CN1895291A - Nano-Chinese medicinal biological product and its preparation - Google Patents

Nano-Chinese medicinal biological product and its preparation Download PDF

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Publication number
CN1895291A
CN1895291A CN 200610044668 CN200610044668A CN1895291A CN 1895291 A CN1895291 A CN 1895291A CN 200610044668 CN200610044668 CN 200610044668 CN 200610044668 A CN200610044668 A CN 200610044668A CN 1895291 A CN1895291 A CN 1895291A
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chinese medicine
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陈永丽
崔翔
崔天一
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陈永丽
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Abstract

A nano-class biologic product of Chinese-medicinal material for higher biological utilization rate and target nature, lower toxic by-effect and improved curative effect is prepared through preparing the nanoparticles of Chinese-medicinal materials, and preparing nano-class (50-80 nm) biologic product.

Description

Nanometer Chinese traditional medicine biology goods and preparation method thereof
Affiliated technical field
The present invention relates to nanometer Chinese traditional medicine biology goods and preparation method thereof.
Background technology
Along with the transformation of health-preserving health-care hospital pattern and starting of back to nature trend, and people constantly enlarge the purposes and the influence of the Chinese medicine in international and domestic health-preserving health care market to the deep understanding of chemical drugs side effect.Only depend on single modern medicine technology can not deal with the new situation of this complexity.Countries in the world government need suppress rising steadily of medical expense simultaneously, alleviates the burden of public welfare spending, has therefore strengthened the attention of the living health care of centering health preserving with drugs.Enter new century, along with the variation of situation both at home and abroad, development has proposed new requirements at the higher level to Chinese medicine.Because it is backward in technique, problems such as innovation ability weakness, restricted giving full play to of Chinese medicine advantage and characteristic, development of Chinese herb products and industry development can't be satisfied the demand of mankind nowadays health-preserving health care well, the situation that can not adapt to competition in the international market well can not fundamentally change the backwardness of Chinese medicine health-preserving healthcare field.
The participation of modern high technology if can be arranged, improve the science and technology amount of Chinese medicine health-preserving health product, strengthen the confidence of national governments and consumer, thereby promoted the continuous progress of Chinese medicine cause, make Chinese medicine break away from over the production of " workshop " formula, for the health care of Chinese medicine health-preserving realizes modernization, go to the world and take part in international competition, lay the foundation, research and development Chinese medicine health-preserving health care frontier, fundamentally change the backwardness of Chinese medicine health-preserving healthcare field, the backward situation of the Chinese medicine health-preserving that takes on a new look on the whole health care is very urgent.
Summary of the invention
Nanotechnology is the big scientific and technological revolution of 21 century, and it will produce far-reaching influence to every field.Chinese medicine is the rarity of the Chinese nation, and it is done for the prosperity of China and appears huge contribution.The utilization nanotechnology can be improved the application of Chinese medicine in the daily health-preserving healthcare field of people effectively energetically, nanometer Chinese traditional medicine biology goods and preparation method thereof give Chinese medicine new function, accelerate to realize the modernization internationalization of Chinese medicine health-preserving health care, inject new vitality for domestic Chinese medicine industry, its market prospect is extensive, and social benefit and economic benefit are all very remarkable.
Nanometer Chinese traditional medicine biology goods and preparation method thereof comprise:
1. botanical herbs, fungus Chinese medicine are pulverized, being crushed to its particle size distribution is particle diameter 8um-15um; Mineral Chinese medicine, animal Chinese medicine are pulverized, and being crushed to its particle size distribution is particle diameter 10um-30um.
2. the Chinese medicinal granule after the 1st step being pulverized is further made the 50-80 nano-particle.
(1) mineral Chinese medicine, animal Chinese medicine: mineral Chinese medicine, animal Chinese medicine Chinese medicinal granule after the 1st step pulverized are crushed to nano grinder makes the 70-80 nano-particle, carries out supersound extraction again and obtains the 50-80 nano-particle;
(2) botanical herbs, fungus Chinese medicine: in the botanical herbs after the pulverizing of the 1st step, fungus
The medicine Chinese medicinal granule carries out water extract-alcohol precipitation or alcohol extracting-water precipitating obtains the 50-80 nano-particle.
