CN102755558B - Innervate trifoliate orange traditional Chinese medicine compound and preparation method and application thereof - Google Patents
Innervate trifoliate orange traditional Chinese medicine compound and preparation method and application thereof Download PDFInfo
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- CN102755558B CN102755558B CN201210278256.XA CN201210278256A CN102755558B CN 102755558 B CN102755558 B CN 102755558B CN 201210278256 A CN201210278256 A CN 201210278256A CN 102755558 B CN102755558 B CN 102755558B
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Abstract
The invention discloses an innervate trifoliate orange traditional Chinese medicine compound which comprises the following components by weight: 9-15 parts of dried rehmannia root, 9-15 parts of prepared rehmannia root, 6-12 parts of Chinese wolfberry fruit, 6-12 parts of astragalus complanatus, 9-15 parts of full trifoliate orange, 10-15 parts of medicinal cyathula root, 15-30 parts of oldenlandia diffusa, 10-15 parts of achyranthes root, 9-15 parts of mulberry, 5-10 parts of radix bupleuri, 3-10 parts of broiled leach, 5-10 parts of red flower, 6-10 parts of spina gleditsiae, 9-15 parts of teasel, 6-12 parts of prepared fleece flower root, 10-30 parts of calcined oyster shell, 5-10 parts of dry earthworm and 10-30 parts of cogongrass rhizome. A preparation method and the application of the innervate trifoliate orange traditional Chinese medicine compound are further disclosed. The innervate trifoliate orange traditional Chinese medicine compound is remarkable in effect, adopts decoction or end product granular preparation, and is stable in quality, constant in drug concentration, convenient to take, economical and easy to popularize.
Description
Technical field
The invention belongs to Chinese medicine compound technical field, be specifically related to a kind of poly-smart Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) Chinese medicine compound and its preparation method and application.
Background technology
Treatment of azoospermia is because bilateral essence road-blockage causes having no sperm or spermatogenic cell in the urine after seminal fluid or ejaculation.Be divided into that testis intrinsic obstruction, epididymis block, deferent duct blocks, ejaculatory duct obstruction, smart road far-end Functional obstruction.Congenitally block often with congenital bilateral absence of vas deferens (CBAVD), YOUNG Cotard, Miller pipe or urethra gential sinus cyst, ejaculatory duct cyst etc. because of the dysfunction, the epididymis that have between testis net and ductuli efferentes testis.Posteriority factor, as struvite and traumatic blocking, also can originate from surgical operation and block, as cyst of epididymis excision, the operation technique of epididymis far-end; Birth control and row vasoligation, deferent duct blocks that also can to betide hernia repair postoperative; This may be due to local nerve sexual factor for essence road far-end Functional obstruction.
All blood endocrine and the normal azoospermia of testicular volume or severe oligozoospermia should be considered blocking of smart road clinically.
The western medical treatment of Treatment of azoospermia is mainly taking operation as main.The result of surgical reconstruction depend in the reason of blocking and position, art find, the professional standards of surgeon, conventional operation has vasovasostomy, epididymovasostomy and TURED art.Surgery is got smart art MESA, TESE and testis fine needle aspiration sperm aspiration (TEFNA), and the sperm that these methods are obtained or tissue should freezingly be preserved, in order to ICSI treatment.
The side effect of operation is also apparent.One operation has wound; Its two operations somewhat expensive; Its three part can Drug therapy case by over-treatment.
The exhaustion of constitutional spermatogenesis refers to that the spermatogenesis due to various hypothalamus disease of pituitary gland changes, and is referred to as Non-obstructive Azoospermia clinically.The sickness rate of Non-obstructive Azoospermia accounts for 2% in population, in male sterility up to 10 ~ 20%, the monosperm ooecium interior injection of slurry (ICSI) is doctor trained in Western medicine current method at present, gets the deficiencies such as essence is difficult, sperm quality is poor, pregnancy rate is low but exist.
Some obstruction type azoospermia patients may merge dyszoospermia or blood FSH and raise, to those blood FSH raise, a side testicular volume dwindles and (or) quality deliquescing but suspect that the patient's row testis biopsy that has obstructive factor to exist can be found to be mixed type azoospermia.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind ofly can treat Chinese medicine compound obstructive, mixed type azoospermia.
The technical problem that the present invention also will solve is to provide the preparation method of above-mentioned compound recipe.
The technical problem that the present invention finally will solve is to provide the medical applications of above-mentioned compound recipe.
