CN100344313C - Chinese patent drug for treating infantile cold and repeated cold, and its prepn. method - Google Patents
Chinese patent drug for treating infantile cold and repeated cold, and its prepn. method Download PDFInfo
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Abstract
The present invention relates to a medicine and a preparation method thereof, wherein the medicine is especially used for treating infantile common colds, particularly infantile repeated common colds. The applicant puts forward the therapeutic principle of benefiting qi, dissipating the superficial, clearing heat, detoxicating, relieving cough and asthma, strengthening body resistance and eliminating evil; hereby, the medicine of the present invention adopts 5 to 15 portions of beggarticks, 5 to 15 portions of wild flos chrysanthemi, 1 to 4 portions of American ginseng, 20 to 40 portions of astragalus roots, 15 to 20 portions of isatis roots, 4 to 8 portions of peucedanum roots, 3 to 8 portions of caladium, 1.5 to 4 portions of Chinese ephedra, 4 to 8 portions of licorice roots and 9.5 to 12.5 portions of lentinus edodes. The preparation method of the oral liquid of the present invention mainly comprises the steps: wet distillation is carried out for the wild flos chrysanthemi; active ingredients are extracted from the American ginseng, the Chinese ephedra and the caladium by ethanol reflux; active ingredients of the other medicines are extracted by decoction with water. The medicine of the present invention is a pure traditional Chinese medicine preparation which has the advantages of rapid absorption, rapid drug effect, high content of the active ingredients, less dosage, good taste, high safety, no toxic side effect and convenient administration, and the total curative effective rate reaches 94.8%.
Description
Technical field
The invention belongs to the field of Chinese medicines, is the special for treating children flu, particularly treats medicine of infantile recurrent common cold and preparation method thereof.
Background technology
In recent years, because Global climate change is unusual, factors such as atmospheric pollution in addition, pathogen variation, flu, the particularly sickness rate of infantile common cold are high always, and the situation of infantile recurrent common cold increases day by day.Children's has a delicate constitution, how sick, easily catch a cold, and easily increase the weight of, easily repeatedly.Modern medicine study shows, the cause of disease more complicated of infantile common cold.From traditional Chinese medicine angle: children's is the body of young sun, and cloudy gas does not win, the yang-energy weakness, and body does not fill, and the flesh natural fibre line of meat is dredged thin, defends outer function and consolidates; Or can not drive heresy because of other reasons causes the positive QI-insufficiency of children's, Gu and morbidity repeatedly, and the ill easy reality of institute is easily empty, easily cold easily heat.In a word, motherland's medical science and modern medicine are intimately tied up with repeated cold child's understanding.At present the Chinese and western drugs of treatment infantile common cold is a lot, is antiinflammatory (detoxifcation) basically, the medicine of bring down a fever (heat clearing away), cough-relieving class, plays a part symptom is alleviated.With regard to present Chinese medicine, the specific aim of the Chinese patent medicine of treatment infantile common cold is more single, cure mainly children's exogenous fever, headache, cough as " the peaceful oral liquid of youngster's cold and abating fever " on the market, " XIAOER KECUANLING " cures mainly infant upper respiratory tract infection, tracheitis, pneumonia.The treatment face of these medicines is generally narrower, particularly to the disease of infantile recurrent common cold, does not also have better medicine at present.
Summary of the invention
Problem to be solved by this invention provides a kind of often medicine of flu and caused fever, cough, asthma, laryngopharynx swelling and pain of induced by children's deficiency of qi that is applicable to, a kind of Chinese patent medicine for the treatment of infantile common cold and repeated cold and preparation method thereof promptly is provided.
The applicant thinks: children's's body does not fill, and the flesh natural fibre line of meat is dredged thin, defends outer function and consolidates, and fine adaptation is still failed in the in addition variation of extraneous weather, so especially easily invaded by ailment said due to cold or exposure.The Therapeutic Principle that the applicant proposes is: the QI invigorating relieving the exterior syndrome, and heat-clearing and toxic substances removing, relieving cough and asthma is set upright with eliminating evil and is taken into account.
