CN1814188A - Vitaminc lonicera and forsythia capsule and preparing method - Google Patents
Vitaminc lonicera and forsythia capsule and preparing method Download PDFInfo
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- CN1814188A CN1814188A CN 200510023739 CN200510023739A CN1814188A CN 1814188 A CN1814188 A CN 1814188A CN 200510023739 CN200510023739 CN 200510023739 CN 200510023739 A CN200510023739 A CN 200510023739A CN 1814188 A CN1814188 A CN 1814188A
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Abstract
The invention discloses a Vitamin C Yinqiao capsule, prepared ofHoneysuckle Flower, weeping forsythia, Fineleaf Schizonepeta Herb, Fermented Soybean, Common Lophatherum Herb, Great Burdock Achene, Reed Rhizome, Platycodon Root, Liquorice Root, Chlorphenamine Maleate, Paracetamol, Vitamin C, and menthence in weight shares. It contains traditional Chinese medicinal components and also menthence, Chlorphenamine Maleate and Vitamin C coated with auxiliaries, and as prepared, adopts step extraction, having functions of cooling and inducing sweat and clearing heat and detoxifying, and able to cure fever and headache, cough, thirst, and throat ache. It is convenient to take, treats both principal and secondary aspect of disease, having obvious effect and able to meet the requirements of the people.
Description
Technical field
The present invention relates to a kind of heat clearing away and alleviate pain, treat the medicine of flu, relate in particular to the medicine that flu is alleviated pain, treated in a kind of heat clearing away that contains Flos Lonicerae and Fructus Forsythiae.
Background technology
Flu is a kind of common disease, and the patient generally is accompanied by fever and headache etc., and the lighter influences daily life and work, and severe patient will lead to complications, harm people's health.
The medicine of treatment flu generally has Chinese medicine and Western medicine, and Western medicine is generally chemical synthetic drug, and as " Paracetamol and Amantadine Compound sheet " etc., its therapeutic effect is remarkable, and curative effect is fast, still, also has certain drawback, as " amantadine hydrochloride " medicine certain side effect is arranged.
Chinese medicine adopts traditional theory of medicine, giving consideration to both the incidental and fundamental.But traditional application method is with the mode of medicine by decocting, and extracts effective ingredient wherein, and is oral then, is used for the treatment of.Obviously there is certain defective in above-mentioned method, and oral dose is big, takes inconvenience, and therapeutic effect is slow, can not satisfy patient's needs, and this also is the common fault of Chinese medicine, demands urgently improving.
WEI C YINQIAO PIAN, taking convenience, during the treatment flu, giving consideration to both the incidental and fundamental, evident in efficacy, however because the defective of preparation method causes the vitamin C in the prescription easily to go to pot, the quality instability.
Summary of the invention
The technical issues that need to address of the present invention are to disclose a kind of Vitaminc lonicera and forsythia capsule and preparation method thereof, to overcome the above-mentioned defective that prior art exists.
Vitaminc lonicera and forsythia capsule of the present invention comprises capsule and is seated in the feedstock production that comprises following parts by weight in the capsule:
Flos Lonicerae 175～185g, Fructus Forsythiae 175～185g, Herba Schizonepetae 70～74g, Semen Sojae Preparatum 85～95g,
Herba Lophatheri 70～74g, Fructus Arctii 106～112g, Rhizoma Phragmitis 106～112g, Radix Platycodonis 106～112g,
Radix Glycyrrhizae 85～95g, chlorphenamine maleate 1.03～1.07g, acetaminophen 03～107g,
Vitamin C 48～51g, Oleum menthae 1.06～1.1ml.
Wherein:
The main effect of chlorphenamine maleate: antiallergic.Can alleviate the nasal congestion that upper respiratory tract infection causes, make the nasal mucosa drying, can eliminate rapidly or alleviate that flu causes sheds tears, sneeze and clear water sample watery nasal discharge, cooperate, can alleviate cold symptoms with the antipyretic analgesic acetaminophen.
