AR015553A1 - Composiciones de ziprasidona, y procedimiento para prepararlas - Google Patents

Composiciones de ziprasidona, y procedimiento para prepararlas

Info

Publication number
AR015553A1
AR015553A1 ARP990102822A ARP990102822A AR015553A1 AR 015553 A1 AR015553 A1 AR 015553A1 AR P990102822 A ARP990102822 A AR P990102822A AR P990102822 A ARP990102822 A AR P990102822A AR 015553 A1 AR015553 A1 AR 015553A1
Authority
AR
Argentina
Prior art keywords
solution resulting
prepare
crystalline
ziprasidone
approximately
Prior art date
Application number
ARP990102822A
Other languages
English (en)
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22216447&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR015553(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of AR015553A1 publication Critical patent/AR015553A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Feeding Of Articles By Means Other Than Belts Or Rollers (AREA)
  • Polyamides (AREA)
  • Detergent Compositions (AREA)

Abstract

Composiciones que comprenden partículas de base libre de ziprasidona cristalino o de hidrocloruro de ziprasidona cristalino, que tienen un tamano medio departículas inferior a 85 micrones, y un vehículo farmacéuticamente aceptable sonsustancialment e bioequivalentes y se pueden usar paa tratar psicosis, comoesquizofrenia. Se describe tambilén el uso de dichoas partículas para preparar la composicion y un procedimiento para preparar cristales grandes dehidrocloruro de ziprasidonamonohidrato, qu e comprende las etapas de: 1) disolver base libre de ziprasidona en un disolvente que comprende THF y agua, en unarelacion volumétrica de aproximadamente 22-35 unidades de volumen de THF a aproximadamente 1,5-8 unidades de volumen deagua 2) calentar la solucion resultantede la etapa (1),3) anadir HCI a la solucion resultante de la etapa (2) y (4) enfriar la solucion resultante de la etapa (3).
ARP990102822A 1998-06-15 1999-06-11 Composiciones de ziprasidona, y procedimiento para prepararlas AR015553A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8922998P 1998-06-15 1998-06-15

Publications (1)

Publication Number Publication Date
AR015553A1 true AR015553A1 (es) 2001-05-02

Family

ID=22216447

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990102822A AR015553A1 (es) 1998-06-15 1999-06-11 Composiciones de ziprasidona, y procedimiento para prepararlas

Country Status (45)

Country Link
US (1) US6150366A (es)
EP (1) EP0965343B1 (es)
JP (2) JP3441676B2 (es)
KR (1) KR100338915B1 (es)
CN (1) CN1307994C (es)
AP (1) AP1216A (es)
AR (1) AR015553A1 (es)
AT (1) ATE240732T1 (es)
AU (1) AU753820B2 (es)
BG (1) BG64691B1 (es)
BR (1) BR9902268A (es)
CA (1) CA2274338C (es)
CO (1) CO5070579A1 (es)
CY (1) CY2003002I1 (es)
CZ (1) CZ297954B6 (es)
DE (1) DE69908021T2 (es)
DK (1) DK0965343T3 (es)
EA (1) EA002223B1 (es)
ES (1) ES2197581T3 (es)
GT (1) GT199900080A (es)
HK (1) HK1024184A1 (es)
HN (1) HN1999000089A (es)
HR (1) HRP990193B1 (es)
HU (1) HU226487B1 (es)
ID (1) ID23546A (es)
IL (1) IL130424A (es)
IS (1) IS2182B (es)
MA (1) MA26647A1 (es)
MY (1) MY121397A (es)
NO (1) NO316713B1 (es)
NZ (1) NZ336271A (es)
OA (1) OA11064A (es)
PA (1) PA8475601A1 (es)
PE (1) PE20000632A1 (es)
PL (2) PL195209B1 (es)
PT (1) PT965343E (es)
RS (1) RS49611B (es)
SG (1) SG77243A1 (es)
SI (1) SI0965343T1 (es)
SK (1) SK286245B6 (es)
TR (1) TR199901379A2 (es)
TW (1) TW590774B (es)
UA (1) UA59383C2 (es)
UY (1) UY25649A1 (es)
ZA (1) ZA993938B (es)

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Also Published As

Publication number Publication date
KR100338915B1 (ko) 2002-05-30
US6150366A (en) 2000-11-21
OA11064A (en) 2002-03-13
CZ212799A3 (cs) 2000-09-13
PL333737A1 (en) 1999-12-20
PE20000632A1 (es) 2000-07-26
IL130424A (en) 2003-10-31
DE69908021D1 (de) 2003-06-26
CO5070579A1 (es) 2001-08-28
AP1216A (en) 2003-10-19
EA199900467A3 (ru) 2000-04-24
HRP990193B1 (en) 2003-08-31
RS49611B (sr) 2007-06-04
EA199900467A2 (ru) 1999-12-29
MA26647A1 (fr) 2004-12-20
NO316713B1 (no) 2004-04-13
SK76999A3 (en) 2000-12-11
AU3398399A (en) 1999-12-23
TW590774B (en) 2004-06-11
PL195209B1 (pl) 2007-08-31
SK286245B6 (sk) 2008-06-06
JP4187423B2 (ja) 2008-11-26
HUP9901960A3 (en) 2000-09-28
HK1024184A1 (en) 2000-10-05
IS5079A (is) 1999-12-16
IL130424A0 (en) 2000-06-01
SI0965343T1 (en) 2003-10-31
AP9901579A0 (en) 1999-06-30
DK0965343T3 (da) 2003-08-04
AU753820B2 (en) 2002-10-31
HUP9901960A2 (hu) 2000-08-28
EA002223B1 (ru) 2002-02-28
IS2182B (is) 2006-12-15
HU226487B1 (en) 2009-03-02
JP2000007566A (ja) 2000-01-11
BG64691B1 (bg) 2005-12-30
CN1307994C (zh) 2007-04-04
HU9901960D0 (en) 1999-08-30
ES2197581T3 (es) 2004-01-01
EP0965343B1 (en) 2003-05-21
ID23546A (id) 2000-05-04
YU27199A (sh) 2002-12-10
HN1999000089A (es) 1999-11-03
CY2003002I1 (el) 2009-11-04
PT965343E (pt) 2003-08-29
SG77243A1 (en) 2000-12-19
JP3441676B2 (ja) 2003-09-02
BG103489A (en) 2000-07-31
HRP990193A2 (en) 2000-02-29
KR20000006143A (ko) 2000-01-25
UA59383C2 (uk) 2003-09-15
GT199900080A (es) 2000-11-29
BR9902268A (pt) 2000-05-02
CA2274338C (en) 2003-04-15
CZ297954B6 (cs) 2007-05-09
CA2274338A1 (en) 1999-12-15
ZA993938B (en) 2000-12-14
EP0965343A2 (en) 1999-12-22
JP2002003492A (ja) 2002-01-09
EP0965343A3 (en) 2000-02-23
NZ336271A (en) 2000-10-27
NO992892D0 (no) 1999-06-14
TR199901379A2 (xx) 2000-01-21
DE69908021T2 (de) 2003-11-27
UY25649A1 (es) 2000-02-23
ATE240732T1 (de) 2003-06-15
CN1242987A (zh) 2000-02-02
PA8475601A1 (es) 2000-09-29
MY121397A (en) 2006-01-28
PL195606B1 (pl) 2007-10-31
NO992892L (no) 1999-12-16

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