CN1456254A - Preparation of immunoregulation effervescent tablets - Google Patents
Preparation of immunoregulation effervescent tablets Download PDFInfo
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- CN1456254A CN1456254A CN 03118653 CN03118653A CN1456254A CN 1456254 A CN1456254 A CN 1456254A CN 03118653 CN03118653 CN 03118653 CN 03118653 A CN03118653 A CN 03118653A CN 1456254 A CN1456254 A CN 1456254A
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- sodium bicarbonate
- citric acid
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- effervescent
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Abstract
A process for preparing Chinese medicine "Guyuan effervescent particles" for treating the immune and hematopoiesis disfunctions caused by chemicotherapy and radiotherapy includes such steps as pulverizing ginseng and reed rhizome, adding astragalus polyose, effervescent agent and additive, mixing, and granulating. Its advantages are high curative effect and safety.
Description
Technical field
This invention relates to the processing technology technical field of Chinese patent medicine effervescent granule, relates in particular to the preparation method of primordial QI reinforcing effervescent granule.
Background technology
Effervescent granule is a kind of new form of Chinese drug, according to the relevant drug act of China, changes dosage form as a kind of new drug research, and former dosage form primordial QI reinforcing sheet has been listed in the 20th of the Drug Standard of Ministry of Public Health of the Peoples Republic of China " Chinese traditional patent formulation preparation ".The technology of former dosage form is: Rhizoma Ginseng is ground into fine powder, adds astragalus polysaccharides and appropriate amount of auxiliary materials, and mixing is granulated, tabletting, and sugar coating forms.This tablets dosage is bigger, and dysphagia to the empty senior people of body is especially.The quality standard of controlling product quality simultaneously is lower, and based on the shortcoming that exists in the tablet, we use the modern pharmaceutical technology this product technology is made significant improvement, form new preparation, guarantee the quality monitoring of product, improves drug effect, benefits the common people.
Summary of the invention
The preparation method that the purpose of this invention is to provide a kind of primordial QI reinforcing effervescent granule is improved the quality of products and curative effect, increases the stability of product, satisfies needs of medical treatment better.
The objective of the invention is such realization:
The preparation method of primordial QI reinforcing effervescent granule comprises the steps:
One, the prescription of primordial QI reinforcing effervescent granule is formed
Astragalus polysaccharides 450～850g Rhizoma Ginseng 120～230g
Right amount of auxiliary materials is made 1000 bags altogether.
Its optimum formula is:
Astragalus polysaccharides 650g Rhizoma Ginseng 167g
Right amount of auxiliary materials is made 1000 bags altogether.
Two, primordial QI reinforcing effervescent granule preparation technology
Technology one cleans Rhizoma Ginseng, removes impurity, and it is standby to be up to the standards; Get Rhizoma Ginseng and be ground into fine powder, add astragalus polysaccharides and effervescent and reach the appropriate amount of auxiliary materials mixed pelletization in right amount, drying, packing, quality inspection, packing, promptly.
Three, prepared by above-mentioned technology is effervescent granule.
Added adjuvant can be in the technology: 30 POVIDONE K 30 BP/USP
30, any or multiple mixing in the micropowder silica gel, starch, dextrin, Aspartane, magnesium stearate, essence uses.
Rhizoma Ginseng is ground into fine powder and is generally 80～160 purpose fine powders in the technology, and preferably superfine powder is broken into 200～300 order fine powders.
The preparation of astragalus polysaccharides in the prescription: get the Radix Astragali and decoct with water 2～3 times, each 1～3 hour, collecting decoction filtered, and filtrate is concentrated into fluid extract, added 3～6 times of amount ethanol and left standstill, and filtered, and got and was deposited in 50～80 ℃ of dryings, promptly.The best is: decocts with water 3 times, and 3 hours for the first time, second and third time each 2 hours, the ethanol that adds 5 times of amounts leaves standstill, and is deposited in 60 ℃ of dryings.
The temperature of particle drying is controlled at 50～80 ℃ in the technology, is preferably 60 ℃.
The acid source of effervescent is a kind of or two kinds in citric acid, tartaric acid, the fumaric acid in the technology, and carbon dioxide source is a kind of in sodium carbonate, sodium bicarbonate, the potassium carbonate or two kinds; Be preferably citric acid and sodium bicarbonate, its ratio is a sodium bicarbonate: citric acid is 0.8～1.1: 1.2～1.5, and getting is 1.0: 1.3, and consumption is that sodium bicarbonate is 3～10%, and citric acid is 5～15%, is preferably sodium bicarbonate 6%, and citric acid is 8%.