Based on mentioned above principle, make in the Chinese patent medicine of treatment infantile common cold provided by the present invention and repeated cold that the raw materials of effective components medicine is formed and parts by weight are:
5～15 parts of Herba Bidentis Bipinnatae, 5～15 parts of Flos Chrysanthemi Indicis, 1～4 part of Radix Panacis Quinquefolii, 20～40 parts of the Radixs Astragali, 15～20 parts of Radix Isatidis, 4～8 parts of Radix Peucedanis, 3～8 parts of Bulbus Fritillariae Uninbracteataes, 1.5～4 parts in Herba Ephedrae, 4～8 parts in Radix Glycyrrhizae, 9.5～12.5 parts on Lentinus Edodes.
Each crude drug all has curative effect preferably in above-mentioned scope, and has obtained the proof of clinical trial.
In said medicine, Herba Bidentis Bipinnatae (referring to 219～220 pages of Hunan Province Department of Public Health 1993 versions " Hunan Province's Chinese crude drug standard "), Flos Chrysanthemi Indici are monarch drug.Herba Bidentis Bipinnatae has sweating and heat resolving, heat-clearing and toxic substances removing, the effect of dissipating blood stasis for subsidence of swelling; Flos Chrysanthemi Indici has wind and heat dispersing, the subduing swelling and detoxicating effect, and two medicines share the effect that can strengthen dispelling wind and heat pathogens, heat-clearing and toxic substances removing, relieving sore throat and pain, clearing away lung-heat to relieve cough mutually;
Radix Panacis Quinquefolii, the Radix Astragali are ministerial drug.The QI invigorating effect of Radix Panacis Quinquefolii is near Radix Ginseng, but it is cool in nature, sweet in the mouth, little hardship, and not only cough caused by dryness is controlled in clearind deficient heat, yin nourishing, and excess-fire clearly, and antitussive action arranged, the disease of especially suitable infantile common cold cough due to lung-heat, excessive thirst.So select for use Radix Panacis Quinquefolii to use the effect of its strengthening the body resistance on the one hand, also cool in nature in addition because of it, can strengthen the effect of heat clearing away and cough-relieving.The Radix Astragali can tonifying deficiency, because of its flavor is light, so specially reach table in edema caused by disorder of QI, so energy complement sun, fill space between skin and muscles, is specially adapted to weakness type cold.Here need to prove: for the Radix Astragali, though once the someone thought and Radix Astragali benefit defends solid antiperspirant it should not be used for the diseases caused by exogenous pathogenic factor fever.Actually this is not so, and the Radix Astragali can end the exterior deficiency spontaneous perspiration, lossless to pathogenic factor in the exterior simultaneously, and its body fluid that can help again is to help antiperspirant.So, select the Radix Panacis Quinquefolii and the Radix Astragali for use, be main in the benefit, one mends outer is main, complements each other, and brings out the best in each other, and makes the power of strengthening the body resistance strengthen the also corresponding increase of eliminating evil power.
Above-mentioned monarch, ministerial drug combine, and have formed the basic configuration of strengthening vital QI to eliminate pathogenic factors, and be eliminating evil and just do not hinder, and sets upright and do not stay heresy, such combination just being fit to children's's unfilled infantile YANG, the disease of the diseases caused by exogenous pathogenic factor fever of undeveloped infantile YIN physiological characteristics.
