CN1330353C - Chinese traditional medicine for adjusting contents of blood sugar and blood fat, and preparation method - Google Patents
Chinese traditional medicine for adjusting contents of blood sugar and blood fat, and preparation method Download PDFInfo
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Abstract
The present invention relates to a traditional Chinese medicine used for adjusting contents of blood sugar and blood fat and a preparation method thereof. The prescription of the traditional Chinese medicine contains (weight percentage): 4 to 8% of Gynostemma pentaphylla, 72 to 80% of balsam pear (fresh), 3 to 5% of solomonseal rhizome, 3 to 5% of mulberry leaf, 3 to 5% of haw, 1 to 3 % of notoginseng and 1 to 3% of lotus leaf. In the preparation method, the mulberry leaf and the sliced fresh balsam pear are respectively decocted, filtered and dried, and dry paste of the mulberry leaf and dry paste of the sliced fresh balsam pear are respectively obtained; the Gynostemma pentaphylla, the solomonseal rhizome, the haw and the lotus leaf are decocted together and filtered, filtrate is concentrated and extracted by ethanol to obtain effective components, the effective components are statically placed, filtered, the ethanol is recovered, and dry paste is obtained through concentration and drying; the ethanol is added to extract the notoginseng, extract is concentrated and dried, and dry paste is obtained; the obtained four parts of the dry paste are combined, pulverized and uniformly mixed, and capsules or tablets or granules are prepared according to requirements and packed into finished products. The traditional Chinese medicine prepared with the preparation method has the advantages of significant medicine effect, quick effect, high safety and low toxicity. The present invention performs the functions of obviously reducing the content of blood sugar, the value of serum total cholesterol and triglyceride.
Description
Technical field
The present invention relates to prescription of a kind of compound Chinese medicinal preparation that can reduce blood sugar for human body, lipids contents and preparation method thereof.
Background technology
Blood glucose is meant the glucose that contains in the blood, and blood glucose value is represented the concentration of glucose in the blood.The blood glucose of the normal level that fluctuates in the certain limit is extremely important for the physiological function of each histoorgan of human body.Glucose is essential by human body, but secular hyperglycemia can make each internal organs of whole body and tissue that following pathological change takes place:
(1) concentration of glucose is very high in the blood, but lacks insulin, and glucose can not enter target cell and be utilized, and lacks glucose in the histiocyte, and fat and protein decompose acceleration.
(2) whole body widely the blood capillary tube wall thicken, tube chamber attenuates, erythrocyte is difficult for passing through, the histiocyte anoxia.
(3) glomerular sclerosis, necrosis of renal papillae etc. appear in kidney.
(4) the optical fundus retinal capillary microangioma, retinal hemorrhage occur, oozes out etc.
(5) neurocyte degeneration, nerve fiber generation segmental demyelination pathological changes.
(6) many places arteriosclerosis such as the heart, brain, lower limb.Hyperglycemia is often with hyperlipemia, and coronary artery, cerebrovascular and lower extremities take place early than general normal person and be serious.
In general, glucose content is high for a long time in the blood, can cause cardiovascular disease, renal failure, complication even death such as blind.
Existing blood sugar lowering chemical synthetic drug all has slow, the deficiency such as drug effect is long that takes effect basically, that is to say that the time that needs of patients is grown having dinner before is ahead of time taken medicine; And after its blood glucose was reduced under the appropriate situation, the hypoglycemic effect of medicine may continuous action, causes hypoglycemic appearance easily.Use antidiabetic drug malpractices such as insulin and sulphanylureas and cause postprandial hypoglycemia easily, can occur having palpitation, blurred vision, dizziness or headache etc. are until symptoms such as tic, loss of consciousness and stupors.
At present, very urgent for demand clinically with definite curative effect, hypoglycemic drug safe in utilization.
