CN103083579A - Immune preparation for improving immunocompetence of piglets - Google Patents

Abstract

The invention provides a traditional Chinese medicine composition preparation capable of improving immunologic function of piglets. The traditional Chinese medicine composition preparation comprises the following active pharmaceutical ingredients: fructus forsythiae, Chinese date, barberry root, manyprickle acanto-panax root, medicinal Indianmulberry root, buffalo horn, epimedium herb, pyrrosia leaf, lightyellow sophora root, barbary wolfberry fruit, yerbadetajo herb, cochinchinese asparagus root, pale butterflybush flower, black sesame, American ginseng, Chinese angelica, largehead atractylodes rhizome, coix seed, aleppo avens, membranous milkvetch root, pokeberry root and agaric. The traditional Chinese medicine composition preparation has the advantages of low cost, extensive action, low toxicity, few side effects, no drug residues and no problems of transfer of drug resistance of bacteria in animal bodies to human pathogenic bacteria caused by antibiotics and the like, and can be used for significantly improving the growth performance of the piglets.

Description

Be used for improving the immune formulation of piglet immunological ability

Technical field

The present invention relates to Chinese medicine immune formulation technical field, relate in particular to a kind of Chinese medicine preparation for improving the piglet immunological ability.

  

Background technology

The feeding and management of piglet is the link of most critical in whole Swine Production.Set up not yet fully due to newborn piglet digestive tract and Digest enzyme thereof, the gastrointestinal mucosa structure is not well established, and immune system is grown imperfection, and is strong to the susceptibility of pathogenic microorganism and toxin thereof, is easy to bring out various gastroenteropathys, reduces fertility performance.In Pig Industry is produced, for improving its economic benefit, generally carry out the early weaning piglet technology, poor growth and diarrhoea are " the early weaning irritability syndrome " of principal character after the weaned piglet but usually cause.Because this disease has higher incidence rate and mortality rate, heavy losses have been brought to pig industry.

At present, generally adopt in animal husbandry is produced and add antibiotic, hormone, chemical synthetic drug etc. prevent and treat livestock and poultry diarrhea in feedstuff, these materials of life-time service, cause easily that not only pathogenic microorganism produces the problems such as drug resistance, animal immunizing power decline and deterioration in quality, and can cause the hazard residue in livestock products and environment to increase, human health in serious threat.

The traditional Chinese medical science is emphasized " healthy energy " mastery reaction on disease incidence is learned very much.Theory of Chinese medical science thinks, so-called " healthy energy " is exactly the resistance against diseases of body inherence, therefore, therapeutically, " healthy energy " that the Chinese herbal medicine of the traditional Chinese medical science " righting " commonly used is helped body, the immunologic function of enhancing body, thus the invasion and attack of " exopathogen " resisted, be meaning " strengthening vital QI to eliminate pathogenic factors ".And more modern pharmacological experiments also show, many Fuzheng herbs all have immunoregulation effect.These Chinese herbal medicine not only can affect the weight of animal immune organ, the proliferation and differentiation of Promote immunity cell, the humoral immune function of raising body, the generation of enhancing antibody, also can by activating reticuloendothelial system, inducing cytokine profiles, strengthen Immune Function In Animals.In addition, Chinese herbal medicine is to be taken at nature and to have kept its natural structure and bioactive natural drug, has that the source is abundant, with low cost, effect is extensive, less toxic side effect and other advantages.

The present invention is take theory of Chinese medical science as the basis, a kind of Chinese medicinal composition preparation for improving the piglet immunological function is provided, its have with low cost, effect extensively, toxic and side effects is low, in the animal body that causes without drug residue and antibiotic bacterial drug resistance to the problems such as transfer of human disease bacterium.

  

Summary of the invention

Technical problem to be solved by this invention is to provide a kind of Chinese medicinal composition preparation for improving the piglet immunological function, its have with low cost, effect extensively, toxic and side effects is low, bacterial drug resistance to the problems such as transfer of human disease bacterium, significantly improves the growth performance of piglet in the animal body that causes without drug residue and antibiotic.

In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicinal composition preparation that can improve the piglet immunological function, its crude drug comprises Fructus Forsythiae, Fructus Jujubae, Radix Berberidis, Radix Et Caulis Acanthopanacis Senticosi, Radix Morindae Officinalis, Cornu Bubali, Herba Epimedii, Folium Pyrrosiae, Radix Sophorae Flavescentis, Fructus Lycii, Herba Ecliptae, Radix Asparagi, Flos Buddlejae, Semen Sesami Nigrum, Radix Panacis Quinquefolii, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Semen Coicis, Radix seu Herba Gei aleppici, the Radix Astragali, Radix Phytolaccae and Polyporus.

wherein, in described Chinese medicinal composition preparation, the weight portion of each crude drug is respectively: Fructus Forsythiae 40 weight portions ~ 50 weight portions, Fructus Jujubae 50 weight portions ~ 60 weight portions, Radix Berberidis 20 weight portions ~ 30 weight portions, Radix Et Caulis Acanthopanacis Senticosi 55 weight portions ~ 65 weight portions, Radix Morindae Officinalis 30 weight portions ~ 40 weight portions, Cornu Bubali 10 weight portions ~ 20 weight portions, Herba Epimedii 40 weight portions ~ 50 weight portions, Folium Pyrrosiae 25 weight portions ~ 35 weight portions, Radix Sophorae Flavescentis 15 weight portions ~ 25 weight portions, Fructus Lycii 30 weight portions ~ 40 weight portions, Herba Ecliptae 35 weight portions ~ 45 weight portions, Radix Asparagi 30 weight portions ~ 40 weight portions, Flos Buddlejae 10 weight portions ~ 20 weight portions, Semen Sesami Nigrum 60 weight portions ~ 70 weight portions, Radix Panacis Quinquefolii 80 weight portions ~ 90 weight portions, Radix Angelicae Sinensis 30 weight portions ~ 40 weight portions, the Rhizoma Atractylodis Macrocephalae 55 weight portions ~ 65 weight portions, Semen Coicis 20 weight portions ~ 30 weight portions, Radix seu Herba Gei aleppici 35 weight portions ~ 45 weight portions, the Radix Astragali 70 weight portions ~ 80 weight portions, Radix Phytolaccae 20 weight portions ~ 30 weight portions and Polyporus 30 weight portions ~ 40 weight portions.

wherein, in described Chinese medicinal composition preparation, the weight portion of each crude drug is respectively: Fructus Forsythiae 45 weight portions, Fructus Jujubae 55 weight portions, Radix Berberidis 25 weight portions, Radix Et Caulis Acanthopanacis Senticosi 60 weight portions, Radix Morindae Officinalis 35 weight portions, Cornu Bubali 15 weight portions, Herba Epimedii 45 weight portions, Folium Pyrrosiae 30 weight portions, Radix Sophorae Flavescentis 20 weight portions, Fructus Lycii 35 weight portions, Herba Ecliptae 40 weight portions, Radix Asparagi 35 weight portions, Flos Buddlejae 15 weight portions, Semen Sesami Nigrum 65 weight portions, Radix Panacis Quinquefolii 85 weight portions, Radix Angelicae Sinensis 35 weight portions, the Rhizoma Atractylodis Macrocephalae 60 weight portions, Semen Coicis 25 weight portions, Radix seu Herba Gei aleppici 40 weight portions, the Radix Astragali 75 weight portions, Radix Phytolaccae 25 weight portions and Polyporus 35 weight portions.

