CN1639335A - 通过导入notch基因将骨髓基质细胞诱导分化为神经细胞或骨骼肌细胞的方法 - Google Patents
通过导入notch基因将骨髓基质细胞诱导分化为神经细胞或骨骼肌细胞的方法 Download PDFInfo
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- A61K9/00—Medicinal preparations characterised by special physical form
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2501/42—Notch; Delta; Jagged; Serrate
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
- C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
- C12N2506/1353—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from bone marrow mesenchymal stem cells (BM-MSC)
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- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
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Abstract
Description
Claims (77)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002030003A JP3948971B2 (ja) | 2001-08-30 | 2002-02-06 | Notch遺伝子の導入を用いて骨髄間質細胞を神経細胞及び骨格筋細胞に分化・誘導する方法 |
JP30003/2002 | 2002-02-06 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200910147488XA Division CN101584869B (zh) | 2002-02-06 | 2003-02-06 | 通过导入notch基因将骨髓基质细胞诱导分化为神经细胞或骨骼肌细胞的方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1639335A true CN1639335A (zh) | 2005-07-13 |
CN100497621C CN100497621C (zh) | 2009-06-10 |
Family
ID=27677898
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB038055961A Expired - Lifetime CN100497621C (zh) | 2002-02-06 | 2003-02-06 | 通过导入notch基因将骨髓基质细胞诱导分化为神经细胞或骨骼肌细胞的方法 |
CN200910147488XA Expired - Lifetime CN101584869B (zh) | 2002-02-06 | 2003-02-06 | 通过导入notch基因将骨髓基质细胞诱导分化为神经细胞或骨骼肌细胞的方法 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200910147488XA Expired - Lifetime CN101584869B (zh) | 2002-02-06 | 2003-02-06 | 通过导入notch基因将骨髓基质细胞诱导分化为神经细胞或骨骼肌细胞的方法 |
Country Status (10)
Country | Link |
---|---|
US (7) | US7682825B2 (zh) |
EP (2) | EP1479767B1 (zh) |
CN (2) | CN100497621C (zh) |
AU (1) | AU2003207064B2 (zh) |
CA (1) | CA2475288C (zh) |
DK (1) | DK1479767T3 (zh) |
ES (1) | ES2431518T3 (zh) |
HK (2) | HK1078610A1 (zh) |
PT (1) | PT1479767E (zh) |
WO (1) | WO2003066856A1 (zh) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102027118A (zh) * | 2008-04-30 | 2011-04-20 | 桑比欧公司 | 含有dna甲基化状态改变的神经再生细胞 |
CN104797264A (zh) * | 2012-10-09 | 2015-07-22 | 桑比欧公司 | 用于治疗视网膜变性的方法和组合物 |
CN109718250A (zh) * | 2012-05-16 | 2019-05-07 | 桑比欧公司 | 用于治疗创伤性脑损伤和用于调节神经原性细胞迁移的方法和组合物 |
CN111793607A (zh) * | 2017-07-28 | 2020-10-20 | 杨涛 | 定向诱导hiPSC分化为神经细胞体系中培养神经元细胞的基础培养基 |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
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US7682825B2 (en) | 2002-02-06 | 2010-03-23 | Sanbio, Inc. | Differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells by introduction of notch gene |
US20050265983A1 (en) * | 2002-11-17 | 2005-12-01 | Eldad Melamed | Methods, nucleic acid constructs and cells for treating neurodegenerative disorders |
CA2520445A1 (en) * | 2003-03-25 | 2004-10-07 | Japan Science And Technology Agency | Induction of differentiation of stem cells, and control of differentiation potency of stem cells |
CA2562198C (en) | 2004-04-12 | 2017-05-30 | Sanbio Inc. | Cells exhibiting neuronal progenitor cell characteristics |
