CN1931118A - 多室容器 - Google Patents
多室容器 Download PDFInfo
- Publication number
- CN1931118A CN1931118A CNA2006101536721A CN200610153672A CN1931118A CN 1931118 A CN1931118 A CN 1931118A CN A2006101536721 A CNA2006101536721 A CN A2006101536721A CN 200610153672 A CN200610153672 A CN 200610153672A CN 1931118 A CN1931118 A CN 1931118A
- Authority
- CN
- China
- Prior art keywords
- layer
- film
- deposited
- small container
- multichamber vessel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Classifications
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Landscapes
- Health & Medical Sciences (AREA)
- Mechanical Engineering (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Package Specialized In Special Use (AREA)
- Laminated Bodies (AREA)
- Packages (AREA)
- Wrappers (AREA)
- Vacuum Packaging (AREA)
Abstract
本发明提供一种多室容器,其通过容易地剥离具有易剥离性密封层的连接片,连通多个小容器,可以混合容纳于两个小容器中的内容物。一种多室容器,具有由至少最内层为环状聚烯烃的膜形成的小容器,其特征在于,一个小容器和另一个小容器通过连接片隔开,该连接片部具有包含低密度聚乙烯和丙烯·α-烯烃共聚物的易剥离性密封层。
Description
技术领域
本发明涉及一种多室容器,其具有用具有可以剥离的密封层(称为易剥离性密封层)的连接片隔离开的多个小容器,特别是涉及一种医疗用多层多室容器,更详细地来讲,本发明涉及一种通过剥离具有易剥离性密封层的连接片,连通多个小容器,容纳于两个小容器中的内容物可以混合的多室容器。
背景技术
目前,具有多个分别容纳液剂、粉末剂或固态剂的小容器的多室容器通常由可挠性塑料膜形成。多个小容器中,一个小容器和邻接的另一个小容器通过可以连通的隔开装置隔开。该隔开部是将形成小容器的膜的内面之间直接熔敷,或者通过夹在该内面之间的***膜熔敷。该隔开部通过对容纳有内容物的小容器施加外压而容易剥离,多个小容器的内部连通,可以混合容纳的内容物。
作为用于形成小容器的塑料膜(包括片材),通常使用两层膜或三层膜(专利文献1、专利文献2等),其中,两层膜包含由直链状低密度聚乙烯(LLDPE)和聚丙烯(PP)的混合树脂构成的内层和由直链状密度聚乙烯(LLDPE)构成的外层,三层膜包含由直链状低密度聚乙烯(LLDPE)和聚丙烯(PP)的混合树脂构成的内层、由直链状密度聚乙烯(LLDPE)和乙烯·α-烯烃类弹性体的混合树脂构成的中间层和由直链状低密度聚乙烯(LLDPE)构成的外层。在这些多层膜中,由直链状低密度聚乙烯(LLDPE)和聚丙烯(PP)的混合树脂构成的内层在熔敷温度约110~约130℃下相互密封,形成易剥离性密封层,并且,在熔敷温度约170~约200℃下密封,形成强熔敷层。
