DZ3266A1 - Pyrido[2,3-d]pyrimidine-2,7-diamine inhibiteurs de kinase - Google Patents

Pyrido[2,3-d]pyrimidine-2,7-diamine inhibiteurs de kinase

Info

Publication number: DZ3266A1
Authority: DZ; Algeria
Prior art keywords: pyrido; pyrimidine; diamine; kinase inhibitors; kinase
Prior art date: 2000-01-25

Application number

DZ013266A

Other languages

English (en)

French (fr)

Inventor

Richard J Booth

Ellen M Dobrusin

Vara Prasad V Josyula

Dennis J Mcnamara

Peter L Toogood

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-01-25

Filing date

2001-01-23

Publication date

2001-08-02

2001-01-23 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

2001-08-02 Application granted granted Critical

2001-08-02 Publication of DZ3266A1 publication Critical patent/DZ3266A1/fr

Links

229940043355 kinase inhibitor Drugs 0.000 title 1
239000003757 phosphotransferase inhibitor Substances 0.000 title 1
QRRCMVPZJCHBLQ-UHFFFAOYSA-N pyrido[2,3-d]pyrimidine-2,7-diamine Chemical compound C1=NC(N)=NC2=NC(N)=CC=C21 QRRCMVPZJCHBLQ-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Neurology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Dermatology (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Enzymes And Modification Thereof (AREA)

DZ013266A 2000-01-25 2001-01-23 Pyrido[2,3-d]pyrimidine-2,7-diamine inhibiteurs de kinase DZ3266A1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US17826100P	2000-01-25	2000-01-25
PCT/IB2001/000069 WO2001055147A1 (en)	2000-01-25	2001-01-23	PYRIDO[2,3-d]PYRIMIDINE-2,7-DIAMINE KINASE INHIBITORS

Publications (1)

Publication Number	Publication Date
DZ3266A1 true DZ3266A1 (fr)	2001-08-02

Family

ID=22651853

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DZ013266A DZ3266A1 (fr)	2000-01-25	2001-01-23	Pyrido[2,3-d]pyrimidine-2,7-diamine inhibiteurs de kinase

Country Status (34)