The present invention also provides a kind of Chinese medicine composition decoction liquor that can improve the piglet immunological function, and its crude drug comprises Fructus Forsythiae, Fructus Jujubae, Radix Berberidis, Radix Et Caulis Acanthopanacis Senticosi, Radix Morindae Officinalis, Cornu Bubali, Herba Epimedii, Folium Pyrrosiae, Radix Sophorae Flavescentis, Fructus Lycii, Herba Ecliptae, Radix Asparagi, Flos Buddlejae, Semen Sesami Nigrum, Radix Panacis Quinquefolii, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Semen Coicis, Radix seu Herba Gei aleppici, the Radix Astragali, Radix Phytolaccae and Polyporus.

The present invention also provides a kind of Chinese medicine composition composition powders that can improve the piglet immunological function, and its crude drug comprises Fructus Forsythiae, Fructus Jujubae, Radix Berberidis, Radix Et Caulis Acanthopanacis Senticosi, Radix Morindae Officinalis, Cornu Bubali, Herba Epimedii, Folium Pyrrosiae, Radix Sophorae Flavescentis, Fructus Lycii, Herba Ecliptae, Radix Asparagi, Flos Buddlejae, Semen Sesami Nigrum, Radix Panacis Quinquefolii, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Semen Coicis, Radix seu Herba Gei aleppici, the Radix Astragali, Radix Phytolaccae and Polyporus.

The present invention also provides a kind of Chinese medicine composition composition injection that can improve the piglet immunological function, and its crude drug comprises Fructus Forsythiae, Fructus Jujubae, Radix Berberidis, Radix Et Caulis Acanthopanacis Senticosi, Radix Morindae Officinalis, Cornu Bubali, Herba Epimedii, Folium Pyrrosiae, Radix Sophorae Flavescentis, Fructus Lycii, Herba Ecliptae, Radix Asparagi, Flos Buddlejae, Semen Sesami Nigrum, Radix Panacis Quinquefolii, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Semen Coicis, Radix seu Herba Gei aleppici, the Radix Astragali, Radix Phytolaccae and Polyporus.

The present invention also provides the preparation method of above-mentioned Chinese medicinal composition preparation, when the dosage form of described Chinese medicinal composition preparation is decoction liquor, its step is specially: described each crude drug component is mixed in proportion, send in blender and stirred 20 minutes ~ 30 minutes, add with respect to 5 ~ 8 times of water of crude drug quality sum, decocted 2 ~ 4 hours, decoction liquor is filtered, filtering residue adds again with respect to 2 ~ 4 times of water of crude drug quality sum, again decocted 2 ~ 4 hours, decoction liquor is filtered, and filtrate is merged, heating is concentrated, and obtaining crude drug concentration is the decoction liquor of 1g/ml.

The present invention also provides the preparation method of above-mentioned Chinese medicine composition, when the dosage form of described Chinese medicine composition is powder, its step is specially: each crude drug is mixed in proportion, send in blender and stirred 20 minutes ~ 30 minutes, add with respect to 5 ~ 8 times of water of crude drug quality sum, decocted 2 ~ 4 hours, decoction liquor is filtered, and filtering residue adds again with respect to 2 ~ 4 times of water of crude drug quality sum, again decocted 2 ~ 4 hours, decoction liquor is filtered, and filtrate is merged, and heating is concentrated except anhydrating, obtain and get dry extract, be ground into powder, drying obtains powder.

The present invention also provides the preparation method of above-mentioned Chinese medicine composition, and when the dosage form of described Chinese medicine composition was injection, its step was specially:

The first step, each crude drug is mixed in proportion, send in blender and stirred 20 minutes ~ 30 minutes, add with respect to 5 ~ 8 times of water of crude drug quality sum, decocted 2 ~ 4 hours, decoction liquor is filtered, and filtering residue adds again with respect to 2 ~ 4 times of water of crude drug quality sum, again decocts 2 ~ 4 hours, decoction liquor is filtered, filtrate is merged, add 1～2g active carbon, boiled 10～15 minutes, after natural cooling, through centrifugal, sucking filtration, obtain filtrate, heating is concentrated into the medicinal liquid that determining alcohol is 10g/ml～15g/ml;

Second step is got described medicinal liquid 20ml, adds successively therein 0.75ml tween 80,100mg sodium sulfite, inject water to 100ml after mix homogeneously, and with sodium hydroxide adjust pH to 7.5, be sub-packed at last in cillin bottle, after the boiling water bath heat sterilization, namely get injection.

The present invention also provides the application of above-mentioned Chinese medicine composition in the medicine of preparation raising piglet immunological function.

Beneficial effect of the present invention:

Chinese medicinal composition preparation provided by the invention, its have with low cost, effect extensively, toxic and side effects is low, bacterial drug resistance to the problems such as transfer of human disease bacterium, significantly improves the growth performance of piglet in the animal body that causes without drug residue and antibiotic.

  

The specific embodiment

The invention provides a kind of Chinese medicinal composition preparation that can improve the piglet immunological function, its crude drug comprises Fructus Forsythiae, Fructus Jujubae, Radix Berberidis, Radix Et Caulis Acanthopanacis Senticosi, Radix Morindae Officinalis, Cornu Bubali, Herba Epimedii, Folium Pyrrosiae, Radix Sophorae Flavescentis, Fructus Lycii, Herba Ecliptae, Radix Asparagi, Flos Buddlejae, Semen Sesami Nigrum, Radix Panacis Quinquefolii, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Semen Coicis, Radix seu Herba Gei aleppici, the Radix Astragali, Radix Phytolaccae and Polyporus, and Chinese medicine composition has very strong removing free radical, interrupts the effect that lipid peroxy is immune against attacks antioxidase.

