CN1456214A - Preparing method for cough curing pills - Google Patents
Preparing method for cough curing pills Download PDFInfo
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- CN1456214A CN1456214A CN 03118494 CN03118494A CN1456214A CN 1456214 A CN1456214 A CN 1456214A CN 03118494 CN03118494 CN 03118494 CN 03118494 A CN03118494 A CN 03118494A CN 1456214 A CN1456214 A CN 1456214A
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Abstract
A Chinese medicine "Kechuan tablet" for treating cough and asthma is prepared from 7 Chinese-medicinal materials through decocting ephedra and poppy capsule in acidic water and neutralizing with alkali, pulverizing others and decocting twice, mixing them together, concentrating, mixing with additive, tabletting and coating.
Description
Technical field
This invention relates to the processing technology technical field of Chinese patent medicine tablet, relates in particular to the preparation method of cough-relieving tablets.
Background technology
Tablet is a kind of pharmaceutical formulation commonly used, according to the relevant drug act of China, changing dosage form needs as a kind of new drug research, and the original dosage form of cough-relieving tablets is a KEKE JIAONANG, and has listed Drug Standard of Ministry of Public Health of the Peoples Republic of China (in " Chinese traditional patent formulation preparation " the 17) in.The major defect of former dosage form does not have quantitative target in its quality standard, thereby has the significant drawbacks that influences product quality.Have significant drawback on the quality control based on capsule, we use the modern pharmaceutical technology and mirror survey means are done necessary improvement to this product processes, thereby and the quality of product carried out overall monitor guarantee product quality, benefit the common people.
Summary of the invention
The purpose of this invention is to provide a kind of preparation method of cough-relieving tablets, improve the quality of products, satisfy needs of medical treatment better.
The objective of the invention is such realization:
The preparation method of cough-relieving tablets comprises the steps:
One, the prescription of cough-relieving tablets is formed:
Herba Ephedrae 240g～360g Pericarpium Papaveris 240g～360g Radix Glycyrrhizae 240g～360g
Semen Armeniacae Amarum 240g～360g Semen Raphani 75g～112.5g Radix Platycodonis 75g～112.5g
Gypsum Fibrosum 75g～112.5g right amount of auxiliary materials makes 1000 altogether.
Its optimum formula is:
Herba Ephedrae 360g Pericarpium Papaveris 360g Radix Glycyrrhizae 360g Semen Armeniacae Amarum 360g
Semen Raphani 112.5g Radix Platycodonis 112.5g Gypsum Fibrosum 112.5g
Right amount of auxiliary materials is made 1000 altogether.
Two, cough-relieving tablets preparation technology
Technology one, the seven flavor medicine material is cleaned respectively, remove impurity, it is standby to be up to the standards; Get Herba Ephedrae and Pericarpium Papaveris is ground into fine powder, sieve, respectively stay fine powder 165g standby, the residue fine powder decocts secondary with acidic aqueous solution (with about 10% hydrochloric acid solution adjust pH to 5), each 2 hours, filters, filtrate is with 10% sodium hydroxide solution adjust pH to 7, and medicinal liquid is standby; All the other Radix Glycyrrhizaes, Semen Armeniacae Amarum, Semen Raphani, Radix Platycodonis, Gypsum Fibrosum five tastes medical material are ground into coarse powder and decoct with water secondary, each 1 hour, filter, filtrate and above-mentioned solution merge, being concentrated into relative density is the thick paste of 1.25～1.35 (60 ℃), adds Herba Ephedrae and Pericarpium Papaveris fine powder and appropriate amount of auxiliary materials, mixing, granulate, drying, tabletting, coating, quality inspection, packing promptly.