Hyperlipidemia sickness rate height, China has several ten thousand people to suffer from hyperlipidemia.Hyperlipidemia is abnormally dangerous, is the arch-criminal who causes cardiovascular and cerebrovascular disease, has following harm:
(1) glomerular sclerosis etc.: hyperlipemia can cause that vascular endothelial cell damage and kitchen range shape come off, cause the blood vessel wall permeability to raise, plasma lipoprotein is entered and is deposited on the blood vessel wall inner membrance, cause the cleaning reaction and the vascular smooth muscle cell curing of macrophage and form speckle thereafter, and cause arteriosclerosis, renal arteriosclerosis, luminal stenosis can make kidney generation ischemia, atrophy, interstitial fibers hypertrophy.If the kidney angiemphraxis is the respective regions infarction then, form cicatrix after the infarction kitchen range machineization.So cause glomerular sclerosis.Outside kidney, then can quicken the generation of coronary atherosclerosis, cause coronary heart disease and increase the danger that myocardial infarction takes place the patient.Equally, the arteriosclerosis at other position then causes corresponding disease, as cerebral arteriosclerosis, cerebral infarction etc.
(2) glomerular injury: hyperlipemia can cause that lipid deposits in glomerule, low density lipoprotein, LDL can activate in the circulation mononuclear cell and cause monocyte infiltration in the glomerule, and cause or the exacerbate inflammation reaction, the mesangial cell of glomerule, endotheliocyte all can produce the activation oxygen molecule simultaneously, promote lipid peroxidation, the low density lipoprotein, LDL of oxidation (OX-LDL) has extremely strong cytotoxicity, causes the nephridial tissue damage.In addition, hyperlipemia can also cause that collagen in the glomerular mesangium substrate, laminin and fibrin increase, and these compositions are all directly related with glomerular sclerosis.
Traditional fat regulation medicine especially influences cholesterol and the bile acid lipid lowerers through bile and defecate, can make bile cholesterol be saturated or hypersaturated state, and be easy to form cholelithiasis.Take lipid regulating agent for a long time and can cause that the body lipid changes, thereby cause the generation of non-cardiovascular disease.In addition, pravastatin has certain infringement to liver.Therefore, the blood lipid regulation Chinese medicine preparation of preparation safety and low toxicity can satisfy the demand of extensive patients.
Summary of the invention
Purpose of the present invention is just in order to address the deficiencies of the prior art, for remedying the deficiency of blood sugar regulation, blood fat medication, provide a kind of drug effect suitable, instant effect can not make the patient produce hypoglycemia and make bile cholesterol be the blood sugar regulation of the safety and low toxicity of saturated or hypersaturated state, Chinese medicine of lipids contents and preparation method thereof.
The objective of the invention is to be achieved through the following technical solutions.
The Chinese medicine of a kind of blood sugar regulation and lipids contents is made by the following raw materials by weight percent medicine: Herb Gynostemmae Pentaphylli 4～8%, bright Fructus Momordicae charantiae 72～80%, Rhizoma Polygonati 3～5%, Folium Mori 3～5%, Fructus Crataegi 3～5%, Radix Notoginseng 1～3%, Folium Nelumbinis 1～3%.
Also be added with ancillary drug in the Chinese medicine of making, described ancillary drug is chromium picolinate or aloe full leaf lyophilized powder.
Preparation method of the present invention is:
1., after Folium Mori decoct with water, filter and obtain filtrate, filtrate is condensed into the thick paste after drying gets dry extract, insert container rapidly, seal stand-by;
2., after Herb Gynostemmae Pentaphylli, Rhizoma Polygonati, Fructus Crataegi, Folium Nelumbinis decoct with water, filter and obtain filtrate, filtrate is condensed into clear paste, again through precipitate with ethanol, leaves standstill, filter, reclaim ethanol, be condensed into thick paste, drying gets dry extract, and inserts container rapidly, seals stand-by;
3., bright Fructus Momordicae charantiae section, after the decoction, filter and obtain filtrate, filtrate is condensed into thick paste, get dry extract through drying under reduced pressure, insert clean container rapidly, seal stand-by;
4., Radix Notoginseng adds soak with ethanol, after heat is extracted, filters and obtains filtrate, reclaims ethanol, and filtrate is condensed into thick paste, drying gets dry extract, and inserts container rapidly, seals stand-by;
5., with aforementioned 1., 2., 3., 4. the stand-by dried cream of gained four parts merges, and pulverizes mixing;
6., be made into capsule or tablet or granule by demand after, packed products.