The main effect of acetaminophen: antipyretic-antalgic.
Flos Lonicerae, Fructus Forsythiae are gently declared expelling pathogenic factors from the exterior, heat-clearing and toxic substances removing; The hot pathogenic factor in the exterior that looses of Herba Schizonepetae, Oleum menthae, Semen Sojae Preparatum, diathermanous going out, the hot using warming therapy product of Nepeta, but temperature is not and dry, and with Flos Lonicerae, Fructus Forsythiae, Herba Lophatheri compatibility, warm nature is made, and can increase the diffusing merit of inducing sweat of suffering of this product; Fructus Arctii Radix Platycodonis, Radix Glycyrrhizae are share, energy resolving toxin and disinhibiting the throat eliminating stagnation, and lung qi dispersing eliminates the phlegm; Rhizoma Phragmitis, the sweet cool heat clearing away of Herba Lophatheri, promoting the production of body fluid to quench thirst; The Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.
Vitamin C participates in amino acid metabolism, synthetic, the collagen protein synthesis of neurotransmitter; Can increase resistance, participate in function of detoxification, impel rate and blood-lipid decreased and antihistamine effect infecting; During the human body cold, fever ascorbic requirement is increased severely, so replenish it.
Comprising of preferred raw material with parts by weight:
Flos Lonicerae 180g, Fructus Forsythiae 180g, Herba Schizonepetae 72g, Semen Sojae Preparatum 90g,
Herba Lophatheri 72g, Fructus Arctii 108g, Rhizoma Phragmitis 108g, Radix Platycodonis 108g,
Radix Glycyrrhizae 90g, chlorphenamine maleate 1.05g, acetaminophen 105g,
Vitamin C 49.5g, Oleum menthae 1.08ml.
The preparation method of Vitaminc lonicera and forsythia capsule of the present invention comprises the steps:
(1) with Fructus Forsythiae, Herba Schizonepetae, Flos Lonicerae respectively under airtight environment, be heated to 80～100 ℃, be 1～1.5 hour heat time heating time, collects volatile oil;
(2) medicinal residues and Herba Lophatheri, Semen Sojae Preparatum, Rhizoma Phragmitis, Radix Platycodonis, the Radix Glycyrrhizae that will extract behind the volatile oil decocts with water, and decocts 2～4 hours, filters, and collects filtrate; The weight of water is 6～8 times of medicine;
(3) the Fructus Arctii weight concentration is 30～75% ethanol water reflux, 4～8 hours time, filters, collect filtrate, vacuum distilling is removed ethanol, add paraffin and make dissolving, be cooled to paraffin and float on liquid level. remove paraffin layer, obtain the Fructus Arctii ethanol extraction; The purpose that adds paraffin is an absorbing fats, and the adding weight of paraffin is 1.0～1.5% of Fructus Arctii ethanol extraction; The weight of ethanol extract is 1～1.1 times of Fructus Arctii;
(4) medicinal liquid of combining step (2) and (3) is concentrated into solid content and is 45～50%, 80 ℃ relative density 1.28, and drying is pulverized, and obtains dry extract;
(5) volatile oil, Oleum menthae and the pharmaceutically acceptable auxiliary materials and mixing of dry extract, step (1); Acetaminophen, chlorphenamine maleate and vitamin C microgranule and auxiliary materials and mixing with above-mentioned fine powder mixing, incapsulate, promptly;
Adjuvant is medical starch, magnesium stearate, Pulvis Talci, stomach dissolution type thin film dress material
The interpolation weight of adjuvant is 3～5% of dry extract in the dry extract;
The interpolation weight of adjuvant in acetaminophen, chlorphenamine maleate and the vitamin C microgranule, by dried cream of Chinese medicine and Western medicine total amount, wherein, the addition of magnesium stearate is 0.3%, talcous addition is 3%.
