CN1947779A

CN1947779A - Traditional Chinese medicine granules for treating infantile cough and its prepn. method

Info

Publication number: CN1947779A
Application number: CNA200510047399XA
Authority: CN
Inventors: 李晓锋; 刘茁
Original assignee: 王玫
Priority date: 2005-10-14
Filing date: 2005-10-14
Publication date: 2007-04-18

Abstract

A Chinese medicine in the form of particles for treating infantile cough is prepared from 6 Chinese-medicinal materials including perilla leaf, chrysanthemum flower, tendrilled fritillary bulb, pueraria root, etc. Its preparing process is also disclosed.

Description

A kind of Chinese medicine granules that is used for the treatment of infantile cough and preparation method thereof

Technical field:

The present invention relates to a kind of pure Chinese medicine, be used for the treatment of granule of infantile cough and preparation method thereof.

Technical background:

Cough is the modal disease of infant's respiration system, and nearly all lung pattern disease all has the cough symptom, and it is common minor illness In the view of the adult, but for delicate child, its state of an illness is often serious than the adult, as untimely treatment, delay treatment, very likely initiation potential.Chinese medicine preparation-children's's clearing away lung-heat to relieve cough sheet of existing at present treatment infantile cough, its prescription comes from expelling pathogenic factors from muscles lung heat clearing ball, suitably add and subtract in conjunction with children's's characteristics on this basis, clinically to the cough of treatment infantile lung heat, diseases such as tachypnea abundant expectoration have better curative effect, but it exists the medicine dissolution rate slow, and effect slowly, mouthfeel is bad, and the child such as is difficult for taking at shortcoming.

Summary of the invention:

The objective of the invention is: a kind of not only curative effect height is provided, and mouthfeel good be used for the treatment of Chinese medicine granules of infantile cough and preparation method thereof.

Its technical scheme: a kind of Chinese medicine granules for the treatment of infantile cough is characterized in that each medicine ratio is in its prescription:

10～20 parts of Folium Perillaes, 25～35 parts of Flos Chrysanthemis, 40～50 parts of Radix Puerariaes; 40～50 parts of Bulbus Fritillariae Cirrhosaes, 40～50 parts of Semen Armeniacae Amarums (peeling is fried), 50～70 parts of Folium Eriobotryaes; 10～20 parts of Fructus Perillaes (stir-fry), 40～50 parts of Cortex Mori (processed with honey), 40～50 parts of Radix Peucedanis; 25～35 parts of Rhizoma Belamcandae, 40～50 parts of Fructus Gardeniaes (Rhizoma Zingiberis Recens is processed), 40～50 parts of Radix Scutellariaes; 40～50 parts of the Rhizoma Anemarrhenaes; 40～50 parts of Radix Isatidis, 10～20 parts of Calculus Bovis or artificial Calculus Boviss, 4～12 parts of Borneolum Syntheticums.

Its prescription optimal proportion is:

15 parts of Folium Perillaes, 30 parts of Flos Chrysanthemis, 45 parts of Radix Puerariaes; 45 parts of Bulbus Fritillariae Cirrhosaes, 45 parts of Semen Armeniacae Amarums (peeling is fried), 60 parts of Folium Eriobotryaes; 15 parts of Fructus Perillaes (stir-fry), 45 parts of Cortex Mori (processed with honey), 45 parts of Radix Peucedanis; 30 parts of Rhizoma Belamcandae, 45 parts of Fructus Gardeniaes (Rhizoma Zingiberis Recens is processed), 45 parts of Radix Scutellariaes; 45 parts of the Rhizoma Anemarrhenaes; 45 parts of Radix Isatidis, 15 parts of Calculus Bovis or artificial Calculus Boviss, 8 parts of Borneolum Syntheticums.

Preparation method: (1) is broken into fine powder with Bulbus Fritillariae Cirrhosae, Rhizoma Belamcandae, Radix Scutellariae powder, and Calculus Bovis or artificial Calculus Bovis and Borneolum Syntheticum be porphyrize respectively, and be standby.