The pharmacology of each crude drug is specially:

Fructus Forsythiae: bitter in the mouth, cold nature enters the heart, liver, gallbladder, small intestine meridian, and heat-clearing and toxic substances removing is arranged, and the effect of dispersing swelling and dissipating binds is used for carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease is from the beginning of, warm joining the army, high hot excessive thirst, coma is sent out speckle, the cards such as pyretic stranguria urine retention.

Fructus Jujubae: sweet in the mouth, warm in nature, enter spleen, stomach warp, have the effect of air making-up and spleen enlivening, nourishing blood to tranquillize the mind, harmonizing yingfen and weifen, the mitigation property of medicine, be used for weakness of the spleen and stomach, fatigue and asthenia, anorexia and loose stool, insufficiency of vital energy and blood is had a headache and fever, the cards such as sweating hot blast.

Radix Berberidis: bitter in the mouth, cold in nature, to return to have heat clearing and damp drying, the effect of eliminating fire and detoxication cures mainly damp-heat dysentery, jaundice, eczema, pharyngalgia conjunctival congestion, the cards such as carbuncle sore tumefacting virus.

Radix Et Caulis Acanthopanacis Senticosi: acrid in the mouth, hardship, little sweet, warm in nature enter spleen, kidney, heart channel, has replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization, the effect of expelling wind and removing dampness, be used for anemofrigid-damp arthralgia, lumbocrural pain, muscles and bones flaccidity soft, be slow in action, the card such as the body weakness with emaciation is weak, traumatic injury, fracture, edema, beriberi, uncontrolled urination are itched.

Radix Morindae Officinalis: acrid in the mouth, sweet, warm in nature, return liver, kidney channel, have reinforcing the kidney and supporting YANG; Bone and muscle strengthening; The effect of expelling wind and removing dampness cures mainly impotence due to deficiency of the kidney; The seminal emission premature ejaculation; Few abdomen cold type of pain; Incontinence of urine; Cold womb is infertile; Anemofrigid-damp arthralgia; Soreness of the waist and knees; The cards such as rheumatism limb gas.

Cornu Bubali: bitter in the mouth, salty, cold in nature, GUIXIN, liver, spleen, stomach four warps have the effect of heat clearing away, removing heat from blood, detoxifcation, cure mainly the calentura headache, the high fever coma, macule is told nosebleed, infantile convulsion, the cards such as sore throat pharyngeal swelling.

Herba Epimedii: acrid in the mouth, sweet, warm in nature, enter liver, kidney channel, have kidney-replenishing, bone and muscle strengthening, the effect of wind-damp dispelling is used for that impotence due to deficiency of the kidney, seminal emission premature ejaculation, waist knee joint flaccidity are soft, cold extremities with aversion to cold; The cards such as arthralgia due to cold-dampnes or spasm of the limbs are numb.

Folium Pyrrosiae: sweet in the mouth, hardship, cold nature is returned lung, urinary bladder channel, has relieving stranguria by diuresis, and the effect that lung heat clearing expels the heat-evil cures mainly and drenches pain, hematuria, lithangiuria, nephritis, metrorrhagia, dysentery, cough due to lung-heat, chronic tracheitis, incised wound, the cards such as carbuncle.

Radix Sophorae Flavescentis: bitter in the mouth; Cold in nature, return liver, kidney, large intestine, small intestine meridian, bladder, heart channel has heat clearing and damp drying, and the effect of wind dispelling insecticide cures mainly damp-heat dysentery, discharging fresh blood stool, jaundice, dysuria, edema, leukorrhagia, pudendal pruritus, scabies, leprosy, skin pruritus, the cards such as noxious dampness skin infection.

Fructus Lycii: sweet in the mouth, property are flat, enter liver, kidney channel, have liver and kidney tonifying, nourish blood enrich blood, the effect of replenishing vital essence to improve eyesight, nourishing the lung to arrest cough, cure mainly soreness of the waist and knees, dizziness and tinnitus, seminal emission tinnitus, the unconsciously sweat and tire of Liver and kidney two void, asthenia of essence and blood; The sexual impotence of insufficiency of kidney-YANG, sterile; The cards such as the dim-sighted and deficiency of YIN chronic cough of the eyes of deficiency of YIN-essence, deficiency of liver-blood.

Herba Ecliptae: sweet in the mouth, acid, cold in nature, return liver, kidney channel, play liver and kidney tonifying, the effect of cooling blood for hemostasis, cure mainly have a dizzy spell due to the hepatic and renal YIN deficiency, blurring of vision, soreness of the waist and knees; Being suitable for the deficiency of YIN has hot person, the haematemesis of accumulated heat in stomach, and the cards such as the hemoptysis of injury of blood vessel of the lung by heat, Herba Ecliptae has inhibitory action to staphylococcus aureus, Bacillus typhi, Song's Shigella flexneri, bacillus pyocyaneus, obviously enhancing non-specific immunity and cellular immune function.

Radix Asparagi: sweet in the mouth, hardship, cold in nature, return lung, kidney channel, have nourishing YIN to relieve dryness, the effect that lung heat clearing is promoted the production of body fluid cures mainly cough caused by dryness-heat, deficiency of YIN chronic cough, hyperactivity of fire caused by deficiency of YIN, the laryngopharynx swelling and pain of seminal emission, premature ejaculation and hyperactivity of deficient fire that kidney essense is not solid, calentura Tianjin wound is thirsty, the interior-heat cards such as dryness of the intestine constipation of quenching one's thirst.

Flos Buddlejae: sweet in the mouth, cold nature is returned liver, and gallbladder meridian has the heat clearing away nourishing the liver, and the effect of improving acuity of vision and removing nebula cures mainly conjunctival congestion and swelling pain, many tear photophobia, the nebula of looking unfamiliar film, hepatasthenia dim eyesight, the cards such as blurring of vision.

Semen Sesami Nigrum: sweet in the mouth, property is flat, returns liver, kidney, large intestine channel, has invigorating the liver and kidney, benefiting essence-blood, the effect that intestine moistening is dry is used for dizziness and blurred vision, Hiccough and deaf, early whitening of beard and hair, post disease alopecia, the cards such as dryness of the intestine constipation.

