CO5180578A1 - Inhibidores de metaloproteasas dihetero substituida que son efectivos en el tratamiento de condiciones caracterizadas por la actividad excesiva de estas enzimas - Google Patents

Inhibidores de metaloproteasas dihetero substituida que son efectivos en el tratamiento de condiciones caracterizadas por la actividad excesiva de estas enzimas

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Publication number
CO5180578A1
CO5180578A1 CO00015569A CO00015569A CO5180578A1 CO 5180578 A1 CO5180578 A1 CO 5180578A1 CO 00015569 A CO00015569 A CO 00015569A CO 00015569 A CO00015569 A CO 00015569A CO 5180578 A1 CO5180578 A1 CO 5180578A1
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Colombia
Prior art keywords
compounds
enzymes
effective
inhibitors
conditions characterized
Prior art date
Application number
CO00015569A
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English (en)
Inventor
Cheng Meyan
Gregory Almstead Neil
Michael George Natchus
Pikul Stanislaw
De Biswanath
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Procter & Gamble
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Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of CO5180578A1 publication Critical patent/CO5180578A1/es

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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
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    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
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    • C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
    • C07D271/113—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
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    • C07D285/01—Five-membered rings
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    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
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    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/36—Sulfur atom

Abstract

La presente invención se relaciona con compuestos que son inhibidores de metaloproteasas y que son efectivos en el tratamiento de condiciones caracterizadas por actividad excesiva de estas enzimas. En particular, los compuestos tienen una estructura según la siguiente fórmula (I):<EMI FILE="00015569_1" ID="1" IMF=JPEG >en donde J, M, Q, T, W, X, Z, R1, R2, R3, R4, R4´, R5, R6, R6´, R7, m, y n tienen los significados descritos en la especificación. Esta invención incluye además isómeros ópticos, diastereómeros y enantiómeros de la fórmula de arriba, y sales farmacéuticamente aceptables, amidas biohidrolizables, ésteres, e imidas de los mismos. También se revelan composiciones farmacéuticas que comprenden estos compuestos, y métodos de tratar o prevenir enfermedades relacionadas con la metaloproteasa que emplean los compuestos o las composiciones farmacéuticas.
CO00015569A 1999-03-03 2000-03-03 Inhibidores de metaloproteasas dihetero substituida que son efectivos en el tratamiento de condiciones caracterizadas por la actividad excesiva de estas enzimas CO5180578A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12271899P 1999-03-03 1999-03-03

Publications (1)

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CO5180578A1 true CO5180578A1 (es) 2002-07-30

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CO00015569A CO5180578A1 (es) 1999-03-03 2000-03-03 Inhibidores de metaloproteasas dihetero substituida que son efectivos en el tratamiento de condiciones caracterizadas por la actividad excesiva de estas enzimas

Country Status (25)

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US (2) US6566381B1 (es)
EP (1) EP1165530A2 (es)
JP (1) JP2002538146A (es)
KR (1) KR20010102485A (es)
CN (1) CN1362951A (es)
AR (1) AR022824A1 (es)
AU (1) AU767344B2 (es)
BR (1) BR0009244A (es)
CA (1) CA2366954A1 (es)
CO (1) CO5180578A1 (es)
CZ (1) CZ20013155A3 (es)
HK (1) HK1044935A1 (es)
HU (1) HUP0201714A3 (es)
IL (1) IL145085A0 (es)
MA (1) MA26775A1 (es)
MX (1) MXPA01008857A (es)
NO (1) NO20014243L (es)
NZ (1) NZ513830A (es)
PE (1) PE20001640A1 (es)
PL (1) PL350452A1 (es)
RU (1) RU2001126719A (es)
SK (1) SK12462001A3 (es)
TR (1) TR200102524T2 (es)
WO (1) WO2000051993A2 (es)
ZA (1) ZA200106966B (es)

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KR20020038951A (ko) * 1999-10-14 2002-05-24 데이비드 엠 모이어 베타 이치환된 메탈로프로테아제 저해제
IL151250A0 (en) 2000-03-21 2003-04-10 Procter & Gamble Difluorobutyric acid metalloprotease inhibitors
CZ20023180A3 (cs) * 2000-03-21 2003-02-12 The Procter And Gamble Company Metalloproteázové inhibitory zahrnující vedlejší heterocyklický řetězec
BR0109328A (pt) 2000-03-21 2003-06-10 Procter & Gamble Inibidores de metaloprotease n-substituìdos, contendo cadeia lateral heterocìclica
EP1288199A4 (en) * 2000-04-28 2005-10-12 Shionogi & Co INHIBITORS OF MMP-12
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GB0108097D0 (en) * 2001-03-30 2001-05-23 Pfizer Ltd Compounds
WO2003080042A1 (fr) * 2002-03-27 2003-10-02 Shionogi & Co., Ltd. Inhibiteur de decomposition pour matrice extracellulaire de cartilage
EP1613269B1 (en) 2003-04-04 2015-02-25 Incyte Corporation Compositions, methods and kits relating to her-2 cleavage
EP1635842A4 (en) * 2003-06-20 2007-04-04 Alcon Inc TREATMENT OF AMD WITH A COMBINATION OF INGREDIENTS
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