CN1456231A - Preparation of cold and numbness eliminating pills - Google Patents
Preparation of cold and numbness eliminating pills Download PDFInfo
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- CN1456231A CN1456231A CN 03118616 CN03118616A CN1456231A CN 1456231 A CN1456231 A CN 1456231A CN 03118616 CN03118616 CN 03118616 CN 03118616 A CN03118616 A CN 03118616A CN 1456231 A CN1456231 A CN 1456231A
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Abstract
A process for preparing Chinese medicine "Hanbiting capsule" includes such steps as pulverizing 5 Chinese-medicinal materials including vomiting nut, pulverizing another 5 Chinese-medicinal materials including rehmannia root and decocting to extract volatile oil, mixing volatile with with cyclodextrin, concentrating the decoction and spray drying, mixing all together, adding additive, and loading in capsules.
Description
Technical field
This invention relates to the processing technology technical field of Chinese patent medicine capsule, relates in particular to arthralgia due to cold and stops capsular preparation method.
Background technology
Capsule is a kind of pharmaceutical formulation commonly used, according to the relevant drug act of China, changes dosage form as a kind of new drug research, and arthralgia due to cold is stopped capsular original dosage form and is: arthralgia due to cold is stopped sheet.Arthralgia due to cold is stopped sheet and has been listed in the 10th of the Drug Standard of Ministry of Public Health of the Peoples Republic of China " Chinese traditional patent formulation preparation ".The technology features of former dosage form is that the ground spices such as Semen Strychni in the prescription are broken into fine powder, and with the thick paste of five tastes decocting in water such as all the other Radix Rehmanniae, mixed pelletization, tabletting forms.There is the loss of volatile oil component in the processing technology and the quality standard controlling index significant drawbacks that influences quality such as low in this tablet.Have the significant drawback that influences quality based on tablet, we use the modern pharmaceutical technology this product technology are done certain improvement, form new preparation, and the standard of comprehensively improving the quality of products, and guarantee the quality monitoring of product, to improve drug effect, benefit the common people.
Summary of the invention
The purpose of this invention is to provide a kind of arthralgia due to cold and stop capsular preparation method, improve the quality of products and curative effect, increase the stability of product, satisfy needs of medical treatment better.
The objective of the invention is such realization:
Arthralgia due to cold is stopped capsular preparation method and is comprised the steps:
One, arthralgia due to cold is stopped capsular prescription composition
Semen Strychni (system) 30-100g Olibanum (system) 15-40g Myrrha (processed) 15-40g
Radix Rehmanniae 300-600g Caulis Sinomenii 300-600g Radix Aconiti Preparata 30-60g
Herba Epimedii 60-120g Radix Aconiti Kusnezoffii Preparata 30-60g Semen Coicis 30-60g
Zaocys 60-120g
Right amount of auxiliary materials is made 1000 altogether.
Its optimum formula is:
Semen Strychni (system) 50g Olibanum (system) 26g Myrrha (processed) 26g
Radix Rehmanniae 400g Caulis Sinomenii 300g Radix Aconiti Preparata 40g
Herba Epimedii 80g Radix Aconiti Kusnezoffii Preparata 40g Semen Coicis 30g
Zaocys 80g
Right amount of auxiliary materials is made 1000 altogether.
Two, arthralgia due to cold is stopped capsules preparation technique
Technology one cleans ten flavor medicines respectively, removes impurity, and it is standby to be up to the standards.Semen Strychni, Zaocys, Olibanum, Myrrha, Semen Coicis mixed powder are broken into fine powder, and be standby; The five tastes such as all the other Radix Rehmanniae decoct with water secondary, 3 hours for the first time, 2 hours for the second time, filter merging filtrate, left standstill 24 hours, and got the clear paste that supernatant concentration to relative density is 1.30 (90 ℃), add fine powder and appropriate amount of auxiliary materials, mixing, drying, pulverize, encapsulated, quality inspection, packing, promptly.
Technology two cleans ten flavor medicines respectively, removes impurity, and it is standby to be up to the standards.Semen Strychni, Zaocys, Olibanum, Myrrha, Semen Coicis mixed powder are broken into fine powder, and be standby; Five tastes mixed powders such as all the other Radix Rehmanniae are broken into coarse powder and add water and steam and to carry secondary, and it is standby to collect volatile oil and water boiling liquid; Merge the secondary water boiling liquid, centrifugal, the clear liquid thin film concentration is to the concentrated solution of relative density 1.05-1.15 (60 ℃), spray drying, and it is standby to collect dried cream powder; Above-mentioned volatile oil adds an amount of cyclodextrin, and to make the cyclodextrin of volatile oil clathrate standby or become the volatile oil alcoholic solution standby with an amount of dissolve with ethanol; Get above-mentioned fine powder and dried cream powder and above-mentioned cyclodextrin of volatile oil clathrate or volatile oil alcoholic solution and appropriate amount of auxiliary materials mixing, encapsulated, quality inspection, packing, promptly.