The vitamin C microgranule that the vitamin C microgranule preferably adopts adjuvant peplos to make can adopt commercially available prod stomach dissolution type film-coat material package film to form, as the product of the happy Kanggong of Shanghai card department production;
Said capsule is a conventional products, as optional capsule in order to the gelatin materials preparation, can adopt the commercially available prod, and the trade mark of producing as Fujian, Shunchang, Fujian Province-capsule company limited is the product in " Fujian one ";
According to optimized technical scheme of the present invention, can with the volatile oil of step (1) with beta-cyclodextrin inclusion compound after, to prevent the volatilization of volatile oil.
Vitaminc lonicera and forsythia capsule of the present invention includes traditional Chinese medicine ingredients, the vitamin C that simultaneously contains acetaminophen, chlorphenamine maleate again and make with adjuvant peplos, during preparation, the method that adopts substep to extract, the maintenance of maximum possible the effective ingredient in the Chinese medicine, have relieving the exterior syndrome with drugs of pungent in flavor and cool in nature, heat-clearing toxin-expelling functions can be used for treating fever and headache, cough, xerostomia that influenza causes, has sore throat.During treatment, adopt the oral administration mode, dosage every day is 0.03～0.05 gram/kg body weight, specifically can according to state of an illness age of patient by pharmacist's direction of medication usage.
Vitaminc lonicera and forsythia capsule of the present invention, taking convenience, during the treatment flu, giving consideration to both the incidental and fundamental, effect is obvious, can satisfy people's needs.
The specific embodiment
Embodiment 1
Prescription:
Flos Lonicerae 180g, Fructus Forsythiae 180g, Herba Schizonepetae 72g, Semen Sojae Preparatum 90g,
Herba Lophatheri 72g, Fructus Arctii 108g, Rhizoma Phragmitis 108g, Radix Platycodonis 108g,
Radix Glycyrrhizae 90g, chlorphenamine maleate 1.05g, acetaminophen 105g,
Vitamin C 49.5g, Oleum menthae 1.08ml.
(1) with Fructus Forsythiae, Herba Schizonepetae, Flos Lonicerae respectively under airtight environment, be heated to 80～100 ℃, be 1～1.5 hour heat time heating time, collects volatile oil;
(2) will extract medicinal residues behind the volatile oil and Herba Lophatheri, Semen Sojae Preparatum, Rhizoma Phragmitis, Radix Platycodonis, Radix Glycyrrhizae and add 3000 gram decoctings and boil, decoct 2 times, each 2 hours, filter collection filtrate;
(3) Fructus Arctii is 60% ethanol water reflux with 500 gram weight concentration, 8 hours time, filters, collect filtrate, vacuum distilling is removed ethanol, add 16 gram paraffin and make dissolving, be cooled to paraffin and float on liquid level. remove paraffin layer, obtain the Fructus Arctii ethanol extraction;
(4) medicinal liquid of combining step (2) and (3), being concentrated into solid content is 48%, its relative density 1.28 (80 ℃), drying is pulverized, and obtains dry extract;
(5) volatile oil of dry extract, step (1), Oleum menthae and 14 gram medical starch mixings; Acetaminophen, chlorphenamine maleate and the vitamin C microgranule made from adjuvant peplos and 10 gram Pulvis Talci, 1 gram magnesium stearate mixing;
It is even then (5) two kinds of medicines always to be mixed, the capsule of packing into No. 1, promptly.
Embodiment 2
Adopt the method identical with embodiment 1, wherein, with the volatile oil beta-cyclodextrin inclusion compound of step (1).
Embodiment 3
The pathology test data
Adopt the capsule for treating flu patient of embodiment 1,100 influenza patients are treated.
Instructions of taking: oral, adult amount is every day three times, and each 2, serve on 3, stop taking medicine.Children's is decrement routinely.
