CN1527943A - 过敏原微阵列分析 - Google Patents
过敏原微阵列分析 Download PDFInfo
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- CN1527943A CN1527943A CNA018167969A CN01816796A CN1527943A CN 1527943 A CN1527943 A CN 1527943A CN A018167969 A CNA018167969 A CN A018167969A CN 01816796 A CN01816796 A CN 01816796A CN 1527943 A CN1527943 A CN 1527943A
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- PZJJKWKADRNWSW-UHFFFAOYSA-N trimethoxysilicon Chemical group CO[Si](OC)OC PZJJKWKADRNWSW-UHFFFAOYSA-N 0.000 description 1
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
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Abstract
Description
反应性化学表面/玻片类型 | 生产 | 成本 | 结合能力 | 特异性 | 重复性 | 总体背景 | 检测极限 | 过敏原筛选 | 封闭/偶联 | 储存 |
ProteoBind | + | ++ | ++ | ++ | ++ | ++ | ++ | ++ | 否 | - |
CEL(1) | / | ++ | ++ | ++ | - | - | + | ++ | 是 | ++ |
3D-Link(2) | / | -- | ++ | ++ | + | + | + | - | 是 | - |
Superaldehyde(1) | / | -- | + | + | ++ | - | + | + | 是 | ++ |
Aminosifane(3) | + | ++ | + | + | -- | - | + | + | 否 | ++ |
乙二醛 | - | + | ++ | ++ | -- | - | + | ++ | 是 | ++ |
EGS(3) | - | +/- | ++ | ++ | -- | - | + | + | 否 | - |
Sulfo KMUS(3) | - | +/- | ++ | + | / | - | / | / | 否 | / |
Glutaraldehyde(3) | - | +/- | / | / | -- | - | / | / | / | ++ |
光交联剂(3) | - | +/- | + | + | / | - | / | / | / | / |
PEI/EGS(3) | - | -- | ++ | + | + | + | / | / | / | / |
FAST玻片(4) | / | -- | + | -- | - | -- | -- | -- | 否 | ++ |
CAST玻片(4) | / | -- | + | + | + | -- | -- | -- | 是 | ++ |
未修饰玻璃 | + | ++ | - | / | -- | ++ | -- | / | / | / |
图表1 | 血清1-Sp | 血清4-Sp | 血清19-Sp | 血清30-Sp |
Bet v1a | 52028 | 62529 | 62932 | 18847 |
Bet v1a Mut | 6590 | 237 | 905 | 139 |
Bet v1d | 1576 | 14352 | 252 | 89 |
Bet v2 | 2196 | 1408 | 273 | 1253 |
BP-提取物 | 21013 | 39438 | 11390 | 3174 |
图表2 | 血清5-Sp | 血清7-Sp | 血清9-Sp | 血清17-Sp | 血清18-sp | 血清40-Sp |
Phl pI | 45611 | 12148 | 21588 | 5838 | 23497 | 23424 |
Phl pII | 209 | 52043 | 814 | 2562 | 10984 | 14753 |
Phl pV | 64005 | 63481 | 62953 | 40770 | 63530 | 62029 |
Phl-提取物 | 63987 | 40318 | 14504 | 10183 | 44405 | 19798 |
图表3 | 血清11-Sp | 血清16-Sp | 血清39-sp | 血清40-Sp |
Hev b3 | 416 | 387 | 108 | 235 |
Hev b5-Mal | 350 | 519 | 30601 | 63897 |
Hev b8 | 11146 | 7977 | 134 | 853 |
Hev b9 | 460 | 631 | 105 | 188 |
Hev b10 | 360 | 429 | 73 | 152 |
乳胶B-提取物 | 264 | 202 | 80 | 3426 |
乳胶C-提取物 | 769 | 866 | 5343 | 30970 |
Claims (37)
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Application Number | Priority Date | Filing Date | Title |
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EP00890296A EP1195606A1 (en) | 2000-10-03 | 2000-10-03 | Allergen-microarray assay |
EP00890296.7 | 2000-10-03 |
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CN1527943A true CN1527943A (zh) | 2004-09-08 |
CN1325919C CN1325919C (zh) | 2007-07-11 |
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CNB018167969A Expired - Lifetime CN1325919C (zh) | 2000-10-03 | 2001-10-03 | 过敏原微阵列分析 |
Country Status (21)
Country | Link |
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US (2) | US20050101031A1 (zh) |
EP (2) | EP1195606A1 (zh) |
CN (1) | CN1325919C (zh) |
AT (1) | ATE286597T1 (zh) |
AU (2) | AU1230602A (zh) |
BR (1) | BRPI0114343B8 (zh) |
CA (1) | CA2424661C (zh) |
CZ (1) | CZ305183B6 (zh) |
DE (1) | DE60108256T3 (zh) |
DK (1) | DK1322960T4 (zh) |
EE (1) | EE05465B1 (zh) |
ES (1) | ES2234909T5 (zh) |
HK (1) | HK1066276A1 (zh) |
HU (1) | HU228066B1 (zh) |
MX (1) | MXPA03002750A (zh) |
PT (1) | PT1322960E (zh) |
RU (1) | RU2276790C2 (zh) |
SI (1) | SI1322960T2 (zh) |
SK (1) | SK286541B6 (zh) |
WO (1) | WO2002029415A1 (zh) |
ZA (1) | ZA200302172B (zh) |
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CN108802399A (zh) * | 2017-04-28 | 2018-11-13 | 中国医学科学院基础医学研究所 | 一种检测过敏原的新型蛋白质芯片 |
CN109196361A (zh) * | 2016-03-30 | 2019-01-11 | 宏阵列诊断有限责任公司 | 抗原阵列 |
CN109804247A (zh) * | 2016-07-08 | 2019-05-24 | 拜尔梅里科有限公司 | 抑郁症敏感测试的组合物、设备以及方法 |
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KR101490377B1 (ko) * | 2008-05-08 | 2015-02-05 | 삼성전자주식회사 | 알레르기 질환 진단용 표면탄성파 센서 및 상기 센서를이용한 알레르기 질환 진단방법 |
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CN103454412B (zh) * | 2013-09-16 | 2015-02-18 | 南京博敏达生物科技有限公司 | 一种用于过敏原特异性抗体检测的液相芯片及其制备方法 |
CN103675271A (zh) * | 2013-12-23 | 2014-03-26 | 北京新华联协和药业有限责任公司 | 过敏性疾病变应原胶体金诊断试纸条及其制备方法 |
CN109196361A (zh) * | 2016-03-30 | 2019-01-11 | 宏阵列诊断有限责任公司 | 抗原阵列 |
CN109196361B (zh) * | 2016-03-30 | 2021-12-07 | 宏阵列诊断有限责任公司 | 抗原阵列 |
US11740232B2 (en) | 2016-03-30 | 2023-08-29 | Macroarray Diagnostics Gmbh | Antigen array |
CN109804247A (zh) * | 2016-07-08 | 2019-05-24 | 拜尔梅里科有限公司 | 抑郁症敏感测试的组合物、设备以及方法 |
CN108802399A (zh) * | 2017-04-28 | 2018-11-13 | 中国医学科学院基础医学研究所 | 一种检测过敏原的新型蛋白质芯片 |
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