CN100342877C - Medicine for promoting qi circulation, resolving food retention, benefiting stomach and stopping pain and preparation process thereof - Google Patents
Medicine for promoting qi circulation, resolving food retention, benefiting stomach and stopping pain and preparation process thereof Download PDFInfo
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- CN100342877C CN100342877C CNB2005101129951A CN200510112995A CN100342877C CN 100342877 C CN100342877 C CN 100342877C CN B2005101129951 A CNB2005101129951 A CN B2005101129951A CN 200510112995 A CN200510112995 A CN 200510112995A CN 100342877 C CN100342877 C CN 100342877C
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- 210000002784 stomach Anatomy 0.000 title claims abstract description 22
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- 230000036407 pain Effects 0.000 title claims abstract description 20
- 230000001737 promoting effect Effects 0.000 title claims abstract description 19
- 235000013305 food Nutrition 0.000 title claims abstract description 17
- 230000014759 maintenance of location Effects 0.000 title claims abstract description 17
- 230000004087 circulation Effects 0.000 title claims abstract description 15
- 238000002360 preparation method Methods 0.000 title abstract description 8
- 229940079593 drug Drugs 0.000 title description 10
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims abstract description 42
- 241000218176 Corydalis Species 0.000 claims abstract description 24
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 21
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- 235000017557 sodium bicarbonate Nutrition 0.000 claims abstract description 21
- 210000003038 endothelium Anatomy 0.000 claims description 21
- 239000000843 powder Substances 0.000 claims description 16
- 241000238370 Sepia Species 0.000 claims description 13
- 239000002994 raw material Substances 0.000 claims description 11
- 239000008187 granular material Substances 0.000 claims description 6
- 239000003826 tablet Substances 0.000 claims description 6
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 5
- 239000002775 capsule Substances 0.000 claims description 4
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- 201000006549 dyspepsia Diseases 0.000 abstract description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 5
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- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 abstract 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 abstract 1
- 241000675108 Citrus tangerina Species 0.000 abstract 1
- 206010015137 Eructation Diseases 0.000 abstract 1
- 244000118681 Iresine herbstii Species 0.000 abstract 1
- 235000006484 Paeonia officinalis Nutrition 0.000 abstract 1
- 241001106477 Paeoniaceae Species 0.000 abstract 1
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- 229940041616 menthol Drugs 0.000 abstract 1
- 230000008506 pathogenesis Effects 0.000 abstract 1
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- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 16
- 210000000952 spleen Anatomy 0.000 description 14
- 206010067171 Regurgitation Diseases 0.000 description 6
- -1 filter Substances 0.000 description 6
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- 239000000284 extract Substances 0.000 description 5
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
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- 206010000077 Abdominal mass Diseases 0.000 description 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
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- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
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Abstract
The present invention provides a medicine for promoting qi circulation, resolving stasis, benefiting stomach and stopping pain and a preparation method thereof. The medicine is prepared from seven kinds of Chinese medicinal herbs comprising corydalis tuber, cuttlebone, chicken gizzard membrane, tangerine peel, white paeony root, sodium bicarbonate and menthol. The present invention focuses on the etiology and the pathogenesis of a disease, and the Chinese medicinal herbs are reasonably compounded. The present invention is mainly used for promoting qi circulation, resolving stasis, promoting digestion and alleviating pain, and is used for treating the diseases of stomachache, gastric cavity turgor, belching and acid swallowing, poor appetite with epigastric oppression, indigestion, etc. caused by the stasis and the center burner of qi and blood, and the retention of food and drink. Proved by experiment and research, the medicine of the present invention has outstanding curative effect, rapid action, no toxic or side effect and convenient administration. The present invention is a good medicine for promoting qi circulation, resolving stasis, promoting digestion and alleviating pain.
Description
Technical field
The present invention relates to the Chinese medicine formulation art, especially relate to a kind of medicine for the treatment of promoting qi circulation, resolving food retention, benefiting stomach and stopping pain and preparation method thereof.
