CO5070579A1 - Formulaciones de ziprasidona - Google Patents
Formulaciones de ziprasidonaInfo
- Publication number
- CO5070579A1 CO5070579A1 CO99037319A CO99037319A CO5070579A1 CO 5070579 A1 CO5070579 A1 CO 5070579A1 CO 99037319 A CO99037319 A CO 99037319A CO 99037319 A CO99037319 A CO 99037319A CO 5070579 A1 CO5070579 A1 CO 5070579A1
- Authority
- CO
- Colombia
- Prior art keywords
- ziprasidona
- formulations
- crystalline ziprasidone
- mfi
- schizophrenia
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- MVWVFYHBGMAFLY-UHFFFAOYSA-N ziprasidone Chemical compound C1=CC=C2C(N3CCN(CC3)CCC3=CC=4CC(=O)NC=4C=C3Cl)=NSC2=C1 MVWVFYHBGMAFLY-UHFFFAOYSA-N 0.000 title abstract 2
- 239000002245 particle Substances 0.000 abstract 2
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 229960000607 ziprasidone Drugs 0.000 abstract 1
- 229960003474 ziprasidone hydrochloride Drugs 0.000 abstract 1
- ZCBZSCBNOOIHFP-UHFFFAOYSA-N ziprasidone hydrochloride hydrate Chemical compound [H+].O.[Cl-].C1=CC=C2C(N3CCN(CC3)CCC3=CC=4CC(=O)NC=4C=C3Cl)=NSC2=C1 ZCBZSCBNOOIHFP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Feeding Of Articles By Means Other Than Belts Or Rollers (AREA)
- Polyamides (AREA)
- Detergent Compositions (AREA)
Abstract
Composiciones que comprenden partículas de base libre de ziprasidona cristalina o de hidrocloruro de ziprasidona cristalino, que tienen un tamaño medio de partículas inferior a 85 (m, y un vehículo farmacéuticamente aceptable son sustancialmente bioequivalentes y se pueden usar para tratar psicosis, como esquizofrenia. <EMI FILE="99037319_1" ID="1" IMF=JPEG >
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8922998P | 1998-06-15 | 1998-06-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO5070579A1 true CO5070579A1 (es) | 2001-08-28 |
Family
ID=22216447
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO99037319A CO5070579A1 (es) | 1998-06-15 | 1999-06-15 | Formulaciones de ziprasidona |
Country Status (45)
Families Citing this family (66)
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US20080113025A1 (en) * | 1998-11-02 | 2008-05-15 | Elan Pharma International Limited | Compositions comprising nanoparticulate naproxen and controlled release hydrocodone |
DE60001649T2 (de) * | 1999-05-27 | 2003-08-21 | Pfizer Prod Inc | Ziprasidonsuspension |
US7175855B1 (en) * | 1999-05-27 | 2007-02-13 | Pfizer Inc. | Ziprasidone suspension |
US10179130B2 (en) | 1999-10-29 | 2019-01-15 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
AU764453B2 (en) | 1999-10-29 | 2003-08-21 | Euro-Celtique S.A. | Controlled release hydrocodone formulations |
CN101317825A (zh) | 2000-10-30 | 2008-12-10 | 欧罗赛铁克股份有限公司 | 控释氢可酮制剂 |
UY27668A1 (es) * | 2002-02-20 | 2003-10-31 | Pfizer Prod Inc | Composición de ziprasidona y controles sintéticos |
US20040048876A1 (en) * | 2002-02-20 | 2004-03-11 | Pfizer Inc. | Ziprasidone composition and synthetic controls |
US7109198B2 (en) * | 2002-05-17 | 2006-09-19 | Duke University | Method for treating obesity |
WO2004050655A1 (en) * | 2002-12-04 | 2004-06-17 | Dr. Reddy's Laboratories Limited | Polymorphic forms of ziprasidone and its hydrochloride |
US7488729B2 (en) * | 2002-12-04 | 2009-02-10 | Dr. Reddy's Laboratories Limited | Polymorphic forms of ziprasidone and its hydrochloride salt and process for preparation thereof |
US20050143396A1 (en) * | 2003-04-11 | 2005-06-30 | Hertero Drugs Limited | Novel crystalline forms of ziprasidone hydrochloride |
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CA2528192A1 (en) * | 2003-06-03 | 2005-02-24 | Teva Pharmaceutical Industries Ltd | Cristalline ziprasidone hcl and processes for preparation thereof |