Method of the present invention also can be just 1., 2., 3., 4. the stand-by dried cream of gained four parts merges, and pulverizes, and behind the mixing, adds ancillary drug chromium picolinate or aloe full leaf lyophilized powder again, mixing.
Chinese medicine of the present invention, its prescription adopts pure raw material of Chinese medicine fully, and it is suitable to make the medicine effect that obtains, instant effect, safety and low toxicity all have tangible reduction effect to blood sugar content, serum total cholesterol value and triglyceride.Because chromium is essential trace element in human and animal's body, the major physiological function that has confirmed chromium is to participate in sugar in the animal body, fat, proteinic metabolism, improves the active effect of insulin, enhancing immunity.Add chromium picolinate in the present invention's prescription and can replenish a certain amount of organic chromium, in medicine, add the Drug resistance that chromium picolinate can reduce diabetes patient's blood level and insulin, reduce body inner cholesterol content and body fat.The aloe full leaf lyophilized powder contains effective ingredient such as Aloe, Aloe polysaccharide, compounds matter, rutin, trace element, has effects such as enhancing immunity, loosening bowel to relieve constipation, blood fat reducing, blood glucose.Chinese medicinal preparation method of the present invention, scientific and reasonable, easy operating meets the requirement of GMP authentication.
Further set forth content of the present invention below in conjunction with Figure of description and embodiment.
Description of drawings
Fig. 1 is a process chart of the present invention;
Fig. 2 is the process chart that the present invention adds the ancillary drug chromium picolinate;
Fig. 3 is the process chart that the present invention adds ancillary drug aloe full leaf lyophilized powder.
The specific embodiment
Embodiment one:
As shown in Figure 1, by following percentage by weight compatibility: Herb Gynostemmae Pentaphylli 8%, bright Fructus Momordicae charantiae 80%, Rhizoma Polygonati 3%, Folium Mori 4%, Fructus Crataegi 3%, Radix Notoginseng 1%, Folium Nelumbinis 1%.
1., Folium Mori are decocted with water 1～3 time, or decoct again after soaking a period of time, present embodiment is 3 times, amount of water can be 8～20 times of Folium Mori weight, present embodiment selects three amount of water to be followed successively by 15 times, 10 times, 10 times, decoct at every turn to water boil the back 0.5～2 hour, present embodiment is selected 1 hour, after the filtration, and merging filtrate, it is 1.20～1.25 thick paste that filtrate decompression is condensed into 60 ℃ time relative density, at pressure 0.08Mpa, drying under reduced pressure is 8～10 hours under the condition that temperature is 70 ± 1 ℃, obtains dried cream again, insert clean container rapidly, seal stand-by;
2., with Herb Gynostemmae Pentaphylli, Rhizoma Polygonati, Fructus Crataegi, the Folium Nelumbinis mixing and water adding soaks, decoct 1～3 time, or decoct again after soaking a period of time, present embodiment is 3 times, amount of water can be 5～15 times of compound weight, and present embodiment selects three times amount of water to be followed successively by 10 times, 8 times, 8 times, decoct at every turn to water boil the back 0.5～2 hour, present embodiment is selected 1 hour, filter, merging filtrate, relative density is 1.04～1.08 clear paste when being condensed into 60 ℃, adding ethanol to determining alcohol is 60%, leave standstill, filter, receive alcohol, relative density is 1.20～1.25 thick paste when being condensed into 60 ℃, be 0.08Mpa at pressure again, drying under reduced pressure is 8～10 hours under the condition that temperature is 70 ± 1 ℃, obtains dried cream, insert clean container rapidly, seal stand-by;