另外,作为形成小容器的塑料膜,通常使用铝箔层压体(聚酯/铝箔/聚乙烯的三层膜)、含有二氧化硅蒸镀层的层压膜(PE/SiO2/PET/SiO2/PE)、聚乙烯制的筒状膜(专利文献3、专利文献4)。多室容器由层叠前述铝箔层压体和含有二氧化硅蒸镀层的层压膜的小容器和由聚乙烯筒状膜构成的小容器形成。这样的多个小容器,通过夹在聚乙烯的内面之间的聚乙烯和聚丙烯的聚合物共混物构成的弱熔敷部形成膜熔敷在一起。
以往的弱熔敷部形成膜,通常采用与作为最内层形成材料的聚乙烯的熔敷强度小(弱熔敷)的树脂例如聚乙烯和与其没有相容性的树脂的共混物。
另一方面,在上述多室容器中,由于自线状聚烯烃溶出的低分子量成分及自粘接层溶出的成分等的杂质与作为有效成分的药剂的相互作用,产生药剂含量降低,药剂类似物质增加,药液的浑浊度增加,或不溶性微粒子增加等。
在这种情况下,本发明人提出了医疗用多层多室容器,其由多层膜形成,所述多层膜包括小容器体的最内层由环状聚烯烃或含有环状聚烯烃的聚合物共混物构成的第1层,和与该层邻接的由线状聚烯烃构成的第2层。该多层多室容器作为医疗用多层多室容器,可以进行γ射线灭菌,并且使由这些多层容器溶出的低分子量成分及粘接层成分减少,从而消除由这些成分和药剂的相互作用引起的药剂含量降低,药剂类似物质增加,药剂中的浑浊度增加和不溶性微粒子增加等问题,而且具有药剂稳定性。
〔专利文献1〕专利第3060132号公报
〔专利文献2〕专利第3079403号公报
〔专利文献3〕专利第3016348号公报
〔专利文献4〕特开2003-104391号公报
发明内容
本发明的课题在于在至少一个小容器在最内层主要使用由环状聚烯烃构成的层的多室容器中,提供一种与作为最内层的环状聚烯烃构成的层强熔敷,并且与由环状聚烯烃构成的层可以剥离的密封层(易剥离性密封层),从而在使用时可以混合多室容器内的内容物。
即,本发明涉及一种多室容器,具有由至少最内层为环状聚烯烃的膜形成的小容器,其特征在于,一个小容器和另一个小容器通过连接片隔开,该连接片部具有包含低密度聚乙烯和丙烯·α-烯烃共聚物的易剥离性密封层。
在本发明中,由于最内层的环状聚烯烃层为非晶性的,故难以相互弱熔敷。另外,以往为了赋予易剥离性,一般是通过共混与容器主体的材质同材质的树脂和不同材质的树脂,使其具有该易剥离性功能。但是将环状聚烯烃用于容器主体时,将与该材质不同的材质共混后的容器本体,例如片材会不具有易剥离性,或者在长期保存中会失去易剥离性。在本发明中,通过使用将与环状聚烯烃不同材质的树脂、特别是低密度聚乙烯和丙烯·α-烯烃共聚物共混而成的片材,实现易剥离性从而在使用时可以将容器内的内容物混合,并且可以长期维持其强度。
在本发明中,所谓多室容器,是具有多个小容器的容器,是指一个小容器和另一个小容器通过连接片隔开的容器。作为具体例,可以列举:容纳液剂的液剂小容器和容纳药剂的药剂小容器通过具有易剥离性密封层的连接片液密地隔开的容器。作为其一例,例如:在2个小容器的一个的端部具有相对的一对连接片,在该连接片间***另一个小容器的端部并熔敷,两个小容器通过该接片部隔开。
在本发明中,所谓小容器,是构成多室容器的容器,其中,至少1个小容器是由至少最内层为环状聚烯烃的膜形成的容器。通常是分别容纳液剂、粉末剂或固态剂的小容器。其形状及大小因容纳的内容物而不同。作为构成多室容器的另一个小容器,可以包括由最内层不是环状聚烯烃的树脂形成的小容器。
在本发明中,所谓构成至少1个小容器的膜,是指至少最内层包含环状聚烯烃的单层膜或多层膜。优选为包含最内层为环状聚烯烃的第1层和与该层邻接的由线状聚烯烃构成的第2层的多层膜。
所谓环状聚烯烃,是热塑性饱和降冰片烯型聚合物,这是众所周知的(特开平4-276253号公报、特开平5-317411号公报、特开平8-155007号公报等)。作为其具体例,可以列举具有用化学式1和/或化学式2表示的结构单元的聚合物。
〔化学式1〕
(式中,R1和R2是氢或碳原子数1~10的烃残基,并且各自可以相同或不同,另外,R1和R2可以一起形成环。n是正整数。)
(化学式2)
(式中,R3和R4是氢或碳原子数1~5的烃残基,并且各自可以相同或不同,另外,R3和R4可以一起形成环。l和m是正整数。p是0或正整数。)