This invention its superiority compared with the prior art is: production technology more becomes to improving rationally, has overcome the big deficiency of tablets amount, and quality standard increases again, makes product that the qualitative, quantitative control method of science be arranged, and makes the quality of product that guarantee arranged.The quality control of this product mainly is discriminating, inspection, three aspects of assay.On differentiating, former dosage form is carried out the thin layer discriminating to Rhizoma Ginseng, is now kept.Increased heavy metal limit and must not cross 10/1000000ths on checking, arsenic salt must not cross 2/1000000ths; On assay, Rhizoma Ginseng has been carried out quantitatively.
The specific embodiment
The optimum implementation of this invention is that Rhizoma Ginseng is cleaned, and removes impurity, and it is standby to be up to the standards; Getting the Rhizoma Ginseng superfine powder, to be broken into 200～300 order fine powders standby.The Radix Astragali decocts with water 2～3 times, and each 1～3 hour, collecting decoction filtered, and filtrate is concentrated into fluid extract, adds 3～6 times of amount ethanol and leaves standstill, and filters, and gets and is deposited in 50～80 ℃ of dryings, promptly gets astragalus polysaccharides.The best is: decocts with water 3 times, and 3 hours for the first time, second and third time each 2 hours, the ethanol that adds 5 times of amounts leaves standstill, and is deposited in 60 ℃ of dryings.Add effervescent citric acid and sodium bicarbonate, its ratio is a sodium bicarbonate: citric acid is 0.8～1.1: 1.2～1.5, and getting is 1.0: 1.3, and consumption is that sodium bicarbonate is 3～10%, and citric acid is 5～15%, is preferably sodium bicarbonate 6%, and citric acid is 8%.Add the appropriate amount of auxiliary materials mixed pelletization, drying, packing, quality inspection, packing, promptly.
Claims (2)
1, the preparation method of primordial QI reinforcing effervescent granule is characterized in that it may further comprise the steps:
(1) added adjuvant can be in the technology: 30 POVIDONE K 30 BP/USP
30, any/multiple mixing in the micropowder silica gel, starch, dextrin, Aspartane, magnesium stearate, essence uses.
(2) Rhizoma Ginseng is ground into fine powder and is generally 80～160 purpose fine powders in the technology, and preferably superfine powder is broken into 200～300 order fine powders.
(3) preparation of astragalus polysaccharides in the prescription: get the Radix Astragali and decoct with water 2～3 times, each 1～3 hour, collecting decoction filtered, and filtrate is concentrated into fluid extract, added 3～6 times of amount ethanol and left standstill, and filtered, and got and was deposited in 50～80 ℃ of dryings, promptly.The best is: decocts with water 3 times, and 3 hours for the first time, second and third time each 2 hours, the ethanol that adds 5 times of amounts leaves standstill, and is deposited in 60 ℃ of dryings.
(4) temperature of particle drying is controlled at 50～80 ℃ in the technology, is preferably 60 ℃.
(5) acid source of effervescent is a kind of in citric acid, tartaric acid, the fumaric acid/two kind in the technology, and carbon dioxide source is a kind of/two kind in sodium carbonate, sodium bicarbonate, the potassium carbonate; Be preferably citric acid and sodium bicarbonate, its ratio is a sodium bicarbonate: citric acid is 0.8～1.1: 1.2～1.5, and getting is 1.0: 1.3, and consumption is that sodium bicarbonate is 3～10%, and citric acid is 5～15%, is preferably sodium bicarbonate 6%, and citric acid is 8%.
(6) with (1), (2), (3), (4), (5) standby composition, by national standard prescription the requirements mixing that feeds intake, granulation, drying, a primordial QI reinforcing effervescent material is made in packing.
2, the preparation method of primordial QI reinforcing effervescent granule according to claim 1, it is characterized in that on quality control standard, must not crossing 10/1000000ths to heavy metal, arsenic salt must not be crossed 2/1000000ths limit examine, on assay Rhizoma Ginseng has been carried out quantitatively.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03118653 CN1456254A (en) | 2003-02-20 | 2003-02-20 | Preparation of immunoregulation effervescent tablets |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03118653 CN1456254A (en) | 2003-02-20 | 2003-02-20 | Preparation of immunoregulation effervescent tablets |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1456254A true CN1456254A (en) | 2003-11-19 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03118653 Pending CN1456254A (en) | 2003-02-20 | 2003-02-20 | Preparation of immunoregulation effervescent tablets |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1294918C (en) * | 2004-05-08 | 2007-01-17 | 郭东宇 | Effervesce tablet of ginseng |
| CN105168280A (en) * | 2015-08-28 | 2015-12-23 | 浙江维康药业股份有限公司 | Antitumor microsomes capsule capable of consolidating basis |
-
2003
- 2003-02-20 CN CN 03118653 patent/CN1456254A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1294918C (en) * | 2004-05-08 | 2007-01-17 | 郭东宇 | Effervesce tablet of ginseng |
| CN105168280A (en) * | 2015-08-28 | 2015-12-23 | 浙江维康药业股份有限公司 | Antitumor microsomes capsule capable of consolidating basis |
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