JP4581085B2 (ja) * | 2004-12-24 | 2010-11-17 | 国立大学法人京都大学 | 骨格筋細胞の分化誘導方法 |
AU2006220696B2 (en) * | 2005-03-07 | 2010-08-19 | Sanbio, Inc. | Use of neuronal precursor cells for treatment of central nervous system lesions |
GB0504881D0 (en) * | 2005-03-09 | 2005-04-13 | Univ Edinburgh | Directed neural differentiation |
US8248389B2 (en) * | 2005-03-23 | 2012-08-21 | Epos Development Ltd. | Method and system for digital pen assembly |
ES2524996T3 (es) | 2005-06-16 | 2014-12-16 | Ramot At Tel Aviv University Ltd. | Células aisladas y poblaciones que comprenden a las mismas para el tratamiento de enfermedades del SNC |
WO2008102460A1 (en) * | 2007-02-23 | 2008-08-28 | Sanbio Inc. | Transplantation of bone marrow stromal cell-induced neural stem cells for promoting fuctional recovery after spinal cord injury |
US8945919B2 (en) * | 2007-08-15 | 2015-02-03 | San Bio, Inc. | Methods and composition for treating neural degeneration |
US10702554B2 (en) * | 2007-12-03 | 2020-07-07 | Sanbio, Inc. | Extracellular matrix from pluripotent cells |
EP2985341B1 (en) | 2007-12-03 | 2020-04-01 | SanBio, Inc. | Methods and compositions for modulating differentiation of pluripotential cells |
DK2620493T3 (da) | 2008-05-28 | 2019-07-01 | Univ Ramot | Mesenkymale stamceller til behandling af CNS-sygdomme |
CA2772869A1 (en) * | 2009-06-10 | 2010-12-16 | Brainstem Biotec Ltd. | Methods, systems, and compositions for neuronal differentiation of multipotent stromal cells |
CN103547275B (zh) | 2011-04-06 | 2016-12-28 | 桑比欧公司 | 用于调节外周免疫功能的方法和组合物 |
US20120263681A1 (en) * | 2011-04-12 | 2012-10-18 | Fujifilm Corporation | Composition comprising cell and biocompatible polymer |
JP6023218B2 (ja) | 2012-01-27 | 2016-11-09 | サンバイオ,インコーポレイティド | 血管新生及び血管発生を調節するための方法及び組成物 |
US9803175B2 (en) | 2012-02-22 | 2017-10-31 | Exostem Biotec Ltd. | Generation of neural stem cells and motor neurons |
DK2880151T3 (da) | 2012-08-06 | 2020-08-17 | Brainstorm Cell Therapeutics Ltd | Fremgangsmåder til frembringelse af mesenkymale stemceller, som udskiller neurotrofiske faktorer |
JP5856029B2 (ja) * | 2012-08-31 | 2016-02-09 | 阿部 博幸 | 間葉系幹細胞を未分化増殖させる方法、および間葉系幹細胞を濃縮する方法 |
JP6628253B2 (ja) * | 2014-02-11 | 2020-01-08 | ブレインストーム セル セラペウティクス リミテッド | 細胞の適性を判定する方法 |
CN106663769B (zh) | 2014-05-13 | 2020-06-19 | 赛尔格有限责任公司 | 功能化的多孔膜及其制造和使用方法 |
WO2016161290A1 (en) | 2015-04-01 | 2016-10-06 | Sanbio, Inc. | Methods and compositions for stimulation of cell proliferation and provision of biologically active mixtures of fgf2 isoforms |
CN106399381B (zh) * | 2015-07-30 | 2019-11-26 | 中国农业大学 | miR-34c在体外诱导骨骼肌细胞分化中的应用 |
EP3487989B1 (en) | 2016-07-21 | 2022-05-18 | SanBio, Inc. | Msc growth predictor assays |
CA3047329A1 (en) | 2016-12-28 | 2018-07-05 | Sanbio, Inc. | Cell delivery system and methods of operation thereof |
EP3694985A1 (en) | 2017-10-13 | 2020-08-19 | IMBA-Institut für Molekulare Biotechnologie GmbH | Enhanced reprogramming of somatic cells |
AU2022282539A1 (en) * | 2021-05-27 | 2023-10-19 | Sanbio, Inc. | Cell therapies and methods of treatment for small-volume stroke |
