CN1814125A - Rehmannia-root preparation - Google Patents
Rehmannia-root preparation Download PDFInfo
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- CN1814125A CN1814125A CN 200510125261 CN200510125261A CN1814125A CN 1814125 A CN1814125 A CN 1814125A CN 200510125261 CN200510125261 CN 200510125261 CN 200510125261 A CN200510125261 A CN 200510125261A CN 1814125 A CN1814125 A CN 1814125A
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Abstract
The invention adds Chinese Angelica and Danshen into the original prescription of traditonal Liuwei dihuang pills, and prepares them into medicines in related forms, having functions of nourishing Yin and tonifying kidney, enriching and nourishing blood, and promoting blood circulation and removing blood stasis, and able to nourish Yin and tonify kidney, enrich blood and promote blood circulation, and cure or prevent patients with kidney and blood deficiency, sub-healthy persons, the middle-aged and aged and paitents with diabetes from many related diseases caused by anaemia and blood stasis. And the invention is a 'Dihuang preparation with four tonifying functions and four removing functions'.
Description
Technical field
The present invention relates to the medicine of a kind of enriching yin and nourishing kidney, blood-supplementing blood-nourishing, blood circulation promoting and blood stasis dispelling, specifically is the Chinese patent medicine of feedstock production with the Chinese herbal medicine.
Background technology
LIUWEI DIHUANG WAN is the ancient prescription famous medicine, and is well-known.It adds three kinds of cathartics on the basis of three drugs for nourishing yin, treating YANG within YIN is unique (Chinese Medicine, 2003.8.30,8 editions) in Chinese medicine.With Radix Rehmanniae Preparata enriching yin and nourishing kidney, Fructus Corni temperature compensation Liver and kidney, Rhizoma Dioscoreae spleen invigorating tonifying YIN, be called " three mend " in the side; Rush down the kidney fire clearly with Rhizoma Alismatis again, Cortex Moutan clearing away liver-fire, the light spleen that oozes of Poria wet, and are called " three rush down ".Six medicines cooperate, and having invigorating middle warmer has and rush down, and residence rushes down in the characteristics of mending.Being effective patent medicine of treatment hepatic and renal YIN deficiency associated diseases, also is the medicine of the anti-ageing and auxiliary treatment of numerous patients of suffering from a deficiency of the kidney, subhealth state person, middle-aged and elderly people and some patient (as the diabetes patient) health care of often taking.
Blood is the important substance of nutrition human body, and the circulation whole body goes round and begins again.It is reported that there are nearly 2,000,000,000 people's anemias in the whole world at present.The anemia situation of China is startling, and the female anemia rate is up to 64%, has 30%~40% infant to suffer from anemia approximately, and is troubling.(Chinese newspaper cutting, 2002.7.16) tired, weak, dizzy, the tinnitus of many people, hypomnesis, absent-minded etc. all be the early stage and common symptom of anemia.Diabetes are a large amount of in recent years Chronic consumptionss that take place, must lifelong medication.Take the blood sugar lowering Western medicine for a long time, except the untoward reaction that medicine itself causes, also can cause anemia.(friend of diabetes, 2004 (2), 36~37) for this reason, enrich blood medicine and health product of enriching blood of various on the market become the best-selling product of popular long-term needs.Modern medicine thinks, the people is always from blood and blood vessel, middle-aged and elderly people ubiquity blood stasis phenomenon, the blood stickiness increases, hematogenous blockage, and platelet and Red blood corpuscle aggregation strengthen, lipid increases, and speckle forms, and causes cardiovascular and cerebrovascular diseases such as arteriosclerosis, hyperlipidemia, hypertension.Blood forms blood stasis because of retardance, must remove, and just can make the blood vessels circulation, eliminates morbid state.
LIUWEI DIHUANG WAN is the square substantially of nourishing kidney yin, later age, plus-minus was a lot of, once had researcher that this side is improved, as add Radix Angelicae Sinensis, Radix Paeoniae Alba composition 'Guishao Dihuang ball in the former side of LIUWEI DIHUANG WAN, though can make it increase blood tonification effect, but lack being used of blood stasis dispelling medicine.Write articles according to Wang Jinhong etc.: " though hematonic can be enriched blood and be controlled void, but easily hyperamization is sticking not all right, so the application hematonic also should add the product of the promoting the circulation of blood of invigorating blood circulation, in the hope of being association of activity and inertia tonify without causing stagnation." (the reasonable use of tonic Chinese medicine, Golden Shield publishing house, July in 2000 the 1st edition, 38)
Summary of the invention
The purpose of this invention is to provide a kind of in the enriching yin and nourishing kidney process medicament of blood-supplementing blood-nourishing, blood circulation promoting and blood stasis dispelling simultaneously.
