CN1736449A - Powder for climacteric syndrome and its preparing process - Google Patents
Powder for climacteric syndrome and its preparing process Download PDFInfo
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- CN1736449A CN1736449A CN 200510031982 CN200510031982A CN1736449A CN 1736449 A CN1736449 A CN 1736449A CN 200510031982 CN200510031982 CN 200510031982 CN 200510031982 A CN200510031982 A CN 200510031982A CN 1736449 A CN1736449 A CN 1736449A
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- systems
- poria
- climacteric
- powder
- oryzanol
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- 239000000843 powder Substances 0.000 title claims abstract description 17
- 238000000034 method Methods 0.000 title claims abstract description 5
- 208000011580 syndromic disease Diseases 0.000 title abstract description 3
- 239000000203 mixture Substances 0.000 claims abstract description 8
- 239000003814 drug Substances 0.000 claims description 18
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 12
- 108010052008 colla corii asini Proteins 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 239000008187 granular material Substances 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 8
- 238000002360 preparation method Methods 0.000 claims description 8
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 6
- 208000002173 dizziness Diseases 0.000 claims description 6
- 206010022437 insomnia Diseases 0.000 claims description 6
- 238000005325 percolation Methods 0.000 claims description 6
- 208000019255 Menstrual disease Diseases 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 5
- 239000000470 constituent Substances 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 3
- 239000000706 filtrate Substances 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000012530 fluid Substances 0.000 claims description 3
- 239000011812 mixed powder Substances 0.000 claims description 3
- 238000004064 recycling Methods 0.000 claims description 3
- 239000002904 solvent Substances 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 229930003270 Vitamin B Natural products 0.000 claims 4
- 235000019156 vitamin B Nutrition 0.000 claims 4
- 239000011720 vitamin B Substances 0.000 claims 4
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 abstract description 16
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 abstract description 8
- 239000011726 vitamin B6 Substances 0.000 abstract description 8
- 235000019158 vitamin B6 Nutrition 0.000 abstract description 8
- 229940011671 vitamin b6 Drugs 0.000 abstract description 8
- 235000013399 edible fruits Nutrition 0.000 abstract 2
- 241001127714 Amomum Species 0.000 abstract 1
- 241000213006 Angelica dahurica Species 0.000 abstract 1
- 235000010894 Artemisia argyi Nutrition 0.000 abstract 1
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 abstract 1
- 108010010803 Gelatin Proteins 0.000 abstract 1
- 240000007890 Leonurus cardiaca Species 0.000 abstract 1
- 235000000802 Leonurus cardiaca ssp. villosus Nutrition 0.000 abstract 1
- 244000170916 Paeonia officinalis Species 0.000 abstract 1
- 235000006484 Paeonia officinalis Nutrition 0.000 abstract 1
- 244000197580 Poria cocos Species 0.000 abstract 1
- 235000008599 Poria cocos Nutrition 0.000 abstract 1
- 241000405414 Rehmannia Species 0.000 abstract 1
- 240000006079 Schisandra chinensis Species 0.000 abstract 1
- 235000008422 Schisandra chinensis Nutrition 0.000 abstract 1
- 241000270708 Testudinidae Species 0.000 abstract 1
- 229930188824 alisol Natural products 0.000 abstract 1
- 210000003056 antler Anatomy 0.000 abstract 1
- 244000030166 artemisia Species 0.000 abstract 1
- 229920000159 gelatin Polymers 0.000 abstract 1
- 239000008273 gelatin Substances 0.000 abstract 1
- 235000019322 gelatine Nutrition 0.000 abstract 1
- 235000011852 gelatine desserts Nutrition 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 208000037093 Menstruation Disturbances Diseases 0.000 description 1
- 206010027339 Menstruation irregular Diseases 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- -1 oryzanol Substances 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
Disclosed is a powder for treating climacteric syndrome and its preparing process, wherein the compositions (by weight ratio) include prepared rehmannia root, tortoise shell, deglued antler powder, epimeddium, Chinese angelica root each 6-9%, rhizoma dioscoreae, motherwort each 10-14%, schisandra fruit, bark of peony root, Chinese mugwort leaf and alisol each 3-7%, poria cocos, amomum fruit each 7-10%, donkey-hide gelatin 1-4%, oryzanol 0.05-0.09%, and vitamin B6 0.01-0.05%.
Description
Technical field:
The present invention relates to a kind of Chinese medicine granules and preparation technology's method thereof, relate in particular to climacteric relaxation grain and preparation method thereof.