Family Cites Families (18)
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US5226914A (en) * | 1990-11-16 | 1993-07-13 | Caplan Arnold I | Method for treating connective tissue disorders |
DE4138621A1 (de) * | 1991-11-25 | 1993-06-17 | Boehringer Ingelheim Int | Verfahren zum screenen von substanzen mit modulierender wirkung auf einen rezeptorabhaengigen zellulaeren signaluebertragungsweg |
US5591625A (en) * | 1993-11-24 | 1997-01-07 | Case Western Reserve University | Transduced mesenchymal stem cells |
US5780300A (en) * | 1995-09-29 | 1998-07-14 | Yale University | Manipulation of non-terminally differentiated cells using the notch pathway |
CN1524583A (zh) * | 1996-11-07 | 2004-09-01 | 能够表达Notch-配体的基因在制备用于免疫治疗的药物中的应用 | |
JP2002513545A (ja) * | 1998-05-07 | 2002-05-14 | ザ ユニヴァーシティー オブ サウス フロリダ | 脳および脊髄修復のためのニューロン源としての骨髄細胞 |
WO2000017326A1 (en) * | 1998-09-21 | 2000-03-30 | Musc Foundation For Research Development | Non-hematopoietic cells, including cardiomyocytes and skeletal muscle cells, derived from hematopoietic stem cells and methods of making and using them |
US7105150B2 (en) * | 1999-02-12 | 2006-09-12 | Stemcells California, Inc. | In vivo screening methods using enriched neural stem cells |
US7015037B1 (en) * | 1999-08-05 | 2006-03-21 | Regents Of The University Of Minnesota | Multiponent adult stem cells and methods for isolation |
US6555374B1 (en) * | 1999-08-19 | 2003-04-29 | Artecel Sciences, Inc. | Multiple mesodermal lineage differentiation potentials for adipose tissue-derived stromal cells and uses thereof |
WO2001022978A2 (en) * | 1999-09-30 | 2001-04-05 | Mcgill University | Autologous marrow stem cell (msc) transplantation for myocardial regeneration |
ES2292564T3 (es) | 2000-02-11 | 2008-03-16 | Philadelphia Health And Education Corporation | Diferenciacion de celulas de la medula osea en celulas neuronales y usos asociados. |
KR100449141B1 (ko) * | 2001-04-19 | 2004-09-21 | (주)라이프코드 | 간엽 간세포를 신경세포로 분화시키는 방법 |
US7682825B2 (en) | 2002-02-06 | 2010-03-23 | Sanbio, Inc. | Differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells by introduction of notch gene |
AU2006220696B2 (en) * | 2005-03-07 | 2010-08-19 | Sanbio, Inc. | Use of neuronal precursor cells for treatment of central nervous system lesions |
US8945919B2 (en) * | 2007-08-15 | 2015-02-03 | San Bio, Inc. | Methods and composition for treating neural degeneration |
EP2985341B1 (en) | 2007-12-03 | 2020-04-01 | SanBio, Inc. | Methods and compositions for modulating differentiation of pluripotential cells |
ES2594229T3 (es) * | 2008-04-30 | 2016-12-16 | Sanbio, Inc. | Células de regeneración nerviosa con alteraciones en la metilación del ADN |
-
2003
- 2003-02-06 US US10/503,816 patent/US7682825B2/en active Active
- 2003-02-06 EP EP03703224.0A patent/EP1479767B1/en not_active Expired - Lifetime
- 2003-02-06 PT PT37032240T patent/PT1479767E/pt unknown
- 2003-02-06 CN CNB038055961A patent/CN100497621C/zh not_active Expired - Lifetime
- 2003-02-06 CA CA2475288A patent/CA2475288C/en not_active Expired - Lifetime
- 2003-02-06 AU AU2003207064A patent/AU2003207064B2/en not_active Expired