For solving the problems of the technologies described above, the technical solution used in the present invention is as follows:
Poly-smart Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) Chinese medicine compound, is characterized in that, it comprises the component of following parts by weight:
9 ~ 15 parts of Radix Rehmanniae, 9 ~ 15 parts of Radix Rehmanniae Preparata, 6 ~ 12 parts of Fructus Lycii, 6 ~ 12 parts of Semen Astragali Complanatis, 9 ~ 15 parts of full Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus)s, 10 ~ 15 parts of Radix Cyathulaes, 15 ~ 30 parts of Herba Hedyotidis Diffusaes, 10 ~ 15 parts of Radix Achyranthis Bidentataes, 9 ~ 15 parts of Fructus Mori, 5 ~ 10 parts of Radix Bupleuri, process 3 ~ 10 parts of Hirudos, 5 ~ 10 parts, Flos Carthami, 6 ~ 10 parts of Spina Gleditsiaes, 9 ~ 15 parts of Radix Dipsacis, 6 ~ 12 parts of Radix Polygoni Multiflori Preparata, 10 ~ 30 parts of Concha Ostreae (calcined)s, 5 ~ 10 parts of dry Pheretimas, 10 ~ 30 parts of Rhizoma Imperataes.
Above-mentioned poly-smart Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) Chinese medicine compound, preferably includes the component of following parts by weight:
10 ~ 12 parts of Radix Rehmanniae, 10 ~ 12 parts of Radix Rehmanniae Preparata, 10 ~ 12 parts of Fructus Lycii, 10 ~ 12 parts of Semen Astragali Complanatis, 10 ~ 15 parts of full Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus)s, 10 ~ 15 parts of Radix Cyathulaes, 15 ~ 20 parts of Herba Hedyotidis Diffusaes, 10 ~ 15 parts of Radix Achyranthis Bidentataes, 10 ~ 12 parts of Fructus Mori, 6 ~ 10 parts of Radix Bupleuri, process 3 ~ 10 parts of Hirudos, 6 ~ 10 parts, Flos Carthami, 6 ~ 10 parts of Spina Gleditsiaes, 10 ~ 12 parts of Radix Dipsacis, 10 parts of Radix Polygoni Multiflori Preparata, 30 parts of Concha Ostreae (calcined)s, 10 parts of dry Pheretimas, 15 ~ 30 parts of Rhizoma Imperataes.
Above-mentioned poly-smart Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) Chinese medicine compound, its dosage form is decoction or granule.
A kind of preparation method of above-mentioned poly-smart Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) Chinese medicine compound, the Concha Ostreae (calcined) of formula ratio is decocted first 20 ~ 30 minutes, again with the Radix Rehmanniae of formula ratio, Radix Rehmanniae Preparata, Fructus Lycii, Semen Astragali Complanati, full Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus), Radix Cyathulae, Herba Hedyotidis Diffusae, Radix Achyranthis Bidentatae, Fructus Mori, Radix Bupleuri, process Hirudo, Flos Carthami, Spina Gleditsiae, Radix Dipsaci, Radix Polygoni Multiflori Preparata, dry Pheretima and Rhizoma Imperatae and mix, merceration 1 ~ 2 hour adds water, after intense fire is fried boiling, slow fire boiling 30 ~ 40 minutes, decocts 2 ~ 3 times altogether, collecting decoction, obtains decoction.
The another kind of preparation method of above-mentioned poly-smart Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) Chinese medicine compound, by the Radix Rehmanniae of formula ratio, Radix Rehmanniae Preparata, Fructus Lycii, Semen Astragali Complanati, full Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus), Radix Cyathulae, Herba Hedyotidis Diffusae, Radix Achyranthis Bidentatae, Fructus Mori, Radix Bupleuri, process Hirudo, Flos Carthami, Spina Gleditsiae, Radix Dipsaci, Radix Polygoni Multiflori Preparata, Concha Ostreae (calcined), dry Pheretima and Rhizoma Imperatae and granulate respectively, get single medicinal material granule and mix, after dissolving more after filtration, concentrated, spraying is dry, granulate, dry, granulate, granule sieves to obtain.
The application of above-mentioned poly-smart Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) Chinese medicine compound in preparation treatment Treatment of azoospermia or mixed type azoospermia medicine.