The criterion of therapeutical effect recovery from illness: the clinical symptoms Signs all disappears.Be almost recovered: body temperature is reduced to 37.2 ℃, and other symptom disappears substantially.Take a turn for the better: various clinical symptom reliefs, at least 1/2 clinical symptom disappearance.Invalid: cardinal symptom sign no change.
Adopt the statistical procedures method to observe, its result is as follows:
Total routine number is cured (%) basic (%) improvement (%) invalid (%) that cure
100 61(61％) 23(23％) 12(12％) 4(4％)
The result shows, capsule of the present invention have the effect that significant treatment is caught a cold, and its constant product quality also is better than tablet.
Embodiment 4
The stability test data
(1) research purpose: the WEI C YINQIAO PIAN with prescription is extremely unstable in the storage product quality, because of preparation method problem vitamin C composition easily goes to pot.Investigate this product and under the accelerated test condition, deposit the steadiness of its every quality index, for determining this product stability before the deadline.
(2) research method: accelerated test.Get three batches in the sample of our company trial-production, under the condition of intending the listing packing, deposit by defined terms and time under two appendix XIX of Chinese Pharmacopoeia version in 2000 C medicine stability test method preparation item, and pick test in required time, its steadiness analyzed.
(3) study tour project: character, discriminating, moisture, disintegration, content uniformity, contain survey, microbioassay, packing etc.
(4) used instrument: analytical balance, high performance liquid chromatograph, thermostatic drying chamber, constant incubator, biochemical incubator, autoclave sterilizer, clean work station etc.
(5) sample: three batches of this product of our company's trial-production, lot number is respectively 031112,031113,031114.
(6) investigate result's (table 1～table 3):
(7) conclusion: this product three batch samples are investigated 6 months through accelerated test, and all in acceptability limit, packaging material and sample no change show that this product quality is more stable to its every quality index.
Table 1 Vitaminc lonicera and forsythia capsule accelerated test result
Sample title: Vitaminc lonicera and forsythia capsule lot number: 031112 date of manufacture: on November 12nd, 2003
Table 2 Vitaminc lonicera and forsythia capsule accelerated test result
Sample title: Vitaminc lonicera and forsythia capsule lot number: 031113 date of manufacture: on November 13rd, 2003
Table 3 Vitaminc lonicera and forsythia capsule accelerated test result
Sample title: Vitaminc lonicera and forsythia capsule lot number: 031114 date of manufacture: on November 14th, 2003
Claims (9)
1. a Vitaminc lonicera and forsythia capsule is characterized in that, comprises capsule and is seated in the feedstock production that comprises following parts by weight in the capsule:
Flos Lonicerae 175～185g, Fructus Forsythiae 175～185g, Herba Schizonepetae 70～74g, Semen Sojae Preparatum 85～95g,
Herba Lophatheri 70～74g, Fructus Arctii 106～112g, Rhizoma Phragmitis 106～112g, Radix Platycodonis 106～112g,
Radix Glycyrrhizae 85～95g, chlorphenamine maleate 1.03～1.07g, acetaminophen 03～107g,
Vitamin C 48～51g, Oleum menthae 1.06～1.1ml.
2. Vitaminc lonicera and forsythia capsule according to claim 1 is characterized in that, raw material and parts by weight comprise:
Flos Lonicerae 180g, Fructus Forsythiae 180g, Herba Schizonepetae 72g, Semen Sojae Preparatum 90g,
Herba Lophatheri 72g, Fructus Arctii 108g, Rhizoma Phragmitis 108g, Radix Platycodonis 108g,
Radix Glycyrrhizae 90g, chlorphenamine maleate 1.05g, acetaminophen 105g,
Vitamin C 49.5g, Oleum menthae 1.08ml.