Radix Isatidis, Radix Peucedani, Bulbus Fritillariae Uninbracteatae, Herba Ephedrae, Radix Glycyrrhizae, Lentinus Edodes Six-element medicine are adjuvant.Wherein, Radix Peucedani energy dispelling wind-heat, Herba Ephedrae also has the hot refrigeration function that looses, and two medicines and monarch drug Herba Bidentis Bipinnatae compatibility are separated thermal sweating, dispelling wind-heat effect multiplication; The Radix Isatidis heat-clearing and toxic substances removing, the removing heat from blood sore-throat relieving can be strengthened antipyretic and antidote functions with the monarch drug compatibility; Bulbus Fritillariae Uninbracteatae, Herba Ephedrae, Radix Peucedani, Radix Glycyrrhizae four Chinese medicine compatibility can play relieving cough and asthma, expectorant effect, and wherein, Herba Ephedrae is to relieving asthma, and Radix Peucedani is to eliminate the phlegm, and Bulbus Fritillariae Uninbracteatae, Radix Glycyrrhizae are based on cough-relieving; Lentinus Edodes (referring to second 181～182 pages of Guangxi Zhuang Autonomous Region Department of Public Health 1996 versions " Guangxi Chinese crude drug standard ") has the effect of stomach reinforcing gas, phlegm-eliminiating and qi-regulating, vitamin compensation, it and ministerial drug Radix Panacis Quinquefolii, the Radix Astragali are used together, lung benefiting gas, the strengthening the spleen and stomach active force is strengthened; Radix Glycyrrhizae also makes messenger drug usefulness, based on cough-relieving, and all right flavoring, coordinating the actions of various ingredients in a prescription.
The medicine of the QI invigorating of this drug regimen is more, but the medicine of selected QI invigorating is how warm and not dry, and mainly the QI invigorating composition---Radix Panacis Quinquefolii is also cool in nature, has the clearing away lung-heat antitussive action, the exterior and the interior that does not only influence Herba Bidentis Bipinnatae, Radix Isatidis, Flos Chrysanthemi Indici is two clear, also can increase their effect on the contrary.This shows that combinations thereof makes the effect of each medicine produce synergism, a large amount of clinical trials prove that also its curative effect is very significant.
Selected Radix Panacis Quinquefolii, the Radix Astragali, the Lentinus Edodes of the present invention can also improve the ability of human body opposing pathogenic factor, promptly has the effect that strengthens body immunity.
Bulbus Fritillariae Uninbracteatae in the said medicine is preferably selected Bulbus Fritillariae Thunbergii for use, and the Bulbus Fritillariae Thunbergii bitter cold is heavier, and using pungent drugs for dispersion and bitter drugs for purgation power is big, and the eliminating stagnation of relieving inflammation or internal heat effect is stronger.
The Mel that can also add 10～30 weight portions in addition in the said medicine is as correctives, and Mel itself also has the pharmacological action of replenishing QI to invigorate the spleen, nourishing the lung to arrest cough, and makes taste of medicine better after adding.Certainly also available sucrose is made correctives.
Preferred amount ranges of the present invention is: 10～15 parts of Herba Bidentis Bipinnatae, 6～10 parts of Flos Chrysanthemi Indicis, 1.5～3 parts of Radix Panacis Quinquefoliis, 25～35 parts of the Radixs Astragali, 15～20 parts of Radix Isatidis, 5～7 parts of Radix Peucedanis, 3～5 parts of Bulbus Fritillariae Uninbracteataes, 1.5～2.5 parts in Herba Ephedrae, 5～7 parts in Radix Glycyrrhizae, 9.5～11 parts on Lentinus Edodes.
Preferred dosage form of the present invention is an oral liquid, and the peroral dosage form of other form also belongs to category of the present invention as syrup, granule, capsule, tablet, pill etc.
The preparation method of preferred dosage form of the present invention---oral liquid is:
1) get the raw materials ready: it is standby that proportioning takes by weighing Herba Bidentis Bipinnatae, Flos Chrysanthemi Indici, Radix Panacis Quinquefolii, the Radix Astragali, Radix Isatidis, Radix Peucedani, Bulbus Fritillariae Uninbracteatae, Herba Ephedrae, Radix Glycyrrhizae, Lentinus Edodes by weight;
2) extract volatile matter: get Flos Chrysanthemi Indici, vapor distillation 1.5～3 hours was collected gained volatile oil and distillate in 1: 1 by volume, added solubilizing agent then, and the device preservation is standby in addition behind the mixing; Solubilizing agent can preferably gather Pyrusussuriensis fat-80.