Radix Panacis Quinquefolii: sweet in the mouth, little hardship, cool in nature, GUIXIN, lung, kidney channel have boosting qi and nourishing yin, and the effect of clearing away heat and promoting production of body fluid cures mainly the deficiency of vital energy thanks to cloudy, interior-heat, cough with asthma expectorant blood, deficiency-heat is tired tired, quenches one's thirst, dryness of the mouth and throat.Radix Panacis Quinquefolii has the effect of resisting fatigue, antioxidation, anti-stress, anticoagulant, reduction blood coagulation.

Radix Angelicae Sinensis: sweet in the mouth, suffering, hardship, warm in nature, return liver, the heart, spleen channel, having enriches blood invigorates blood circulation, and regulating menstruation relieves the pain, the effect of loosening bowel to relieve constipation, the head who cures mainly deficiency of heart-blood is giddy, fatigue and weakness, shortness of breath and palpitation, and other syndrome of deficiency of blood; The sea of blood is hollow, and the cards such as the phase of spreading out are less measured in the menoxenia of the cold and deficiency of CHONG and REN meridians or congestion retardance.

The Rhizoma Atractylodis Macrocephalae: sweet in the mouth, hardship, warm in nature, enter spleen, stomach warp, the spleen reinforcing promoting the circulation of QI is arranged, the dampness diuretic, strengthening superficial resistance to stop perspiration, the effect that activating the spleen is moisturized is mainly used in the feeling of fullness diarrhoea due to dysfunction of the spleen in transportation, QI failing to transform into body fluid, the phlegm retention edema; The vexed lazy speech of deficiency of QI in middle-JIAO, metrorrhagia and metrostaxis, proctoptosis with chronic dysentery; The cards such as solid in the playing of deficiency of the spleen causing weakness of QI, sweating due to debility spontaneous perspiration.

Semen Coicis: sweet in the mouth, light, cold nature enters lung, spleen, large intestine channel, has invigorating the spleen to arrest diarrhea, the diuretic eliminating impediment, the effect of row's skin ulcer pus cures mainly having loose bowels of wet tired lung stomach; Damp is invaded the hydrosarca of stain skin, dysuria; The damp and hot resistance in the numbness of QI and blood passes to and the scorchingly hot cards such as lung abscess in the lung intestinal, acute appendicitis that pent up.

Radix seu Herba Gei aleppici: acrid in the mouth, hardship, property is flat, returns liver, spleen, lung meridian, has analgesia, blood pressure lowering, regulating menstruation, the effect of expelling wind and removing dampness cures mainly hypertension, dizziness headache, menoxenia, lower abdominal pain, leucorrhea, infantile convulsion, lumbago, skelalgia of rheumatism; Carbuncle furuncle and phyma poison, the cards such as traumatic injury are controlled in external.

The Radix Astragali: sweet in the mouth, warm in nature, enter spleen, lung meridian, tonification spleen soil is arranged, elevate a turnable ladder yang-energy, strengthening superficial resistance to stop perspiration, the effect of holder skin ulcer granulation promoting cures mainly the weak anorexia and loose stool due to deficiency of both the splenic and pulmonary QI, shortness of breath and palpitation, the visceroptosis of sinking of QI of middle-JIAO, the metrorrhagia of QI failing to control blood is had blood in stool, the chronic diarrhea proctoptosis; The spontaneous sweating of exterior deficiency, the cards such as insufficiency of vital energy and blood.The Radix Astragali strengthens the heart contraction ability, can improve the blood circulation of whole body, can coronary artery dilator, kidney blood vessel and Rhizoma Bistortae peripheral vessel, make cutaneous circulation vigorous; Can improve the nonspecific immunity power of body, protect the liver and fall hypoglycemic effect, staphylococcus, blood dissolubility streptococcus, Diplococcus pneumoniae, dysentery bacterium etc. are had inhibitory action, but Radix Astragali appreciable impact splenocyte Information Conduction be realized immunoregulation effect.

Radix Phytolaccae: bitter in the mouth, cold in nature, return spleen, urinary bladder channel, have logical two just, the effect of removing water retention by purgation eliminating stagnation cures mainly edema, distension, beriberi, sore throat, carbuncle, the cards such as malignant boil.

Polyporus: sweet in the mouth, light, property is flat, enters kidney, urinary bladder channel, has the effect of promoting diuresis to eliminate damp pathogen, is mainly used in the edema of retention of water-damp, dysuria, and the having loose bowels, vomit of stagnation of dampness due to deficiency of the spleen; The cards such as the leucorrhea of damp invasion of lower energizer, nebulousurine.

in described Chinese medicinal composition preparation, the weight portion of each crude drug is respectively: Fructus Forsythiae 40 weight portions ~ 50 weight portions, Fructus Jujubae 50 weight portions ~ 60 weight portions, Radix Berberidis 20 weight portions ~ 30 weight portions, Radix Et Caulis Acanthopanacis Senticosi 55 weight portions ~ 65 weight portions, Radix Morindae Officinalis 30 weight portions ~ 40 weight portions, Cornu Bubali 10 weight portions ~ 20 weight portions, Herba Epimedii 40 weight portions ~ 50 weight portions, Folium Pyrrosiae 25 weight portions ~ 35 weight portions, Radix Sophorae Flavescentis 15 weight portions ~ 25 weight portions, Fructus Lycii 30 weight portions ~ 40 weight portions, Herba Ecliptae 35 weight portions ~ 45 weight portions, Radix Asparagi 30 weight portions ~ 40 weight portions, Flos Buddlejae 10 weight portions ~ 20 weight portions, Semen Sesami Nigrum 60 weight portions ~ 70 weight portions, Radix Panacis Quinquefolii 80 weight portions ~ 90 weight portions, Radix Angelicae Sinensis 30 weight portions ~ 40 weight portions, the Rhizoma Atractylodis Macrocephalae 55 weight portions ~ 65 weight portions, Semen Coicis 20 weight portions ~ 30 weight portions, Radix seu Herba Gei aleppici 35 weight portions ~ 45 weight portions, the Radix Astragali 70 weight portions ~ 80 weight portions, Radix Phytolaccae 20 weight portions ~ 30 weight portions and Polyporus 30 weight portions ~ 40 weight portions.