Background technology
Stomachache claims gastric abscess again, is most commonly in diseases such as gastritis, gastric and duodenal ulcers.In the ancient doctor of traditional Chinese medical science nationality, argumentation is early arranged, say as " element is asked the hexa-atomic big opinion piece of writing of just recording ": " strongly fragrant the sending out of wood, the sick epigastralgia right below the heart of the people." " Ling Shu Miraculous Pivot or Divine Axis pathogen cacosplanchnia shape " piece of writing point out: " stomach patient, abdominal distention, epigastralgia right below the heart.”
People's health relies the nourishing of transporting and transforming function of the spleen and stomach essence of water and grain entirely, so claim that taste are " the foundation of acquired constitution ".Spleen and stomach are lived together in the abdomen, link to each other with film, and a dirty internal organs, the exterior and the interior each other, main lifting altogether, so gastropathy relates in spleen more, the splenopathy also can reach and stomach.If the transformation failure of spleen of spleen, clear QI failing to ascend, can influence stomach received with and fall; As if dyspepsia, stomach-QI being unable to descend normally, also can influence the lucid yang sending up and fortuneization of spleen.Taste are subjected to disease, and the easiest stagnation of QI and pent-up are not loose, and retention of food and drink is not changed and produced cards such as stomachache, gastral cavilty distension, belch acid regurgitation, appetite stimulator.The normal function of the spleen tending to ascent, stomach should fall then and.So selection Rhizoma Corydalis, Pericarpium Citri Reticulatae, Endothelium Corneum Gigeriae Galli, Os Sepiae, the Radix Paeoniae Alba are equipped with sodium bicarbonate, Mentholum is formed this prescription, has promoting qi circulation, resolving food retention, the effect of strong taste is used for the treatment of primary disease.
Summary of the invention
Rhizoma Corydalis 100g Endoconcha Sepiae 60g Endothelium Corneum Gigeriae Galli 60g
Pericarpium Citri Reticulatae 80g Radix Paeoniae Alba 40g sodium bicarbonate 15g
Mentholum 5g
Function and curing mainly
Promoting qi circulation, resolving food retention, benefiting stomach and stopping pain.Be used for the treatment of in the QI and blood stasis cards such as burnt, stomachache due to the retention of food and drink, gastral cavilty distension, belch acid regurgitation, appetite stimulator, dyspepsia.
According to the argumentation of Chinese medical theory to prescription
Taste are barn organs, and main being received and transporting and transforming nutrients from foodstuff is to moisten foster whole body, so be referred to as " the foundation of acquired constitution ".The normal function of the spleen tending to ascent, stomach should fall then and.If spleen loses fortuneization, stomach-QI being unable to descend normally, retention of food and drink then, QI and blood stasis in, and cards such as generation stomachache, gastral cavilty distension, belch acid regurgitation, appetite stimulator, dyspepsia.Control suitable promoting qi circulation, resolving food retention, the method for benefiting stomach and stopping pain.
The side separates
We are monarch drug with the Rhizoma Corydalis.Rhizoma Corydalis is the key medicine of blood-activating and qi-promoting pain relieving, and its merit can be gone into blood system with blood circulation promoting and blood stasis dispelling, can go into edema caused by disorder of QI again and loose stagnant, distinguished with pain relieving effectiveness especially with circulation of qi promoting.
Compendium of Material Medica is estimated it to be had " specially control all over the body up and down all pains, with among, simply fantastic " say.Use the Rhizoma Corydalis blood-activating and qi-promoting, eliminating stasis to stop pain is removed the vexed distending pain of gastral cavity abdomen painful abdominal mass.
Ministerial drug, Pericarpium Citri Reticulatae:
Gas perfume (or spice) is warm in nature, can manage it and can fall, have the activating the spleen of regulating the flow of vital energy, and the merit of fast sirloin in the accent is used for the gastral cavity abdomen feeling of fullness distending pain due to the stagnation of QI in spleen and stomach, cards such as belch vomiting.Endothelium Corneum Gigeriae Galli: the power that helps digestion is stronger, has the merit that activating the spleen is good for the stomach, and cooperates with Pericarpium Citri Reticulatae, strengthens the qi and blood circulation promotion of monarch drug, the merit that dissipating blood stasis stagnates, and burnt mechanism of qi is happy in making, the strong fortune of taste.