3) alcohol extraction:
3.1) get the Radix Panacis Quinquefolii pulverizing, the alcohol heating reflux twice with 60%～80%, each 1.5～3 hours, merge extractive liquid, filtered, and filtrate recycling ethanol is not distinguished the flavor of to there being alcohol, and concentrated solution is standby;
3.2) get Herba Ephedrae, Bulbus Fritillariae Uninbracteatae, the alcohol heating reflux twice with 70%～85%, each 1～2 hour, merge extractive liquid, filtered, and filtrate recycling ethanol is not to there being the alcohol flavor, and concentrated solution is standby;
4) water is carried: get all the other Herba Bidentis Bipinnatae, the Radix Astragali, Radix Isatidis, Radix Peucedani, Radix Glycyrrhizae, Lentinus Edodes, mix with the medicinal residues of above steps, decoct with water twice, each 1.5～3 hours, collecting decoction, filter, filtrate is concentrated precipitate with ethanol, leave standstill, supernatant filters, and filtrate recycling ethanol is not to there being the alcohol flavor, and concentrated solution is standby;
5) with above-mentioned each standby medicinal liquid and concentrated solution mixing, regulate pH value to 4.0～6.5 with sodium hydroxide solution, add water to ormal weight, sterilization promptly gets oral liquid of the present invention.
When need adding correctives, then correctives is in above-mentioned steps 5) in adding, that is: will add correctives behind each standby medicinal liquid and the concentrated solution mixing.
Each related in above-mentioned preparation method technological parameter all obtains through after a large amount of contrast tests, according to said method can extract the effective ingredient in the medicine to greatest extent, and the steady quality of gained medicine.
This oral liquid is a pure Chinese medicinal preparation, absorb fast, drug effect is rapid, active constituent content is high, dose is few, features good taste, safely, have no side effect, and taking convenience especially is fit to child administration.
The preparation process 1 of syrup of the present invention), 2), 3), 4) with the step 1), 2 of above-mentioned oral liquor), 3), 4) corresponding identical, just the correctives that adds in step 5) is the sucrose of 4.5～6.5 parts by weight, with sucrose decocting in water, dissolving, be condensed into syrup, with each standby medicinal liquid and concentrated solution mixing, regulate pH value to 4.0～6.5 again, add water to ormal weight with sodium hydroxide solution, sterilization promptly gets syrup of the present invention.
Step 1), 2 with oral liquor), 3), 4) corresponding identical, step 5) is: with above-mentioned step 3), 4) adjuvant used always of the standby concentrated solution and the granule that obtain mixes, the system soft material, granulate, drying is again with above-mentioned steps 2) gained volatile oil is sprayed on the aforementioned dried granules mixing after with dissolve with ethanol, the packing, get final product granule of the present invention.
By above-mentioned step 2), 3), 4) adopt conventional method also to can be made into peroral dosage forms such as tablet of the present invention, pill again behind the standby volatile oil that obtains and the concentrated solution.In tablet of the present invention, pill preparation, also Radix Panacis Quinquefolii, Bulbus Fritillariae Uninbracteatae can be broken into powder, mix with other medicinal substances extract and adjuvant commonly used again.
The specific embodiment
Example 1
12 parts of Herba Bidentis Bipinnatae, 8 parts of Flos Chrysanthemi Indicis, 2 parts of Radix Panacis Quinquefoliis, 30 parts of the Radixs Astragali, 20 parts of Radix Isatidis, 6 parts of Radix Peucedanis, 4 parts of Bulbus Fritillariae Thunbergiis, 2 parts in Herba Ephedrae, 6 parts in Radix Glycyrrhizae, 10 parts on Lentinus Edodes, 20 parts of Mel.