Technology two, the seven flavor medicine material is cleaned respectively, remove impurity, it is standby to be up to the standards; Get Herba Ephedrae and Pericarpium Papaveris and be ground into coarse powder and decoct secondary with acidic aqueous solution (with about 10% hydrochloric acid solution adjust pH to 5), each 2 hours, filtration, filtrate is with 10% sodium hydroxide solution adjust pH to 7, and medicinal liquid is standby; All the other Radix Glycyrrhizaes, Semen Armeniacae Amarum, Semen Raphani, Radix Platycodonis, Gypsum Fibrosum five tastes medical material are ground into coarse powder and decoct with water secondary, each 1 hour, filter, filtrate and above-mentioned solution merge, and being concentrated into relative density is the concentrated solution of 1.05～1.15 (50 ℃), spray drying, collect dried cream powder, add appropriate amount of auxiliary materials, mixing, granulate, drying, tabletting, coating, quality inspection, packing promptly.
Three, by technology one, two prepared coated tablet, be Film coated tablets, its film-coat material all adopts stomach dissolution type film-coat pre-mixing agent (Opadry).Added adjuvant can be microcrystalline Cellulose, polyvinylpolypyrrolidone, carboxymethylstach sodium, 30 POVIDONE K 30 BP/USP in the prescription
30, any or multiple mixing in the micropowder silica gel, low-substituted hydroxypropyl cellulose, starch, dextrin, magnesium stearate uses.
The technology Chinese crude drug is ground into coarse powder and was generally 5～20 order coarse powder, is preferably 10 order coarse powder.
It was 80～160 purpose fine powders that the technology Chinese crude drug is ground into fine powder, and the best is that superfine powder is broken into 200～300 order fine powders.
In the technology, the relative density of thick paste is 1.20～1.35 (60 ℃), best relative density 1.28～1.30 (60 ℃).
In the technology, the relative density of concentrated solution is 1.05～1.15 (50 ℃), and best relative density is 1.10 (50 ℃).
In the technology, the spray drying inlet temperature is 100～200 ℃, and leaving air temp is 50～150 ℃, and best inlet temperature is 160 ℃, and leaving air temp is 100 ℃.
The particulate baking temperature in back of granulating in the technology should be controlled at 60-80 ℃, preferably is controlled at 60-65 ℃.
Its quality control mainly is: inspection, qualitative, quantitative three aspects, heavy metal and arsenic salt are carried out limit examine on request, and be controlled at disintegrate in 10 minutes, and prescription epheday intermedia, Radix Glycyrrhizae thin layer are differentiated on the basis, increased the thin layer of Pericarpium Papaveris, Radix Platycodonis has been differentiated; And the ephedrine in the Herba Molluginis Pentaphyllae is quantitative.
This invention its superiority compared with the prior art is: production technology more becomes fully rationally, quality standard improves greatly, makes product that the qualitative, quantitative control method of science be arranged, and makes the quality of product that guarantee arranged.The tablet disintegration rate is fast, easily absorbs the performance drug effect.
The specific embodiment
The optimum implementation of this invention is that the seven flavor medicine material is cleaned respectively, removes impurity, and it is standby to be up to the standards; Get Herba Ephedrae and Pericarpium Papaveris and be ground into coarse powder and decoct secondary with acidic aqueous solution (with about 10% hydrochloric acid solution adjust pH to 5), each 2 hours, filtration, filtrate is with 10% sodium hydroxide solution adjust pH to 7, and medicinal liquid is standby; All the other Radix Glycyrrhizaes, Semen Armeniacae Amarum, Semen Raphani, Radix Platycodonis, Gypsum Fibrosum five tastes medical material are ground into coarse powder and decoct with water secondary, each 1 hour, filter, filtrate and above-mentioned solution merge, and being concentrated into relative density is the concentrated solution of 1.05～1.15 (50 ℃), spray drying, collect dried cream powder, add appropriate amount of auxiliary materials, mixing, granulate, drying, tabletting, coating, quality inspection, packing promptly.
Claims (1)
1, the preparation method of cough-relieving tablets is characterized in that it may further comprise the steps:
(1) prescription epheday intermedia and Pericarpium Papaveris partly was ground into 80-160 purpose fine powder, and it is standby that the best is that superfine powder is broken into 200～300 purpose fine powders.Part was ground into 5～20 order coarse powder, preferably crossed 10 order coarse powder and decocted secondary with acidic aqueous solution, and it is standby that decocting liquid transfers to neutral medicinal liquid with alkali.