具有用化学式1表示的结构单元的聚合物是如下制造的饱和聚合物:将使用例如:2-降冰片烯及其烷基和/或亚烷基取代物,例如5-甲基-2-降冰片烯、5,5-二甲基-2-降冰片烯、5-乙基-2-降冰片烯、5-丁基-2-降冰片烯、5-亚乙基-2-降冰片烯等;二环戊二烯、2,3-二氢化二环戊二烯、及其甲基、乙基、丙基、丁基等的烷基取代物;二亚甲基八氢化萘及其烷基和/或亚烷基取代物,例如6-甲基-1,4:5,8-二亚甲基-1,4,4a,5,6,7,8,8a-八氢化萘、6-乙基-1,4:5,8-二亚甲基-1,4,4a,5,6,7,8,8a-八氢化萘、6-亚乙基-1,4:5,8-二亚甲基-1,4,4a,5,6,7,8,8a-八氢化萘等;环戊二烯的3~4聚物,例如4,9:5,8-二亚甲-3a,4,4a,5,8,8a,9,9a,-八氢-1H-苯并茚、5,8-亚甲基-3a,4,4a,5,8,8a,9,9a,-八氢-1H-苯并茚、5,8-亚甲基-1,4,4a,4b,5,8,8a,9b-八氢-1H-芴、4,11:5,10:6,9-三亚甲基-3a,4,4a,5,5a,6,9,9a,10,10a,11,11a-十二氢-1H-环戊二烯并蒽等作为单体,通过公知的开环聚合法聚合得到开环聚合物,通过通常的加氢方法进行加氢,制造饱和聚合物。
另外,具有用化学式2表示的结构单元的聚合物,是利用公知的方法将作为单体的前述的降冰片烯型单体和乙烯共聚合得到的聚合物和/或其加氢产物,都是饱和聚合物。
本发明中使用的环状聚烯烃,可以是其中热塑性饱和降冰片烯型聚合物为极性单体的开环聚合物的氢化产物、该降冰片烯型单体和乙烯的共聚物、及该共聚物的加氢产物。
由环状聚烯烃形成的层,其厚度通常为3~5000μm,优选5~2000μm,作为医疗用多室容器使用时,其厚度通常为10~500μm,优选20~300μm。
作为与环状聚烯烃构成的第1层邻接的线状聚烯烃构成的第2层,可以列举例如:低密度聚乙烯、直链状低密度聚乙烯、中密度聚乙烯、高密度聚乙烯、聚丙烯、丙烯·α-烯烃共聚物等线状聚烯烃的层。由上述线状聚烯烃形成的层,其厚度通常为3~5000μm,优选5~2000μm,作为医疗用多室容器使用时,其厚度通常为10~500μm,优选20~300μm。
构成前述小容器的膜,根据需要,在由前述线状聚烯烃构成的第2层上进一步具有阻气层和/或可印刷的层。所谓可印刷的层,意思是指在容器表面显示文字或图案的时候,可以将印刷油墨等介质印刷的层。另外,所谓阻气层,是具有阻断水分或气体通过的性能的层。在本发明中,作为可印刷的层,例如有聚对苯二甲酸乙二醇酯等的聚酯层、或蒸镀了二氧化硅等无机物的聚酯层。另外,具体的来讲,阻气层有金属箔、金属蒸镀层或无机物蒸镀层,作为金属箔,包括例如铝箔等。作为金属蒸镀层,例如可以列举氧化铝蒸镀的聚酯膜或尼龙膜等。作为无机物蒸镀层,例如可以列举二氧化硅蒸镀的聚酯膜等。
在本发明中,所谓易剥离性密封层,是指形成小容器的膜相互弱熔敷后,在制备药剂时可以容易地剥离的层。通常,易剥离性密封层通过对容纳有内容物的小容器施加外压而容易地剥离,从而多个小容器的内部连通,可以混合容器中的内容物。
在本发明中,所谓隔开小容器的连接片,包括由前述易剥离性密封层构成的弱熔敷密封部和强熔敷密封部。
在本发明中,弱熔敷部的特征在于,具有易剥离性密封层,其为含有低密度聚乙烯和丙烯·α-烯烃共聚物的组合物。
在本发明中,作为低密度聚乙烯,例如可以使用高压法低密度聚乙烯,其是通过使用有机过氧化物等自由基引发剂作为聚合引发剂,通过高压自由基聚合法将乙烯单体聚合而得到的。而且,在本发明中,作为上述的低密度聚乙烯,可以使用熔体流动速率(MFR)在0.5~8.0g/10分钟的范围内、另外,密度为0.900~0.930的低密度聚乙烯树脂。例如,東ソ一制造的“ペトロセン”、日本ポリエチレン制造的“ノバテツク”、住友化学制造的“エクセレン”、宇部丸善ポリエチレン制造的“UBEポリエチレン”、プライムポリマ一制造的“ミラソン”等。另外,作为本发明的丙烯·α-烯烃共聚物的α-烯烃,使用碳原子数2或4~8的α-烯烃,具体地使用乙烯、丁烯、己烯、庚烯、辛烯或这些物质的2种以上。即,作为本发明的丙烯·α-烯烃共聚物的具体例,除丙烯·乙烯共聚物、丙烯·丁烯共聚物等2元共聚物之外,也可以是丙烯·乙烯·丁烯共聚物等的3元共聚物。另外,本发明的丙烯·α-烯烃共聚物的熔点例如为100℃~150℃的范围。作为已经在市场上出售的丙烯·α-烯烃共聚物,例如有日本ポリエチレン制造的“ノバテツクPP”、“ウインテツク”、住友化学制造的“エクセレン”、サンアロマ一和プライムポリマ一制造的聚丙烯等。