The adjuvant drug Os Sepiae:
Astringing to arrest bleeding, relieving gastric hyperacidity to alleviate stomachache.Control the lung gastrorrhagia, the stomachache acid regurgitation.Join the sodium bicarbonate alkalescent medicine, strengthen the antacid effect.Mentholum has certain antiinflammatory, is good for the stomach, function of gallbladder promoting and suppress the gastrointestinal smooth muscle contraction.
The messenger drug Radix Paeoniae Alba:
The yin fluid astringing that nourishes blood, easing the affected liver to relieve pain.In case row looses too with impairment of YIN blood.
In a word, all medicines are played the effect that promoting qi circulation, resolving food retention, pain relieving are good for the stomach altogether.
In order to overcome the deficiencies in the prior art, the invention provides a kind of medicine for the treatment of promoting qi circulation, resolving food retention, benefiting stomach and stopping pain and preparation method thereof.This curative effect of medication is definite, and effect has no side effect taking convenience rapidly.
The inventor of Department of Pharmacy of the present invention is according to theory of Chinese medical science and the compound Chinese medicinal preparation that develops through for many years clinical empirical summary, and adopted name is a ' Weikangning ' tablet for curing gastrosis.Medicine of the present invention is to be prepared from by acceptable excipient on the raw material of Chinese medicine of following weight parts and the pharmaceutics:
Rhizoma Corydalis 75-135 Endoconcha Sepiae 35-95 Endothelium Corneum Gigeriae Galli 35-95
Pericarpium Citri Reticulatae 60-110 Radix Paeoniae Alba 28-75 sodium bicarbonate 5-50
Mentholum 2-15
This medicine promoting qi circulation, resolving food retention, benefiting stomach and stopping pain.Be used for the treatment of in the QI and blood stasis cards such as burnt, stomachache due to the retention of food and drink, gastral cavilty distension, belch acid regurgitation, appetite stimulator, dyspepsia.
According to the argumentation of Chinese medical theory to prescription
Taste are barn organs, and main being received and transporting and transforming nutrients from foodstuff is to moisten foster whole body, so be referred to as " the foundation of acquired constitution ".The normal function of the spleen tending to ascent, stomach should fall then and.If spleen loses fortuneization, stomach-QI being unable to descend normally, retention of food and drink then, QI and blood stasis in, and cards such as generation stomachache, gastral cavilty distension, belch acid regurgitation, appetite stimulator, dyspepsia.Control suitable promoting qi circulation, resolving food retention, the method for benefiting stomach and stopping pain
The weight portion proportion optimization of raw material of Chinese medicine of the present invention:
Rhizoma Corydalis 75 Endoconcha Sepiaes 35 Endothelium Corneum Gigeriae Galli 35
Pericarpium Citri Reticulatae 60 Radix Paeoniae Albas 28 sodium bicarbonate 5
Mentholum 2
The weight portion proportioning of above-mentioned raw materials medicine is also preferred:
Rhizoma Corydalis 100 Endoconcha Sepiaes 60 Endothelium Corneum Gigeriae Galli 60
Pericarpium Citri Reticulatae 80 Radix Paeoniae Albas 40 sodium bicarbonate 15
Mentholum 5g
The weight portion proportioning of above-mentioned raw materials medicine is also preferred:
Rhizoma Corydalis 120 Endoconcha Sepiaes 80 Endothelium Corneum Gigeriae Galli 80
Pericarpium Citri Reticulatae 100 Radix Paeoniae Albas 60 sodium bicarbonate 35
Mentholum 10
The weight portion proportioning of above-mentioned raw materials medicine is also preferred:
Rhizoma Corydalis 135 Endoconcha Sepiaes 95 Endothelium Corneum Gigeriae Galli 95
Pericarpium Citri Reticulatae 110 Radix Paeoniae Albas 75 sodium bicarbonate 50
Mentholum 15
Medicine of the present invention can be carried according to the conventional method such as the water of this area, alcohol extraction etc. is prepared into acceptable oral preparation dosage form on any pharmaceutics.Wherein preferred tablet, capsule, granule, powder or pill.