Solution of the present invention be based on motherland's medical science to suffer from a deficiency of the kidney, blood deficiency and pathogenetic understanding of Blood stasis and Therapeutic Principle, achieve with reference to modern pharmacological research, on the former side's of LIUWEI DIHUANG WAN basis, increase the medicament of the Chinese medicine preparation of blood-supplementing blood-nourishing, blood circulation promoting and blood stasis dispelling.
Radix Angelicae Sinensis is warm in nature, is the key medicine of enriching blood, disease such as be applicable to that shallow complexion, the dizzy body due to the heart-liver blood deficiency is tired, shortness of breath and palpitation, brothers' flaccidity are weak, and can nourshing blood and promoting blood circulation, blood fat reducing, it is then logical that dispersing cold for relieving pain, blood are lived, and general rule always is regarded as panacea in the blood not bitterly.The Radix Salviae Miltiorrhizae cold nature, the function blood circulation promoting and blood stasis dispelling, pain relieving is stimulated the menstrual flow, removing heat from blood, relieving restlessness is calmed the nerves, and can treat because of the caused various diseases of blood stasis, and the multiple disease of department of obstetrics and gynecology is had good efficacy, and Chinese medicine is referred to as that " Radix Salviae Miltiorrhizae simply, merit is with four things." thisly on the basis of LIUWEI DIHUANG WAN " three mend three rushes down ", increase the Radix Angelicae Sinensis of blood-supplementing blood-nourishing and medicament that the Radix Salviae Miltiorrhizae that rushes down (changes) stasis of blood of invigorating blood circulation is made, form " four benefits, four rehmannia preparations that rush down " of the present invention.
The specific embodiment
Medicine of the present invention is made by following component:
Radix Rehmanniae Preparata, Fructus Corni (system), Rhizoma Dioscoreae, Poria, Cortex Moutan, Rhizoma Alismatis, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae.
Raw material weight (part) ratio range of preparation medicine of the present invention is:
Radix Rehmanniae Preparata 4~16 Fructus Corni (system) 2~8 Rhizoma Dioscoreaes 2~8 Poria 1~6
Cortex Moutan 1~6 Rhizoma Alismatis 1~6 Radix Angelicae Sinensis 1~4 Radix Salviae Miltiorrhizae 1~4.
Formula optimization weight (part) ratio range of preparation medicine of the present invention is:
Radix Rehmanniae Preparata 6~10 Fructus Corni (system) 3~6 Rhizoma Dioscoreaes 3~6 Poria 2~4
Cortex Moutan 2~4 Rhizoma Alismatis 2~4 Radix Angelicae Sinensis 1~3 Radix Salviae Miltiorrhizae 1~3.
The optimum weight of medicine of the present invention (part) proportioning is:
Radix Rehmanniae Preparata 8 Fructus Corni (system) 4 Rhizoma Dioscoreaes 4 Poria 3
Cortex Moutan 3 Rhizoma Alismatis 3 Radix Angelicae Sinensis 2 Radix Salviae Miltiorrhizaes 2.
Can select for use equal quantity multiple to get material to each flavor Chinese medicine in above ratio with identical unit of weight.
Above-mentioned raw materials is adopted existing processing (comprising micronizing etc.) or extractive technique, in resulting machining object or extract, add conventional adjuvant, make dosage form said on any pharmaceutics, comprise the dosage form of various oral formulations or parenterai administration; Peroral dosage form comprises capsule, soft capsule, tablet, slow releasing tablet, effervescent tablet, pill, concentrated pill, honeyed pill, the watered pill, paste pill, drop pill, granule, nanometer, micropowder, microcapsule, micropill, oral liquid, syrup, extractum, soft extract; The parenterai administration dosage form comprises injection, membrane, aerosol.Medicine of the present invention causes the production technology difference because of the dosage form difference, resulting machining object and extract weight also have nothing in common with each other, and dose differs greatly, and can only calculate according to exsiccant primary crude drug weight at this, general consumption is to amount to every day raw medicinal herbs 8~20g, divides equally 2~3 times and takes.Write articles according to Cui Xin: " curative effect can improve in six drugs containing rehmanniae side after micronizing, reduce consumption, saves natural resources of Chinese medicinal materials.The dosage of ultrafine Chinese herb generally all has only 1/3 of present clinical prescription consumption, and what have can reach 1/5, and some big pharmaceutical factories are applied to the broken technology of the micropowder of Chinese medicine in the middle of the pharmacy, and its purpose reduces cost exactly and improves the quality." (Chinese Medicine: 2002.9.17,11 editions; 2002.11.5,11 editions.) therefore, the medicament with raw material of the present invention adopts superfine grinding method to prepare can reduce dose significantly.