低密度聚乙烯和丙烯·α-烯烃共聚物的重量混合比率,优选为80∶20~20∶80,更优选为75∶25~25∶75,最优选为70∶30~30∶70。当低密度聚乙烯超过80重量%时,通过制作的膜形成易剥离性密封层时,用于剥离该易剥离性密封层的弱熔敷密封强度增加,当低于20重量%时,用于剥离该易剥离性密封层的弱熔敷密封强度变得不稳定。
本发明的连接片(也叫做易剥离性片材)由前述低密度聚乙烯和丙烯·α-烯烃共聚物的混合物按照常规方法制造。该混合物的混合方法没有特别限定,但优选使用预先将树脂颗粒进行干混的方法或者使用双螺杆挤出机熔体混合的方法。
为了提高阻气性、易剥离性、力学性质等,本发明的易剥离性片材可以是将易剥离性密封层作为至少一个表面层,使其它树脂层层压而形成的易剥离性层压膜。前述其它的树脂及其它树脂的层数,可以根据用途适当选择。具体地来讲,所谓其它的树脂,例如可以列举:直链状低密度聚乙烯树脂、环状聚烯烃型树脂等的热塑性树脂或这些树脂的混合物等。
本发明的易剥离性片材可以通过T形模成形、吹制成形等,与一般的热塑性树脂使用的成形方法同样的方法制造成片状。另外,易剥离性层压片材可以通过共挤出成形、干层压、挤出涂层等方法制造。
用上述的方法得到的本发明的易剥离性片材,厚度优选为约5~约500μm,更优选为20~400μm。当厚度比5μm薄时,膜的强度有时不充分,难以形成优良的易剥离性密封层。另外,当比500μm厚时,膜的柔软性降低,膜的熔敷也变得困难。
另外,本发明的易剥离性层压片材,厚度为10~500μm,优选为20~400μm。在该片材中,具有易剥离性的片材所占的比例为片材全部厚度的5%以上,优选10%以上。当少于5%时,由该片材形成的易剥离性密封层的剥离强度降低。
在本发明中,所谓强熔敷,是指将形成小容器的膜进行热熔敷,液密地容纳内容物的同时,熔敷到通过来自外部的压力等不能剥离的程度。为了将形成本发明的最内层的环状聚烯烃构成的层相互强熔敷,例如可以通过在150~200℃下、1~3秒、用压力0.2~0.5MPa熔敷来实现。为了保持质量,例如保证3年的制品的情况下,在60℃下保存7周后的T形剥离强度优选维持20N/15mm以上的强度。
另外,所谓在60℃下保存7周,在需要将施行放射线灭菌的制品保证3年质量时,为了短期内确认效果,通常按照标准(IAEA:TECDOC-539(1990)),相当于60℃×7日=180日来实施。
在本发明中,所谓弱熔敷,是指将上述连接片相互熔敷,或者将连接片和形成小容器的膜的最内层相互熔敷后,形成在制备药剂时可以容易剥离的状态。为了将由本发明的低密度聚乙烯和丙烯·α-烯烃共聚物的共混物构成的连接片相互之间,或将该连接片和由环状聚烯烃构成的层进行弱熔敷,例如可以通过在130~170℃下、0.5~2秒、以压力0.1~0.3MPa熔敷来实现。为了维持弱熔敷密封强度的质量,优选例如在60℃下保存7周后的T形剥离强度为0.5~3N/15mm范围。
作为形成本发明的易剥离性密封层的方法,没有特别限定,可以采用与易剥离性密封层有关的目前公知的制造方法。这样的方法例如有以下方法。
1)在最内层具有环状聚烯烃的一个膜上,将构成易剥离性密封层的小片膜强熔敷,且将在最内层具有环状聚烯烃的另一个膜弱熔敷在该小片膜上。
2)在最内层具有环状聚烯烃的2个膜间,***构成易剥离性密封层的小片膜,在2个金属模具中设置温度差,从面在一个膜侧强熔敷,在另一个膜侧弱熔敷。
3)在最内层具有环状聚烯烃的膜上,将构成易剥离性密封层的小片膜弱熔敷,在该小片膜上强熔敷具有其它层的膜。