US20050049295A1 (en) * | 2003-06-12 | 2005-03-03 | Dr. Reddy's Laboratories Limited | Process for the preparation of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1piperazinyl) ethyl)-6-chloro-1, 3-dihydro-2h-indol-2-one hydrochloride (ziprasidone hydrochloride) and its intermediate |
CA2537413A1 (en) * | 2003-09-02 | 2005-03-10 | Imran Ahmed | Sustained release dosage forms of ziprasidone |
US7667037B2 (en) * | 2003-10-24 | 2010-02-23 | Teva Pharmaceutical Industries Ltd. | Processes for preparation of ziprasidone |
AU2003285600A1 (en) * | 2003-11-28 | 2005-06-24 | Siddiqui Mohammed Jaweed Mukarram | Process for the preparing ziprasidone monohydrochloride hydrate |
EP1592688A2 (en) * | 2003-12-18 | 2005-11-09 | Teva Pharmaceutical Industries Ltd. | Polymorphic form b2 of ziprasidone base |
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US7713959B2 (en) * | 2004-01-13 | 2010-05-11 | Duke University | Compositions of an anticonvulsant and mirtazapine to prevent weight gain |
EP1734955A2 (en) * | 2004-01-13 | 2006-12-27 | Duke University | Compositions of an anticonvulsant and an antipsychotic drug for affecting weigt loss |
ES2334800T3 (es) * | 2004-02-27 | 2010-03-16 | Ranbaxy Laboratories Limited | Proceso para la preparacion de ziprasidona. |
CN1968692A (zh) * | 2004-05-03 | 2007-05-23 | 杜克大学 | 影响体重减轻的组合物 |
EP1744750A2 (en) * | 2004-05-06 | 2007-01-24 | Sandoz AG | Pharmaceutical composition comprising hydrophobic drug having improved solubility |
CA2467538C (en) * | 2004-05-14 | 2010-08-24 | Apotex Pharmachem Inc. | New amorphous ziprasidone hydrochloride (5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2h-indol-2-one hydrochloride) and processes to produce the same |
US20070237828A1 (en) * | 2004-06-11 | 2007-10-11 | Dr. Reddy's Laboratories Limited | Ziprasidone Dosage Form |
CA2471219A1 (en) * | 2004-06-14 | 2005-12-14 | Apotex Pharmachem Inc. | Improved preparation of an anhydrate form of 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2h-indol-2-one hydrochloride (ziprasidone hydrochloride) |
US9044503B2 (en) * | 2004-08-27 | 2015-06-02 | University Of Kentucky Research Foundation | Amyloid peptide inactivating enzyme to treat alzheimer's disease peripherally |
US20090142404A1 (en) * | 2004-08-31 | 2009-06-04 | Pfizer Inc | Pharmaceutical dosage forms comprising a low-solubility drug and a polymer |
EP2623095A1 (en) * | 2004-11-16 | 2013-08-07 | Elan Pharma International Limited | Injectable nanoparticulate olanzapine formulations |
WO2006085168A2 (en) * | 2005-01-07 | 2006-08-17 | Ranbaxy Laboratories Limited | Solid oral dosage forms of ziprasidone containing colloidal silicone dioxide |
US7749529B2 (en) * | 2005-02-08 | 2010-07-06 | Ash Access Technology, Inc. | Catheter lock solution comprising citrate and a paraben |
CA2593497A1 (en) * | 2005-02-11 | 2006-08-17 | Judith Aronhime | Amorphous ziprasidone mesylate |
ITMI20050346A1 (it) | 2005-03-07 | 2006-09-08 | Dipharma Spa | Forma solida di ziprasidone cloridrato |
CA2500667C (en) * | 2005-03-11 | 2013-01-15 | Apotex Pharmachem Inc. | Preparation of acid addition salts of ziprasidone and intermediates thereof by solid phase-gas phase reactions |
EP1858892A1 (en) * | 2005-03-14 | 2007-11-28 | Teva Pharmaceutical Industries Ltd | Anhydrous ziprasidone mesylate and a process for its preparation |
EP1858891A2 (en) * | 2005-03-14 | 2007-11-28 | Teva Pharmaceutical Industries Ltd. | Crystalline forms of ziprasidone mesylate |
US20080305161A1 (en) * | 2005-04-13 | 2008-12-11 | Pfizer Inc | Injectable depot formulations and methods for providing sustained release of nanoparticle compositions |