The technology Chinese crude drug is ground into fine powder, is generally to be ground into 80-160 purpose fine powder, and the best is that superfine powder is broken into 200-300 purpose fine powder.
Need be ground into the medical material of coarse powder in the technology, generally be ground into 5-20 purpose coarse powder, preferably be ground into 10 purpose coarse powder.
Cyclodextrin of volatile oil clathrate preparation in the technology: cyclodextrin can adopt a kind of in beta-schardinger dextrin-, the hydroxyl beta-schardinger dextrin-, the ratio of volatile oil and beta-schardinger dextrin-is: 1: 5-15 (ml/g), optimal proportion is: 1: 9 (ml/g), the ratio of volatile oil and hydroxyl beta-schardinger dextrin-is: 1: 3-10 (ml/g), optimal proportion is: 1: 6 (ml/g).
Any or the multiple mixing that adds adjuvant in the technology and can be in beta-schardinger dextrin-, hydroxyl beta-schardinger dextrin-, micropowder silica gel, magnesium stearate, starch, the dextrin is used.
In the technology decocting boil/water steams the condition carry secondary and is: amount of water is that 6-12 doubly measures for the first time, and time 1-4 hour, amount of water was that 4-10 doubly measures for the second time, time is 0.5-3 hour, and best is that amount of water is 10 times for the first time, and the time is 3 hours, amount of water is 6 times of amounts for the second time, and the time is 2 hours.
The relative density of clear paste is 1.20-1.38 (90 ℃) in the technology, and the best is relative density 1.30 (90 ℃).
The relative density of concentrated solution is 1.05-1.15 (60 ℃) in the technology two, and the spray drying inlet temperature is 100-200 ℃, leaving air temp 50-150 ℃; The relative density of best concentrated solution is 1.08 (60 ℃), and spray-dired inlet temperature is 150 ℃, and leaving air temp is 100 ℃.
Volatile ingredient can obtain keeping preferably after process modification, and its quality standard is improved comprehensively, on original basis that Radix Aconiti, Semen Strychni thin layer are differentiated, has increased the thin layer of Herba Epimedii, Olibanum, Caulis Sinomenii, Radix Rehmanniae, Semen Coicis is differentiated in the discriminating; Increase heavy metal limit in the inspection and must not cross 10/1000000ths, arsenic salt must not cross 2/1000000ths, and original strychnine has been increased on the quantitative basis to aconitine quantitatively.
This invention its superiority compared with the prior art is: production technology more becomes to improving rationally, keep better that stability improves greatly under the volatility active substance prerequisite, effect duration can reach more than 2 years, quality standard is much improved, make product that the qualitative, quantitative control method of science be arranged, make the quality of product and curative effect that guarantee arranged.
The specific embodiment
The optimum implementation of this invention is: ten flavor medicines are cleaned respectively, remove impurity, it is standby to be up to the standards.Semen Strychni, Zaocys, Olibanum, Myrrha, Semen Coicis mixed powder are broken into fine powder, and be standby; Five tastes mixed powders such as all the other Radix Rehmanniae are broken into coarse powder and add water and steam and to carry secondary, and it is standby to collect volatile oil and water boiling liquid; Merge the secondary water boiling liquid, centrifugal, the clear liquid thin film concentration is to the concentrated solution of relative density 1.05-1.15 (60 ℃), spray drying, and it is standby to collect dried cream powder; Above-mentioned volatile oil adds an amount of cyclodextrin, and to make the cyclodextrin of volatile oil clathrate standby or become the volatile oil alcoholic solution standby with an amount of dissolve with ethanol; Get above-mentioned fine powder and dried cream powder and above-mentioned cyclodextrin of volatile oil clathrate or volatile oil alcoholic solution and appropriate amount of auxiliary materials mixing, encapsulated, quality inspection, packing, promptly.