From another angle, the present invention also is equivalent to the reusable hematonic Radix Paeoniae Alba in the 'Guishao Dihuang ball is used instead the Radix Salviae Miltiorrhizae of blood circulation promoting and blood stasis dispelling, more meets the principles of formulating prescriptions of the former side of LIUWEI DIHUANG WAN " invigorating middle warmer has and rushes down, and residence rushes down in mending ".
Clinical drug of the present invention uses the result to show that following advantage is arranged:
1, the user can obtain to enrich blood in enriching yin and nourishing kidney, nourishes blood, invigorates blood circulation, blood fat reducing, improve many-sided beneficial effects such as high blood coagulation state, mediation microcirculation, enhancing human body immunity power.Test statistics shows: with medicament of the present invention the patient of 100 deficiency of the liver and kindey, blood deficiency and blood stasis is done therapeutic test, that obtains significant curative effect accounts for 73%, substantially effectively accounts for 23%, and invalid accounts for 4%, and total effective rate reaches 96%.
2, each raw material among the present invention all is clinical treatment diabetes Chinese medicine commonly used, can bring into play the cooperative compensating potentiation by the compound recipe of their combinations, further improves the curative effect of treatment diabetes, can reduce or the diabetes-alleviating complication simultaneously.Therefore, four benefits, four rehmannia preparations that rush down of the present invention can be used for auxiliary treatment or prevent diabetes too.
LIUWEI DIHUANG WAN has been used hundreds of years, determined curative effect.But modern study finds that the Rhizoma Alismatis Herb in this medicine is poisonous, can cause multiple untoward reaction such as gastroenteritis, stomachache, diarrhoea, vomiting behind people's clothes; The nephrotoxicity that Rhizoma Alismatis causes can cause acute tubular necrosis; After eating, cattle causes poisoning, the performance hematuria.Motherland's medical science points out that for a long time Rhizoma Alismatis can not be obeyed many clothes for a long time.Because the effect of Rhizoma Alismatis in LIUWEI DIHUANG WAN be to rush down the kidney fire, can use the same Cortex Lycii that can rush down the kidney fire to substitute Rhizoma Alismatis (the applicant applies for a patent separately) in the LIUWEI DIHUANG WAN.Therefore, the raw material Rhizoma Alismatis among the present invention also can adopt Cortex Lycii to substitute, and the consumption of Cortex Lycii is identical with the Rhizoma Alismatis consumption.
Medicine of the present invention can adopt common process to be prepared into related preparations.Brief description part embodiment of the present invention:
Embodiment 1
Cortex Moutan, Fructus Corni, Poria powder are broken into fine powder, sieve, mixing.Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Cortex Lycii, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae decoct with water 3 times, and first and second time respectively is 2 hours, are 1 hour for the third time, collecting decoction filters, and filtrate is condensed into cream, with above-mentioned powder mixes, cold drying is pulverized, and adds right amount of auxiliary materials, mixing, make dried granule, dry again, promptly get a material agent.
Embodiment 2
Dried granule, drying, compacting that embodiment 1 obtains is in blocks, and coating makes tablet.
Embodiment 3
With the dried granule that embodiment 1 obtains, adopt routine to mould the method for making pill, drying, polishing makes concentrated pill.
Embodiment 4
Dried granule, drying with embodiment 1 obtains incapsulate, and promptly get capsule.
Embodiment 5
With each flavor Chinese medicine, be ground into fine powder, sieve mixing.Every 100g powder adds refined honey 35~50g and an amount of water, general ball, and drying is made water-honeyed pill; Or add refined honey 80~110g and make big honeyed pills or small honey pill.
Embodiment 6
With each flavor Chinese medicine drying, use pulverizing mill (Chinese medicine cell grade disintegrating apparatus) to become≤70 microns micropowder with comminution by gas stream, adopt common process to be prepared into the oral preparation of Denging, be mainly tablet, pill, capsule or oral liquid.