3. the preparation method of Vitaminc lonicera and forsythia capsule according to claim 1 and 2 is characterized in that comprising the steps:
(1) with Fructus Forsythiae, Herba Schizonepetae, Flos Lonicerae respectively under airtight environment, volatile oil is collected in heating;
(2) medicinal residues and Herba Lophatheri, Semen Sojae Preparatum, Rhizoma Phragmitis, Radix Platycodonis, the Radix Glycyrrhizae that will extract behind the volatile oil decocts with water, and filters, and collects filtrate;
(3) Fructus Arctii ethanol water reflux, 4～8 hours time, filter, collect filtrate, vacuum distilling is removed ethanol, adds paraffin and makes dissolving, is cooled to paraffin and floats on liquid level. and remove paraffin layer, obtain the Fructus Arctii ethanol extraction;
(4) medicinal liquid of combining step (2) and (3) is concentrated into solid content and is 45～50%, 80 ℃ relative density 1.27～1.29, and drying is pulverized, and obtains dry extract;
(5) volatile oil, Oleum menthae and the pharmaceutically acceptable auxiliary materials and mixing of dry extract, step (1); Acetaminophen, chlorphenamine maleate and vitamin C microgranule and auxiliary materials and mixing with above-mentioned fine powder mixing, incapsulate, promptly;
4. method according to claim 3 is characterized in that, Fructus Forsythiae, Herba Schizonepetae, Flos Lonicerae respectively under airtight environment, are heated to 80～100 ℃, and be 1～1.5 hour heat time heating time.
5. method according to claim 3 is characterized in that, medicinal residues and Herba Lophatheri, Semen Sojae Preparatum, Rhizoma Phragmitis, Radix Platycodonis, Radix Glycyrrhizae behind the extraction volatile oil are decocted with water, and decocts 2～4 hours.
6. method according to claim 3 is characterized in that, the Fructus Arctii weight concentration is 30～75% ethanol water reflux.
7. method according to claim 3 is characterized in that, the adding weight of paraffin is 0.8～1.5% of Fructus Arctii ethanol extraction.
8. method according to claim 3 is characterized in that, the vitamin C microgranule that vitamin c powder adopts adjuvant peplos to make.
9. according to each described method of claim 3～8, it is characterized in that, the volatile oil beta-cyclodextrin inclusion compound of step (1).
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| CN 200510023739 CN1814188A (en) | 2005-02-01 | 2005-02-01 | Vitaminc lonicera and forsythia capsule and preparing method |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009027955A3 (en) * | 2007-08-31 | 2009-04-30 | Shannon Minerals Patents Ltd | Detoxification composition and method of detoxifying the body |
| CN102188493A (en) * | 2011-04-25 | 2011-09-21 | 新疆全安药业有限公司 | Compound Yinqiao Anmin capsule |
| CN102614400A (en) * | 2012-03-28 | 2012-08-01 | 江西济民可信药业有限公司 | Preparation method of Chinese herba preparation vitamin C yinqiao tablet |
| CN104013841A (en) * | 2014-05-30 | 2014-09-03 | 广西博科药业有限公司 | Preparation method of vitamin C fructus forsythiae capsule |
-
2005
- 2005-02-01 CN CN 200510023739 patent/CN1814188A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009027955A3 (en) * | 2007-08-31 | 2009-04-30 | Shannon Minerals Patents Ltd | Detoxification composition and method of detoxifying the body |
| CN102188493A (en) * | 2011-04-25 | 2011-09-21 | 新疆全安药业有限公司 | Compound Yinqiao Anmin capsule |
| CN102188493B (en) * | 2011-04-25 | 2012-06-27 | 新疆全安药业有限公司 | Compound Yinqiao Anmin capsule |
| CN102614400A (en) * | 2012-03-28 | 2012-08-01 | 江西济民可信药业有限公司 | Preparation method of Chinese herba preparation vitamin C yinqiao tablet |
| CN102614400B (en) * | 2012-03-28 | 2014-03-26 | 江西济民可信药业有限公司 | Preparation method of Chinese herba preparation vitamin C yinqiao tablet |
| CN104013841A (en) * | 2014-05-30 | 2014-09-03 | 广西博科药业有限公司 | Preparation method of vitamin C fructus forsythiae capsule |
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