For obstructive, mixed type azoospermia, to suffer from a deficiency of the kidney, stagnant heat is seted forth one's views; Principle for the treatment of is invigorating kidney, promoting blood circulation, the clearing away damp-heat of holding concurrently.Radix Rehmanniae Preparata, Radix Rehmanniae, Fructus Lycii, Semen Astragali Complanati, Fructus Mori, Radix Polygoni Multiflori Preparata nourishing the liver and kidney in side; Radix Dipsaci is warm in nature, has the meaning for the treatment of YANG within YIN in group's drugs for nourishing yin, and hard swollen effect in addition disappears; Radix Cyathulae, Radix Achyranthis Bidentatae invigorating the liver and kidney, eliminating blood stasis and inducing menstruation, priming are descending; Radix Bupleuri, Flos Carthami, Hirudo dispersing liver and promoting blood circulation; Full Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus), Spina Gleditsiae, Concha Ostreae (calcined) relieving stagnant and resolving masses; Rhizoma Imperatae clearing away damp-heat from lower-JIAO; Herba Hedyotidis Diffusae heat-clearing and toxic substances removing, diuresis of blood circulation promoting; Dry Pheretima is got the use of its dredging collateral.
Beneficial effect: smart Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) Chinese medicine compound successful of the present invention, adopt decoction or finished particle preparation, steady quality, drug level is constant, taking convenience, and economical and practical, be easy to promote.
Detailed description of the invention
According to following embodiment, the present invention may be better understood.But, those skilled in the art will readily understand, the described content of embodiment is only for the present invention is described, and should also can not limit the present invention described in detail in claims.
Embodiment 1: poly-smart Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) Chinese medicine compound decoction.
Gather smart Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) Chinese medicine compound decoction, comprise the component of following parts by weight:
10 parts of Radix Rehmanniae, 10 parts of Radix Rehmanniae Preparata, 10 parts of Fructus Lycii, 10 parts of Semen Astragali Complanatis, 10 parts of full Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus)s, 15 parts of Radix Cyathulaes, 20 parts of Herba Hedyotidis Diffusaes, 15 parts of Radix Achyranthis Bidentataes, 10 parts of Fructus Mori, 10 parts of Radix Bupleuri, process 10 parts of Hirudos, 10 parts, Flos Carthami, 10 parts of Spina Gleditsiaes, 10 parts of Radix Dipsacis, 10 parts of Radix Polygoni Multiflori Preparata, 30 parts of Concha Ostreae (calcined)s, 10 parts of dry Pheretimas, 30 parts of Rhizoma Imperataes.
Preparation method:
The container of boiling medicine should be used marmite, enamel pan, stainless steel ware.
Decocting method: the Concha Ostreae (calcined) of formula ratio is decocted first 20 ~ 30 minutes, mix with above-mentioned other decoction pieces of formula ratio again, add drinking water merceration 1 ~ 2 hour, after first (big fire) is fried boiling with high heat, using slow fire (little fire) instead decocts, keep slight boiling condition agitation as appropriate, decoct altogether 2 ~ 3 times, after this compound recipe head is fried boiling, slow fire is decocted about 40 minutes again, two decoct or three decoct about 30 minutes after being fried boiling again, merge decocting liquid twice, mix, for subsequent use.Head is decocted amount of water and exceed powder 2 ~ 3cm after being soaked, and two decoct or three decoct amount of water to powder.
Medicine time: respectively at morning and evening 90 minutes after meal decoction being taken warmly.
Store method: do not boil medicine and put the dry place of shady and cool ventilation.The Chinese medicine of having decocted should be put refrigerator cold-storage.
Embodiment 2: poly-smart Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) Chinese medicine compound decoction.
Gather smart Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) Chinese medicine compound decoction, comprise the component of following parts by weight:
9 parts of Radix Rehmanniae, 9 parts of Radix Rehmanniae Preparata, 6 parts of Fructus Lycii, 6 parts of Semen Astragali Complanatis, 9 parts of full Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus)s, 10 parts of Radix Cyathulaes, 15 parts of Herba Hedyotidis Diffusaes, 10 parts of Radix Achyranthis Bidentataes, 9 parts of Fructus Mori, 5 parts of Radix Bupleuri, process 3 parts of Hirudos, 5 parts, Flos Carthami, 6 parts of Spina Gleditsiaes, 9 parts of Radix Dipsacis, 6 parts of Radix Polygoni Multiflori Preparata, 10 parts of Concha Ostreae (calcined)s, 5 parts of dry Pheretimas, 10 parts of Rhizoma Imperataes.
Preparation method, medicine time and store method are with embodiment 1.
Embodiment 3: poly-smart Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) Chinese medicine compound decoction.