Country	Link
EP (1)	EP1254137A1 (es)
JP (1)	JP4047010B2 (es)
KR (1)	KR20020065939A (es)
CN (1)	CN1395578A (es)
AP (1)	AP2002002586A0 (es)
AR (1)	AR030044A1 (es)
AU (1)	AU2542501A (es)
BG (1)	BG106850A (es)
BR (1)	BR0107751A (es)
CA (1)	CA2397961C (es)
CO (1)	CO5261549A1 (es)
CR (1)	CR6706A (es)
CZ (1)	CZ20022475A3 (es)
DZ (1)	DZ3266A1 (es)
EA (1)	EA200200643A1 (es)
EE (1)	EE200200405A (es)
GT (1)	GT200100016A (es)
HN (1)	HN2001000013A (es)
HU (1)	HUP0204141A3 (es)
IL (1)	IL150545A0 (es)
IS (1)	IS6443A (es)
MA (1)	MA26868A1 (es)
MX (1)	MXPA02007221A (es)
NO (1)	NO20023527L (es)
OA (1)	OA12161A (es)
PA (1)	PA8510701A1 (es)
PE (1)	PE20011066A1 (es)
PL (1)	PL356802A1 (es)
SK (1)	SK10632002A3 (es)
SV (1)	SV2002000294A (es)
TN (1)	TNSN01014A1 (es)
WO (1)	WO2001055147A1 (es)
YU (1)	YU50402A (es)
ZA (1)	ZA200205879B (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7235551B2 (en)	2000-03-02	2007-06-26	Smithkline Beecham Corporation	1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
MXPA03003612A (es)	2000-10-23	2003-06-19	Smithkline Beecham Corp	Compuestos novedosos.
PE20030008A1 (es) *	2001-06-19	2003-01-22	Bristol Myers Squibb Co	Inhibidores duales de pde 7 y pde 4
BR0309053A (pt)	2002-04-19	2005-02-22	Smithkline Beecham Corp	Compostos
WO2004048343A1 (en) *	2002-11-28	2004-06-10	Schering Aktiengesellschaft	Chk-, pdk- and akt-inhibitory pyrimidines, their production and use as pharmaceutical agents
US7157455B2 (en) *	2003-02-10	2007-01-02	Hoffmann-La Roche Inc.	4-Aminopyrimidine-5-one derivatives
TW200502236A (en)	2003-03-28	2005-01-16	Hoffmann La Roche	Novel pyrido[2,3-d]pyrimidin-7-carboxylic acid derivatives, their manufacture and use as pharmaceutical agents
FR2873118B1 (fr)	2004-07-15	2007-11-23	Sanofi Synthelabo	Derives de pyrido-pyrimidine, leur application en therapeutique
CN101014600A (zh) *	2004-09-21	2007-08-08	霍夫曼-拉罗奇有限公司	用作蛋白激酶抑制剂的6－(2－烷基－苯基)－吡啶并[2,3－d]嘧啶类
AR053450A1 (es)	2005-03-25	2007-05-09	Glaxo Group Ltd	Derivados de 3,4-dihidro-pirimido(4,5-d)pirimidin-2-(1h)-ona 1,5,7 trisustituidos como inhibidores de la quinasa p38
US7423042B2 (en)	2005-03-25	2008-09-09	Glaxo Group Limited	Compounds
PE20100737A1 (es)	2005-03-25	2010-11-27	Glaxo Group Ltd	Nuevos compuestos
CN101495475A (zh)	2005-03-25	2009-07-29	葛兰素集团有限公司	制备吡啶并[2,3-d]嘧啶-7-酮和3,4-二氢嘧啶并[4,5-d]嘧啶-2(1H)-酮衍生物的方法
FR2887882B1 (fr)	2005-07-01	2007-09-07	Sanofi Aventis Sa	Derives de pyrido[2,3-d] pyrimidine, leur preparation, leur application en therapeutique
KR100962723B1 (ko) *	2005-07-21	2010-06-09	에프. 호프만-라 로슈 아게	단백질 티로신 포스파타제1ｂ 억제제로서의피리도[2,3-ｄ]피리미딘-2,4-다이아민 화합물
ES2351939T3 (es)	2005-08-09	2011-02-14	Irm Llc	Compuestos y composiciones como inhibidores de proteínas cinasas.
FR2896246B1 (fr)	2006-01-13	2008-08-15	Sanofi Aventis Sa	Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique.
EP1914234A1 (en)	2006-10-16	2008-04-23	GPC Biotech Inc.	Pyrido[2,3-d]pyrimidines and their use as kinase inhibitors
JO2985B1 (ar)	2006-12-20	2016-09-05	Takeda Pharmaceuticals Co	مثبطات كينازmapk/erk
FR2910813B1 (fr) *	2006-12-28	2009-02-06	Sanofi Aventis Sa	Nouvelle utilisation therapeutique pour le traitement des leucemies
EP2112150B1 (en)	2008-04-22	2013-10-16	Forma Therapeutics, Inc.	Improved raf inhibitors
MX2011005720A (es) *	2008-12-01	2011-06-17	Merck Patent Gmbh	Pirido [4,3-d] pirimidinas 2,5-diamino sustituidas como inhibidores de autotaxina contra cancer.
GB201104267D0 (en)	2011-03-14	2011-04-27	Cancer Rec Tech Ltd	Pyrrolopyridineamino derivatives
GB201216017D0 (en)	2012-09-07	2012-10-24	Cancer Rec Tech Ltd	Inhibitor compounds
GB201216018D0 (en)	2012-09-07	2012-10-24	Cancer Rec Tech Ltd	Pharmacologically active compounds
WO2014151682A1 (en) *	2013-03-14	2014-09-25	Icahn School Of Medicine At Mount Sinai	Pyrimidine compounds as kinase inhibitors
GB201403536D0 (en)	2014-02-28	2014-04-16	Cancer Rec Tech Ltd	Inhibitor compounds
KR101671404B1 (ko) *	2014-09-02	2016-11-02	한국원자력의학원	항암 효과, 방사선 병용치료 효과 및 당뇨병 치료 효과를 갖는 피리미딘 유도체 및 이의 의학적 용도
CN107286180B (zh) *	2016-04-11	2019-07-02	上海勋和医药科技有限公司	杂代吡啶并嘧啶酮衍生物作为cdk抑制剂及其应用
GB201709840D0 (en)	2017-06-20	2017-08-02	Inst Of Cancer Research: Royal Cancer Hospital	Methods and medical uses