in described Chinese medicinal composition preparation, the weight portion of each crude drug further preferably is respectively: Fructus Forsythiae 43 weight portions ~ 47 weight portions, Fructus Jujubae 53 weight portions ~ 57 weight portions, Radix Berberidis 23 weight portions ~ 27 weight portions, Radix Et Caulis Acanthopanacis Senticosi 58 weight portions ~ 62 weight portions, Radix Morindae Officinalis 33 weight portions ~ 37 weight portions, Cornu Bubali 13 weight portions ~ 17 weight portions, Herba Epimedii 43 weight portions ~ 47 weight portions, Folium Pyrrosiae 28 weight portions ~ 32 weight portions, Radix Sophorae Flavescentis 18 weight portions ~ 22 weight portions, Fructus Lycii 33 weight portions ~ 37 weight portions, Herba Ecliptae 38 weight portions ~ 42 weight portions, Radix Asparagi 33 weight portions ~ 37 weight portions, Flos Buddlejae 13 weight portions ~ 17 weight portions, Semen Sesami Nigrum 63 weight portions ~ 67 weight portions, Radix Panacis Quinquefolii 83 weight portions ~ 87 weight portions, Radix Angelicae Sinensis 33 weight portions ~ 37 weight portions, the Rhizoma Atractylodis Macrocephalae 58 weight portions ~ 62 weight portions, Semen Coicis 23 weight portions ~ 27 weight portions, Radix seu Herba Gei aleppici 38 weight portions ~ 42 weight portions, the Radix Astragali 73 weight portions ~ 77 weight portions, Radix Phytolaccae 23 weight portions ~ 27 weight portions and Polyporus 33 weight portions ~ 37 weight portions.

in described Chinese medicinal composition preparation, the weight portion of each crude drug most preferably is respectively: Fructus Forsythiae 45 weight portions, Fructus Jujubae 55 weight portions, Radix Berberidis 25 weight portions, Radix Et Caulis Acanthopanacis Senticosi 60 weight portions, Radix Morindae Officinalis 35 weight portions, Cornu Bubali 15 weight portions, Herba Epimedii 45 weight portions, Folium Pyrrosiae 30 weight portions, Radix Sophorae Flavescentis 20 weight portions, Fructus Lycii 35 weight portions, Herba Ecliptae 40 weight portions, Radix Asparagi 35 weight portions, Flos Buddlejae 15 weight portions, Semen Sesami Nigrum 65 weight portions, Radix Panacis Quinquefolii 85 weight portions, Radix Angelicae Sinensis 35 weight portions, the Rhizoma Atractylodis Macrocephalae 60 weight portions, Semen Coicis 25 weight portions, Radix seu Herba Gei aleppici 40 weight portions, the Radix Astragali 75 weight portions, Radix Phytolaccae 25 weight portions and Polyporus 35 weight portions.

The present invention also provides the preparation method of above-mentioned Chinese medicinal composition preparation, when the dosage form of described Chinese medicinal composition preparation is decoction liquor, be specially: described each crude drug component is mixed in proportion, send in blender and stirred 20 minutes ~ 30 minutes, add with respect to 5 ~ 8 times of water of crude drug quality sum, decocted 2 ~ 4 hours, decoction liquor is filtered, filtering residue adds again with respect to 2 ~ 4 times of water of crude drug quality sum, again decocted 2 ~ 4 hours, decoction liquor is filtered, and filtrate is merged, heating is concentrated, and obtaining crude drug concentration is the decoction liquor of 1g/ml.

The present invention also provides the preparation method of above-mentioned Chinese medicine composition, when the dosage form of described Chinese medicine composition is powder, its step is specially each crude drug is mixed in proportion, send in blender and stirred 20 minutes ~ 30 minutes, add with respect to 5 ~ 8 times of water of crude drug quality sum, decocted 2 ~ 4 hours, decoction liquor is filtered, and filtering residue adds again with respect to 2 ~ 4 times of water of crude drug quality sum, again decocted 2 ~ 4 hours, decoction liquor is filtered, and filtrate is merged, and heating is concentrated except anhydrating, obtain and get dry extract, be ground into powder, drying obtains powder.

The present invention also provides the preparation method of above-mentioned Chinese medicine composition, and when the dosage form of described Chinese medicine composition was injection, its step was specially:

The first step, each crude drug is mixed in proportion, send in blender and stirred 20 minutes ~ 30 minutes, add with respect to 5 ~ 8 times of water of crude drug quality sum, decocted 2 ~ 4 hours, decoction liquor is filtered, and filtering residue adds again with respect to 2 ~ 4 times of water of crude drug quality sum, again decocts 2 ~ 4 hours, decoction liquor is filtered, filtrate is merged, add 1～2g active carbon, boiled 10～15 minutes, after natural cooling, through centrifugal, sucking filtration, obtain filtrate, heating is concentrated into the medicinal liquid that determining alcohol is 10g/ml～15g/ml;

Second step is got described medicinal liquid 20ml, adds successively therein 0.75ml tween 80,100mg sodium sulfite, inject water to 100ml after mix homogeneously, and with sodium hydroxide adjust pH to 7.5, be sub-packed at last in cillin bottle, after the boiling water bath heat sterilization, namely get injection.

Below adopt embodiment to describe embodiments of the present invention in detail, how the application technology means solve technical problem to the present invention whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.

Embodiment 1 decocting for Chinese herbal medicine liquid 1

with Fructus Forsythiae 45g, Fructus Jujubae 55g, Radix Berberidis 25g, Radix Et Caulis Acanthopanacis Senticosi 60g, Radix Morindae Officinalis 35g, Cornu Bubali 15g, Herba Epimedii 45g, Folium Pyrrosiae 30g, Radix Sophorae Flavescentis 20g, Fructus Lycii 35g, Herba Ecliptae 40g, Radix Asparagi 35g, Flos Buddlejae 15g, Semen Sesami Nigrum 65g, Radix Panacis Quinquefolii 85g, Radix Angelicae Sinensis 35g, Rhizoma Atractylodis Macrocephalae 60g, Semen Coicis 25g, Radix seu Herba Gei aleppici 40g, Radix Astragali 75g, Radix Phytolaccae 25g and Polyporus 35g mix, send in blender and stirred 30 minutes, the water that adds 5.5kg, decocted 4 hours, decoction liquor is filtered, filtering residue adds the water of 2.7kg again, again decocted 4 hours, decoction liquor is filtered, filtrate is merged, heating is concentrated, obtaining crude drug concentration is the decoction liquor of 1g/ml.

