SG11201810834WA - Hepatitis b antiviral agents - Google Patents
Hepatitis b antiviral agentsInfo
- Publication number
- SG11201810834WA SG11201810834WA SG11201810834WA SG11201810834WA SG11201810834WA SG 11201810834W A SG11201810834W A SG 11201810834WA SG 11201810834W A SG11201810834W A SG 11201810834WA SG 11201810834W A SG11201810834W A SG 11201810834WA SG 11201810834W A SG11201810834W A SG 11201810834WA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- road
- pct
- hepatitis
- hbv
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
PUBLISHEDUNDER THE PATENT COOPERATION TREATY (PCT) WIPO I PCT () INTERNATIONAL APPLICATION (19) World Intellectual Property Organization International Bureau (43) International Publication Date 14 December 2017 (14.12.2017) omit VIII Hot o III OH olo mil mu Eno lII ois (10) International Publication Number WO 2017/214395 Al (51) International Patent Classification: A61K 31/519 (2006.01) C07D 487/04 (2006.01) CO7D 239/20 (2006.01) (21) International Application Number: PCT/US2017/036553 (22) International Filing Date: 08 June 2017 (08.06.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/348,419 10 June 2016 (10.06.2016) US 62/443,245 06 January 2017 (06.01.2017) US (71) Applicant: ENANTA PHARMACEUTICALS, INC. [US/US]; 500 Arsenal Street, Watertown, MA 02472 (US). (72) Inventors: QIU, Yao-Ling; 29 Linda Road, Andover, MA 01810 (US). CAO, Hui; 53 Hill Road, Belmont, MA 02478 (US). PENG, Xiaowen; 85 Horse Pond Road, Sudbury, MA 01776 (US). LI, Wei; 22 April Lane, Lexington, MA 02421 (US). KASS, Jorden; 29 Wilson Ave, Apt. #2, Belmont, MA 02478 (US). GAO, Xuri; 179 Allerton Road, Unit 2, Newton, MA 02461 (US). JIN, Meizhong; 64-105 Hastings St., Wellesley, MA 02481 (US). OR, Yat, Sun; 169 Fayette Street, Watertown, MA 02472 (US). (74) Agent: HARLAN, Edgar, W. et al.; Elmore Patent Law Group, P.C., 484 Groton Road, Westford, MA 01886 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 2 I (3)) (54) Title: HEPATITIS B ANTIVIRAL AGENTS W O 20 17 / 214395 Al X B (57) : The present invention discloses compounds of Formula (I), or phar- maceutically acceptable salts, thereof: which inhibit the protein(s) encoded by hepati- tis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for ad- ministration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662348419P | 2016-06-10 | 2016-06-10 | |
| US201762443245P | 2017-01-06 | 2017-01-06 | |
| PCT/US2017/036553 WO2017214395A1 (en) | 2016-06-10 | 2017-06-08 | Hepatitis b antiviral agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201810834WA true SG11201810834WA (en) | 2018-12-28 |
Family
ID=60573663
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201810834WA SG11201810834WA (en) | 2016-06-10 | 2017-06-08 | Hepatitis b antiviral agents |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US10189846B2 (en) |
| EP (1) | EP3468561A4 (en) |
| JP (1) | JP2019521972A (en) |
| KR (1) | KR20190027814A (en) |
| CN (1) | CN109843296A (en) |
| AU (1) | AU2017277664A1 (en) |
| BR (1) | BR112018075465A2 (en) |
| CA (1) | CA3028228A1 (en) |
| CL (1) | CL2018003492A1 (en) |
| CO (1) | CO2019000069A2 (en) |
| IL (1) | IL263535A (en) |
| MX (1) | MX2018015315A (en) |
| PH (1) | PH12018550201A1 (en) |
| SG (1) | SG11201810834WA (en) |
| WO (1) | WO2017214395A1 (en) |
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-
2017
- 2017-06-08 KR KR1020197000474A patent/KR20190027814A/en unknown
- 2017-06-08 SG SG11201810834WA patent/SG11201810834WA/en unknown
- 2017-06-08 BR BR112018075465-0A patent/BR112018075465A2/en not_active IP Right Cessation
- 2017-06-08 US US15/617,445 patent/US10189846B2/en active Active
- 2017-06-08 AU AU2017277664A patent/AU2017277664A1/en not_active Abandoned
- 2017-06-08 CN CN201780048555.5A patent/CN109843296A/en active Pending
- 2017-06-08 EP EP17811015.1A patent/EP3468561A4/en not_active Withdrawn
- 2017-06-08 MX MX2018015315A patent/MX2018015315A/en unknown
- 2017-06-08 WO PCT/US2017/036553 patent/WO2017214395A1/en unknown
- 2017-06-08 JP JP2018563674A patent/JP2019521972A/en not_active Withdrawn
- 2017-06-08 CA CA3028228A patent/CA3028228A1/en not_active Abandoned
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2018
- 2018-12-03 PH PH12018550201A patent/PH12018550201A1/en unknown
- 2018-12-05 CL CL2018003492A patent/CL2018003492A1/en unknown
- 2018-12-06 IL IL263535A patent/IL263535A/en unknown
- 2018-12-14 US US16/220,267 patent/US10640511B2/en active Active
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2019
- 2019-01-04 CO CONC2019/0000069A patent/CO2019000069A2/en unknown
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2020
- 2020-03-30 US US16/834,259 patent/US20200317678A1/en not_active Abandoned
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| PH12018550201A1 (en) | 2019-04-08 |
| US10640511B2 (en) | 2020-05-05 |
| CL2018003492A1 (en) | 2019-04-05 |
| CO2019000069A2 (en) | 2019-02-08 |
| CN109843296A (en) | 2019-06-04 |
| US20200317678A1 (en) | 2020-10-08 |
| KR20190027814A (en) | 2019-03-15 |
| US20190119288A1 (en) | 2019-04-25 |
| JP2019521972A (en) | 2019-08-08 |
| WO2017214395A1 (en) | 2017-12-14 |
| AU2017277664A1 (en) | 2019-01-24 |
| MX2018015315A (en) | 2019-04-25 |
| BR112018075465A2 (en) | 2019-03-19 |
| US20170355701A1 (en) | 2017-12-14 |
| EP3468561A4 (en) | 2019-12-04 |
| CA3028228A1 (en) | 2017-12-14 |
| EP3468561A1 (en) | 2019-04-17 |
| IL263535A (en) | 2019-01-31 |
| US10189846B2 (en) | 2019-01-29 |
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