CN102872206A - Traditional Chinese medicine compound capable of improving immunity, resisting fatigue and improving sexual function - Google Patents
Traditional Chinese medicine compound capable of improving immunity, resisting fatigue and improving sexual function Download PDFInfo
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- CN102872206A CN102872206A CN2012103860208A CN201210386020A CN102872206A CN 102872206 A CN102872206 A CN 102872206A CN 2012103860208 A CN2012103860208 A CN 2012103860208A CN 201210386020 A CN201210386020 A CN 201210386020A CN 102872206 A CN102872206 A CN 102872206A
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Abstract
The invention discloses a traditional Chinese medicine compound capable of improving immunity, resisting fatigue and improving sexual function. The traditional Chinese medicine comprises the following raw materials by part of weight: 25-35 parts of maca, 1-6 parts of herba epimedii extractive, 5-15 parts of rhodiola rosea extractive, 1-10 parts of cistanche extractive, 5-15 parts of acanthopanax extractive and 5-20 parts of pallas pit viper extractive. According to animal experiments, the traditional Chinese medicine compound has the obvious effect of improving immunity, resisting fatigue and improving sexual function and can be prepared into various medicines, health care products, food and the like together with excipient, additives and the like for improving immunity, resisting fatigue and improving sexual function.
Description
Technical field
The present invention relates to a kind of Chinese herbal compounds, is a kind of health food that improves immunity, resisting fatigue, improves sexual function.
Background technology
Lepidinm meyenii Walp (MACA) is crucifer, mainly is grown in the area, plateau, Andes of more than 4000 meter of Peru's height above sea level, because this area's ecological environment is abominable, is unwell to other plant growths, and Lepidinm meyenii Walp just becomes one of food source of locals.Lepidinm meyenii Walp has very high nutritive value, except containing abundant carbohydrate, protein, natural fiber and mineral, Lepidinm meyenii Walp alkaloid, glucosinolate, isothiocyanate, Lepidinm meyenii Walp amide and sterol etc. also may be its effect materials that improves fertility, the effect of adaptation originality, so Lepidinm meyenii Walp is enjoyed the laudatory title of " Peru's Radix Ginseng " and " South America Radix Ginseng ".
Find that according to research Lepidinm meyenii Walp has the effects such as the immunity of raising, physical strength reinforcing, sexual function improving, slow down aging, and without any side effects, is a kind of natural health food.Clinical observation is also found, some lassitudes, the fatiguability patient take Lepidinm meyenii Walp after a period of time muscle power be restored.
At present, the health food quantity with enhancing immunity function by State Food and Drug Administration and Ministry of Public Health approval reaches kind more than 3000, its raw material mostly is greatly Ganoderma spore powder, Radix Panacis Quinquefolii, the Radix Astragali, Fructus Lycii etc., according to the survey these produce market life-spans not long, the product that has is not even by known to the people.Selection cooperates the having raising immunity and promoting the health food of sexual function to there is not yet report as raw material production such as pallas pit viper powder take Lepidinm meyenii Walp as major ingredient.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese herbal compounds that improves body immunity, resisting fatigue, improves sexual function, be a kind of health food that contains Lepidinm meyenii Walp.
In order to realize purpose of the present invention, a kind of Chinese herbal compounds of the present invention comprises the raw material of following weight portion:
Lepidinm meyenii Walp 25-35 part, Herba Epimedii 1-6 part, Radix Rhodiolae 5-15 part, Herba Cistanches 1-10 part, Radix Et Caulis Acanthopanacis Senticosi 5-15 part, pallas pit viper powder 5-20 part.
Weight portion of the present invention can be the known content units of field of medicaments such as mg, g, kg.
The preparation method of Chinese herbal compounds of the present invention comprises the steps:
Lepidinm meyenii Walp, Agkistrodon halys make powder after crushed.
Radix Rhodiolae, Radix Et Caulis Acanthopanacis Senticosi adopt water extraction, after the gained extracting solution suitably concentrates, and the spray-dried extract that gets the complex component.