(2) Cortex Mori, Radix Puerariae, Radix Isatidis, Fructus Gardeniae, Fructus Perillae, the Rhizoma Anemarrhenae, Radix Peucedani, Folium Eriobotryae decoct with water three times, and 3 hours for the first time, 1 hour for the second time, 30 minutes for the third time, merging filtrate filtered.

(3) Folium Perillae, chrysanthemum with water hot dipping are three times, and 2 hours for the first time, 1 hour for the second time, 30 minutes for the third time, merge leachate, filter.

(4) Semen Armeniacae Amarum is with 50～90% alcohol heating reflux secondaries, and 3 hours for the first time, 2 hours for the second time, merge extractive liquid, filtered, and reclaims ethanol, to relative density be 1.15～1.20 (50 ℃).

(5) above-mentioned three kinds of medicinal liquids are merged, be evaporated to thick paste.Add three flavor fine powders such as Bulbus Fritillariae Cirrhosae, mixing, drying is pulverized, and adds Calculus Bovis or artificial Calculus Bovis's fine powder, promptly gets mixed powder.

(6) the medical material mixed powder is pulverized, excipient crushing screenings such as suitable amount of sucrose, Borneolum Syntheticum are dissolved in the appropriate solvent, and be standby.

(7) get the beta-schardinger dextrin-of 2～3 times of amounts, add the water of 2～5 times of amounts, mix grinding well at 50 ℃ down, add the medical material mixed powder, fully be ground to into paste dress thing, cold drying is pulverized, and it is even to add mixed with excipients.

(8) with above-mentioned mixed powder, to granulate, drying evenly sprays into Borneolum Syntheticum solution and suitable essence such as apple essence in dried granule, mixing, packing, promptly.

It is characterized in that adopting in the preparation process beta-cyclodextrin inclusion compound method: the mixed powder of the medical material in will writing out a prescription after extracting or pulverizing, carry out enclose with beta-schardinger dextrin-with polishing earlier, granulate again described granule.

Treatment by Chinese herbs infantile cough granule by the preparation of above method has clearing away heat and expelling pathogen in the exterior, and the effect of relieving cough and resolving phlegm can be used for children's's interior-heat lung-fire, the fever of the body cough that affection due to external wind and heat causes, and the tachypnea abundant expectoration, irritated thirsty, disease such as be hard and dry.

Compare with former preparation children's clearing away lung-heat to relieve cough sheet, owing to adopted the method for beta-cyclodextrin inclusion compound, the dispersion effect of prescription Chinese medicine and the storage rate of effumability composition have been improved, make its effect rapidly, be easy to absorb and can enhanced stability, and solved the tablet children's and be difficult for taking and absorb and the bad problem of mouthfeel.

The specific embodiment:

Embodiment 1: Folium Perillae 15g, Flos Chrysanthemi 30g, Radix Puerariae 45g; Bulbus Fritillariae Cirrhosae 45g, Semen Armeniacae Amarum (peeling is fried) 45g, Folium Eriobotryae 60g; Fructus Perillae (stir-fry) 15g, Cortex Mori (processed with honey) 45g, Radix Peucedani 45g; Rhizoma Belamcandae 30g, Fructus Gardeniae (Rhizoma Zingiberis Recens is processed) 45g, Radix Scutellariae 45g; Rhizoma Anemarrhenae 45g; Radix Isatidis 45g, artificial Calculus Bovis 15g, Borneolum Syntheticum 8g.