Background technology:
Granule is a kind of pharmaceutical dosage form commonly used, according to the relevant laws and regulations of China's drug control, changes dosage form and manages as new drug research.The original dosage form of this product is a tablet, has listed the national drug standards in.
The easypro sheet of existing climacteric is that the medicine composition is the Chinese medicinal tablet of Radix Rehmanniae Preparata, Carapax Et Plastrum Testudinis (stir-fry), Cornu Cervi Degelatinatum, Herba Epimedii, Radix Angelicae Sinensis, Rhizoma Dioscoreae, Herba Leonuri (four systems), Fructus Schisandrae Chinensis, Cortex Moutan, Folium Artemisiae Argyi (four systems), Rhizoma Alismatis, Poria, Fructus Amomi, Colla Corii Asini, oryzanol, vitamin B6, it is with part pulverizing medicinal materials in the prescription, all the other medicinal material extract, concentrated back add aforementioned medical material fine powder mixing, granulation, drying, tabletting, promptly, the easypro sheet of climacteric is used for the treatment of the caused menoxenia of climacteric obstacle, dizziness, cardiopalmus, insomnia disease.
The onset of the easypro sheet of existing climacteric is fast not as granule.
Summary of the invention:
The purpose of this invention is to provide a kind of can effectively control and ensure drug quality, the treatment onset is faster, be used for the treatment of the caused menoxenia of climacteric obstacle, dizzy, Chinese medicine preparation of cardiopalmus, insomnia disease and preparation method thereof, overcome the above-mentioned drawback of prior art, improve the quality and the curative effect of product, satisfy the needs of medical treatment better.
Technical solution of the present invention is a kind of climacteric relaxation grain, it is the caused menoxenia of a kind of treatment climacteric obstacle, dizzy, the Chinese patent medicine of cardiopalmus, insomnia disease, it be the medicine composition be Radix Rehmanniae Preparata, Carapax Et Plastrum Testudinis (stir-fry), Cornu Cervi Degelatinatum, Herba Epimedii, Radix Angelicae Sinensis each 7.33%, Rhizoma Dioscoreae, Herba Leonuri (four systems) each 12.21%, Fructus Schisandrae Chinensis, Cortex Moutan, Folium Artemisiae Argyi (four systems), Rhizoma Alismatis each 4.88%, Poria, Fructus Amomi each 8.43%, Colla Corii Asini 2.45%, oryzanol 0.07%, the granule of vitamin B6 0.03%.
The preparation method of climacteric relaxation grain:
(1) get it filled thing constituent and percentage by weight thereof is: Radix Rehmanniae Preparata, Carapax Et Plastrum Testudinis (stir-fry), Cornu Cervi Degelatinatum, Herba Epimedii, Radix Angelicae Sinensis each 6~9%, Rhizoma Dioscoreae, Herba Leonuri (four systems) each 10~14%, Fructus Schisandrae Chinensis, Cortex Moutan, Folium Artemisiae Argyi (four systems), Rhizoma Alismatis each 3~7%, Poria, Fructus Amomi each 7~10%, Colla Corii Asini 1~4%, oryzanol 0.05~0.09%, vitamin B6 0.01~0.05%;
(2) in the medicine of (1), get Fructus Amomi, 20% Poria, mix, be ground into the fine powder of 40~200 mesh sieves, sieve, standby;
(3) in the medicine of (1), get Radix Angelicae Sinensis, Cortex Moutan, Fructus Schisandrae Chinensis powder and be broken into coarse powder, according to the percolation under fluid extract and the extractum item (" appendix IO of Chinese pharmacopoeia), make solvent with 70% ethanol, slowly percolation is collected diacolation liquid recycling ethanol to becoming the thick paste shape till the colourless or little yellow of the liquid of filtering;
(4) with eight flavors of residue Poria and all the other Herba Leonuris etc. in (1), decoct with water and extract 1~3 time, add the water of 5~20 times of amounts at every turn, decocted each 1~3 hour; Optimised process adds 10 times of water gagings for the first time and decocted 2 hours for decocting with water 2 times, adds 8 times of water gagings for the second time and decocts 1.5 hours;
(5) decocting liquid that repeatedly decocts gained in (4) is merged, filter;
(6) with the filtrate of (5) gained, add Colla Corii Asini, stir and make dissolving, be evaporated to the thick paste that relative density is 1.1~1.4 (50~60 ℃) below 60 ℃; Best for being concentrated into the thick paste that relative density is 1.2~1.3 (50~60 ℃);
(7) with oryzanol, vitamin B6 mixing in appropriate amount of auxiliary materials and above-mentioned (2) gained fine powder, above-mentioned (1);
(8) thick paste with (6) gained adds in the mixed powder of (7) gained, and mixing is granulated, drying, promptly.