More than seven the flavor, get Endoconcha Sepiae, Endothelium Corneum Gigeriae Galli, sodium bicarbonate is ground into fine powder, and is standby;
Other gets Rhizoma Corydalis and pulverizes coarse powder, adding 60-85% ethanol 5-8 doubly measures, extracted 1-2 hour, and merged alcohol extract, filter, filtrate decompression is with receiving ethanol and being concentrated into the thick paste that relative density is 1.30-1.35 (60 ℃ of survey), boil liquid with above-mentioned thick paste and fine powder, filter, filtrate is concentrated into the thick paste that relative density is 1.30-1.35 (60 ℃ of survey), technology is made acceptable oral preparation dosage form on the pharmaceutics routinely then, as capsule, tablet, granule, powder or pill.
The preparation method of medicine of the present invention is preferred:
More than seven the flavor, get Endoconcha Sepiae, Endothelium Corneum Gigeriae Galli, sodium bicarbonate is ground into fine powder, and is standby;
Other gets Rhizoma Corydalis and pulverizes coarse powder, adds 6 times of amounts of 80% ethanol, extracts 1.5 hours, merges alcohol extract, filters, and filtrate decompression with receiving ethanol and being concentrated into relative density is
1.30-1.35 the thick paste of (60 ℃ of surveys) boils liquid with above-mentioned thick paste and fine powder, filters, filtrate is concentrated into the thick paste that relative density is 1.30-1.35 (60 ℃ of survey), with above-mentioned thick paste, and the fine powder mixing, drying is pulverized, and granulates, add Mentholum fine powder and magnesium stearate, mixing, compress tablet coating, promptly.
Promptly get tablet of the present invention
The weight portion proportion optimization of embodiment raw material of Chinese medicine of the present invention:
Embodiment 1
Rhizoma Corydalis 75 Endoconcha Sepiaes 35 Endothelium Corneum Gigeriae Galli 35
Pericarpium Citri Reticulatae 60 Radix Paeoniae Albas 28 sodium bicarbonate 5
Mentholum 2
Make granule of the present invention according to a conventional method.
Embodiment 2
Rhizoma Corydalis 100 Endoconcha Sepiaes 60 Endothelium Corneum Gigeriae Galli 60
Pericarpium Citri Reticulatae 80 Radix Paeoniae Albas 40 sodium bicarbonate 15
Mentholum 5
Formulation method is made oral formulations of the present invention routinely.
Embodiment 3
Rhizoma Corydalis 135 Endoconcha Sepiaes 95 Endothelium Corneum Gigeriae Galli 95
Pericarpium Citri Reticulatae 110 Radix Paeoniae Albas 75 sodium bicarbonate 50
Mentholum 15
Make capsule of the present invention according to a conventional method.
Embodiment 4
Rhizoma Corydalis 120 Endoconcha Sepiaes 80 Endothelium Corneum Gigeriae Galli 80
Pericarpium Citri Reticulatae 100 Radix Paeoniae Albas 60 sodium bicarbonate 35
Mentholum 10
Make pill of the present invention according to a conventional method.
Embodiment 5
Rhizoma Corydalis 100 Endoconcha Sepiaes 60 Endothelium Corneum Gigeriae Galli 60
Pericarpium Citri Reticulatae 80 Radix Paeoniae Albas 40 sodium bicarbonate 15
Mentholum 5
More than seven the flavor, get Endoconcha Sepiae, Endothelium Corneum Gigeriae Galli, sodium bicarbonate is ground into fine powder, and is standby; Other gets Rhizoma Corydalis and pulverizes coarse powder, adds 6 times of amounts of 80% ethanol, extracts 1.5 hours, merge alcohol extract, filter, filtrate decompression is with receiving ethanol and being concentrated into the thick paste that relative density is 1.30-1.35 (60 ℃ of survey), boil liquid with above-mentioned thick paste and fine powder, filter, filtrate is concentrated into the thick paste that relative density is 1.30-1.35 (60 ℃ of survey), with above-mentioned thick paste, and the fine powder mixing, drying, pulverize, granulate, add Mentholum fine powder and magnesium stearate, mixing, compress tablet coating, promptly.
Promptly get tablet of the present invention
Claims (6)
1. the medicine of a promoting qi circulation, resolving food retention, benefiting stomach and stopping pain is characterized in that it is the oral formulations that is prepared from by acceptable excipient on following weight parts Chinese medicinal raw materials and the pharmaceutics:
Rhizoma Corydalis 75-135 Endoconcha Sepiae 35-95 Endothelium Corneum Gigeriae Galli 35-95
Pericarpium Citri Reticulatae 60-110 Radix Paeoniae Alba 28-75 sodium bicarbonate 5-50
Mentholum 2-15.