- 2003-02-06 EP EP10179969A patent/EP2270146A1/en not_active Ceased
- 2003-02-06 ES ES03703224T patent/ES2431518T3/es not_active Expired - Lifetime
- 2003-02-06 DK DK03703224.0T patent/DK1479767T3/da active
- 2003-02-06 WO PCT/JP2003/001260 patent/WO2003066856A1/ja active Application Filing
- 2003-02-06 CN CN200910147488XA patent/CN101584869B/zh not_active Expired - Lifetime
-
2005
- 2005-11-18 HK HK05110355.3A patent/HK1078610A1/xx not_active IP Right Cessation
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2009
- 2009-09-10 US US12/584,657 patent/US8361456B2/en not_active Expired - Lifetime
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2010
- 2010-02-02 US US12/658,104 patent/US8133725B2/en not_active Expired - Fee Related
- 2010-05-14 HK HK10104703.8A patent/HK1139039A1/xx not_active IP Right Cessation
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2011
- 2011-09-15 US US13/233,701 patent/US8969078B2/en not_active Expired - Lifetime
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2013
- 2013-01-03 US US13/733,510 patent/US9399046B2/en active Active
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2016
- 2016-06-24 US US15/192,671 patent/US10196605B2/en not_active Expired - Lifetime
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2019
- 2019-01-07 US US16/241,802 patent/US11512284B2/en not_active Expired - Lifetime
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102027118A (zh) * | 2008-04-30 | 2011-04-20 | 桑比欧公司 | 含有dna甲基化状态改变的神经再生细胞 |
CN109718250A (zh) * | 2012-05-16 | 2019-05-07 | 桑比欧公司 | 用于治疗创伤性脑损伤和用于调节神经原性细胞迁移的方法和组合物 |
CN109718250B (zh) * | 2012-05-16 | 2022-08-30 | 桑比欧公司 | 用于治疗创伤性脑损伤和用于调节神经原性细胞迁移的方法和组合物 |
CN115381855A (zh) * | 2012-05-16 | 2022-11-25 | 桑比欧公司 | 用于治疗创伤性脑损伤和用于调节神经原性细胞迁移的方法和组合物 |
CN104797264A (zh) * | 2012-10-09 | 2015-07-22 | 桑比欧公司 | 用于治疗视网膜变性的方法和组合物 |
CN111793607A (zh) * | 2017-07-28 | 2020-10-20 | 杨涛 | 定向诱导hiPSC分化为神经细胞体系中培养神经元细胞的基础培养基 |
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HK1139039A1 (en) | 2010-09-10 |
EP1479767A1 (en) | 2004-11-24 |
US20060166362A1 (en) | 2006-07-27 |
US20100310523A1 (en) | 2010-12-09 |
US8133725B2 (en) | 2012-03-13 |
EP2270146A1 (en) | 2011-01-05 |
US20120009160A1 (en) | 2012-01-12 |
EP1479767A4 (en) | 2005-02-16 |
CN101584869B (zh) | 2013-03-27 |
US20100144034A1 (en) | 2010-06-10 |
US8969078B2 (en) | 2015-03-03 |
ES2431518T3 (es) | 2013-11-26 |
AU2003207064B2 (en) | 2006-07-13 |
CN100497621C (zh) | 2009-06-10 |
US9399046B2 (en) | 2016-07-26 |
DK1479767T3 (da) | 2013-11-25 |
CA2475288C (en) | 2014-09-02 |
WO2003066856A1 (en) | 2003-08-14 |
AU2003207064A1 (en) | 2003-09-02 |
US7682825B2 (en) | 2010-03-23 |
US8361456B2 (en) | 2013-01-29 |
US20160304835A1 (en) | 2016-10-20 |
US20130209428A1 (en) | 2013-08-15 |
PT1479767E (pt) | 2013-11-07 |
US11512284B2 (en) | 2022-11-29 |
CN101584869A (zh) | 2009-11-25 |
HK1078610A1 (en) | 2006-03-17 |
CA2475288A1 (en) | 2003-08-14 |
US10196605B2 (en) | 2019-02-05 |
US20160151418A9 (en) | 2016-06-02 |
EP1479767B1 (en) | 2013-08-21 |
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