US20080193542A1 (en) * | 2005-04-13 | 2008-08-14 | Pfizer Inc. | Injectable Deopot Formulations and Methods For Providing Sustained Release of Nanoparticle Compositions |
PE20061318A1 (es) * | 2005-04-22 | 2006-12-28 | Wyeth Corp | Nuevas combinaciones terapeuticas para el tratamiento o la prevencion de trastornos psicoticos |
DK1884242T3 (da) | 2005-05-26 | 2013-05-06 | Dainippon Sumitomo Pharma Co | Farmaceutisk sammensætning omfattende lurasidon |
JP2008546781A (ja) * | 2005-06-20 | 2008-12-25 | エラン・ファルマ・インターナショナル・リミテッド | アリール−複素環式化合物を含んでなるナノ粒状及び制御放出の組成物 |
EA200800092A1 (ru) * | 2005-06-20 | 2008-06-30 | Элан Фарма Интернэшнл Лимитед | Композиции в виде наночастиц и с контролируемым высвобождением, включающие арил-гетероциклические соединения |
EP1951212A2 (en) | 2005-11-22 | 2008-08-06 | Orexigen Therapeutics, Inc. | Compositions and methods for increasing insulin sensitivity |
DK1954241T3 (da) * | 2005-11-28 | 2012-06-18 | Orexigen Therapeutics Inc | Zonisamid-formulering med vedvarende frigivelse |
PL379569A1 (pl) * | 2006-04-28 | 2007-10-29 | Pliva Kraków Zakłady Farmaceutyczne Spółka Akcyjna | Sposób wytwarzania kompozycji farmaceutycznej zawierającej substancję aktywną ziprasidone lub jego farmaceutycznie dopuszczalną sól zwiększający rozpuszczalność i biodostępność tego leku, kompozycja farmaceutyczna i zastosowanie hydrofilowych substancji pomocniczych |
US8916195B2 (en) | 2006-06-05 | 2014-12-23 | Orexigen Therapeutics, Inc. | Sustained release formulation of naltrexone |
EP1889844A3 (en) * | 2006-08-02 | 2008-03-05 | Krka | Polymorphic forms of ziprasidone sulphates |
EP1892243A1 (en) * | 2006-08-02 | 2008-02-27 | KRKA, tovarna zdravil, d.d., Novo mesto | Polymorphic forms of ziprasidone sulphate salts |
KR20090090316A (ko) | 2006-11-09 | 2009-08-25 | 오렉시젠 세러퓨틱스 인크. | 체중 감량 약물을 투여하기 위한 단위 용량 팩키지 및 투여 방법 |
TW201811315A (zh) | 2006-11-09 | 2018-04-01 | 美商歐瑞根治療有限公司 | 層狀醫藥調配物 |
JP2010527925A (ja) * | 2007-05-18 | 2010-08-19 | サイドース・エルエルシー | ジプラシドン製剤 |
EP2197446A4 (en) * | 2007-08-31 | 2012-01-25 | Reddys Lab Ltd Dr | PREPARATION OF HYDROCHLORIDE OF ZIPRASIDONE MONOHYDRATE |
US8410268B2 (en) * | 2008-03-11 | 2013-04-02 | Alkem Laboratories Limited | Process for the preparation of ziprasidone |
CA2725930A1 (en) | 2008-05-30 | 2009-12-30 | Orexigen Therapeutics, Inc. | Methods for treating visceral fat conditions |
DE102008045854A1 (de) | 2008-09-05 | 2010-03-11 | Tiefenbacher Pharmachemikalien Alfred E. Tiefenbacher Gmbh & Co. Kg | Partikel aus Ziprasidone und einem Sprengmittel enthaltende Pharmazeutische Zusammensetzung |
CA2937222C (en) | 2009-06-25 | 2019-06-04 | Alkermes Pharma Ireland Limited | Prodrugs of nh-acidic compounds |
EP2340834A1 (en) | 2009-12-30 | 2011-07-06 | Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi | Enhanced Solubility of Ziprasidone |
ES2762113T3 (es) | 2010-01-11 | 2020-05-22 | Nalpropion Pharmaceuticals Inc | Métodos de proporcionar terapia de pérdida de peso en pacientes con depresión mayor |
SI3257500T1 (sl) | 2010-02-25 | 2019-12-31 | Bristol-Myers Squibb Holdings Ireland Unlimited Company | Formulacije apiksabana |
US20130108701A1 (en) | 2010-05-25 | 2013-05-02 | Krishna Murthy Bhavanasi | Solid Dosage Forms of Antipsychotics |
SI23610A (sl) | 2011-01-13 | 2012-07-31 | Diagen@d@o@o | Nove adicijske soli ziprasidona postopek za njihovo pripravo in njihova uporaba v terapiji |
EP4104824A1 (en) | 2012-06-06 | 2022-12-21 | Nalpropion Pharmaceuticals LLC | Composition for use in a method of treating overweight and obesity in patients with high cardiovascular risk |