3., with the section of bright Fructus Momordicae charantiae, decoct 1～2 time, present embodiment is 2 times, amount of water can be 1～3 times of Fructus Momordicae charantiae weight, and present embodiment selects each amount of water to be 2 times, decoct at every turn to water boil the back 0.5～2 hour, present embodiment is selected 1 hour, filters merging filtrate, relative density is 1.20～1.25 thick paste when being condensed into 60 ℃, at pressure 0.08Mpa, drying under reduced pressure is 10 hours under the condition that temperature is 60 ± 1 ℃, obtains dried cream again, insert clean container rapidly, seal stand-by;
4., Radix Notoginseng is added 60% soak with ethanol, extract 1～2 time, present embodiment is 2 times, the single alcohol adding amount can be 4～10 times of three seven weight, twice alcohol adding amount of present embodiment is followed successively by 15 times, 10 times, each extraction time is 1～2 hour, and present embodiment is 1.5 hours, filters, merging filtrate, reclaim ethanol, relative density is 1.20～1.25 thick paste when being condensed into 60 ℃, again at pressure 0.08Mpa, drying under reduced pressure is 8～10 hours under the condition that temperature is 70 ± 1 ℃, obtain dried cream, insert clean container rapidly, seal stand-by;
5., with above-mentioned 1., 2., 3., 4. the stand-by dried cream that makes of four parts merges, and pulverizes mixing;
6., be prepared into capsule or tablet or electuary according to demand.Through moisture, loading amount after the assay was approved, bottling, outer package is finished product.
Embodiment two:
Press following percentage by weight compatibility: Herb Gynostemmae Pentaphylli 7%, bright Fructus Momordicae charantiae 72%, Rhizoma Polygonati 5%, Folium Mori 5%, Fructus Crataegi 5%, Radix Notoginseng 3%, Folium Nelumbinis 3%.Preparation method by embodiment one prepares finished product again.
Embodiment three:
Press following percentage by weight compatibility: Herb Gynostemmae Pentaphylli 7%, bright Fructus Momordicae charantiae 77%, Rhizoma Polygonati 4%, Folium Mori 3%, Fructus Crataegi 5%, Radix Notoginseng 2%, Folium Nelumbinis 2%, chromium picolinate is an amount of.
As shown in Figure 2,1.～4. the preparation method of part operation is identical with embodiment one, afterwards, enter the 5. procedure, promptly above-mentioned 1., 2., 3., 4. the stand-by dried cream that makes of four parts merges, and pulverizes mixing, add the chromium picolinate of the powder weight 5% (present embodiment is 0.05%) that is not higher than mixing again, mixing; At last, with the medicated powder filling capsule that makes.Through moisture, loading amount after the assay was approved, bottling, outer package is finished product.
Embodiment four:
Press following percentage by weight compatibility: Herb Gynostemmae Pentaphylli 4%, bright Fructus Momordicae charantiae 79%, Rhizoma Polygonati 4%, Folium Mori 3%, Fructus Crataegi 4%, Radix Notoginseng 3%, Folium Nelumbinis 3%, the aloe full leaf lyophilized powder is an amount of.
As shown in Figure 3,1.～4. the preparation method of part operation is identical with embodiment one, afterwards, enter the 5. procedure, promptly above-mentioned 1., 2., 3., 4. the stand-by dried cream that makes of four parts merges, and pulverizes mixing, add the aloe full leaf lyophilized powder that is not higher than mixing powder weight 8% (present embodiment is 2%), mixing again; At last, the medicated powder pressing mold that makes is made tablet.Through moisture, loading amount after the assay was approved, bottling, outer package is finished product.
Embodiment five:
Press following weight compatibility: Herb Gynostemmae Pentaphylli 500g, bright Fructus Momordicae charantiae 8000g, Rhizoma Polygonati 300g, Folium Mori 300g, Fructus Crataegi 300g, Radix Notoginseng 200g, Folium Nelumbinis 200g, chromium picolinate 0.24g.