Specific embodiments:
The present invention further specifies as follows in conjunction with specific embodiments:
A kind of climacteric relaxation grain, it is the caused menoxenia of a kind of treatment climacteric obstacle, dizzy, the Chinese patent medicine of cardiopalmus, insomnia disease, it is that the medicine composition is the granule of Radix Rehmanniae Preparata, Carapax Et Plastrum Testudinis (stir-fry), Cornu Cervi Degelatinatum, Herba Epimedii, Radix Angelicae Sinensis, Rhizoma Dioscoreae, Herba Leonuri (four systems), Fructus Schisandrae Chinensis, Cortex Moutan, Folium Artemisiae Argyi (four systems), Rhizoma Alismatis, Poria, Fructus Amomi, Colla Corii Asini, oryzanol, vitamin B6.
A kind of optimum implementation of climacteric relaxation grain preparation method:
(1) get it filled thing constituent and optimum weight percentage ratio thereof is: Radix Rehmanniae Preparata, Carapax Et Plastrum Testudinis (stir-fry), Cornu Cervi Degelatinatum, Herba Epimedii, Radix Angelicae Sinensis each 7.33%, Rhizoma Dioscoreae, Herba Leonuri (four systems) each 12.21%, Fructus Schisandrae Chinensis, Cortex Moutan, Folium Artemisiae Argyi (four systems), Rhizoma Alismatis each 4.88%, Poria, Fructus Amomi each 8.43%, Colla Corii Asini 2.45%, oryzanol 0.07%, vitamin B6 0.03%;
(2) in the above medicine, get Fructus Amomi, 20% Poria, mix, be ground into fine powder; Radix Angelicae Sinensis, Cortex Moutan, Fructus Schisandrae Chinensis powder are broken into coarse powder, according to the percolation under fluid extract and the extractum item (" appendix IO of Chinese pharmacopoeia), make solvent with 70% ethanol, and slowly percolation is till the colourless or little yellow of the liquid of filtering, and diacolation liquid recycling ethanol is to becoming the thick paste shape; Eight flavors such as remaining Poria and all the other Herba Leonuris decoct with water secondary, and 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate adds Colla Corii Asini, stirs and makes dissolving, is concentrated into the thick paste shape under 60 ℃; Mixing fine powders, oryzanol, vitamin B6 and the appropriate amount of auxiliary materials mixing of getting Fructus Amomi and Poria are even, and above-mentioned thick paste is added in the mixed powder, and mixing is made granule, promptly.
Advantage of the present invention is: powder for climacteric syndrome can be brought into play rapid-action characteristics behind the drug administration fully, is used for the treatment of The caused irregular menstruation of climacteric obstacle, dizziness, palpitaition, insomnia disease can satisfy the clinical treatment needs better.
Claims (3)
1, a kind of climacteric relaxation grain, it is a kind of climacteric menoxenia of causing of obstacle that is used for the treatment of, dizzy, the Chinese medicine granules of cardiopalmus, insomnia disease, it is characterized in that it be medicine composition and percentage by weight thereof be Radix Rehmanniae Preparata, Carapax Et Plastrum Testudinis (stir-fry), Cornu Cervi Degelatinatum, Herba Epimedii, Radix Angelicae Sinensis each 6~9%, Rhizoma Dioscoreae, Herba Leonuri (four systems) each 10~14%, Fructus Schisandrae Chinensis, Cortex Moutan, Folium Artemisiae Argyi (four systems), Rhizoma Alismatis each 3~7%, Poria, Fructus Amomi each 7~10%, Colla Corii Asini 1~4%, oryzanol 0.05~0.09%, vitamin B
60.01~0.05% granule.