作为制造本发明的小容器的方法,没有特别限定,可以采用与小容器有关的目前公知的制造方法。作为这样的方法,例如有以下方法。
1)使2个膜前后重叠,同时,在比两个膜的最下端部稍微靠上方的部分间夹住构成易剥离性密封层的膜,在两膜的左右两侧部将不包括下端部的部分强熔敷使其不能剥离。然后,弱熔敷易剥离性密封层。由此,2个膜的上部侧形成向上方开口的袋状,下端部形成前后相对的一对连接片部。这些连接片部间在左右两侧及向下方开放。或者对构成易剥离性密封层的膜的下端部将两个膜弱熔敷,形成隔开部(弱熔敷密封部),同时,在其左右两侧将两个膜强熔敷使其不能剥离。
由此,两个膜的上部侧形成向上方开口的袋状,下端形成前后相对的一对连接片,这些连接片部间在左右两侧及向下方开放。对其填充药剂的同时,将两个膜的上部强熔敷使其不能剥离,形成第1小容器(参照专利文献4、图3)。
2)在上下开口状的管的上端部***构成易剥离性密封层的膜,将管和构成易剥离性密封层的膜弱熔敷,形成隔开部(弱熔敷密封部),同时,在其左右两侧将管的前后壁部强熔敷使其不能剥离。然后,在管的下端部***连接端口(接続ポ一ト),将其强熔敷使其不能剥离,同时,将管的下端部的剩余开口部强熔敷使其不能剥离。
然后,将液状内容物通过连接端口填充到小容器内,通过栓塞封闭连接端口,形成第2小容器(参照专利文献4、图5)。
作为连接本发明的小容器的方法,没有特别限定,可以采用与小容器有关的目前公知的制造方法。作为这样的方法,例如有以下方法。
将第1小容器的两个连接片部间向下方大大地开放,在两个连接片部间,由下方***第2小容器的上端部,将其热熔敷,连接两个小容器,将其一体化。
〔实施例〕
下面,使用实施例将本发明作以具体地说明。
在实施例中,T形剥离强度使用万能实验机,通过将2片膜的两端扩展为180℃,并用设置的卡盘(チヤツク)夹持两端来测定。在该状态下,将一端向上方拉,测定与熔敷部分的剥离相关的应力。根据容器的大小或使用方式多样地设定弱密封强度,例如使用100mL的输液容器时,只要是溶解操作时的弱密封强度为0.5~3N/15mm,可以说就是适合的状态。
实施例1~3
将环状聚烯烃(日本ゼオン制造、商品名ゼオノア)在250℃下挤出,制成膜(60μm)。在该膜A(100mm×155mm)上放置将低密度聚乙烯(密度0.922g/cm3、東ソ一制造、商品名ペトロセン)和丙烯·α-烯烃共聚物(Tm135℃、日本ポリプロレン制造、商品名ノバテツクPP)共混成的小片膜(混合重量比为70/30、50/50、30/70、60mm×30mm),且用模具温度180℃的金属模具强熔敷2秒。然后,在前述小片膜上,放置不同的环状聚烯烃膜B(100mm×155mm),且用模具温度150℃的金属模具弱熔敷1.5秒,制造了熔敷有小片膜的2片环状聚烯烃膜(A和B)。
将试样进行放射线灭菌后,切割成试片(15mm×50mm)的大小,使用万能试验机(インストロン),测定膜B和小片膜剥离的T形剥离强度。另外,还测定了将试样在60℃下保存了1周、3周或7周时的T形剥离强度。将其结果在表1中表示。
需要说明的是,膜A和小片膜之间的T形剥离强度(刚制造后)为15N/15mm。
〔表1〕
实施例 | LDPE/r-PP(重量比) | T形剥离强度(N/15mm) | |||
刚制造后 | 60℃×1W | 60℃×3W | 60℃×7W | ||
1 | 70/30 | 2.2 | 1.3 | 1.3 | 0.9 |
2 | 50/50 | 2.1 | 1.5 | 1.0 | 1.0 |
3 | 30/70 | 0.9 | 0.8 | 0.6 | 0.6 |
实施例4~6