Herba Cistanches, Herba Epimedii adopt alcohol extraction, after the gained extracting solution suitably concentrates, and the spray-dried extract that gets the complex component.
For ease of taking, above-mentioned each raw material components is made the concentrated soft capsule formulation according to the technology of preparing of routine.
Prescription of the present invention is according to the Chinese medical theory derivation, uses modern preparation technique to make the double suitable health care complex of medicine food this prescription.The compositions such as the protein that contains in the Lepidinm meyenii Walp, aminoacid, reducing sugar, amide alkaloid, glucosinolate, sterol are physical strength reinforcing, the main matter that improves immunity, sexual function improving.The Lepidinm meyenii Walp experimental studies results shows that it can prolong the mice burden swimming time, increases the storage level of Mouse Liver glycogen etc.But Herba Epimedii invigorating the liver and kidney, bone and muscle strengthening are usually used in treating the disease such as impotence and seminal emission, muscles and bones flaccidity be soft clinically.Studies have shown that in a large number Radix Rhodiolae has the effects such as resisting fatigue, anti-hypoxia.But the Herba Cistanches kidney-replenishing is usually used in treating sexual impotence, infertile clinically.Radix Et Caulis Acanthopanacis Senticosi has the effect of replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization, is used for the empty disease such as weak of deficiency of spleen-YANG and kidneyYANG, body.Pallas pit viper powder has the effect that promotes human body metabolism, physical strength reinforcing.
To sum up, the present invention is nutritious, is applicable to the crowd of the empty symptom such as weak of weakness of the spleen and kidney, impotence and seminal emission, body, has physical strength reinforcing, promotes sexual function, improves the remarkable result of immunity.
Health food provided by the invention is selected capsule formulation, the ratio that accounts for because of Lepidinm meyenii Walp in the formula for a product is maximum and be directly to be ground into raw material, other raw material is dry extract mostly, therefore easily makes capsule formulation, and the simple and capsule preparations of technological operation carries, transports, stores the advantages such as convenient.
The specific embodiment
Embodiment 1 capsule
Take by weighing raw materials of traditional Chinese medicinal materials according to following deal: pueraria root powder 400g, pallas pit viper powder 200g, Herba Epimedii 300g, Radix Rhodiolae 150g, Herba Cistanches 100g, Radix Et Caulis Acanthopanacis Senticosi 200g.
Lepidinm meyenii Walp, Agkistrodon halys are made powder after crushed; Radix Rhodiolae, Radix Et Caulis Acanthopanacis Senticosi were soaked 40 minutes, and the water surface is higher than raw material Chinese medicine, adds water inventory and be 8 times of total dose, keep liquid level after water boils and be higher than raw material Chinese medicine height, decocted 2 hours, and crossed leaching filtrate, add again the water of 6 times of total doses, keep liquid level after water boils and be higher than raw material Chinese medicine height, decocted 2 hours, and filtered twice filtrate of merging, through being evaporated to dried cream, pulverize, cross the extract that 300 mesh sieves namely get the complex component.Herba Cistanches, Herba Epimedii added soak with ethanol 30 minutes, and the water surface is higher than raw material Chinese medicine, added water inventory and be 10 times of total dose, keep liquid level after water boils and be higher than raw material Chinese medicine height, decocted 2 hours, and crossed leaching filtrate, add again the water of 10 times of total doses, keep liquid level after water boils and be higher than raw material Chinese medicine height, decocted 2 hours, and filtered twice filtrate of merging, through being evaporated to dried cream, pulverize, cross the extract that 300 mesh sieves namely get the complex component.Above-mentioned each raw material components is made soft capsule dosage form according to the technology of preparing of routine.
Embodiment 2
Take by weighing raw materials of traditional Chinese medicinal materials according to following deal: pueraria root powder 400g, pallas pit viper powder 250g, Herba Epimedii 380g, Radix Rhodiolae 100g, Herba Cistanches 200g, Radix Et Caulis Acanthopanacis Senticosi 100g.