Wherein said Chinese medicine is:
Ginseng, human hair, BU mustard, catechu, star anise, cloves, beans, Panax, triangular, ginger, Dry paint, wide white, wide, wide Dan, rhubarb, Euphorbia, jujube, garlic, Daji, thistle, Wheat, Berberis, lily, camellia, kaempferol, Yamaga, mountain dates, Gardenia, mountain ginger, yam, Hawthorn, Sichuan Qiang, rhubarb, Kawatsure, River Park, Chuan Wu, Chuan Bo, Agrestis, Sichuan off, Sichuan pepper, Fritillary, Chuanxiong, Malan, Marcin, horse food, Malian, Marble, puffballs, Iris, Wei Mao, Sub-Ling, aspartame, day insects, Denon, Tianxiong, Tianma, Yuan Hu, Yuan ginseng, papaya, fungus, Magnolia, wood, wood, wood thieves, pigeonpea, wooden pen, wooden blue, tooth soap, Poisson, Wawei, Kaiko, mother of pearl, white teeth, oregano, bezoar, Achyranthes, burdock, Sorrowful, hand ginseng, chickens, Buttercup, hair ginger, black cohosh, up board, cinnabar, Dan, Salvia, Wuxi, black leek, aggregata, Aconitum, tallow, ebony, Fang Hai, six, Daqing salt, and vigorously participate vigorously son, Hydnocarpus Big Mother of Pearl, a large flying, big puffball, rhubarb charcoal, big hole fruit, a large tea medicine, anise, soy Volumes, large seed, Daji charcoal, Arecae large comfrey, Gardenia skin, Gardenia tea, dogwood, Goat horn, tonkinensis, lobelia, banksia, mountain sesame, dogwood, mountain aloes, landslides Son, Mountain nails, Arrowhead Mountain, Hill Road, pheasant pepper, Litsea, mountain conch, amaranth, Jin dial, Homalomena, Senecio, Trinidad Ming, the daughter of positive Lythrum Wing, Trinidad and, one thousand Paper, Melaleuca tower, Sichuan woody, Chuanmutong, Fritillaria, Sichuan Angelica, Cyathula, Chuan Tong skin, Chuan Dong Son, Chuan Shan Jia, Chuan pseudolaric, Sichuan turmeric, wide turmeric, pheretima, wide wood, wide to the Ding, fangchi, patchouli, Ligustrum lucidum, daughter of incense, flying swords, flying grass, fly talc, Small flying, thistle charcoal, Encyclopedia, stone Wei, a small lotus, red ginseng, small flax, Betty Flowers, small split bone, lobular Park, a small peel, fennel, small through grass, Wenyuan, clams, Ren Qi, Double flowers, double skin, spray, Shui-ping, grasses and water Mang, leeches, Croton, cinnamon, Polygonatum, Yujin, nard, licorice, euphorbia, leaves, Ai tablets, mugwort, Shi Wei, Umbilicaria, lime, Dendrobium, gypsum, pomegranate, Shi Yan, carnation, Shimi, gentian, dragon teeth, keel, Solanum nigrum, Borneol, longan, the final end, snail, Shen Jiang, habitat, ginger, raw troops, Curculigoside, and had, Piece Ling, white, and, Baiji, seeking, white peony root, angelica, white English, alum, ginkgo, White front, white ugly, white ginseng, perilla, white drop, white honey, white Kou, Ampelopsis, white micro, Scrophulariaceae, Breit, earthworm, to yellow, ground pepper, Burnet, ground shoots, Verbena, wolfberries, Puxiao, Glauber's salt, Puxiao, watermelon, Xiqiang, Orobanche, lily, one hundred, angelica, when the drug, in the grass, Qu Lin, Passepartout, Gnaphalium, Vitex, Semen, poppy, Coix seed, peppermint oil, belladonna Grass, Wedelia, glutinous rice roots, eagles are not parked, Mahonia, Vaccaria, fingers peaches, Romania Mama cloth, smelly Indus leaves, purple azaleas, Gynura, centipeda, breaking bowl flower, Cinnamon, meat fruit, cinnabar, forward, bamboo, bamboo Ling, Zhu Li, bamboo mushrooms, Zhuhuang blood I, Blood scorpion, scorpion, full participation, full grass, acacia, co-Meng, gecko, borneol, Cassia, MI Ren, Horns, goat, sheep hoof, Dengcao, Menispermaceae, wind, safflower, red root, Pink, red