将环状聚烯烃(日本ゼオン制造、商品名ゼオノア)在250℃下挤出,制作膜(60μm)。在该膜A(100mm×155mm)上放置将低密度聚乙烯(密度0.926g/cm3、宇部丸善ポリエチレン制造、商品名UBEポリエチレン)和丙烯·α-烯烃共聚物(Tm135℃、日本ポリプロレン制造、商品名ノバテツクPP)共混成的小片膜(混合重量比为70/30、50/50、30/70、60mm×30mm),且用模具温度180℃的金属模具强熔敷2秒。然后,在前述小片膜上,放置不同的环状聚烯烃膜B(100mm×155mm),且用模具温度155℃的金属模具弱熔敷1.5秒,制造熔敷有小片膜的2片环状聚烯烃膜(A和B)。
将试样进行放射线灭菌后,切割成试片(15mm×50mm)的大小,使用万能试验机(インストロン),测定膜B和小片膜剥离的T形剥离强度。另外,还测定了将试样在60℃下保存了1周、3周或7周时的T形剥离强度。将其结果在表2中表示。
〔表2〕
实施例 | LDPE/r-PP(重量比) | T形剥离强度(N/15mm) | |||
刚制造后 | 60℃×1W | 60℃×3W | 60℃×7W | ||
4 | 70/30 | 1.6 | 1.0 | 1.0 | 0.6 |
5 | 50/50 | 1.9 | 1.5 | 0.7 | 0.9 |
6 | 30/70 | 0.6 | 0.6 | 0.6 | 0.6 |
比较例1~6
取代实施例1中的小片膜,使用在表3所示的小片膜,与实施例1同样地熔敷2片环状聚烯烃膜,作成试样。将膜B和小片膜之间的T形剥离强度在表3中表示。表3中缩写如下所示。
LDPE(a):密度0.922g/cm3的低密度聚乙烯,(東ソ一制造、商品名ペトロセン)
LDPE(b):密度0.922g/cm3的低密度聚乙烯,(宇部丸善ポリエチレン制造、商品名UBEポリエチレン)
LLDPE:直链状低密度聚乙烯
r-pp:丙烯·α-烯烃共聚物
h-pp:聚丙烯均聚物
〔表3〕
比较例 | 聚合物 | 组成(重量比) | T形剥离强度(N/15mm) | |||
刚制造后 | 60℃×1W | 60℃×3W | 60℃×7W | |||
1 | LDPE(a) | 100 | 2.6 | 0.3 | 0.2 | N.D. |
2 | LDPE(b) | 100 | 1.0 | 0.4 | 0.2 | N.D. |
3 | LLDPE/r-PP | 70/30 | 70.1 | N.D. | N.D. | N.D. |
4 | LLDPE/r-PP | 30/70 | 33.3 | N.D. | N.D. | N.D. |
5 | LDPE(a)/h-PP | 70/30 | 0.2 | N.D. | N.D. | N.D. |
6 | LDPE(a)/h-PP | 30/70 | 0.2 | N.D. | N.D. | N.D. |
比较例7~9
取代实施例1中的小片膜,使用表4所示的小片膜,与实施例1同样地熔敷2片环状聚烯烃膜,做成试样。将膜B和小片膜之间的T形剥离强度在表4中表示。表4中缩写如下所示。
LDPE(a):密度0.922g/cm3的低密度聚乙烯,(東ソ一制造、商品名ペトロセン)
COP:环状聚烯烃
〔表4〕
比较例 | 聚合物 | 组成(重量比) | T形剥离强度(N/15mm) | |||
刚制造后 | 60℃×1W | 60℃×3W | 60℃×7W | |||
7 | LDPE/COP | 70/30 | 1.3 | 0.3 | 0.2 | N.D. |
8 | LDPE/COP | 80/20 | 1.4 | 0.3 | 0.3 | N.D. |
9 | LDPE/COP | 60/40 | 1.6 | 0.4 | 0.3 | N.D. |
由表1~表4可知,使用低密度聚乙烯和丙烯·α-烯烃共聚物的小片在60℃下保存7周后还可以保持易剥离性密封。
实施例7
将环状聚乙烯(日本ゼオン制造、商品名ゼオノア)与中密度聚乙烯(密度0.938)一起使用共挤出机在250℃下挤出,制作2层膜(前者30μm、后者20μm)。在该2层膜的中密度聚乙烯层上通过聚烯烃型粘合树脂,依次层压聚对苯二甲酸乙二醇酯膜(三菱化学制、厚度12μm)及中密度聚乙烯膜(密度0.938、厚度40μm),做成4层膜(前膜)。