Lepidinm meyenii Walp, Agkistrodon halys are made powder after crushed; Radix Rhodiolae, Radix Et Caulis Acanthopanacis Senticosi were soaked 40 minutes, and the water surface is higher than raw material Chinese medicine, adds water inventory and be 5 times of total dose, keep liquid level after water boils and be higher than raw material Chinese medicine height, decocted 1 hour, and crossed leaching filtrate, add again the water of 4 times of total doses, keep liquid level after water boils and be higher than raw material Chinese medicine height, decocted 1 hour, and filtered twice filtrate of merging, through being evaporated to dried cream, pulverize, cross the extract that 300 mesh sieves namely get the complex component.Herba Cistanches, Herba Epimedii added soak with ethanol 30 minutes, and the water surface is higher than raw material Chinese medicine, added water inventory and be 10 times of total dose, keep liquid level after water boils and be higher than raw material Chinese medicine height, decocted 2 hours, and crossed leaching filtrate, add again the water of 10 times of total doses, keep liquid level after water boils and be higher than raw material Chinese medicine height, decocted 2 hours, and filtered twice filtrate of merging, through being evaporated to dried cream, pulverize, cross the extract that 300 mesh sieves namely get the complex component.With the technology of preparing granulation dosage form of above-mentioned each raw material components according to routine.
Embodiment 3
Take by weighing raw materials of traditional Chinese medicinal materials according to following deal: pueraria root powder 300g, pallas pit viper powder 100g, Herba Epimedii 180g, Radix Rhodiolae 190g, Herba Cistanches 150g, Radix Et Caulis Acanthopanacis Senticosi 230g.
Lepidinm meyenii Walp, Agkistrodon halys are made powder after crushed; Radix Rhodiolae, Radix Et Caulis Acanthopanacis Senticosi were soaked 60 minutes, and the water surface is higher than raw material Chinese medicine, adds water inventory and be 8 times of total dose, keep liquid level after water boils and be higher than raw material Chinese medicine height, decocted 2 hours, and crossed leaching filtrate, add again the water of 6 times of total doses, keep liquid level after water boils and be higher than raw material Chinese medicine height, decocted 2 hours, and filtered twice filtrate of merging, through being evaporated to dried cream, pulverize, cross the extract that 300 mesh sieves namely get the complex component.Herba Cistanches, Herba Epimedii added soak with ethanol 30 minutes, and the water surface is higher than raw material Chinese medicine, added water inventory and be 6 times of total dose, keep liquid level after water boils and be higher than raw material Chinese medicine height, decocted 3 hours, and crossed leaching filtrate, add again the water of 5 times of total doses, keep liquid level after water boils and be higher than raw material Chinese medicine height, decocted 3 hours, and filtered twice filtrate of merging, through being evaporated to dried cream, pulverize, cross the extract that 300 mesh sieves namely get the complex component.Above-mentioned each raw material components is made tablet according to the technology of preparing of routine.
Embodiment 4
Take above-mentioned Chinese medicine composition as sample, investigate the impact on fruit bat property vigor.
U.S.'s wild type Drosophila melanogaster is adopted in experiment, collect the fruit bat adult that sprouts wings in the 8h, with pressing isolating female from male culture behind the etherization, the matched group basal medium, experimental group gives above-mentioned Chinese medicine composition culture medium, positive group gives the NANBAO JIAONANG culture medium, feeds continuously 15d, last carrying out property of 1d vitality test.Measure and to put in the male fly pipe with the ratio of 3:1 with the virgin fly in 3 ~ 4 day age, record copulation incubation period, flutter its wings up and down number of times and mating time.The results are shown in Table 1:
Table 1. Lepidinm meyenii Walp Chinese medicine composition is on the impact of fruit bat property vigor
| Group | Copulation incubation period (min) | The number of times of fluttering its wings up and down | Mating time (min) |
| Matched group | 35.2±16.1 | 15.6±6.5 | 14.1±10.6 |
| Lepidinm meyenii Walp compositions (0.5%) | 18.9±4.5 * | 18.8±3.1 | 26.4±11.9 * |
| Lepidinm meyenii Walp compositions (1%) | 16.3±10.5 * | 20.9±4.3 | 26.1±7.3 * |
| NANBAO (0.5%) | 25.7±7.9 | 14.7±8.1 | 29.7±8.7 * |
" * " expression is compared P ﹤ 0.05. with matched group
Experimental result shows that Lepidinm meyenii Walp Chinese medicine composition dosage group can significantly shorten the copulation incubation period of fruit bat, prolongs mating time.Illustrate that above-mentioned Chinese medicine composition has the effect that promotes sexual function.