The preparation method of its oral liquid is:
1) get Flos Chrysanthemi Indici, vapor distillation 2 hours was collected gained volatile oil and distillate in 1: 1 by volume, added solubilizing agent then---poly-Pyrusussuriensis fat-80, and the device preservation is standby in addition behind the mixing;
3) get Radix Panacis Quinquefolii powder and be broken into coarse powder, the alcohol heating reflux twice with 70%, each 2 hours, merge extractive liquid, filtered, and filtrate recycling ethanol is not to there being the alcohol flavor, and medicinal liquid is standby;
4) get Herba Ephedrae, Bulbus Fritillariae Uninbracteatae, the alcohol heating reflux twice with 80%, each 1 hour, merge extractive liquid, filtered, and reclaimed ethanol and was evaporated to and do not have the alcohol flavor, and medicinal liquid is standby;
5) get all the other Herba Bidentis Bipinnatae, the Radix Astragali, Radix Isatidis, Radix Peucedani, Radix Glycyrrhizae, Lentinus Edodes, mix with the medicinal residues of above steps, decoct with water twice, each 2 hours, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is 1.1～1.2 (60 ℃), add ethanol again and reach 60% to containing the alcohol amount, leave standstill, filter, filtrate recycling ethanol is not to there being the alcohol flavor, and medicinal liquid is standby;
6) with above-mentioned each standby medicinal liquid and concentrated solution mixing, add 20 parts of Mel again, stir evenly, regulate pH value to 6.5, add water to ormal weight, sterilize, promptly get the oral liquid of treatment infantile common cold of the present invention and repeated cold with the sodium hydroxide solution of 2mol/L.
Example 2
Get 5 parts of Herba Bidentis Bipinnatae, 15 parts of Flos Chrysanthemi Indicis, 1 part of Radix Panacis Quinquefolii, 40 parts of the Radixs Astragali, 15 parts of Radix Isatidis, 8 parts of Radix Peucedanis, 8 parts of Bulbus Fritillariae Thunbergiis, 4 parts in Herba Ephedrae, 8 parts in Radix Glycyrrhizae, 12.5 parts on Lentinus Edodes, 20 parts of Mel.The preparation method of its oral liquid is with example 1.
Example 3
Get 15 parts of Herba Bidentis Bipinnatae, 5 parts of Flos Chrysanthemi Indicis, 4 parts of Radix Panacis Quinquefoliis, 20 parts of the Radixs Astragali, 15 parts of Radix Isatidis, 4 parts of Radix Peucedanis, 3 parts of Bulbus Fritillariae Thunbergiis, 1.5 parts in Herba Ephedrae, 4 parts in Radix Glycyrrhizae, 11 parts on Lentinus Edodes, 20 parts of Mel.The preparation method of its oral liquid is with example 1.
Example 4
Get 11 parts of Herba Bidentis Bipinnatae, 11 parts of Flos Chrysanthemi Indicis, 3 parts of Radix Panacis Quinquefoliis, 35 parts of the Radixs Astragali, 17 parts of Radix Isatidis, 5 parts of Radix Peucedanis, 6 parts of Bulbus Fritillariae Thunbergiis, 3 parts in Herba Ephedrae, 6 parts in Radix Glycyrrhizae, 9.5 parts on Lentinus Edodes, 20 parts of Mel.The preparation method of its oral liquid is with example 1.
The applicant proves that by a large amount of clinical trials above embodiment all can reach effect preferably.
Toxicity test
Test drug is a preparation of the present invention, and every 1ml oral liquid contains crude drug 1g.Experimental animal is an ICR kind white mice, body weight 20g ± 2g, male and female half and half, totally 20.Test unit: Clinical pathological study institute of Xi'an Communications University.Test method is: fasting is after 12 hours, gives mice lavage by 20g/Kg (be recommend clinical dosage 120 times), observes then 7 days, and not seeing has overt toxicity.Press 10g/Kg dosage and give white mice continuous irrigation stomach 3 months, also no abnormality seen.The safety that shows this medicine is big, belongs to nontoxic rank.
Clinical trial
Subjects is the infant that is diagnosed as upper respiratory tract infection; " flu and influenza diagnostic point and prevention effect criterion (draft) " that curative effect determinate standard is formulated with reference to the anti-scientific research cooperation forum that cures cold in the whole nation; There are four hospitals such as Traditional Chinese Medicine Research Institute, Shanxi Province Affiliated Hospital, first Affiliated Hospital of Xi'an Communications University in test unit; Test method adopts parallel control design, random packet.Test group is taken oral liquid of the present invention, and specification is that 10ml/ props up.Below 1 year old, each 1/2,3 times on the one; 1～3 year old each 1,3 times on the one; 3～6 years old, each 1,4 times on the one; 6～12 years old, each 1,5 times on the 1st.Matched group is taken " QINGRE JIEDU KOUFUYE ", and Luoyang, Henan Province people's livelihood pharmaceutical factory produces.