Claims (1)
1, arthralgia due to cold is stopped capsular preparation method, it is characterized in that it may further comprise the steps:
(1) Semen Strychni, Olibanum, Myrrha, Semen Coicis, Zaocys five tastes mixed powder were broken into 80-160 purpose fine powder in the technology, and it is standby that best superfine powder was broken into 200-300 purpose fine powder.、
(2) Radix Rehmanniae, Caulis Sinomenii, Radix Aconiti Preparata, Herba Epimedii, Radix Aconiti Kusnezoffii Preparata five kinds of Chinese medicine mixed powder are broken into 5-20 purpose coarse powder in the technology, and it is standby to be preferably 10 order coarse powder.
(3) Radix Rehmanniae, Caulis Sinomenii, Radix Aconiti Preparata, Herba Epimedii, Radix Aconiti Kusnezoffii Preparata five kinds of Chinese medicine coarse powder decoct with water secondary/add water and steam and carry secondary in the technology, steam the volatile oil carried and form cyclodextrin of volatile oil clathrate/standby with an amount of dissolve with ethanol with cyclodextrin inclusion compound; Secondary water decoction/water steams extract, and being condensed into relative density and being the clear paste of 1.20-1.38 (90 ℃)/be condensed into relative density is the concentrated solution of 1.05-1.15 (60 ℃), and it is standby to be spray dried to dried cream powder.
(4) in the technology decocting boil/water steams the method carry secondary and is: amount of water is that 6-12 doubly measures for the first time, time 1-4 hour, amount of water is that 4-10 doubly measures for the second time, time is 0.5-3 hour, best is that amount of water is 10 times for the first time, time is 3 hours, and amount of water is 6 times of amounts for the second time, and the time is 2 hours.
(5) cyclodextrin of volatile oil clathrate preparation in the technology: cyclodextrin can adopt a kind of in beta-schardinger dextrin-, the hydroxyl beta-schardinger dextrin-, the ratio of volatile oil and beta-schardinger dextrin-is: 1: 7 ~ 13 (ml/g), optimal proportion is: 1: 9 (ml/g), the ratio of volatile oil and hydroxyl beta-schardinger dextrin-is: 1: 3 ~ 10 (ml/g), optimal proportion is: 1: 6 (ml/g).
(6) adding adjuvant in the technology can be that any/multiple mixing in beta-schardinger dextrin-, hydroxyl beta-schardinger dextrin-, micropowder silica gel, magnesium stearate, starch, the dextrin is used.
(7) with the standby composition of (1), (2), (3), (4), (5), (6) by the mixing, encapsulated that feeds intake of national standard prescription consumption standard, quality inspection is made arthralgia due to cold and is stopped capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03118616 CN1456231A (en) | 2003-02-12 | 2003-02-12 | Preparation of cold and numbness eliminating pills |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03118616 CN1456231A (en) | 2003-02-12 | 2003-02-12 | Preparation of cold and numbness eliminating pills |
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| CN1456231A true CN1456231A (en) | 2003-11-19 |
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| CN 03118616 Pending CN1456231A (en) | 2003-02-12 | 2003-02-12 | Preparation of cold and numbness eliminating pills |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1935203B (en) * | 2005-09-20 | 2010-07-28 | 成都中医药大学 | Radix aconiti agrestis extract and its preparing method |
| CN102488749A (en) * | 2011-12-22 | 2012-06-13 | 华东理工大学 | Preparation method of nux vomica powder preparation |
| CN102600397A (en) * | 2012-04-09 | 2012-07-25 | 河南百年康鑫药业有限公司 | Method for producing arthritis treatment tablet for treatment of arthritis via micro powder technology |
| CN103550345A (en) * | 2013-11-15 | 2014-02-05 | 张丽 | Medicinal liquor for treating rheumatic pain |
-
2003
- 2003-02-12 CN CN 03118616 patent/CN1456231A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1935203B (en) * | 2005-09-20 | 2010-07-28 | 成都中医药大学 | Radix aconiti agrestis extract and its preparing method |
| CN102488749A (en) * | 2011-12-22 | 2012-06-13 | 华东理工大学 | Preparation method of nux vomica powder preparation |
| CN102488749B (en) * | 2011-12-22 | 2013-09-18 | 华东理工大学 | Preparation method of nux vomica powder preparation |
| CN102600397A (en) * | 2012-04-09 | 2012-07-25 | 河南百年康鑫药业有限公司 | Method for producing arthritis treatment tablet for treatment of arthritis via micro powder technology |
| CN103550345A (en) * | 2013-11-15 | 2014-02-05 | 张丽 | Medicinal liquor for treating rheumatic pain |
| CN103550345B (en) * | 2013-11-15 | 2015-08-26 | 张丽 | A kind of medicated wine for the treatment of rheumatalgia |
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