(2) all the other Radix Glycyrrhizaes, Semen Armeniacae Amarum, Semen Raphani, Radix Platycodonis, the Gypsum Fibrosum five tastes medical material in the prescription was ground into 5～20 order coarse powder, preferably be ground into 10 purpose coarse powder, the water decoction that decocts with water secondary decoct with above-mentioned sour water and with alkali transfer to neutral medicinal liquid merge the back reconcentration and become the thick paste of relative density 1.20～1.35 (60 ℃) standby/that the fluid extract that is condensed into relative density 1.05～1.15 (60 ℃) is spray dried to dried cream powder is standby.
(3) added adjuvant can be microcrystalline Cellulose, polyvinylpolypyrrolidone, carboxymethylstach sodium, 30 POVIDONE K 30 BP/USP in the prescription
30, any also multiple mixing in the micropowder silica gel, low-substituted hydroxypropyl cellulose, starch, dextrin, magnesium stearate uses.
(4) the particulate baking temperature in granulation back should be controlled at 60-80 ℃, preferably is controlled at 60-65 ℃.
(5) coating material of tablet adopts stomach dissolution type film-coat pre-mixing agent (Opadry).
(6) (1), (2), (3), (4), (5) standby composition are fed intake by national standard prescription consumption, mixing, tabletting, coating are made cough-relieving tablets.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03118494 CN1456214A (en) | 2003-01-16 | 2003-01-16 | Preparing method for cough curing pills |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03118494 CN1456214A (en) | 2003-01-16 | 2003-01-16 | Preparing method for cough curing pills |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1456214A true CN1456214A (en) | 2003-11-19 |
Family
ID=29411307
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03118494 Pending CN1456214A (en) | 2003-01-16 | 2003-01-16 | Preparing method for cough curing pills |
Country Status (1)
| Country | Link |
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| CN (1) | CN1456214A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101904918A (en) * | 2010-07-27 | 2010-12-08 | 海南新中正制药有限公司 | Cough-relieving tablets and preparation method thereof |
| CN102210748A (en) * | 2011-06-02 | 2011-10-12 | 中山市中智药业集团有限公司 | Preparation method of Keke preparation |
| CN101474270B (en) * | 2008-01-05 | 2011-11-30 | 中山市恒生药业有限公司 | Keke tablets |
| CN106987883A (en) * | 2017-05-16 | 2017-07-28 | 广东伟业铝厂集团有限公司 | A kind of Aluminum Coloring water wash system |
| CN107714776A (en) * | 2017-10-23 | 2018-02-23 | 贵州拜特制药有限公司 | A kind of preparation method of relieving cough and relieving asthma preparation |
-
2003
- 2003-01-16 CN CN 03118494 patent/CN1456214A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101474270B (en) * | 2008-01-05 | 2011-11-30 | 中山市恒生药业有限公司 | Keke tablets |
| CN101904918A (en) * | 2010-07-27 | 2010-12-08 | 海南新中正制药有限公司 | Cough-relieving tablets and preparation method thereof |
| CN102210748A (en) * | 2011-06-02 | 2011-10-12 | 中山市中智药业集团有限公司 | Preparation method of Keke preparation |
| CN102210748B (en) * | 2011-06-02 | 2013-01-02 | 中山市中智药业集团有限公司 | Preparation method of Keke preparation |
| CN106987883A (en) * | 2017-05-16 | 2017-07-28 | 广东伟业铝厂集团有限公司 | A kind of Aluminum Coloring water wash system |
| CN107714776A (en) * | 2017-10-23 | 2018-02-23 | 贵州拜特制药有限公司 | A kind of preparation method of relieving cough and relieving asthma preparation |
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| C12 | Rejection of a patent application after its publication | ||
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