Preparation method is as shown in Figure 2:
1., Folium Mori 300g is soaked, decoct 3 times, 3 times amount of water is followed successively by 15 times, 10 times, 10 times, decocts 1 hour at every turn, filter, merging filtrate, concentrating under reduced pressure become thick paste (60 ℃ time relative density be 1.20～1.25), drying under reduced pressure (pressure 0.08Mpa, 70 ± 1 ℃ of temperature, 8～10 hours time) get dry extract, insert clean container rapidly, seal stand-by;
2., Herb Gynostemmae Pentaphylli 500g, Rhizoma Polygonati 300g, Fructus Crataegi 300g, Folium Nelumbinis 200g are soaked, decoct 3 times, 3 times amount of water is followed successively by 10 times, 8 times, 8 times, the each decoction 1 hour, filter, merging filtrate is condensed into clear paste (60 ℃ time relative density be 1.04～1.08), adding ethanol to determining alcohol is 60%, leave standstill, filter, receive alcohol, be condensed into thick paste (60 ℃ time relative density be 1.20～1.25), drying under reduced pressure (pressure is 0.08Mpa, 70 ± 1 ℃ of temperature, 8～10 hours time) gets dry extract, insert clean container rapidly, seal stand-by;
3., with bright Fructus Momordicae charantiae 8000g section, decoct 2 times, each amount of water is 2 times, decocts 1 hour at every turn, filter, merging filtrate is condensed into thick paste (60 ℃ time relative density be 1.20～1.25), drying under reduced pressure (pressure 0.08Mpa, 60 ± 1 ℃ of temperature, 10 hours time) get dry extract, insert clean container rapidly, seal stand-by;
4., Radix Notoginseng 200g is added 60% soak with ethanol, extract 2 times, 2 times alcohol adding amount is followed successively by 8 times, 6 times, each extraction time is 1.5 hours, filter, merging filtrate reclaims ethanol, be condensed into thick paste (60 ℃ time relative density be 1.20～1.25), drying under reduced pressure (pressure 0.08Mpa, 70 ± 1 ℃ of temperature, 8～10 hours time) gets dry extract, insert clean container rapidly, seal stand-by;
5., with above-mentioned 1., 2., 3., 4. the tetrameric articles for use for the treatment of merge, and pulverize, mixing adds chromium picolinate 0.24g, mixing.
6., the filling No. 0 capsule, be prepared into 1000 grains and heavily be the capsule of 0.5g (wherein containing Herb Gynostemmae Pentaphylli, Rhizoma Polygonati, Fructus Crataegi, Folium Nelumbinis extract 169g, Fructus Momordicae charantiae extract 160g, Folium Mori extract 81g, Radix Notoginseng extract 40g, chromium picolinate 0.24g).Through moisture, loading amount after the assay was approved, bottling, outer package is finished product.
Embodiment six:
Press following weight compatibility: Herb Gynostemmae Pentaphylli 350g, bright Fructus Momordicae charantiae 4500g, Rhizoma Polygonati 200g, Folium Mori 200g, Fructus Crataegi 200g, Radix Notoginseng 100g, Folium Nelumbinis 100g, aloe full leaf lyophilized powder 10g.