然后,将环状聚乙烯(日本ゼオン制造、商品名ゼオノア)与中密度聚乙烯(密度0.938)一起使用共挤出机在250℃下挤出,制作2层膜(前者30μm、后者20μm)。另外,将铝箔(サンアルミ制造、厚度20μm)和聚对苯二甲酸乙二醇酯模(東洋紡制造、厚度16μm)使用聚氨酯型粘合剂(武田薬品工業制造)进行层压,得到2层层压体。在前述2层膜的中密度聚乙烯层上通过聚烯烃型粘合树脂,层压2层层压体的铝箔,制作4层膜(后膜)。
将四方形的前述4层膜(前膜)和前述4层膜(后膜)重叠,在其基端间***将低密度聚乙烯和丙烯·α-烯烃共聚物共混而成的小片膜(混合重量比70/30),在上部金属模具温度80℃、下部金属模具温度140℃下、压力0.3Mpa下强熔敷一个面,弱熔敷另一面。然后,使该基端侧的两端在170℃、压力0.3Mpa下强熔敷,形成药剂隔开室(纵140mm×横115mm的药剂侧袋状容器)。在两膜的基端侧剩余未夹持前述膜的未熔敷部分。
该药剂隔开室在袋状物的状态下施行γ射线灭菌,从前端无菌地填充粉末状抗生素1.0g,将该前端强熔敷形成袋状容器。
Claims (10)
1.一种多室容器,具有由至少最内层为环状聚烯烃的膜形成的小容器,其特征在于,一个小容器和另一个小容器通过连接片隔开,该连接片部具有包含低密度聚乙烯和丙烯·α-烯烃共聚物的易剥离性密封层。
2.如权利要求1所述的多室容器,其中,所述易剥离性密封层是含有低密度聚乙烯和丙烯·α-烯烃共聚物的组合物,其重量比为80∶20~20∶80。
3.如权利要求1所述的多室容器,其中,所述易剥离性密封层是易剥离性单层膜或表面具有易剥离性层的多层膜。
4.如权利要求1所述的多室容器,其中,所述连接片部包括弱熔敷密封部和强熔敷密封部,所述弱熔敷密封部由所述易剥离性密封层构成。
5.如权利要求1所述的多室容器,其中,构成所述小容器的膜是多层膜,包含最内层为环状聚烯烃的第1层和与该层邻接的由线状聚烯烃构成的第2层。
6.如权利要求5所述的多室容器,其中,构成所述小容器的膜,在由所述线状聚烯烃构成的第2层上,还具有阻气层和/或可印刷的层。
7.如权利要求6所述的多室容器,其中,所述阻气层是金属箔、金属蒸镀层或无机物蒸镀层。
8.如权利要求6所述的多室容器,其中,所述可印刷的层是聚酯层或具有无机物蒸镀膜的聚酯层。
9.如权利要求1所述的多室容器,其中,所述小容器是容纳液剂的小容器和容纳药剂的小容器。
10.如权利要求1所述的多室容器,其中,所述多室容器是如下所述的容器:在2个小容器的一个的端部具有相对的一对连接片,在该连接片间,***另一个小容器的端部并熔敷,两个小容器通过该连接片部隔开。
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CN101668506B (zh) * | 2007-04-27 | 2013-07-17 | 味之素株式会社 | 多室容器 |
CN111806015A (zh) * | 2020-07-20 | 2020-10-23 | 山东齐鲁乙烯化工股份有限公司 | 聚丙烯高温易揭食品包装膜及其制备方法 |
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ATE454982T1 (de) | 2010-01-15 |
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CN1931118B (zh) | 2012-01-11 |
EP1762379A2 (en) | 2007-03-14 |
TW200720088A (en) | 2007-06-01 |
EP1762379A3 (en) | 2007-09-12 |
DE602006011689D1 (de) | 2010-03-04 |
EP1762379B1 (en) | 2010-01-13 |
JP4888646B2 (ja) | 2012-02-29 |
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