ginseng, Brown sugar, SFAS, red rose, tempeh, Radix, malt, red peony, red medicine, Chijian, Daphne, Coriander, BREE, Amomum, pepper, mustard, herb, Wu weed, celery, Gorgon, aloe vera, Reed rhizome, rutin, Suzi, hematoxylin, sage, almonds, bumper plates, Eucommia, Du Heng, juniper, Cinnabar, garden ginseng, celery, Eclipta, Gang Song, Kong Mei, oysters, DU Gui, saponins, bergamot, Buddha sheets, strip Ling, shells, turtle shell, lotus, magnolia, galangal, Guya, Notopterygium, Polygala, Forsythia, Radix, sea buckthorn, incense, myrrh, myrobalan, no stone, Lu Ying, Ganoderma lucidum, beheaded, Gelatin, ferulic, orange peel, tuber, Schisandra, fingers orange, gall, five fruits, five convergence Son, tie Punta fruit, pillar Polygonum, seamless son, unnamed son, unknown differences, Sapindus, Plantago, Plantain, corrugated sub, sub-ridge tile, tile cut grass, Fritillaria flowers, Dan charcoal, Pae, Male D Incense, cattle vigorously, cattle cc, burdock, books with grass, Maodongqing, wool myrobalan, rose, Month flower, mandrakes flowers, weathered nitrate, wind Xianhua, Phoenix, clothing, wind tail grass, aconitine, squid Bone, black snake, Cayratia japonica, sixth song, Liuyuexue, pomelo skin, Wenguan wood, Polygonum, Hemp seed, double butterfly, water rest, water, peanuts, waterwheel ago, water keel, water buffalo, water half Summer, water Yang Mei, water centipedes, water turnip, Croton cream, Morinda, corn, Mahonia, Section licorice, licorice slightly, Gan Luzi, nard, ancient mountain dragon, travertine, stone see through, stone hanging Portland, abalone, Long Rui, stone drill, Shichangpu, stone pepper grass, heather leaves, garnet, Peel, stone sulfur, stalactites, stone lotus leaf, stone lotus seeds, stone Hu die of hunger, seaweed, paniculata Leaves, gentian, longan, dragon Lee leaves, cocklebur, dipterocarp, Fritillaria, ground wood, Menispermi, North Scrophulariaceae, littoralis, Bupleurum, North Chrysanthemum, leaf beads, beads Securinega Quartet Rattan, four leaf ginseng, holly leaf, four grass fields Panax, Hypericum, Swastika grass, turtle bones, Ginger skin, ginseng, gypsum, Rehmannia, raw Selaginella, raw Guya, daidaihua, Daizhe Stone, cactus, Epimedium, immortal survivor of grain, fairy Breit, Xiantao grass, Agrimony, Lysimachia, Bald beard, bulbul, Mustard Seed, white tuber, root rabbits, cogongrass rhizome, celandine, white Fu Ling, Bai Yao son, Baishouwu, white beans, fresh white skin, white Kou-jen, white white teeth, white-backed leaves, Nosed pit viper, Imperata flowers, white bakelite, white plastic fragrant, white pokeweed, white chrysanthemums, white quartz, white Lei Pills, Shirakawa car, white bone, Bai Pingzai, white pepper, white eggplant root, white fungus, white cardamom, Tribulus terrestris, fresh white skin, white silkworm, birds do not sink, melon wilt kernels, melon wilt son, melon wilt roots, seeds Gold, vegetables benevolence, peel, fruit, Artemisia annua, indigo, bitter wood, Sophora, bitter herbs, bitter, Tomato root, yi, Mao raspberries, Chine, loquat, turpentine, pine tones, turpentine, pine cone, pine alcohol, Turmeric, tiger battle, tiger thorn, bones, fruit guide, kelp, rock Tuo, Anemarrhena, cedar, frankincense, Moxibustion grass, Perrin, dog treasure, Woodwardia, Diego da, Magnolia, Beijing ink Guangui, green space, Selaginella, Lancifolium, onion, French summer, Zeeland, Alisma, Ginseng, dalbergia, caramel, Asarum, tortoiseshell, Pearls, Nepeta, madder, Piper pull, Aconitum, grass and fruit, tea, wormwood, Poria, Fu Shen, Shepherd's purse, chestnut