US10154988B2 (en) | 2012-11-14 | 2018-12-18 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
CN112423754A (zh) | 2018-03-05 | 2021-02-26 | 奥克梅斯制药爱尔兰有限公司 | 阿立哌唑的给药策略 |
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1999
- 1999-05-27 US US09/320,985 patent/US6150366A/en not_active Expired - Lifetime
- 1999-06-04 HN HN1999000089A patent/HN1999000089A/es unknown
- 1999-06-08 EP EP99304451A patent/EP0965343B1/en not_active Expired - Lifetime
- 1999-06-08 PT PT99304451T patent/PT965343E/pt unknown
- 1999-06-08 DE DE69908021T patent/DE69908021T2/de not_active Withdrawn - After Issue
- 1999-06-08 SI SI9930316T patent/SI0965343T1/xx unknown
- 1999-06-08 GT GT199900080A patent/GT199900080A/es unknown
- 1999-06-08 ES ES99304451T patent/ES2197581T3/es not_active Expired - Lifetime
- 1999-06-08 AT AT99304451T patent/ATE240732T1/de active
- 1999-06-08 DK DK99304451T patent/DK0965343T3/da active
- 1999-06-09 SK SK769-99A patent/SK286245B6/sk not_active IP Right Cessation
- 1999-06-09 TW TW088109645A patent/TW590774B/zh not_active IP Right Cessation
- 1999-06-09 AU AU33983/99A patent/AU753820B2/en not_active Ceased
- 1999-06-10 IL IL13042496A patent/IL130424A/xx not_active IP Right Cessation
- 1999-06-10 SG SG1999002794A patent/SG77243A1/en unknown
- 1999-06-10 AP APAP/P/1999/001579A patent/AP1216A/en active
- 1999-06-11 MY MYPI99002412A patent/MY121397A/en unknown
- 1999-06-11 IS IS5079A patent/IS2182B/is unknown
- 1999-06-11 TR TR1999/01379A patent/TR199901379A2/xx unknown
- 1999-06-11 AR ARP990102822A patent/AR015553A1/es active IP Right Grant
- 1999-06-11 CA CA002274338A patent/CA2274338C/en not_active Expired - Lifetime
- 1999-06-11 PE PE1999000523A patent/PE20000632A1/es not_active Application Discontinuation
- 1999-06-14 HR HR990193A patent/HRP990193B1/xx not_active IP Right Cessation
- 1999-06-14 CN CNB991111192A patent/CN1307994C/zh not_active Expired - Fee Related
- 1999-06-14 UA UA99063279A patent/UA59383C2/uk unknown
- 1999-06-14 PL PL333737A patent/PL195209B1/pl not_active IP Right Cessation
- 1999-06-14 BG BG103489A patent/BG64691B1/bg unknown
- 1999-06-14 JP JP16677399A patent/JP3441676B2/ja not_active Expired - Lifetime
- 1999-06-14 PL PL380276A patent/PL195606B1/pl not_active IP Right Cessation
- 1999-06-14 NO NO19992892A patent/NO316713B1/no not_active IP Right Cessation
- 1999-06-14 CZ CZ0212799A patent/CZ297954B6/cs not_active IP Right Cessation
- 1999-06-14 ID IDP990571D patent/ID23546A/id unknown
- 1999-06-14 HU HU9901960A patent/HU226487B1/hu not_active IP Right Cessation
- 1999-06-14 MA MA25621A patent/MA26647A1/fr unknown
- 1999-06-14 ZA ZA9903938A patent/ZA993938B/xx unknown
- 1999-06-14 RS YUP-271/99A patent/RS49611B/sr unknown
- 1999-06-14 PA PA19998475601A patent/PA8475601A1/es unknown
- 1999-06-14 OA OA9900126A patent/OA11064A/en unknown
- 1999-06-14 KR KR1019990021977A patent/KR100338915B1/ko not_active IP Right Cessation
- 1999-06-14 NZ NZ336271A patent/NZ336271A/xx not_active IP Right Cessation
- 1999-06-15 EA EA199900467A patent/EA002223B1/ru not_active IP Right Cessation
- 1999-06-15 CO CO99037319A patent/CO5070579A1/es unknown
- 1999-06-15 BR BR9902268-0A patent/BR9902268A/pt not_active Application Discontinuation
- 1999-08-10 UY UY25649A patent/UY25649A1/es unknown
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2000
- 2000-06-16 HK HK00103630A patent/HK1024184A1/xx not_active IP Right Cessation
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2001
- 2001-06-11 JP JP2001175276A patent/JP4187423B2/ja not_active Expired - Lifetime
-
2003
- 2003-11-20 CY CY200300002C patent/CY2003002I1/el unknown
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