2, a kind of preparation method of climacteric relaxation grain is characterized in that:
(1) get it filled thing constituent and percentage by weight thereof is: Radix Rehmanniae Preparata, Carapax Et Plastrum Testudinis (stir-fry), Cornu Cervi Degelatinatum, Herba Epimedii, Radix Angelicae Sinensis each 6~9%, Rhizoma Dioscoreae, Herba Leonuri (four systems) each 10~14%, Fructus Schisandrae Chinensis, Cortex Moutan, Folium Artemisiae Argyi (four systems), Rhizoma Alismatis each 3~7%, Poria, Fructus Amomi each 7~10%, Colla Corii Asini 1~4%, oryzanol 0.05~0.09%, vitamin B
60.01~0.05%;
(2) in the medicine of (1), get Fructus Amomi, 20% Poria, mix, be ground into the fine powder of 40~200 mesh sieves, sieve, standby;
(3) in the medicine of (1), get Radix Angelicae Sinensis, Cortex Moutan, Fructus Schisandrae Chinensis powder and be broken into coarse powder, according to the percolation under fluid extract and the extractum item (" Chinese pharmacopoeia appendix I O), make solvent with 70% ethanol, slowly percolation is collected diacolation liquid recycling ethanol to becoming the thick paste shape till the colourless or little yellow of the liquid of filtering;
(4) with eight flavors of residue Poria and all the other Herba Leonuris etc. in (1), decoct with water and extract 1~3 time, add the water of 5~20 times of amounts at every turn, decocted each 1~3 hour; Optimised process adds 10 times of water gagings for the first time and decocted 2 hours for decocting with water 2 times, adds 8 times of water gagings for the second time and decocts 1.5 hours;
(5) decocting liquid that repeatedly decocts gained in (4) is merged, filter;
(6) with the filtrate of (5) gained, add Colla Corii Asini, stir and make dissolving, be evaporated to the thick paste that relative density is 1.1~1.4 (50~60 ℃) below 60 ℃; Best for being concentrated into the thick paste that relative density is 1.2~1.3 (50~60 ℃);
(7) with oryzanol, vitamin B in appropriate amount of auxiliary materials and above-mentioned (2) gained fine powder, above-mentioned (1)
6Mixing;
(8) thick paste with (6) gained adds in the mixed powder of (7) gained, and mixing is granulated, drying, promptly.
3, climacteric relaxation grain according to claim 1, the optimum weight percentage ratio that it is characterized in that its medicine constituent be Radix Rehmanniae Preparata, Carapax Et Plastrum Testudinis (stir-fry), Cornu Cervi Degelatinatum, Herba Epimedii, Radix Angelicae Sinensis each 7.33%, Rhizoma Dioscoreae, Herba Leonuri (four systems) each 12.21%, Fructus Schisandrae Chinensis, Cortex Moutan, Folium Artemisiae Argyi (four systems), Rhizoma Alismatis each 4.88%, Poria, Fructus Amomi each 8.43%, Colla Corii Asini 2.45%, oryzanol 0.07%, vitamin B
60.03%.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN 200510031982 CN1736449A (en) | 2005-08-08 | 2005-08-08 | Powder for climacteric syndrome and its preparing process |
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CN 200510031982 CN1736449A (en) | 2005-08-08 | 2005-08-08 | Powder for climacteric syndrome and its preparing process |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101884640A (en) * | 2010-07-01 | 2010-11-17 | 北京世纪博康医药科技有限公司 | Application of oryzanol |
CN102847075A (en) * | 2012-09-27 | 2013-01-02 | 郭秀翠 | Medicine composition for treating insomnia |
CN105560827A (en) * | 2015-12-25 | 2016-05-11 | 东阿阿胶股份有限公司 | Ointment for conditioning perimenopausal syndromes and preparation method thereof |
CN105769879A (en) * | 2016-03-15 | 2016-07-20 | 山东仁和堂药业有限公司 | Medicinal preparation for calming and helping sleep and preparation method thereof |
-
2005
- 2005-08-08 CN CN 200510031982 patent/CN1736449A/en active Pending
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101884640A (en) * | 2010-07-01 | 2010-11-17 | 北京世纪博康医药科技有限公司 | Application of oryzanol |
CN101884640B (en) * | 2010-07-01 | 2012-04-18 | 北京世纪博康医药科技有限公司 | Application of oryzanol |
CN102847075A (en) * | 2012-09-27 | 2013-01-02 | 郭秀翠 | Medicine composition for treating insomnia |
CN105560827A (en) * | 2015-12-25 | 2016-05-11 | 东阿阿胶股份有限公司 | Ointment for conditioning perimenopausal syndromes and preparation method thereof |
CN105560827B (en) * | 2015-12-25 | 2019-03-15 | 东阿阿胶股份有限公司 | A kind of ointment and preparation method thereof for perimenopausal syndrome conditioning |
CN105769879A (en) * | 2016-03-15 | 2016-07-20 | 山东仁和堂药业有限公司 | Medicinal preparation for calming and helping sleep and preparation method thereof |
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Effective date of registration: 20060310 Address after: Xinqiao village, Mawangdui Township, Changsha City, Hunan Applicant after: Shi Yu Address before: No. seven, 20 Mile Road, Chenzhou, Hunan, Chenzhou, Hunan, China Applicant before: Huang Kaiqi |
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