Embodiment 3
Take above-mentioned Chinese medicine composition as sample, do anti-fatigue test.
Healthy Kunming mouse is selected in experiment, mice is pressed the body weight random packet after adapting to experimental situation, matched group gives normal saline, the medicine group gives the Lepidinm meyenii Walp Chinese medicine composition of various dose, positive group gives Radix Panacis Quinquefolii buccal tablets, each carries out the swimming with a load attached to the body experiment after organizing continuous gastric infusion 30d, mouse tail bears a heavy burden and is equivalent to behind the galvanized wire of heavy sensation of the whole body 5%, put into water temperature (30 ± 1) ℃, the swimming trunk went swimming of depth of water 400mm, the mouse head underwater 7s that submerges no longer floats and then is judged to be fatigue, record mice swimming time.The results are shown in Table 2:
Table 2. Lepidinm meyenii Walp Chinese medicine composition is on the impact of mice swimming time
| Group | Dosage (mg/kg) | Time (min) |
| Matched group | － | 43.12±1.35 |
| Lepidinm meyenii Walp compositions low dose group | 130 | 44.56±1.79 |
| Dosage group in the Lepidinm meyenii Walp compositions | 260 | 53.78±1.65 * |
| Lepidinm meyenii Walp compositions high dose group | 390 | 54.16±2.27 * |
| Radix Panacis Quinquefolii sheet group | 530 | 53.79±1.13 * |
" * " expression is compared P ﹤ 0.05. with matched group
Experimental result shows that the Lepidinm meyenii Walp Chinese medicine composition group of middle high dose and positive group can obviously prolong the mice swimming time with the matched group comparison, illustrate that the Lepidinm meyenii Walp Chinese medicine composition has remarkable anti-fatigue effect.
Healthy Kunming mouse is selected in experiment, mice is pressed the body weight random packet after adapting to experimental situation, matched group gives normal saline, the medicine group gives the Lepidinm meyenii Walp Chinese medicine composition of various dose, positive group gives Radix Panacis Quinquefolii buccal tablets, each organizes continuous gastric infusion 30d, behind the last gavage 30min, mice is put into water temperature (30 ± 1) ℃, pick up and pull out immediately the eyeball blood sampling behind the swimming trunk went swimming 90min of depth of water 400mm, get serum and measure serum urea nitrogen with diacetyl-oxime method, get simultaneously liver and measure hepatic glycogen content with anthrone method.The results are shown in Table 3:
Table 3. Lepidinm meyenii Walp Chinese medicine composition is on the impact of Mouse Liver glycogen, serum urea nitrogen
| Group | Hepatic glycogen g/100g tissue | Serum urea nitrogen mmol/L |
| Matched group | 3.34±0.22 | 20.39±1.41 |
| Lepidinm meyenii Walp compositions low dose group | 3.38±0.42 | 18.87±1.39 |
| Dosage group in the Lepidinm meyenii Walp compositions | 3.87±0.15 * | 21.13±1.47 |
| Lepidinm meyenii Walp compositions high dose group | 4.31±0.29 * | 16.86±1.17 * |
| Radix Panacis Quinquefolii sheet group | 3.95±0.26 * | 16.11±1.19 * |
" * " expression is compared P ﹤ 0.05. with matched group
Experimental result shows that high dose group can obviously improve the hepatic glycogen storage level in the Lepidinm meyenii Walp Chinese medicine composition, and high dose group can obviously reduce the serum urea nitrogen content, illustrates that above-mentioned Chinese medicine composition has significant anti-fatigue effect.