2. medicine according to claim 1 is characterized in that the weight portion proportioning of raw material of Chinese medicine is:
Rhizoma Corydalis 75 Endoconcha Sepiaes 35 Endothelium Corneum Gigeriae Galli 35
Pericarpium Citri Reticulatae 60 Radix Paeoniae Albas 28 sodium bicarbonate 5
Mentholum 2.
3. medicine according to claim 1 is characterized in that the weight portion proportioning of raw material of Chinese medicine is:
Rhizoma Corydalis 100 Endoconcha Sepiaes 60 Endothelium Corneum Gigeriae Galli 60
Pericarpium Citri Reticulatae 80 Radix Paeoniae Albas 40 sodium bicarbonate 15
Mentholum 5.
4. medicine according to claim 1 is characterized in that the weight portion proportioning of raw material of Chinese medicine is:
Rhizoma Corydalis 120 Endoconcha Sepiaes 80 Endothelium Corneum Gigeriae Galli 80
Pericarpium Citri Reticulatae 100 Radix Paeoniae Albas 60 sodium bicarbonate 35
Mentholum 10.
5. medicine according to claim 1 is characterized in that the weight portion proportioning of raw material of Chinese medicine is:
Rhizoma Corydalis 135 Endoconcha Sepiaes 95 Endothelium Corneum Gigeriae Galli 95
Pericarpium Citri Reticulatae 110 Radix Paeoniae Albas 75 sodium bicarbonate 50
Mentholum 15.
6. according to each described medicine of claim 1-5, it is characterized in that: this medicine is capsule, tablet, granule, powder or pill.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2005101129951A CN100342877C (en) | 2005-10-18 | 2005-10-18 | Medicine for promoting qi circulation, resolving food retention, benefiting stomach and stopping pain and preparation process thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2005101129951A CN100342877C (en) | 2005-10-18 | 2005-10-18 | Medicine for promoting qi circulation, resolving food retention, benefiting stomach and stopping pain and preparation process thereof |
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| CN100342877C true CN100342877C (en) | 2007-10-17 |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1214921A (en) * | 1997-10-21 | 1999-04-28 | 冯根源 | Weikangning powder for gastric disease |
| CN1546066A (en) * | 2003-09-15 | 2004-11-17 | 史 忠 | Gastrointestinal ulcer treating Chinese traditional medicine |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1214921A (en) * | 1997-10-21 | 1999-04-28 | 冯根源 | Weikangning powder for gastric disease |
| CN1546066A (en) * | 2003-09-15 | 2004-11-17 | 史 忠 | Gastrointestinal ulcer treating Chinese traditional medicine |
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Assignee: Tonghua Wantong Pharmaceutical Co., Ltd. Assignor: Pan Shoude Contract record no.: 2010220000046 Denomination of invention: Medicine for promoting qi circulation, resolving food retention, benefiting stomach and stopping pain and preparation process thereof Granted publication date: 20071017 License type: Exclusive License Open date: 20060510 Record date: 20100926 |
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Assignee: Tonghua Wantong Pharmaceutical Co., Ltd. Assignor: Pan Shoude Contract record no.: 2010220000046 Date of cancellation: 20140320 |
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Application publication date: 20060510 Assignee: Tonghua Wantong Pharmaceutical Co., Ltd. Assignor: Pan Shoude Contract record no.: 2014220000021 Denomination of invention: Medicine for promoting qi circulation, resolving food retention, benefiting stomach and stopping pain and preparation process thereof Granted publication date: 20071017 License type: Exclusive License Record date: 20140324 |
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Owner name: TONGHUA WANTONG PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: PAN SHOUDE Effective date: 20150616 |
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Effective date of registration: 20150616 Address after: Tonghua City, Jilin Province Wan Tong 134001 Dongchang District No. 66 Patentee after: Tonghua Wantong Pharmaceutical Co., Ltd. Address before: 134000 Tonghua City, Jilin Province Wan Road, No. 66 Patentee before: Pan Shoude |