es)
AU (1) AU2542501A (es)
BG (1) BG106850A (es)
BR (1) BR0107751A (es)
CA (1) CA2397961C (es)
CO (1) CO5261549A1 (es)
CR (1) CR6706A (es)
CZ (1) CZ20022475A3 (es)
DZ (1) DZ3266A1 (es)
EA (1) EA200200643A1 (es)
EE (1) EE200200405A (es)
GT (1) GT200100016A (es)
HN (1) HN2001000013A (es)
HU (1) HUP0204141A3 (es)
IL (1) IL150545A0 (es)
IS (1) IS6443A (es)
MA (1) MA26868A1 (es)
MX (1) MXPA02007221A (es)
NO (1) NO20023527L (es)
OA (1) OA12161A (es)
PA (1) PA8510701A1 (es)
PE (1) PE20011066A1 (es)
PL (1) PL356802A1 (es)
SK (1) SK10632002A3 (es)
SV (1) SV2002000294A (es)
TN (1) TNSN01014A1 (es)
WO (1) WO2001055147A1 (es)
YU (1) YU50402A (es)
ZA (1) ZA200205879B (es)

Families Citing this family (30)

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US7235551B2 (en) 2000-03-02 2007-06-26 Smithkline Beecham Corporation 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
HU229471B1 (en) 2000-10-23 2014-01-28 Smithkline Beecham Corp 2,4,8-trisubstituted-8h-pyrido[2,3d]pyrimidine-7-one compounds, for the treatment of diseases mediated by csbp/p38 kinase
PE20030008A1 (es) * 2001-06-19 2003-01-22 Bristol Myers Squibb Co Inhibidores duales de pde 7 y pde 4
CA2482022A1 (en) 2002-04-19 2003-10-30 Smithkline Beecham Corporation Novel compounds
US7504410B2 (en) * 2002-11-28 2009-03-17 Schering Aktiengesellschaft Chk-, Pdk- and Akt-inhibitory pyrimidines, their production and use as pharmaceutical agents
US7157455B2 (en) * 2003-02-10 2007-01-02 Hoffmann-La Roche Inc. 4-Aminopyrimidine-5-one derivatives
TW200502236A (en) * 2003-03-28 2005-01-16 Hoffmann La Roche Novel pyrido[2,3-d]pyrimidin-7-carboxylic acid derivatives, their manufacture and use as pharmaceutical agents
FR2873118B1 (fr) 2004-07-15 2007-11-23 Sanofi Synthelabo Derives de pyrido-pyrimidine, leur application en therapeutique
CN101014600A (zh) * 2004-09-21 2007-08-08 霍夫曼-拉罗奇有限公司 用作蛋白激酶抑制剂的6－(2－烷基－苯基)－吡啶并[2,3－d]嘧啶类
KR20080002865A (ko) 2005-03-25 2008-01-04 글락소 그룹 리미티드 피리도[２,３-ｄ]피리미딘-７-온 및３,４-디히드로피리미도[４,５-ｄ]피리미딘-２(１ｈ)-온유도체의 제조 방법
PE20100737A1 (es) 2005-03-25 2010-11-27 Glaxo Group Ltd Nuevos compuestos
EP1868612A4 (en) 2005-03-25 2010-03-24 Glaxo Group Ltd NOVEL CONNECTIONS
TW200724142A (en) 2005-03-25 2007-07-01 Glaxo Group Ltd Novel compounds
FR2887882B1 (fr) 2005-07-01 2007-09-07 Sanofi Aventis Sa Derives de pyrido[2,3-d] pyrimidine, leur preparation, leur application en therapeutique
ATE449097T1 (de) * 2005-07-21 2009-12-15 Hoffmann La Roche Pyridoä2,3-düpyrimidin-2,4-diamin-verbindungen als ptpib-hemmer
JP2009504665A (ja) * 2005-08-09 2009-02-05 アイアールエム・リミテッド・ライアビリティ・カンパニー タンパク質キナーゼ阻害剤としての化合物および組成物
FR2896246B1 (fr) 2006-01-13 2008-08-15 Sanofi Aventis Sa Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique.
EP1914234A1 (en) 2006-10-16 2008-04-23 GPC Biotech Inc. Pyrido[2,3-d]pyrimidines and their use as kinase inhibitors
JO2985B1 (ar) 2006-12-20 2016-09-05 Takeda Pharmaceuticals Co مثبطات كينازmapk/erk
FR2910813B1 (fr) * 2006-12-28 2009-02-06 Sanofi Aventis Sa Nouvelle utilisation therapeutique pour le traitement des leucemies
EP2112150B1 (en) 2008-04-22 2013-10-16 Forma Therapeutics, Inc. Improved raf inhibitors
EP2352732B1 (en) * 2008-12-01 2013-02-20 Merck Patent GmbH 2,5-DIAMINO-SUBSTITUTED PYRIDO[4, 3-d]PYRIMIDINES AS AUTOTAXIN INHIBITORS AGAINST CANCER
GB201104267D0 (en) 2011-03-14 2011-04-27 Cancer Rec Tech Ltd Pyrrolopyridineamino derivatives
GB201216017D0 (en) 2012-09-07 2012-10-24 Cancer Rec Tech Ltd Inhibitor compounds
GB201216018D0 (en) 2012-09-07 2012-10-24 Cancer Rec Tech Ltd Pharmacologically active compounds
ES2817448T3 (es) * 2013-03-14 2021-04-07 Icahn School Med Mount Sinai Compuestos de pirimidina como inhibidores de quinasas
GB201403536D0 (en) 2014-02-28 2014-04-16 Cancer Rec Tech Ltd Inhibitor compounds
KR101671404B1 (ko) * 2014-09-02 2016-11-02 한국원자력의학원 항암 효과, 방사선 병용치료 효과 및 당뇨병 치료 효과를 갖는 피리미딘 유도체 및 이의 의학적 용도
CN107286180B (zh) * 2016-04-11 2019-07-02 上海勋和医药科技有限公司 杂代吡啶并嘧啶酮衍生物作为cdk抑制剂及其应用
GB201709840D0 (en) 2017-06-20 2017-08-02 Inst Of Cancer Research: Royal Cancer Hospital Methods and medical uses

