CN1456261A - Slight fever acne capsule preparing method - Google Patents
Slight fever acne capsule preparing method Download PDFInfo
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- CN1456261A CN1456261A CN 03118660 CN03118660A CN1456261A CN 1456261 A CN1456261 A CN 1456261A CN 03118660 CN03118660 CN 03118660 CN 03118660 A CN03118660 A CN 03118660A CN 1456261 A CN1456261 A CN 1456261A
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Abstract
A process for preparing Chinese medicine "Qingre Anchuan capsule" for treating acne, furuncle and carbuncle includes such steps as pulverizing honeysuckle flower and liquorice root, mixing the extracts of 5 Chinese-medicinal materials including green chiretta with said powder, granulating, drying, pulverizing, mixing with ox gallstone, pearl powder and additive, and loading in capsules. Its advantage is high curative effect and safety.
Description
Technical field
This invention relates to the processing technology technical field of Chinese patent medicine capsule, relates in particular to the capsular preparation method of heat clearing away skin sore.
Background technology
Capsule is a kind of pharmaceutical formulation commonly used, according to the relevant drug act of China, changing dosage form needs as a kind of new drug research, the original dosage form of heat clearing away skin sore capsule is: QINGRE ANCHUANG PIAN, listed in the Drug Standard of Ministry of Public Health of the Peoples Republic of China (" Chinese traditional patent formulation preparation " the 6th), prescription is made up of nine flavor medicines.The technology features of former dosage form is: fine powder and the adjuvant of five tastes extractum such as creat extract and Flos Lonicerae, Radix Glycyrrhizae, and mixing is granulated, and tabletting is a bottom with Calculus Bovis, Margarita layer powder, and sugar coating forms.Especially the coated tablet disintegrate is slower for tablet, and coating is more loaded down with trivial details, has the lower shortcoming of quality standard simultaneously.Have shortcoming influence quality based on tablet, we use the modern pharmaceutical technology this product technology are done necessary improvement, form new preparation, improve simultaneously and improve quality standard, guarantee the quality monitoring raising curative effect of product, benefit the common people.
Summary of the invention
The purpose of this invention is to provide the capsular preparation method of a kind of heat clearing away skin sore, improve the quality of products, satisfy needs of medical treatment better.
The objective of the invention is such realization:
The capsular preparation method of heat clearing away skin sore comprises the steps:
One, the capsular prescription of heat clearing away skin sore is formed:
Flos Lonicerae 330～670g extractum rhei 80～170g creat extract 170～340g
Calculus Bovis 10～20g extract of taraxacum 120～240g Margarita layer powder 25～50g
Radix Sophorae Tonkinensis extractum 80～160g Radix Glycyrrhizae 70～130g Fructus Gardeniae extractum 80～170g
Right amount of auxiliary materials is made 5000 altogether.
Its optimum formula is:
Flos Lonicerae 500g extractum rhei 125g creat extract 250g
Calculus Bovis 15g extract of taraxacum 175g Margarita layer powder 37.5g
Radix Sophorae Tonkinensis extractum 120g Radix Glycyrrhizae 100g Fructus Gardeniae extractum 125g
Right amount of auxiliary materials is made 5000 altogether.
Two, heat clearing away skin sore capsules preparation technique
Technology one cleans Flos Lonicerae, Radix Glycyrrhizae respectively, removes impurity, and it is standby to be up to the standards; Extracting honeysuckle, Radix Glycyrrhizae powder are broken into fine powder, behind creat extract, extract of taraxacum, Radix Sophorae Tonkinensis extractum, Fructus Gardeniae extractum, extractum rhei mixing, granulate, and drying, encapsulated behind Calculus Bovis, Margarita layer powder and appropriate amount of auxiliary materials mixing, quality inspection, packing, promptly.
Technology two cleans Flos Lonicerae, Radix Glycyrrhizae respectively, removes impurity, and it is standby to be up to the standards; Extracting honeysuckle, Radix Glycyrrhizae powder are broken into coarse powder, behind creat extract, extract of taraxacum, Radix Sophorae Tonkinensis extractum, Fructus Gardeniae extractum, extractum rhei mixing, and drying; be ground into fine powder, behind adding Calculus Bovis, Margarita layer powder and the appropriate amount of auxiliary materials mixing, encapsulated; quality inspection, packing, promptly.
Three, prepared by technology one, two is capsule.
Added adjuvant can be any or multiple mixing use in micropowder silica gel, starch, the dextrin etc. in the technology.
Flos Lonicerae, Radix Glycyrrhizae powder are broken into coarse powder and were generally 5～30 order coarse powder in the technology, are preferably 10 order coarse powder.
Flos Lonicerae, Radix Glycyrrhizae/become fine powder to be generally 80～160 order fine powders with extractum mixing crushed after being dried such as Herba Andrographis in the technology, being preferably superfine powder, to be broken into 200～300 order fine powders standby.
The preparation of creat extract, extractum rhei in the prescription: get Herba Andrographis, the Radix Et Rhizoma Rhei pulverize separately becomes coarse powder, adds ethanol extraction twice, filter, the extracting solution decompression recycling ethanol, drying, promptly.