Gather smart Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) Chinese medicine compound decoction, comprise the component of following parts by weight:
15 parts of Radix Rehmanniae, 15 parts of Radix Rehmanniae Preparata, 12 parts of Fructus Lycii, 12 parts of Semen Astragali Complanatis, 15 parts of full Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus)s, 12 parts of Radix Cyathulaes, 30 parts of Herba Hedyotidis Diffusaes, 12 parts of Radix Achyranthis Bidentataes, 15 parts of Fructus Mori, 8 parts of Radix Bupleuri, process 8 parts of Hirudos, 8 parts, Flos Carthami, 8 parts of Spina Gleditsiaes, 15 parts of Radix Dipsacis, 12 parts of Radix Polygoni Multiflori Preparata, 20 parts of Concha Ostreae (calcined)s, 8 parts of dry Pheretimas, 20 parts of Rhizoma Imperataes.
Preparation method, medicine time and store method are with embodiment 1.
Embodiment 4: poly-smart Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) Chinese native medicine compound prescription pellet agent.
Gather the agent of smart Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) Chinese native medicine compound prescription pellet, comprise the component of following parts by weight:
10 parts of Radix Rehmanniae, 10 parts of Radix Rehmanniae Preparata, 10 parts of Fructus Lycii, 10 parts of Semen Astragali Complanatis, 10 parts of full Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus)s, 10 parts of Radix Cyathulaes, 30 parts of Herba Hedyotidis Diffusaes, 10 parts of Radix Achyranthis Bidentataes, 10 parts of Fructus Mori, 6 parts of Radix Bupleuri, process 3 parts of Hirudos, 6 parts, Flos Carthami, 6 parts of Spina Gleditsiaes, 10 parts of Radix Dipsacis, 10 parts of Radix Polygoni Multiflori Preparata, 30 parts of Concha Ostreae (calcined)s, 10 parts of dry Pheretimas, 20 parts of Rhizoma Imperataes.
Process for producing granula:
By the Radix Rehmanniae of formula ratio, Radix Rehmanniae Preparata, Fructus Lycii, Semen Astragali Complanati, full Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus), Radix Cyathulae, Herba Hedyotidis Diffusae, Radix Achyranthis Bidentatae, Fructus Mori, Radix Bupleuri, process Hirudo, Flos Carthami, Spina Gleditsiae, Radix Dipsaci, Radix Polygoni Multiflori Preparata, Concha Ostreae (calcined), dry Pheretima and Rhizoma Imperatae by STP-GG-006(technological procedure general rule) granulate respectively, get single medicinal material granule and mix and obtain granule.
Granule is sealed off and is placed in container, adds 60 ~ 70 DEG C of boiled water, and limit adds waterside stirs, and after fully dissolving, puts to room temperature.
Medicine time, the same decoction of store method.
Embodiment 5: poly-smart Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) Chinese native medicine compound prescription pellet agent.
Gather the agent of smart Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) Chinese native medicine compound prescription pellet, comprise the component of following parts by weight:
9 parts of Radix Rehmanniae, 9 parts of Radix Rehmanniae Preparata, 6 parts of Fructus Lycii, 6 parts of Semen Astragali Complanatis, 9 parts of full Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus)s, 12 parts of Radix Cyathulaes, 15 parts of Herba Hedyotidis Diffusaes, 12 parts of Radix Achyranthis Bidentataes, 9 parts of Fructus Mori, 5 parts of Radix Bupleuri, process 5 parts of Hirudos, 5 parts, Flos Carthami, 8 parts of Spina Gleditsiaes, 9 parts of Radix Dipsacis, 6 parts of Radix Polygoni Multiflori Preparata, 10 parts of Concha Ostreae (calcined)s, 5 parts of dry Pheretimas, 10 parts of Rhizoma Imperataes.
Preparation method, medicine time and store method are with embodiment 4.
Embodiment 6: poly-smart Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) Chinese native medicine compound prescription pellet agent.
Gather the agent of smart Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) Chinese native medicine compound prescription pellet, comprise the component of following parts by weight:
15 parts of Radix Rehmanniae, 15 parts of Radix Rehmanniae Preparata, 12 parts of Fructus Lycii, 12 parts of Semen Astragali Complanatis, 15 parts of full Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus)s, 15 parts of Radix Cyathulaes, 20 parts of Herba Hedyotidis Diffusaes, 15 parts of Radix Achyranthis Bidentataes, 15 parts of Fructus Mori, 10 parts of Radix Bupleuri, process 10 parts of Hirudos, 10 parts, Flos Carthami, 10 parts of Spina Gleditsiaes, 15 parts of Radix Dipsacis, 12 parts of Radix Polygoni Multiflori Preparata, 20 parts of Concha Ostreae (calcined)s, 8 parts of dry Pheretimas, 30 parts of Rhizoma Imperataes.