grass, sedge, Mangcao, medicine celery, fennel, walnuts, pepper, Southern Star, South vine, Alum, hay, dry Ling, willow, Liuya, switchgrass, Citrus aurantium, Citrus aurantium, gardenia, Chinese wolfberry, Shi Di, persimmon, magnolia, Amomum, sugar, arsenolite, arsenic, light powder, equivalent insects, placenta, Generals, Uncaria, Gelsemium, Cyperus, citron, Hong Song, mushroom, Elsholtzia, re-building, gall wood, Vitriol, bile star, NMT, independent living, letter stone, ghost beads, white ghost, ghost thorn, Bidens, salt, Roasted ginger, turmeric, ginger, ginger skin, Peucedanum, Radix, Hong Lian, lentils, flat storage, flat Lei, Divine Comedy, flea, Guanzhong, Guan Zhong, Gentiana, Qin skin, lotus seeds, lotus, lotus, lotus core, Lotus required, Curcuma, lotus leaf, Hedi, charge stems, Gui Xin, Guizhi, water chestnuts, sedges, real evil, Bellflower, peach, peach juice, salt snake, Bupleurum, Cliff incense, Codonopsis, mussels flowers, iron, aluminum, lead, Silkworm sand, Shegan, leopard bone, L., Polygonum, puzzle, hippocampus, Dragon, calla lilies, algae, Jellyfish, pumice, duckweed, Babel, through the grass, mulberry leaf, mulberry, mulberry, mulberry, skullcap, Astragalus, berberine, sumac, Cork, Huang Jing, Huang Teng, Huang Dan, yellow alone, Engelhardtia Huang Xuan, Yellow wax, yellow tiller, water chestnut, iris, chicory, daisy, solid camp, radish, cabbage blue, plum, Mei Yan, plum slices, Hemsleya, Changshan, wild ginger, wild Ai, Chrysanthemum, wild turbot, snake, snake slough, Duchesnea, earthworms, ginkgo, white fungus, honeysuckle, silver, Alice, Polyporus, pocket bell, sesame oil, ephedra, Maren, antlers, antler, commercial land, commercial branches, teasel, Sui grass edge bean, amber, spotted sting, Cantharides, gourds, light blue, arrowroot, Ge Hua, flat storage, Basella, chestnut shell, sulfur, realgar, Acuminata, pepper head, brown boards, palm ginseng, basil, purple Ping, Rosie, comfrey, asters, purple strains Cyanosis, Bignoniaceae, clamshells, Gecko, black ugly, black tin, black diamond, black dishes, cynomorium, like shellfish, Austrian Ga, hedgehog, talc, Kansui, Tongbian, rhinoceros horn, thistles, Puhuang, Pu Qin, Chun skin, Bud, locust real, SJ, Huaijiao, borax, Lei Wan, Shujiao, centipedes, honeycomb, beeswax, Honey, waist yellow brocade pattern, Fu Pi, pistachio nuts, betel nuts, sour pulp, sorrel, alkali flowers, magnets, Beans, ginger, Chan Yi, and the bear, cicada, Polygonum, ocher, Rui Ren, Acutobin, camphor, rice shoots, Silkworm, mole crickets, carp, foxglove, Loulu, Lappula, scallion white, vegetation juice, mint, orange white, Orange peel, orange, Ju, bird's nest, indigo, Rhlomidis, pangolin, geckos, sandalwood, Artemisia, Acanthaceae, Oujie, mineral stones, Dianthus, rugosa, mushrooms, turtle shell, Toad, musk, a see hi, See a consumer, a little red, Yi Zhixiang, securinine, a whip, two leaf law, eugenol, Dinggong Rattan, seven grass, Hayata, white people, August Sapporo, alangium, octagonal lotus, farthings hemp, Guri that paniculata, Kowloon roots, nine tea, Aspongopus, a brother king, cuts wood, Panax Grass, trigeminal pain, one-third of three, three Pennisetum, three guns, triangular grass, three needles, dried Dendrobium, Elecampane, Bolbostemma, soil Panax, udo, earth wattle bark, soil Fuling, soil Codonopsis, large soil Yellow, Achyranthes aspera, Talinum, civil turtle, pseudolaric, woodlouse, the bulk of Chen cuneata, Big Red Leaves, small xanthate, evergreen, Golden Horseshoe, purslane, horse before the child, horsetail