Embodiment 2 decocting for Chinese herbal medicine liquid 2

with Fructus Forsythiae 40g, Fructus Jujubae 50g, Radix Berberidis 20g, Radix Et Caulis Acanthopanacis Senticosi 55g, Radix Morindae Officinalis 30g, Cornu Bubali 10g, Herba Epimedii 40g, Folium Pyrrosiae 25g, Radix Sophorae Flavescentis 15g, Fructus Lycii 30g, Herba Ecliptae 35g, Radix Asparagi 30g, Flos Buddlejae 10g, Semen Sesami Nigrum 60g, Radix Panacis Quinquefolii 80g, Radix Angelicae Sinensis 30g, Rhizoma Atractylodis Macrocephalae 55g, Semen Coicis 20g, Radix seu Herba Gei aleppici 35g, Radix Astragali 70g, Radix Phytolaccae 20g and Polyporus 30g mix, send in blender and stirred 30 minutes, the water that adds 5kg, decocted 4 hours, decoction liquor is filtered, filtering residue adds the water of 2.4kg again, again decocted 4 hours, decoction liquor is filtered, filtrate is merged, heating is concentrated, obtaining crude drug concentration is the decoction liquor of 1g/ml.

Embodiment 3 decocting for Chinese herbal medicine liquid 3

with Fructus Forsythiae 50g, Fructus Jujubae 60g, Radix Berberidis 30g, Radix Et Caulis Acanthopanacis Senticosi 65g, Radix Morindae Officinalis 40g, Cornu Bubali 20g, Herba Epimedii 50g, Folium Pyrrosiae 35g, Radix Sophorae Flavescentis 25g, Fructus Lycii 40g, Herba Ecliptae 45g, Radix Asparagi 40g, Flos Buddlejae 20g, Semen Sesami Nigrum 70g, Radix Panacis Quinquefolii 90g, Radix Angelicae Sinensis 40g, Rhizoma Atractylodis Macrocephalae 65g, Semen Coicis 30g, Radix seu Herba Gei aleppici 45g, Radix Astragali 80g, Radix Phytolaccae 30g and Polyporus 40g mix, send in blender and stirred 30 minutes, the water that adds 6kg, decocted 4 hours, decoction liquor is filtered, filtering residue adds the water of 3kg again, again decocted 4 hours, decoction liquor is filtered, filtrate is merged, heating is concentrated, obtaining crude drug concentration is the decoction liquor of 1g/ml.

Embodiment 4 Chinese powder medicines

with Fructus Forsythiae 45g, Fructus Jujubae 55g, Radix Berberidis 25g, Radix Et Caulis Acanthopanacis Senticosi 60g, Radix Morindae Officinalis 35g, Cornu Bubali 15g, Herba Epimedii 45g, Folium Pyrrosiae 30g, Radix Sophorae Flavescentis 20g, Fructus Lycii 35g, Herba Ecliptae 40g, Radix Asparagi 35g, Flos Buddlejae 15g, Semen Sesami Nigrum 65g, Radix Panacis Quinquefolii 85g, Radix Angelicae Sinensis 35g, Rhizoma Atractylodis Macrocephalae 60g, Semen Coicis 25g, Radix seu Herba Gei aleppici 40g, Radix Astragali 75g, Radix Phytolaccae 25g and Polyporus 35g mix, send in blender and stirred 30 minutes, the water that adds 5.5kg, decocted 4 hours, decoction liquor is filtered, filtering residue adds the water of 2.7kg again, again decocted 4 hours, decoction liquor is filtered, filtrate is merged, heating is concentrated except anhydrating, obtain and get dry extract, be ground into powder, dry, obtain powder.

Embodiment 5 Chinese medicine injections

with Fructus Forsythiae 45g, Fructus Jujubae 55g, Radix Berberidis 25g, Radix Et Caulis Acanthopanacis Senticosi 60g, Radix Morindae Officinalis 35g, Cornu Bubali 15g, Herba Epimedii 45g, Folium Pyrrosiae 30g, Radix Sophorae Flavescentis 20g, Fructus Lycii 35g, Herba Ecliptae 40g, Radix Asparagi 35g, Flos Buddlejae 15g, Semen Sesami Nigrum 65g, Radix Panacis Quinquefolii 85g, Radix Angelicae Sinensis 35g, Rhizoma Atractylodis Macrocephalae 60g, Semen Coicis 25g, Radix seu Herba Gei aleppici 40g, Radix Astragali 75g, Radix Phytolaccae 25g and Polyporus 35g mix, and send in blender and stir 30 minutes, add the water of 5.5kg, decocted 4 hours, decoction liquor is filtered, and filtering residue adds the water of 2.7kg again, again decocts 4 hours, decoction liquor is filtered, filtrate is merged, add the 2g active carbon, boiled 15 minutes, after natural cooling, through centrifugal, sucking filtration obtains filtrate, and heating is concentrated into the medicinal liquid that determining alcohol is 15g/ml, gets described medicinal liquid 20ml, adds successively therein the 0.75ml tween 80, the 100mg sodium sulfite injects water to 100ml after mix homogeneously, and with sodium hydroxide adjust pH to 7.5, is sub-packed at last in cillin bottle, after the boiling water bath heat sterilization, namely gets injection.

Embodiment 6 raising data

Medicine

The decocting for Chinese herbal medicine liquid 1 of embodiment 1 preparation adopts conventional feeding to begin to gavage after 7 days piglet, and every day 1 time, each 200ml fed 30 days continuously.

The animal experiment design

Test arrangement carries out in certain plant.Experimental animal be 172 20 age in days Du Luoke * length of identical raising condition white * Dasanyuan hybridization piglet, initial body weight is close, group difference is not remarkable.Be divided at random 2 groups, matched group is 80, adopts conventional feeding method feeding, and test group is 92, adopts the conventional method feeding, and gavage the decocting for Chinese herbal medicine liquid 1 of the 200ml embodiment of the present invention 1 preparation every day in the feeding process.

Feeding and management

Pig house, raising condition, hygienic conditions, feed quality and other feedings and managements etc. are all identical, free choice feeding and drinking-water.

Blood specimen collection and processing

Each group is when raising gavage decocting for Chinese herbal medicine liquid when finishing in the 1st day and finishing in the 30th day, and random blood sampling is 6 respectively. in blood sampling 7:00-10:00 on the same day, every at every turn from vena cava anterior blood sampling 5 mL, be placed to separate out serum after, in 3000 rmin ^-1Centrifugal 15min draws supernatant, is distributed into fractional pack, in-20 ℃ of preservations, test serum index.

Immune indexes is measured

Immunoglobulin (IgG, IgM, IgA) and complement (C ₃, C ₄) assay employing end-point method, determining instrument is XD811 semi-automatic biochemical analyzer (upper Hisoon reaches medical apparatus corporation, Ltd and produces), reagent is provided by Zhejiang Province Yilikang Bioisystech Co., Ltd, the serum IL-2 assay adopts the ELISA method, pig IL-2 test kit is by U.S. Altru Biomedicines, Inc. and Canadian Fulda Biomedicines, Inc. Joint Production, Beijing Bang Ding Biomedicines, Inc. provides, and the concrete operations by specification carries out.

