CO2019003938A2 - Compuestos del péptido tirosina tirosina cíclico como moduladores de receptores de neuropéptido y - Google Patents

Compuestos del péptido tirosina tirosina cíclico como moduladores de receptores de neuropéptido y

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Publication number
CO2019003938A2
CO2019003938A2 CONC2019/0003938A CO2019003938A CO2019003938A2 CO 2019003938 A2 CO2019003938 A2 CO 2019003938A2 CO 2019003938 A CO2019003938 A CO 2019003938A CO 2019003938 A2 CO2019003938 A2 CO 2019003938A2
Authority
CO
Colombia
Prior art keywords
tyrosine
compounds
modulators
cyclic
peptide
Prior art date
Application number
CONC2019/0003938A
Other languages
English (en)
Inventor
Mark Macielag
Raymond J Patch
Rui Zhang
Martin A Case
Mark Wall
Yue-Mei Zhang
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of CO2019003938A2 publication Critical patent/CO2019003938A2/es

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    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/567—Framework region [FR]
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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Abstract

La presente invención comprende compuestos de Fórmula I. Fórmula I en donde: Z4, Z7, Z9, Z11, Z22, Z23, Z26, Z30, Z34, Z35, p, m, n, q, y PUENTE se definen en la especificación. La invención también se relaciona con composiciones farmacéuticas y con métodos para usarlas. Los compuestos novedosos son útiles para prevenir, tratar o mejorar enfermedades y trastornos, tales como obesidad, diabetes tipo 2, síndrome metabólico, resistencia a la insulina y dislipidemia, entre otros.
CONC2019/0003938A 2016-10-27 2019-04-17 Compuestos del péptido tirosina tirosina cíclico como moduladores de receptores de neuropéptido y CO2019003938A2 (es)

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CONC2019/0004186A CO2019004186A2 (es) 2016-10-27 2019-04-26 Inmunoglobulinas y usos de estas
CONC2019/0004203A CO2019004203A2 (es) 2016-10-27 2019-04-26 Compuestos del péptido tirosina tirosina cíclico con anticuerpo acoplado como moduladores de receptores de neuropéptido y

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