Lotus, milkweed, Malan head, Malan grass, horse teeth nitrate, horse Niaopao, Aristolochia, lantana flower, Capers, verbena, also bald, Asparagus, TCS, day bamboo, Tianzhu Huang, bamboo Root, Arisaema, aspartic, Araceae, day pulp shell, day ambrette, sodium sulfate, gold grass, Open golden, mica stone, cloud woody, cloud real leather, Kapok, wood kidneys, Althea, wood butterfly Butterfly, hibiscus, Polygonum vine wood, wood turtle, wood fangchi, wooden pen flowers, Equisetum flowers, jackfruit, Wood fungus, Litsea, wood Sapindus, heterophylla, sunflowers, Wujiapi, Wulingzhi, melons, ginger Skin, Dong Kuizi, cordyceps, melon skin, melon kernels, rubescens, Mallow fruit, Xuan Ming powder, Xuan Hu Faso, Pinellia song, barbata, semipinnata, half cathayensis, lobelia, half Lei, Han muscle Song, Han Gong, Chinese peach, pedestal grass, mother cloves, Taiwan aggregata, loofah, sponge gourd vine, Old boy, old not large, Geranium, Geranium mouth, crows flap auspicious grass, linseed, Asia peace Slaves, Ya Jima, humifusa, Kochia scoparia, Digupi, land turtle worms, ground ear grass, earthworm charcoal, Ground maple bark, gall grass, chestnut flour, stick stick alive, trays root, watermelon, ginseng, River Liu, one hundred two gold, Barry Frost, a hundred cores grass, one hundred drug fried, Bai Caoshuang light Arrowhead, when Siemens, Angelica tail, Angelica body, one hundred wax worms, fruit Luzon, back to back, meat, beans at the end, Eclipta, meat, beans Kou, Cistanche, lost his stick, natural copper, blood over charcoal, Albizia, Cassia, rushes, Benzoin, agricultural auspicious, actinolite, Corydalis, Ophiopogon, red bean, halloysite, rue Grass, lettuce British dishes, flower, stone, cocklebur, Styrax, two needles, Evodia, moutan, Polygonum, herb, amla, Eriocaulon, turtle shell, magnolia flowers, Glechomae, complanatus Son, psoralen, stove subsoil, honeysuckle, Gallus gallus domesticus, Millettla, cockscomb, JGC, Green boxes, bitter, bitter neem bark, leaves, chestnut shell, Ban Langen, turpentine, stabbed five Plus, Yuli, Mangosteen, Patrinia, sarmentosum, so that a gentleman, Sands rattan, loosestrife, Honeysuckle, Rosa laevigata, periwinkle, Houttuynia, Dicliptera, molle flowers, calamine, Poria Skin, Chong Wei son, litchi, Bozi, Clematis, Pharbitidis, javanica, Drynaria, Stalactites, raspberry, Limonitum, impatient, pangolin, Andrographis, worn stone, baby Ginseng, contact Ishido, jasmine flowers, radish seed, lotus, walnut, Xiatianwu, Prunella, Commelina, upside down grass, Xu Changqing, Campsis, wide bars rattan, galangal, treating diabetes, Yimu Grass, sea breeze rattan, Bodhisattva, cuttlebone, Dodder, antelope horn, and delivered will be, wild chrysanthemum, Cnidium, snake bile, Cat's Claw, antler, Antlers, Pyrolae, Inula flower, yam Medicine, Epimedium, SSP, Buddleia, Coltsfoot, gourd tea, Tinglizi, Placenta, Senna, calcite, flowers bloom, castor bean, dandelion. ...
3. the Chinese medicine of the particle diameter 50-80 nanometer that the 2nd step was obtained is made granule, capsule, tablet, drop pill, oral liquid formulation nanometer Chinese traditional medicine biology goods or solution-type, emulsion type, suspension type, solid powder nanometer Chinese traditional medicine biology goods or bath agent, lotion, liniment, tincture, oil preparation, ointment, plaster, paste, is pressed agent, liniment, membrane, gel, cataplasma, point-application agent, paster agent nanometer Chinese traditional medicine biology goods or stick, powder nanometer Chinese traditional medicine biology goods.
