CO2023000858A2 - Inhibidores de atr y usos de estos - Google Patents

Inhibidores de atr y usos de estos

Info

Publication number
CO2023000858A2
CO2023000858A2 CONC2023/0000858A CO2023000858A CO2023000858A2 CO 2023000858 A2 CO2023000858 A2 CO 2023000858A2 CO 2023000858 A CO2023000858 A CO 2023000858A CO 2023000858 A2 CO2023000858 A2 CO 2023000858A2
Authority
CO
Colombia
Prior art keywords
compounds
atr inhibitors
pharmaceutical compositions
atr
administration
Prior art date
Application number
CONC2023/0000858A
Other languages
English (en)
Inventor
Bo Shan
Bing Hou
Zhongyang Shi
Peng Chen
Hui Yuwen
Jay Mei
Original Assignee
Antengene Discovery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Antengene Discovery Ltd filed Critical Antengene Discovery Ltd
Publication of CO2023000858A2 publication Critical patent/CO2023000858A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

La presente divulgación se refiere a nuevos compuestos útiles como inhibidores de la cinasa ATR, así como a composiciones farmacéuticas que comprenden estos compuestos y métodos de tratamiento mediante la administración de estos compuestos o las composiciones farmacéuticas.
CONC2023/0000858A 2020-07-03 2023-01-26 Inhibidores de atr y usos de estos CO2023000858A2 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN2020100088 2020-07-03
CN2020110396 2020-08-21
CN2020134732 2020-12-09
CN2020135604 2020-12-11
PCT/CN2021/104232 WO2022002245A1 (en) 2020-07-03 2021-07-02 Atr inhibitors and uses thereof

Publications (1)

Publication Number Publication Date
CO2023000858A2 true CO2023000858A2 (es) 2023-02-16

Family

ID=79317475

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2023/0000858A CO2023000858A2 (es) 2020-07-03 2023-01-26 Inhibidores de atr y usos de estos

Country Status (13)

Country Link
US (1) US20230339927A1 (es)
EP (1) EP4175948A1 (es)
JP (1) JP2023532303A (es)
KR (1) KR20230035070A (es)
CN (1) CN116134022A (es)
AU (1) AU2021302146A1 (es)
BR (1) BR112022024700A2 (es)
CA (1) CA3185491A1 (es)
CO (1) CO2023000858A2 (es)
IL (1) IL299510A (es)
MX (1) MX2023000198A (es)
TW (1) TW202216701A (es)
WO (1) WO2022002245A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023131234A1 (en) * 2022-01-06 2023-07-13 Shanghai Antengene Corporation Limited Crystalline forms of an atr inhibitor

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI656121B (zh) * 2014-08-04 2019-04-11 德商拜耳製藥公司 ２－（嗎啉－４－基）－１，７－萘啶
US11690911B2 (en) * 2017-08-04 2023-07-04 Bayer Aktiengesellschaft Combination of ATR kinase inhibitors and PD-1/PD-L1 inhibitors
RS65147B1 (sr) * 2018-02-07 2024-02-29 Wuxi Biocity Biopharmaceutics Co Ltd Inhibitor atr i njegova primena
ES2954572T3 (es) * 2018-09-07 2023-11-23 Merck Patent Gmbh Derivados de 5-morfolin-4-il-pirazolo[4,3-b]piridina

Also Published As

Publication number Publication date
MX2023000198A (es) 2023-02-22
AU2021302146A1 (en) 2023-01-19
EP4175948A1 (en) 2023-05-10
CN116134022A (zh) 2023-05-16
TW202216701A (zh) 2022-05-01
IL299510A (en) 2023-02-01
BR112022024700A2 (pt) 2023-12-05
JP2023532303A (ja) 2023-07-27
KR20230035070A (ko) 2023-03-10
WO2022002245A1 (en) 2022-01-06
CA3185491A1 (en) 2022-01-06
US20230339927A1 (en) 2023-10-26

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