Date processing

Test data represents with average ± standard deviation, carries out the variance analysis of single factor multiple-factor. all data are processed and are analyzed with statistic software SPSS 10. 0.

Result

The impact of decocting for Chinese herbal medicine liquid on the piglet immunological globulin the results are shown in Table 1.

The impact of table 1 decocting for Chinese herbal medicine liquid on the piglet immunological globulin

Immunoglobulin be animal be subjected to produce in body after antigenic stimulus can with the interactional class globulin of antigenic specificity.Wherein, IgG has antibiotic, antivirus action, and can neutralize a toxin and make it lose toxicity, conditioning, coagulation and Precipitation Antigen, the most important in humoral immunization; IgM combines with complement after body is subjected to pathogen infection, the dissolving pathogen; IgA is except the performance antibiosis and antiviral functions, the local mucous membrane immunity such as body respiratory tract, digestive tract are also played important " barrier " effect, can find out by table 1, adopt decocting for Chinese herbal medicine liquid of the present invention can significantly improve the level of IgG, IgM and IgA, P＜0.05 proves that Chinese medicine composition of the present invention can strengthen piglet humoral immunity of organism function.

Decocting for Chinese herbal medicine liquid is to piglet SC C ₃, C ₄The impact of mass concentration the results are shown in Table 2.

Table 2 decocting for Chinese herbal medicine liquid is to piglet SC C ₃, C ₄The impact of mass concentration

Complement is the key component of body specific immunity; participate in immunne response and the homeostatic function of body protective; assist antibody and phagocyte pathogenic microbe killing; improve the non-specific anti-infectious function of body; as can be seen from Table 2; after adopting Chinese medicine composition of the present invention, piglet SC C ₃, C ₄All obtain to significantly improve, P＜0.05 proves that this Chinese medicine composition can improve the humoral immunity of organism function, the enhancing body resistance.

The impact of decocting for Chinese herbal medicine liquid on the piglet interleukin the results are shown in Table 3.

The impact of table 3 decocting for Chinese herbal medicine liquid on the piglet interleukin

Interleukin (IL-2) is to study at present more cytokine, IL-2 is produced and is promoted the factor of T lymphocyte growth by the T lymphocyte of activation, it is the key link that ensures the normal immunologic function of body, can by impelling clone's property propagation of a certain specific T cell colony, pass through T _HThe raising of cell number and function strengthens whole function.Studies show that mammiferous, IL-2 promotes a large amount of propagation of thymus and secretion, promotes the performance of B cell proliferation and expression and function.The lymphocytic function of IL-2 active reaction, the particularly function of T cell as can be seen from Table 3, adopt Chinese medicine composition of the present invention can significantly improve Immune Function.

Chinese medicine composition of the present invention can not only Promote immunity globulin (IgG, IgM, IgA) and complement (C ₃, C ₄) generation, can also improve the level of IL-2, thereby improve humoral immune function and the cellular immune function of body.

The piglet mortality statistics the results are shown in Table 4.

Table 4 piglet mortality statistics

Group	Death toll	Mortality rate
			Test group	7	91.3%
Matched group	1	98.9%

As can be seen from Table 4, adopt Chinese medicine composition of the present invention can significantly reduce the mortality rate of piglet.

The impact of Chinese medicine composition on piglet growth performance the results are shown in Table 5.

The impact of table 5 piglet growth performance

Group	Average starting weight/kg	Average end weight/kg	Average daily gain/g	Average daily ingestion amount/kg	Feedstuff/weightening finish
						Matched group	7.44± 0.03	14.00± 0.02	220.33± 5.78	0.52± 0.05	2.36± 0.05
Chinese drug-treated group	7.41± 0.03	15.22± 0.40	249.67± 5.77	0.60± 0.09	2.43± 0.04

As can be seen from Table 5, adopt the average last representation work of Chinese medicine composition of the present invention higher than matched group, Chinese drug-treated group average daily gain and average daily ingestion amount also are significantly higher than matched group, and P＜0.05 proves that this Chinese medicine composition can significantly improve piglet growth performance.

This intellectual property of primary enforcement that all are above-mentioned is not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above is only preferred embodiment of the present invention, is not to be the present invention to be done the restriction of other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not break away to any simple modification, equivalent variations and remodeling that above embodiment does, still belongs to the protection domain of technical solution of the present invention according to technical spirit of the present invention.

  

Claims (10)

1. Chinese medicinal composition preparation that can improve the piglet immunological function, it is characterized in that: the crude drug of described Chinese medicinal composition preparation comprises Fructus Forsythiae, Fructus Jujubae, Radix Berberidis, Radix Et Caulis Acanthopanacis Senticosi, Radix Morindae Officinalis, Cornu Bubali, Herba Epimedii, Folium Pyrrosiae, Radix Sophorae Flavescentis, Fructus Lycii, Herba Ecliptae, Radix Asparagi, Flos Buddlejae, Semen Sesami Nigrum, Radix Panacis Quinquefolii, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Semen Coicis, Radix seu Herba Gei aleppici, the Radix Astragali, Radix Phytolaccae and Polyporus.

2. Chinese medicinal composition preparation as claimed in claim 1, it is characterized in that: in described Chinese medicinal composition preparation, the weight portion of each crude drug is respectively Fructus Forsythiae 40 weight portions ~ 50 weight portions, Fructus Jujubae 50 weight portions ~ 60 weight portions, Radix Berberidis 20 weight portions ~ 30 weight portions, Radix Et Caulis Acanthopanacis Senticosi 55 weight portions ~ 65 weight portions, Radix Morindae Officinalis 30 weight portions ~ 40 weight portions, Cornu Bubali 10 weight portions ~ 20 weight portions, Herba Epimedii 40 weight portions ~ 50 weight portions, Folium Pyrrosiae 25 weight portions ~ 35 weight portions, Radix Sophorae Flavescentis 15 weight portions ~ 25 weight portions, Fructus Lycii 30 weight portions ~ 40 weight portions, Herba Ecliptae 35 weight portions ~ 45 weight portions, Radix Asparagi 30 weight portions ~ 40 weight portions, Flos Buddlejae 10 weight portions ~ 20 weight portions, Semen Sesami Nigrum 60 weight portions ~ 70 weight portions, Radix Panacis Quinquefolii 80 weight portions ~ 90 weight portions, Radix Angelicae Sinensis 30 weight portions ~ 40 weight portions, the Rhizoma Atractylodis Macrocephalae 55 weight portions ~ 65 weight portions, Semen Coicis 20 weight portions ~ 30 weight portions, Radix seu Herba Gei aleppici 35 weight portions ~ 45 weight portions, the Radix Astragali 70 weight portions ~ 80 weight portions, Radix Phytolaccae 20 weight portions ~ 30 weight portions and Polyporus 30 weight portions ~ 40 weight portions.