Claims (4)
1. Chinese medicine composition that improves immunity, resisting fatigue, improves sexual function, it is characterized in that, it comprises the raw material of following weight portion: Lepidinm meyenii Walp 25-35 part, Herba Epimedii extract 1-6 part, Radix Rhodiolae extract 5-15 part, Herba Cistanches extract 1-10 part, Radix Et Caulis Acanthopanacis Senticosi extract 5-15 part, pallas pit viper powder 5-20 part.
2. a kind of Chinese medicine composition that improves immunity, resisting fatigue, improves sexual function as claimed in claim 1 is characterized in that, Radix Rhodiolae, Radix Et Caulis Acanthopanacis Senticosi adopt water extraction, gets the extract of composition component behind the suitable concentrate drying of gained extracting solution; Herba Cistanches, Herba Epimedii adopt ethanol extraction, get the extract of composition component behind the suitable concentrate drying of gained extracting solution.
3. as claimed in claim 2ly a kind ofly improve immunity, resisting fatigue, improve the extract in the Chinese medicine composition of sexual function, it is characterized in that, extract comprises immersion, decoction, percolation, backflow, supersound extraction etc. with conventional extracting method, drying means comprises concentrating under reduced pressure drying, spray drying, lyophilization, concentrate drying etc., and the used concentration of alcohol of alcohol extraction is 50%-100%.
4. such as claim 1,2 described a kind of Chinese medicine compositions that improve immunity, resisting fatigue, improve sexual function, it is characterized in that, said composition is used with the excipient of pharmaceutically accepting, additive, is prepared into the medicine, health product, the food that are applied to improve immunity, resisting fatigue, improvement of sexual function.
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| CN103859412A (en) * | 2014-04-02 | 2014-06-18 | 南京慧博生物科技有限公司 | Health-care food for male and preparation method thereof |
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| CN103289876A (en) * | 2013-06-26 | 2013-09-11 | 泸州品创科技有限公司 | Production method of Maca health wine |
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| CN103859412A (en) * | 2014-04-02 | 2014-06-18 | 南京慧博生物科技有限公司 | Health-care food for male and preparation method thereof |
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| CN103948039A (en) * | 2014-05-14 | 2014-07-30 | 郭友用 | Health-care food with function of relieving physical fatigue and preparation method of health-care food |
| CN103948039B (en) * | 2014-05-14 | 2016-03-30 | 郭友用 | A kind of have health food of alleviating physical fatigue function and preparation method thereof |
| CN104026568B (en) * | 2014-05-20 | 2016-01-13 | 青海伟康生物科技有限公司 | A kind of Halth-care composition |
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| CN104013663A (en) * | 2014-06-20 | 2014-09-03 | 苏州法莫生物技术有限公司 | Preparation for effectively relieving exercise induced fatigue |
| CN104013664A (en) * | 2014-06-20 | 2014-09-03 | 苏州法莫生物技术有限公司 | Preparation containing maca |
| CN105942521A (en) * | 2016-05-09 | 2016-09-21 | 乌鲁木齐金骏阳光生物科技有限公司 | Composition containing herba cistanches and herba epimedii extracts, and preparation method and application thereof |
| CN105919136A (en) * | 2016-05-21 | 2016-09-07 | 陕西泓逺金道生物科技有限公司 | Nutrition supplement composition with fatigue resisting and immunity improving effects and preparation and preparation method thereof |
| CN107753567A (en) * | 2016-08-18 | 2018-03-06 | 江苏康缘药业股份有限公司 | A kind of fatigue-resistant drug composition and preparation method and application |
| CN107753567B (en) * | 2016-08-18 | 2020-07-24 | 江苏康缘药业股份有限公司 | Anti-fatigue pharmaceutical composition and preparation method and application thereof |
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