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GEP20012444B (en) *	1994-11-14	2001-05-25	Warner Lambert Company Us	6-Aryl Pyrido[2,3-d]Pyrimidines and Naphthyridines, Pharmaceutical Composition on Their Basis and Application for Inhibiting Cellular Proliferation
IL115256A0 (en) *	1994-11-14	1995-12-31	Warner Lambert Co	6-Aryl pyrido (2,3-d) pyrimidines and naphthyridines and their use
US5620981A (en) *	1995-05-03	1997-04-15	Warner-Lambert Company	Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation
ES2310039T3 (es) *	1998-05-26	2008-12-16	Warner-Lambert Company Llc	Pirimidinas biciclicas y 3,4-dihidropirimidinas biciclicas como inhibidores de la proliferacion celular.

2001
- 2001-01-23 AR ARP010100285A patent/AR030044A1/es not_active Application Discontinuation
- 2001-01-23 AU AU25425/01A patent/AU2542501A/en not_active Abandoned
- 2001-01-23 MX MXPA02007221A patent/MXPA02007221A/es not_active Application Discontinuation
- 2001-01-23 PA PA20018510701A patent/PA8510701A1/es unknown
- 2001-01-23 CN CN01804048A patent/CN1395578A/zh active Pending
- 2001-01-23 JP JP2001561006A patent/JP4047010B2/ja not_active Expired - Fee Related
- 2001-01-23 OA OA1200200213A patent/OA12161A/en unknown
- 2001-01-23 GT GT200100016A patent/GT200100016A/es unknown
- 2001-01-23 WO PCT/IB2001/000069 patent/WO2001055147A1/en not_active Application Discontinuation
- 2001-01-23 AP APAP/P/2002/002586A patent/AP2002002586A0/en unknown
- 2001-01-23 BR BR0107751-1A patent/BR0107751A/pt not_active IP Right Cessation
- 2001-01-23 KR KR1020027009516A patent/KR20020065939A/ko not_active Application Discontinuation
- 2001-01-23 HU HU0204141A patent/HUP0204141A3/hu unknown
- 2001-01-23 EA EA200200643A patent/EA200200643A1/ru unknown
- 2001-01-23 CZ CZ20022475A patent/CZ20022475A3/cs unknown
- 2001-01-23 SK SK1063-2002A patent/SK10632002A3/sk not_active Application Discontinuation
- 2001-01-23 CA CA002397961A patent/CA2397961C/en not_active Expired - Fee Related
- 2001-01-23 EE EEP200200405A patent/EE200200405A/xx unknown
- 2001-01-23 IL IL15054501A patent/IL150545A0/xx unknown
- 2001-01-23 EP EP01900591A patent/EP1254137A1/en not_active Withdrawn
- 2001-01-23 PE PE2001000072A patent/PE20011066A1/es not_active Application Discontinuation
- 2001-01-23 DZ DZ013266A patent/DZ3266A1/fr active
- 2001-01-23 YU YU50402A patent/YU50402A/sh unknown
- 2001-01-23 PL PL01356802A patent/PL356802A1/xx not_active Application Discontinuation
- 2001-01-24 TN TNTNSN01014A patent/TNSN01014A1/fr unknown
- 2001-01-24 SV SV2001000294A patent/SV2002000294A/es not_active Application Discontinuation
- 2001-01-24 HN HN2001000013A patent/HN2001000013A/es unknown
- 2001-01-24 CO CO01005268A patent/CO5261549A1/es not_active Application Discontinuation
2002
- 2002-06-20 BG BG106850A patent/BG106850A/bg unknown
- 2002-06-25 IS IS6443A patent/IS6443A/is unknown
- 2002-07-17 CR CR6706A patent/CR6706A/es not_active Application Discontinuation
- 2002-07-22 MA MA26736A patent/MA26868A1/fr unknown
- 2002-07-23 ZA ZA200205879A patent/ZA200205879B/en unknown
- 2002-07-24 NO NO20023527A patent/NO20023527L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
PL356802A1 (en)	2004-07-12
IS6443A (is)	2002-06-25
WO2001055147A1 (en)	2001-08-02
CA2397961A1 (en)	2001-08-02
TNSN01014A1 (fr)	2005-11-10
CO5261549A1 (es)	2003-03-31
EE200200405A (et)	2003-12-15
ZA200205879B (en)	2003-09-29
MXPA02007221A (es)	2002-11-29
KR20020065939A (ko)	2002-08-14
PE20011066A1 (es)	2001-10-22
IL150545A0 (en)	2003-02-12
AP2002002586A0 (en)	2002-09-30
HUP0204141A3 (en)	2005-03-29
HUP0204141A2 (hu)	2003-04-28
GT200100016A (es)	2001-10-19
MA26868A1 (fr)	2004-12-20
JP4047010B2 (ja)	2008-02-13
AU2542501A (en)	2001-08-07
CR6706A (es)	2005-04-04
SV2002000294A (es)	2002-07-16
OA12161A (en)	2006-05-08
BR0107751A (pt)	2002-11-12
PA8510701A1 (es)	2002-12-11
YU50402A (sh)	2005-11-28
EP1254137A1 (en)	2002-11-06
CN1395578A (zh)	2003-02-05
NO20023527L (no)	2002-09-10
BG106850A (bg)	2003-02-28
NO20023527D0 (no)	2002-07-24
EA200200643A1 (ru)	2002-12-26
SK10632002A3 (sk)	2003-06-03
AR030044A1 (es)	2003-08-13
CZ20022475A3 (cs)	2003-03-12
JP2003523357A (ja)	2003-08-05
CA2397961C (en)	2008-08-26
HN2001000013A (es)	2001-06-18