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69515898T2 (de) * 1994-11-14 2000-08-17 Warner Lambert Co 6-ARYL-PYRIDO[2,3-d]PYRIMIDINE UND -NAPHTHYRIDINE ZUR HEMMUNG DER DURCH PROTEIN-TYROSIN-KINASE HERVORGERUFENEN ZELLVERMEHRUNG
IL115256A0 (en) * 1994-11-14 1995-12-31 Warner Lambert Co 6-Aryl pyrido (2,3-d) pyrimidines and naphthyridines and their use
US5620981A (en) * 1995-05-03 1997-04-15 Warner-Lambert Company Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation
CN1138778C (zh) * 1998-05-26 2004-02-18 沃尼尔·朗伯公司 用作细胞增殖抑制剂的二环嘧啶及二环3,4-二氢嘧啶化合物及用途

Also Published As

Publication number Publication date
HN2001000013A (es) 2001-06-18
CN1395578A (zh) 2003-02-05
MA26868A1 (fr) 2004-12-20
MXPA02007221A (es) 2002-11-29
AP2002002586A0 (en) 2002-09-30
NO20023527D0 (no) 2002-07-24
OA12161A (en) 2006-05-08
IS6443A (is) 2002-06-25
PL356802A1 (en) 2004-07-12
CA2397961C (en) 2008-08-26
WO2001055147A1 (en) 2001-08-02
BR0107751A (pt) 2002-11-12
CZ20022475A3 (cs) 2003-03-12
PA8510701A1 (es) 2002-12-11
CR6706A (es) 2005-04-04
CA2397961A1 (en) 2001-08-02
EP1254137A1 (en) 2002-11-06
BG106850A (bg) 2003-02-28
AR030044A1 (es) 2003-08-13
YU50402A (sh) 2005-11-28
JP4047010B2 (ja) 2008-02-13
IL150545A0 (en) 2003-02-12
EA200200643A1 (ru) 2002-12-26
ZA200205879B (en) 2003-09-29
SV2002000294A (es) 2002-07-16
JP2003523357A (ja) 2003-08-05
HUP0204141A3 (en) 2005-03-29
TNSN01014A1 (fr) 2005-11-10
KR20020065939A (ko) 2002-08-14
EE200200405A (et) 2003-12-15
DZ3266A1 (fr) 2001-08-02
SK10632002A3 (sk) 2003-06-03
HUP0204141A2 (hu) 2003-04-28
PE20011066A1 (es) 2001-10-22
AU2542501A (en) 2001-08-07
NO20023527L (no) 2002-09-10
GT200100016A (es) 2001-10-19

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