Clinical test results is as follows:
1) acute going up felt: observe case 152 examples altogether, the results are shown in Table 1.
Table 1
| Group | The example number | Recovery from illness | Produce effects | Effectively | Invalid | Total effective rate |
| Test group | 152 | 95(62.5％) | 34(22.4％) | 15(9.9％) | 8(5.2％) | 94.8％ |
The total effective rate of matched group is 84.4%.
2) children's often catches a cold: test group is observed 112 examples altogether, the results are shown in Table 2
Table 2
| Group | The example number | Recovery from illness | Produce effects | Effectively | Invalid | Total effective rate |
| Test group | 112 | 43(38.4％) | 43(38.4％) | 16(14.3％) | 10(8.9％) | 91.1％ |
The total effective rate of matched group is 86.0%.
Below as can be seen, of the present invention evident in efficacy, particularly the treatment effective percentage that children's is often caught a cold reaches 91.1%.
Oral liquid of the present invention shows through the pharmacodynamics test that Xi'an Communications University's clinical pharmacology institute carries out: this oral liquid has analgesic significantly, analgesia, antitussive effect, significantly antiinflammatory action, the effect (effect of relievining asthma is promptly arranged) of lax bronchial smooth muscle significantly.This oral liquid has stronger broad-spectrum disease resistance toxic action, and is particularly more remarkable to the respiratory tract disease toxic action, but not obvious to the adenovirus effect.Test shows that also this oral liquid has the effect of significant enhancing cellular immune function.
Claims (10)
1, a kind of Chinese patent medicine for the treatment of infantile common cold and repeated cold is characterized in that making that the raw materials of effective components medicine is formed and parts by weight are:
5～15 parts of Herba Bidentis Bipinnatae, 5～15 parts of Flos Chrysanthemi Indicis, 1～4 part of Radix Panacis Quinquefolii, 20～40 parts of the Radixs Astragali, 15～20 parts of Radix Isatidis, 4～8 parts of Radix Peucedanis, 3～8 parts of Bulbus Fritillariae Uninbracteataes, 1.5～4 parts in Herba Ephedrae, 4～8 parts in Radix Glycyrrhizae, 9.5～12.5 parts on Lentinus Edodes.
2, Chinese patent medicine according to claim 1, the consumption that it is characterized in that each crude drug is: 10～15 parts of Herba Bidentis Bipinnatae, 6～10 parts of Flos Chrysanthemi Indicis, 1.5～3 parts of Radix Panacis Quinquefoliis, 25～35 parts of the Radixs Astragali, 15～20 parts of Radix Isatidis, 5～7 parts of Radix Peucedanis, 3～5 parts of Bulbus Fritillariae Uninbracteataes, 1.5～2.5 parts in Herba Ephedrae, 5～7 parts in Radix Glycyrrhizae, 9.5～11 parts on Lentinus Edodes.
3, Chinese patent medicine according to claim 1 and 2 is characterized in that also including in the crude drug Mel of 10～30 parts by weight.
4, Chinese patent medicine according to claim 1 and 2 is characterized in that also including in the crude drug sucrose of 4.5～6.5 parts by weight.
5, Chinese patent medicine according to claim 1 and 2 is characterized in that said Bulbus Fritillariae Uninbracteatae is a Bulbus Fritillariae Thunbergii.
6, Chinese patent medicine according to claim 3 is characterized in that said Bulbus Fritillariae Uninbracteatae is a Bulbus Fritillariae Thunbergii.
7, Chinese patent medicine according to claim 4 is characterized in that said Bulbus Fritillariae Uninbracteatae is a Bulbus Fritillariae Thunbergii.