Publication	Publication Date	Title
DZ3266A1 (fr)	2001-08-02	Pyrido[2,3-d]pyrimidine-2,7-diamine inhibiteurs de kinase
HRP20020798A2 (en)	2004-02-29	5-ALKYLPYRIDO[2,3-d]PYRIMIDINES TYROZINE KINASE INHIBITORS
DK1416935T3 (da)	2008-07-07	4-Amino-6-phenyl-pyrrolo[2,3-d]pyrimidinderivater
NO20021694L (no)	2002-05-27	Pyrazolo[4,3-d]pyrimidinderivater
PT1235830E (pt)	2004-04-30	Compostos de pirrolo¬2,3-d\|pirimidina como inibidores das proteina cinases
ATE309245T1 (de)	2005-11-15	5-amino-5-phenyl-7-cyclobutyl-pyrrolo(2,3- d)pyrimidin-derivate
IL181957A0 (en)	2009-02-11	Pyrimidine-4-one derivatives as ldl-pla2 inhibitors
HK1054034A1 (en)	2003-11-14	Substituted pyrrolopyridinone derivatives useful as phosphodiesterase inhibitors.
DE50001191D1 (de)	2003-03-06	Pyrazolo[4, 3-d]pyrimidine
NO20026247D0 (no)	2002-12-27	5-aminoalkyl-pyrazolo[4,3-d]pyrimidiner med en fosfodiesterase V-inhiberende virkning
MA26967A1 (fr)	2004-12-20	Derives de pyrimidine
DK1294729T3 (da)	2005-01-17	2-aminoalkyl-thieno[2,3-d]pyrimidiner
PT1326866E (pt)	2005-08-31	3,4-di-hidropirido[1,2-a]pirimidinas substituidas
ZA200206528B (en)	2003-03-13	Pyrimidine-4-one derivatives as LDL-PLA2 inhibitors.
DK1326866T3 (da)	2005-08-01	Substituerede 3,4-dihydro-pyrido[1,2-a]pyrimidiner