Preparation method, medicine time and store method are with embodiment 4.
Embodiment 7: clinical data.
Contrast in table 1 with sign before and after the routine patient of compound treatment 8 of the present invention.
Table 1
Claims (6)
1. a Chinese medicine composition that is used for the treatment of Treatment of azoospermia or mixed type azoospermia, is characterized in that,
It is made up of the component of following parts by weight:
9～15 parts of Radix Rehmanniae, 9～15 parts of Radix Rehmanniae Preparata, 6～12 parts of Fructus Lycii, 6～12 parts of Semen Astragali Complanatis, 9～15 parts of full Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus)s, 10～15 parts of Radix Cyathulaes, 15～30 parts of Herba Hedyotidis Diffusaes, 10～15 parts of Radix Achyranthis Bidentataes, 9～15 parts of Fructus Mori, 5～10 parts of Radix Bupleuri, process 3～10 parts of Hirudos, 5～10 parts, Flos Carthami, 6～10 parts of Spina Gleditsiaes, 9～15 parts of Radix Dipsacis, 6～12 parts of Radix Polygoni Multiflori Preparata, 10～30 parts of Concha Ostreae (calcined)s, 5～10 parts of dry Pheretimas, 10～30 parts of Rhizoma Imperataes.
2. Chinese medicine composition according to claim 1, is characterized in that, it is made up of the component of following parts by weight:
10～12 parts of Radix Rehmanniae, 10～12 parts of Radix Rehmanniae Preparata, 10～12 parts of Fructus Lycii, 10～12 parts of Semen Astragali Complanatis, 10～15 parts of full Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus)s, 10～15 parts of Radix Cyathulaes, 15～20 parts of Herba Hedyotidis Diffusaes, 10～15 parts of Radix Achyranthis Bidentataes, 10～12 parts of Fructus Mori, 6～10 parts of Radix Bupleuri, process 3～10 parts of Hirudos, 6～10 parts, Flos Carthami, 6～10 parts of Spina Gleditsiaes, 10～12 parts of Radix Dipsacis, 10 parts of Radix Polygoni Multiflori Preparata, 30 parts of Concha Ostreae (calcined)s, 10 parts of dry Pheretimas, 15～30 parts of Rhizoma Imperataes.
3. Chinese medicine composition according to claim 1, is characterized in that, its dosage form is decoction or granule.
4. the preparation method of Chinese medicine composition claimed in claim 1, it is characterized in that, the Concha Ostreae (calcined) of formula ratio is decocted first 20～30 minutes, again with the Radix Rehmanniae of formula ratio, Radix Rehmanniae Preparata, Fructus Lycii, Semen Astragali Complanati, full Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus), Radix Cyathulae, Herba Hedyotidis Diffusae, Radix Achyranthis Bidentatae, Fructus Mori, Radix Bupleuri, process Hirudo, Flos Carthami, Spina Gleditsiae, Radix Dipsaci, Radix Polygoni Multiflori Preparata, dry Pheretima and Rhizoma Imperatae and mix, merceration 1～2 hour adds water, after intense fire is fried boiling, slow fire boiling 30～40 minutes, decoct altogether 2～3 times, collecting decoction, obtains decoction.
5. the preparation method of Chinese medicine composition claimed in claim 1, it is characterized in that, by the Radix Rehmanniae of formula ratio, Radix Rehmanniae Preparata, Fructus Lycii, Semen Astragali Complanati, full Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus), Radix Cyathulae, Herba Hedyotidis Diffusae, Radix Achyranthis Bidentatae, Fructus Mori, Radix Bupleuri, process Hirudo, Flos Carthami, Spina Gleditsiae, Radix Dipsaci, Radix Polygoni Multiflori Preparata, Concha Ostreae (calcined), dry Pheretima and Rhizoma Imperatae and granulate respectively, get single medicinal material granule and mix, after dissolving more after filtration, concentrated, spraying is dry, granulate, dry, granulate, granule sieves to obtain.
6. the application of Chinese medicine composition claimed in claim 1 in preparation treatment Treatment of azoospermia or mixed type azoospermia medicine.
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