Nanometer Chinese traditional medicine biology goods and preparation method thereof have been given Chinese medicine with new function, improve bioavailability, the intensifier target tropism, reduce toxic and side effects, present new drug effect, widen the adaptation field of Chinese medicine, enrich the dosage form selection of Chinese medicine, reduce dosage, save natural resources of Chinese medicinal materials etc.Nanometer Chinese traditional medicine biology goods and preparation method thereof have improved the scientific and technological content of Chinese medicine health-preserving health product; Safe, the effective and controllability of product guarantees to some extent, strengthened the confidence of national governments and consumer, promoted the continuous progress of Chinese medicine cause, Chinese medicine has been broken away from the production of " workshop " formula in the past, for the health care of Chinese medicine health-preserving realizes modernization, go to the world and take part in international competition, lay a good foundation, research and development nanometer Chinese traditional medicine biology health-preserving health care frontier, fundamentally change the backwardness of Chinese medicine health-preserving healthcare field, the backward situation of the Chinese medicine health-preserving that takes on a new look on the whole health care.
Embodiment one:
Radix Panacis Quinquefolii: 1. Radix Panacis Quinquefolii is cleaned and pulverized, making its particle size distribution is the granule of particle diameter 8um-15um.2. the american ginseng granules after the 1st step being pulverized carries out alcohol extracting-water precipitating and obtains the 50-80 nano-particle.3. the Radix Panacis Quinquefolii of 50-80 nano-particle is made granule, capsule, tablet, drop pill, oral liquid formulation Radix Panacis Quinquefolii nanometer Chinese traditional medicine biology goods or solution-type, the suspension type, solid powder Radix Panacis Quinquefolii nanometer Chinese traditional medicine biology goods or bath agent, lotion, liniment, tincture, oil preparation, ointment, plaster, paste, press agent, liniment, membrane, gel, cataplasma, the point-application agent, paster agent Radix Panacis Quinquefolii nanometer Chinese traditional medicine biology goods or stick, powder Radix Panacis Quinquefolii nanometer Chinese traditional medicine biology goods.
Embodiment two:
Mirabilitum crystallina: 1. Mirabilitum crystallina is cleaned and pulverized, making its particle size distribution is the granule of particle diameter 10um-30um.2. the Mirabilitum crystallina granule after the 1st step being pulverized carries out nano grinder and is crushed to and makes the 70-80 nano-particle, carries out supersound extraction again and obtains the 50-80 nano-particle.3. the Mirabilitum crystallina of 50-80 nano-particle is made granule, capsule, tablet, drop pill, oral liquid formulation Mirabilitum crystallina nanometer Chinese traditional medicine biology goods or solution-type, the suspension type, solid powder Mirabilitum crystallina nanometer Chinese traditional medicine biology goods or bath agent, lotion, liniment, tincture, oil preparation, ointment, plaster, paste, press agent, liniment, membrane, gel, cataplasma, the point-application agent, paster agent Mirabilitum crystallina nanometer Chinese traditional medicine biology goods or stick, powder Mirabilitum crystallina nanometer Chinese traditional medicine biology goods.
After those skilled in the art read this description, in conjunction with above embodiment, the technical scheme of using this description to provide can be made required nanometer Chinese traditional medicine biology goods to Chinese medicine listed in this description.

Claims (1)

1. the present invention relates to nanometer Chinese traditional medicine biology goods and preparation method thereof, (1). botanical herbs, fungus Chinese medicine are pulverized, and being crushed to its particle size distribution is particle diameter 8um-15um; Mineral Chinese medicine, animal Chinese medicine are pulverized, and being crushed to its particle size distribution is particle diameter 10um-30um; (2). the Chinese medicinal granule after will pulverizing is further made the 50-80 nano-particle: the mineral Chinese medicine after will pulverizing, animal Chinese medicine Chinese medicinal granule are crushed to nano grinder and make the 70-80 nano-particle, carry out supersound extraction again and obtain the 50-80 nano-particle; With the botanical herbs after pulverizing, fungus Chinese medicine Chinese medicinal granule carries out water extract-alcohol precipitation or alcohol extracting-water precipitating obtains the 50-80 nano-particle.
CN 200610044668 2006-06-09 2006-06-09 Nano-Chinese medicinal biological product and its preparation Pending CN1895291A (en)

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