3. Chinese medicinal composition preparation as claimed in claim 1 or 2, it is characterized in that: in described Chinese medicinal composition preparation, the weight portion of each crude drug is respectively Fructus Forsythiae 45 weight portions, Fructus Jujubae 55 weight portions, Radix Berberidis 25 weight portions, Radix Et Caulis Acanthopanacis Senticosi 60 weight portions, Radix Morindae Officinalis 35 weight portions, Cornu Bubali 15 weight portions, Herba Epimedii 45 weight portions, Folium Pyrrosiae 30 weight portions, Radix Sophorae Flavescentis 20 weight portions, Fructus Lycii 35 weight portions, Herba Ecliptae 40 weight portions, Radix Asparagi 35 weight portions, Flos Buddlejae 15 weight portions, Semen Sesami Nigrum 65 weight portions, Radix Panacis Quinquefolii 85 weight portions, Radix Angelicae Sinensis 35 weight portions, the Rhizoma Atractylodis Macrocephalae 60 weight portions, Semen Coicis 25 weight portions, Radix seu Herba Gei aleppici 40 weight portions, the Radix Astragali 75 weight portions, Radix Phytolaccae 25 weight portions and Polyporus 35 weight portions.

4. Chinese medicine composition decoction liquor that can improve the piglet immunological function, it is characterized in that: the crude drug of described Chinese medicine composition decoction liquor comprises Fructus Forsythiae, Fructus Jujubae, Radix Berberidis, Radix Et Caulis Acanthopanacis Senticosi, Radix Morindae Officinalis, Cornu Bubali, Herba Epimedii, Folium Pyrrosiae, Radix Sophorae Flavescentis, Fructus Lycii, Herba Ecliptae, Radix Asparagi, Flos Buddlejae, Semen Sesami Nigrum, Radix Panacis Quinquefolii, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Semen Coicis, Radix seu Herba Gei aleppici, the Radix Astragali, Radix Phytolaccae and Polyporus.

5. Chinese medicine composition composition powders that can improve the piglet immunological function, it is characterized in that: the crude drug of described Chinese medicine composition composition powders comprises Fructus Forsythiae, Fructus Jujubae, Radix Berberidis, Radix Et Caulis Acanthopanacis Senticosi, Radix Morindae Officinalis, Cornu Bubali, Herba Epimedii, Folium Pyrrosiae, Radix Sophorae Flavescentis, Fructus Lycii, Herba Ecliptae, Radix Asparagi, Flos Buddlejae, Semen Sesami Nigrum, Radix Panacis Quinquefolii, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Semen Coicis, Radix seu Herba Gei aleppici, the Radix Astragali, Radix Phytolaccae and Polyporus.

6. Chinese medicine composition composition injection that can improve the piglet immunological function, it is characterized in that: the crude drug of described Chinese medicine composition composition injection comprises Fructus Forsythiae, Fructus Jujubae, Radix Berberidis, Radix Et Caulis Acanthopanacis Senticosi, Radix Morindae Officinalis, Cornu Bubali, Herba Epimedii, Folium Pyrrosiae, Radix Sophorae Flavescentis, Fructus Lycii, Herba Ecliptae, Radix Asparagi, Flos Buddlejae, Semen Sesami Nigrum, Radix Panacis Quinquefolii, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Semen Coicis, Radix seu Herba Gei aleppici, the Radix Astragali, Radix Phytolaccae and Polyporus.

7. as the preparation method of Chinese medicinal composition preparation as described in claims 1 to 3, it is characterized in that: when the dosage form of described Chinese medicinal composition preparation is decoction liquor, its step is specially, described each crude drug component is mixed in proportion, send in blender and stirred 20 minutes ~ 30 minutes, add with respect to 5 ~ 8 times of water of crude drug quality sum, decocted 2 ~ 4 hours, decoction liquor is filtered, filtering residue adds again with respect to 2 ~ 4 times of water of crude drug quality sum, again decocted 2 ~ 4 hours, decoction liquor is filtered, filtrate is merged, heating is concentrated, obtaining crude drug concentration is the decoction liquor of 1g/ml.

8. as the preparation method of Chinese medicinal composition preparation as described in claims 1 to 3, it is characterized in that: when the dosage form of described Chinese medicine composition is powder, its step is specially, each crude drug is mixed in proportion, send in blender and stirred 20 minutes ~ 30 minutes, add with respect to 5 ~ 8 times of water of crude drug quality sum, decocted 2 ~ 4 hours, decoction liquor is filtered, filtering residue adds again with respect to 2 ~ 4 times of water of crude drug quality sum, again decocted 2 ~ 4 hours, decoction liquor is filtered, filtrate is merged, heating is concentrated except anhydrating, obtain and get dry extract, be ground into powder, dry, obtain powder.

9. as the preparation method of Chinese medicinal composition preparation as described in claims 1 to 3, it is characterized in that: when the dosage form of described Chinese medicine composition was injection, its step was specially,

The first step, each crude drug is mixed in proportion, send in blender and stirred 20 minutes ~ 30 minutes, add with respect to 5 ~ 8 times of water of crude drug quality sum, decocted 2 ~ 4 hours, decoction liquor is filtered, and filtering residue adds again with respect to 2 ~ 4 times of water of crude drug quality sum, again decocts 2 ~ 4 hours, decoction liquor is filtered, filtrate is merged, add 1～2g active carbon, boiled 10～15 minutes, after natural cooling, through centrifugal, sucking filtration, obtain filtrate, heating is concentrated into the medicinal liquid that determining alcohol is 10g/ml～15g/ml;

Second step is got described medicinal liquid 20ml, adds successively therein 0.75ml tween 80,100mg sodium sulfite, inject water to 100ml after mix homogeneously, and with sodium hydroxide adjust pH to 7.5, be sub-packed at last in cillin bottle, after the boiling water bath heat sterilization, namely get injection.

10. the application of the described Chinese medicine composition of claims 1 to 3 in the medicine of preparation raising piglet immunological function.