The preparation of extract of taraxacum, Fructus Gardeniae extractum in the prescription: get Herba Taraxaci, the Fructus Gardeniae pulverize separately becomes coarse powder, adds hydro-thermal and carries twice, the extracting solution concentrating under reduced pressure becomes fluid extract, puts cold, add equivalent ethanol, stir evenly, left standstill 8 hours, get the supernatant decompression recycling ethanol, concentrate, drying, promptly.
The preparation of Radix Sophorae Tonkinensis extractum in the prescription: get Radix Sophorae Tonkinensis and be ground into coarse powder, add pH value and be 4 salt sour water, warm (60 ℃) extract 3 times, filter, merging filtrate is concentrated into fluid extract, puts coldly, adds 3.5 times of ethanol and stirs evenly, standing over night is got supernatant concentration, drying, promptly.
Baking temperature is 50～80 ℃ in the technology, and the best is 60 ℃.
This invention its superiority compared with the prior art is: production technology more becomes to improving rationally, and quality standard improves greatly, makes product that the qualitative, quantitative control method of science be arranged, and makes the quality of product and curative effect more secure.Technology is more easy after process modification, and quality standard has also obtained comprehensive raising, and differentiating has increased the thin layer of Fructus Gardeniae discriminating on the basis that original Calculus Bovis, Herba Andrographis, Radix Et Rhizoma Rhei, Radix Sophorae Tonkinensis thin layer are differentiated; Increased heavy metal limit in the inspection and must not cross 10/1000000ths, arsenic salt must not cross 2/1000000ths; On the assay Herba Andrographis has been carried out quantitatively.
The specific embodiment
The optimum implementation of this invention is that Flos Lonicerae, Radix Glycyrrhizae are cleaned respectively, removes impurity, and it is standby to be up to the standards; Extracting honeysuckle, Radix Glycyrrhizae powder are broken into coarse powder, behind creat extract, extract of taraxacum, Radix Sophorae Tonkinensis extractum, Fructus Gardeniae extractum, extractum rhei mixing, and drying; be ground into fine powder, behind adding Calculus Bovis, Margarita layer powder and the appropriate amount of auxiliary materials mixing, encapsulated; quality inspection, packing, promptly.
Claims (2)
1, the capsular preparation method of a kind of heat clearing away skin sore is characterized in that it may further comprise the steps:
(1) added adjuvant can be that any/multiple mixing in micropowder silica gel, starch, the dextrin etc. is used in the technology.
(2) Flos Lonicerae, Radix Glycyrrhizae powder are broken into coarse powder and were generally 5～30 order coarse powder in the technology, are preferably 10 order coarse powder.
(3) Flos Lonicerae coarse powder, Radix Glycyrrhizae coarse powder/become fine powder to be generally 80～160 order fine powders with creat extract, extract of taraxacum, Radix Sophorae Tonkinensis extractum, Fructus Gardeniae extractum, extractum rhei mixing crushed after being dried in the technology, being preferably superfine powder, to be broken into 200～300 order fine powders standby.
(4) preparation of creat extract, extractum rhei in the prescription: get Herba Andrographis, the Radix Et Rhizoma Rhei pulverize separately becomes coarse powder, adds ethanol extraction twice, filter, the extracting solution decompression recycling ethanol, drying, promptly.
(5) preparation of extract of taraxacum, Fructus Gardeniae extractum in the prescription: get Herba Taraxaci, the Fructus Gardeniae pulverize separately becomes coarse powder, adds hydro-thermal and carries twice, the extracting solution concentrating under reduced pressure becomes fluid extract, puts cold, add equivalent ethanol, stir evenly, left standstill 8 hours, get the supernatant decompression recycling ethanol, concentrate, drying, promptly.
(6) preparation of Radix Sophorae Tonkinensis extractum in the prescription: get Radix Sophorae Tonkinensis and be ground into coarse powder, add pH value and be 4 salt sour water, warm (60 ℃) extract 3 times, filter, merging filtrate is concentrated into fluid extract, puts coldly, adds 3.5 times of ethanol and stirs evenly, standing over night is got supernatant concentration, drying, promptly.
(7) baking temperature is 50～80 ℃ in the technology, and the best is 60 ℃.
(8) (1), (2), (3), (4), (5), (6), (7) standby composition are fed intake by national standard prescription consumption, mix the encapsulated heat clearing away skin sore capsule of making.
2, the capsular preparation method of heat clearing away skin sore according to claim 1, it is characterized in that on the quality control standard Fructus Gardeniae having been carried out the thin layer discriminating, must not cross 10/1000000ths to heavy metal limit, arsenic salt must not be crossed 2/1000000ths and detect, and on the assay Herba Andrographis has been carried out quantitatively.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03118660 CN1456261A (en) | 2003-02-20 | 2003-02-20 | Slight fever acne capsule preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03118660 CN1456261A (en) | 2003-02-20 | 2003-02-20 | Slight fever acne capsule preparing method |
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| CN1456261A true CN1456261A (en) | 2003-11-19 |
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| CN 03118660 Pending CN1456261A (en) | 2003-02-20 | 2003-02-20 | Slight fever acne capsule preparing method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102935128A (en) * | 2011-12-14 | 2013-02-20 | 江西普正制药有限公司 | Preparation method for heat-clearing acne capsule |
-
2003
- 2003-02-20 CN CN 03118660 patent/CN1456261A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102935128A (en) * | 2011-12-14 | 2013-02-20 | 江西普正制药有限公司 | Preparation method for heat-clearing acne capsule |
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