Bulbus Fritillariae Cirrhosae, Rhizoma Belamcandae, Radix Scutellariae powder are broken into fine powder, and artificial Calculus Bovis and Borneolum Syntheticum be porphyrize respectively, and be standby; Cortex Mori, Radix Puerariae, Radix Isatidis, Fructus Gardeniae, Fructus Perillae, the Rhizoma Anemarrhenae, Radix Peucedani, Folium Eriobotryae decoct with water three times, and 3 hours for the first time, 1 hour for the second time, 30 minutes for the third time, merging filtrate filtered; Folium Perillae, chrysanthemum with water hot dipping three times, 2 hours for the first time, 1 hour for the second time, 30 minutes for the third time, merge leachate, filter; Semen Armeniacae Amarum is with 80% alcohol heating reflux secondary, and 3 hours for the first time, 2 hours for the second time, merge extractive liquid, filtered, and reclaims ethanol, to relative density be 1.15～1.20 (50 ℃); Above-mentioned three kinds of medicinal liquids are merged, and being evaporated to relative density is the thick paste of 1.35～1.40 (50 ℃).Add three flavor fine powders such as Bulbus Fritillariae Cirrhosae, mixing, drying is pulverized, and adds artificial Calculus Bovis's fine powder, promptly gets mixed powder; The medical material mixed powder is pulverized, and excipient crushing screenings such as suitable amount of sucrose, Borneolum Syntheticum are dissolved in the appropriate solvent, and be standby; The water of getting 2～5 times of amounts of beta-schardinger dextrin-adding of 2～3 times of amounts mixes, and grinds well, and adds the medical material mixed powder, fully is ground to into paste dress thing, and drying is pulverized, and the adding mixed with excipients is even; With above-mentioned mixed powder, to granulate, drying evenly sprays into Borneolum Syntheticum solution in dried granule, mixing, packing promptly gets 250 bags (every bag of 4g).

Claims

1. Chinese medicine granules that is used for the treatment of infantile cough; each medicine ratio is in its prescription: 10～20 parts of Folium Perillaes; 25～35 parts of Flos Chrysanthemis; 40～50 parts of Radix Puerariaes; 40～50 parts of Bulbus Fritillariae Cirrhosaes, 40～50 parts of Semen Armeniacae Amarums (peeling is fried), 50～70 parts of Folium Eriobotryaes; 10～20 parts of Fructus Perillaes (stir-fry); 40～50 parts of Cortex Mori (processed with honey), 40～50 parts of Radix Peucedanis, 25～35 parts of Rhizoma Belamcandae; 40～50 parts of Fructus Gardeniaes (Rhizoma Zingiberis Recens is processed); 40～50 parts of Radix Scutellariaes, 40～50 parts of the Rhizoma Anemarrhenaes, 40～50 parts of Radix Isatidis; 10～20 parts of Calculus Bovis or artificial Calculus Boviss, 4～12 parts of Borneolum Syntheticums.

2. Chinese medicine granules according to claim 1, its prescription optimal proportion is: 15 parts of Folium Perillaes, 30 parts of Flos Chrysanthemis; 45 parts of Radix Puerariaes, 45 parts of Bulbus Fritillariae Cirrhosaes, 45 parts of Semen Armeniacae Amarums (peeling is fried); 60 parts of Folium Eriobotryaes, 15 parts of Fructus Perillaes (stir-fry), 45 parts of Cortex Mori (processed with honey); 45 parts of Radix Peucedanis, 30 parts of Rhizoma Belamcandae, 45 parts of Fructus Gardeniaes (Rhizoma Zingiberis Recens is processed); 45 parts of Radix Scutellariaes, 45 parts of the Rhizoma Anemarrhenaes, 45 parts of Radix Isatidis; 15 parts of Calculus Bovis or artificial Calculus Boviss, 8 parts of Borneolum Syntheticums.

3. according to the preparation method of the described Chinese medicine granules of claim 1, it is characterized in that may further comprise the steps:

(1) Bulbus Fritillariae Cirrhosae, Rhizoma Belamcandae, Radix Scutellariae powder are broken into fine powder, Calculus Bovis or artificial Calculus Bovis and Borneolum Syntheticum be porphyrize respectively, and be standby.

4. according to the preparation method of the described Chinese medicine granules of claim 3, it is characterized in that adopting the beta-cyclodextrin inclusion compound method: the mixed powder of the medical material in will writing out a prescription after extracting or pulverizing, earlier carry out enclose with polishing with beta-schardinger dextrin-, granulate again described granule.