Claims (9)
1, a kind of four mends four rehmannia preparations that rush down, it is characterized in that it is the medicament that adds the feedstock production of blood-supplementing blood-nourishing and blood circulation promoting and blood stasis dispelling in LIUWEI DIHUANG WAN.
2, according to claim 1 four mend four rehmannia preparations that rush down, it is characterized in that it is the medicament of being made by the following weight proportion raw material:
Radix Rehmanniae Preparata 4~16 Fructus Corni (system) 2~8 Rhizoma Dioscoreaes 2~8 Poria 1~6
Cortex Moutan 1~6 Rhizoma Alismatis 1~6 Radix Angelicae Sinensis 1~4 Radix Salviae Miltiorrhizae 1~4.
3, according to claim 2 four mend four rehmannia preparations that rush down, wherein the weight proportion of each raw material is:
Radix Rehmanniae Preparata 6~10 Fructus Corni (system) 3~6 Rhizoma Dioscoreaes 3~6 Poria 2~4
Cortex Moutan 2~4 Rhizoma Alismatis 2~4 Radix Angelicae Sinensis 1~3 Radix Salviae Miltiorrhizae 1~3.
4, according to claim 2 four mend four rehmannia preparations that rush down, wherein the weight proportion of each raw material is:
Radix Rehmanniae Preparata 8 Fructus Corni (system) 4 Rhizoma Dioscoreaes 4 Poria 3
Cortex Moutan 3 Rhizoma Alismatis 3 Radix Angelicae Sinensis 2 Radix Salviae Miltiorrhizaes 2.
5, mend four rehmannia preparations that rush down according to claim 2,3 or 4 described four, it is characterized in that each raw material to be adopted existing processing or extractive technique and adding conventional adjuvant or excipient, make said dosage form on any pharmaceutics, comprise the dosage form of oral formulations or parenterai administration.
6, according to claim 5 four mend four rehmannia preparations that rush down, it is characterized in that described peroral dosage form comprises capsule, soft capsule, tablet, slow releasing tablet, effervescent tablet, pill, concentrated pill, honeyed pill, the watered pill, paste pill, drop pill, granule, nanometer, micropowder, microcapsule, micropill, oral liquid, syrup, extractum, soft extract; The parenterai administration dosage form comprises injection, membrane, aerosol.
7, mend the application of four rehmannia preparations that rush down in the medicine of preparation enriching yin and nourishing kidney, blood-supplementing blood-nourishing, blood circulation promoting and blood stasis dispelling according to claim 2,3 or 4 described four.
8, mend the application of four rehmannia preparations that rush down in the medicine of preparation auxiliary treatment or prevent diabetes according to claim 2,3 or 4 described four.
9, mend four rehmannia preparations that rush down according to claim 2,3 or 4 described four, it is characterized in that the Rhizoma Alismatis in its raw material to be used instead Cortex Lycii and substitute.
Priority Applications (1)
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CN 200510125261 CN1814125A (en) | 2005-02-05 | 2005-11-20 | Rehmannia-root preparation |
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CN200510052257.2 | 2005-02-05 | ||
CN200510052257 | 2005-02-05 | ||
CN200510096795.1 | 2005-09-02 | ||
CN 200510125261 CN1814125A (en) | 2005-02-05 | 2005-11-20 | Rehmannia-root preparation |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110840982A (en) * | 2019-12-17 | 2020-02-28 | 张家赫 | A pharmaceutical composition for treating hyperlipidemia and fatty liver and stabilizing plaque, and its preparation method |
CN113318181A (en) * | 2021-06-16 | 2021-08-31 | 江门市倬华科技有限公司 | Chinese patent medicine formula for relieving diabetes |
CN114099624A (en) * | 2020-08-26 | 2022-03-01 | 黄玉龙 | Chinese medicinal composition for treating, preventing or relieving diseases caused by microcirculation disturbance |
-
2005
- 2005-11-20 CN CN 200510125261 patent/CN1814125A/en active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110840982A (en) * | 2019-12-17 | 2020-02-28 | 张家赫 | A pharmaceutical composition for treating hyperlipidemia and fatty liver and stabilizing plaque, and its preparation method |
CN114099624A (en) * | 2020-08-26 | 2022-03-01 | 黄玉龙 | Chinese medicinal composition for treating, preventing or relieving diseases caused by microcirculation disturbance |
CN113318181A (en) * | 2021-06-16 | 2021-08-31 | 江门市倬华科技有限公司 | Chinese patent medicine formula for relieving diabetes |
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