CO2020002980A2 - Agentes antivirales contra la hepatitis b. - Google Patents

Agentes antivirales contra la hepatitis b.

Info

Publication number
CO2020002980A2
CO2020002980A2 CONC2020/0002980A CO2020002980A CO2020002980A2 CO 2020002980 A2 CO2020002980 A2 CO 2020002980A2 CO 2020002980 A CO2020002980 A CO 2020002980A CO 2020002980 A2 CO2020002980 A2 CO 2020002980A2
Authority
CO
Colombia
Prior art keywords
hbv
antiviral agents
present
compounds
hepatitis
Prior art date
Application number
CONC2020/0002980A
Other languages
English (en)
Inventor
Yao-Ling Qiu
Xuri Gao
Wei Li
Hui Cao
Yat Sun Or
Jordan Kass
Xiaowen Peng
Byung-Chul Suh
Original Assignee
Enanta Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enanta Pharm Inc filed Critical Enanta Pharm Inc
Publication of CO2020002980A2 publication Critical patent/CO2020002980A2/es

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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
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    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
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    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
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Abstract

La presente invención revela compuestos de Fórmula (I), o sales, ésteres o profármacos de los mismos de uso farmacéutico aceptable: X-A-Y-L-R (I) los cuales inhiben la(s) proteína(s) codificada(s) por el virus de la hepatitis B (HBV) o interfieren con la función del ciclo de vida del HBV del virus de la hepatitis B y también son agentes antivirales útiles. La presente invención además se relaciona a composiciones farmacéuticas que comprenden los compuestos antes mencionados para la administración a un sujeto que sufre de infección por HBV. La invención también se relaciona a los métodos para tratar una infección por HBV en un sujeto mediante la administración de una composición farmacéutica que comprende los compuestos de la presente invención.
CONC2020/0002980A 2017-08-28 2020-03-13 Agentes antivirales contra la hepatitis b. CO2020002980A2 (es)

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