8, Chinese patent medicine according to claim 6 is characterized in that the consumption of each crude drug is:
12 parts of Herba Bidentis Bipinnatae, 8 parts of Flos Chrysanthemi Indicis, 2 parts of Radix Panacis Quinquefoliis, 30 parts of the Radixs Astragali, 20 parts of Radix Isatidis, 6 parts of Radix Peucedanis, 4 parts of Bulbus Fritillariae Thunbergiis, 2 parts in Herba Ephedrae, 6 parts in Radix Glycyrrhizae, 10 parts on Lentinus Edodes, 20 parts of Mel.
9, the oral liquor of the described Chinese patent medicine of claim 1 is characterized in that comprising the following steps:
1) get the raw materials ready: it is standby that proportioning takes by weighing Herba Bidentis Bipinnatae, Flos Chrysanthemi Indici, Radix Panacis Quinquefolii, the Radix Astragali, Radix Isatidis, Radix Peucedani, Bulbus Fritillariae Uninbracteatae, Herba Ephedrae, Radix Glycyrrhizae, Lentinus Edodes by weight;
2) extract volatile matter: get Flos Chrysanthemi Indici, vapor distillation 1.5～3 hours was collected gained volatile oil and distillate in 1: 1 by volume, added solubilizing agent then, and the device preservation is standby in addition behind the mixing;
3) alcohol extraction:
3.1) get the Radix Panacis Quinquefolii pulverizing, the alcohol heating reflux twice with 60%～80%, each 1.5～3 hours, merge extractive liquid, filtered, and filtrate recycling ethanol is not distinguished the flavor of to there being alcohol, and concentrated solution is standby;
3.2) get Herba Ephedrae, Bulbus Fritillariae Uninbracteatae, the alcohol heating reflux twice with 70%～85%, each 1～2 hour, merge extractive liquid, filtered, and filtrate recycling ethanol is not to there being the alcohol flavor, and concentrated solution is standby;
4) water is carried: get all the other Herba Bidentis Bipinnatae, the Radix Astragali, Radix Isatidis, Radix Peucedani, Radix Glycyrrhizae, Lentinus Edodes, mix with the medicinal residues of above steps, decoct with water twice, each 1.5～3 hours, collecting decoction, filter, filtrate is concentrated precipitate with ethanol, leave standstill, supernatant filters, and filtrate recycling ethanol is not to there being the alcohol flavor, and concentrated solution is standby;
5) with above-mentioned each standby medicinal liquid and concentrated solution mixing, regulate pH value to 4.0～6.5 with sodium hydroxide solution, add water to ormal weight, sterilization promptly gets oral liquid of the present invention.
10, according to the preparation method of the described oral liquid of claim 9, it is characterized in that after step 5) is with above-mentioned each standby medicinal liquid mixing, adding again 10～30 parts Mel, stir evenly, regulate pH value to 4.0～6.5 then.
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| CN104689036B (en) * | 2015-03-13 | 2018-04-06 | 广州一品红制药有限公司 | A kind of preparation method for treating cold in children and repeated cold oral liquid |
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| CN105396105A (en) * | 2015-12-10 | 2016-03-16 | 杨献美 | A method of preparing a traditional Chinese medicine composition for preventing and treating recurrent common cold in children |
| CN105477430A (en) * | 2015-12-30 | 2016-04-13 | 暨南大学 | Traditional Chinese medicine preparation containing folium artemisiae argyi for preventing and/or treating infantile repeated colds |
| CN112402544A (en) * | 2020-11-11 | 2021-02-26 | 广州一品红制药有限公司 | Application of fragrant-flavor cinnoline oral liquid in preparation of medicine for preventing and/or treating asthma and diminishing inflammation |
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| CN1634244A (en) * | 2004-09-24 | 2005-07-06 | 贵阳云岩西创药物科技开发有限公司 | Chinese medicinal formulation for treating children's cold and its preparation method |
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| CN1634244A (en) * | 2004-09-24 | 2005-07-06 | 贵阳云岩西创药物科技开发有限公司 | Chinese medicinal formulation for treating children's cold and its preparation method |
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| 中医药防治小儿反复呼吸道感染近况 李谱智，河北中医，第6期 1998 * |
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