Preparation method is as shown in Figure 3:
1., Folium Mori 200g is soaked, decoct 3 times, 3 times amount of water is followed successively by 15 times, 10 times, 8 times, decocts 1 hour at every turn, filter, merging filtrate, concentrating under reduced pressure become thick paste (60 ℃ time relative density be 1.20～1.25), drying under reduced pressure (pressure 0.08Mpa, 70 ± 1 ℃ of temperature, 8～10 hours time) get dry extract, insert clean container rapidly, seal stand-by;
2., Herb Gynostemmae Pentaphylli 350g, Rhizoma Polygonati 200g, Fructus Crataegi 200g, Folium Nelumbinis 100g are soaked, decoct 3 times, 3 times amount of water is followed successively by 15 times, 10 times, 5 times, the each decoction 1 hour, filter, merging filtrate is condensed into clear paste (60 ℃ time relative density be 1.04～1.08), add ethanol to determining alcohol and be 60% pure liquid, leave standstill, filter, receive alcohol, be condensed into thick paste (60 ℃ time relative density be 1.20～1.25), drying under reduced pressure (pressure is 0.08Mpa, 70 ± 1 ℃ of temperature, 8～10 hours time) gets dry extract, insert clean container rapidly, seal stand-by;
3., with bright Fructus Momordicae charantiae 4500g section, decoct 2 times, 2 times amount of water is 2 times, decocts 1 hour at every turn, filter, merging filtrate is condensed into thick paste (60 ℃ time relative density be 1.20～1.25), drying under reduced pressure (pressure 0.08Mpa, 60 ± 1 ℃ of temperature, 10 hours time) get dry extract, insert clean container rapidly, seal stand-by;
4., Radix Notoginseng 100g is added 60% soak with ethanol, extract 2 times, 2 times alcohol adding amount is followed successively by 20 times, 10 times, each 1.5 hours extraction times, filter, merging filtrate reclaims ethanol, be condensed into thick paste (60 ℃ time relative density be 1.20～1.25), drying under reduced pressure (pressure 0.08Mpa, 70 ± 1 ℃ of temperature, 8～0 hours time) gets dry extract, insert clean container rapidly, seal stand-by;
5., with above-mentioned 1., 2., 3., 4. four extracting section things merge, and pulverize, mixing adds aloe full leaf lyophilized powder 10g, mixing.
6., the medicated powder pressing mold that makes is made 1000 grains and heavily be the tablet of 0.5g.Through moisture, loading amount after the assay was approved, bottling, outer package is finished product.
The aloe full leaf lyophilized powder is selected sophisticated Aloe Barbadensis Miller fresh leaf for use, and through science extraction, stabilizing treatment, the degerming of room temperature film, reuse membrance separation room temperature concentration technology is made concentrated juice, and last lyophilization is made.
Claims (4)
1, the Chinese medicine of a kind of blood sugar regulation and lipids contents is characterized in that being made by the following raw materials by weight percent medicine: Herb Gynostemmae Pentaphylli 4～8%, bright Fructus Momordicae charantiae 72～80%, Rhizoma Polygonati 3～5%, Folium Mori 3～5%, Fructus Crataegi 3～5%, Radix Notoginseng 1～3%, Folium Nelumbinis 1～3%.
2, the Chinese medicine of a kind of blood sugar regulation according to claim 1 and lipids contents is characterized in that, also is added with ancillary drug in the Chinese medicine of making, and described ancillary drug is chromium picolinate or aloe full leaf lyophilized powder.
3, the preparation method of Chinese medicine of a kind of blood sugar regulation as claimed in claim 1 and lipids contents is characterized in that, preparation method is:
1., after Folium Mori decoct with water, filter and obtain filtrate, filtrate is condensed into the thick paste after drying gets dry extract, insert container rapidly, seal stand-by;
2., after Herb Gynostemmae Pentaphylli, Rhizoma Polygonati, Fructus Crataegi, Folium Nelumbinis decoct with water, filter and obtain filtrate, filtrate is condensed into clear paste, again through precipitate with ethanol, leaves standstill, filter, reclaim ethanol, be condensed into thick paste, drying gets dry extract, and inserts container rapidly, seals stand-by;
3., bright Fructus Momordicae charantiae section, after the decoction, filter and obtain filtrate, filtrate is condensed into thick paste, get dry extract through drying under reduced pressure, insert clean container rapidly, seal stand-by;
4., Radix Notoginseng adds soak with ethanol, after heat is extracted, filters and obtains filtrate, reclaims ethanol, and filtrate is condensed into thick paste, drying gets dry extract, and inserts container rapidly, seals stand-by;
5., with aforementioned 1., 2., 3., 4. the stand-by dried cream of gained four parts merges, and pulverizes mixing;
6., be made into capsule or tablet or granule by demand after, packed products.
4, the preparation method of Chinese medicine of a kind of blood sugar regulation according to claim 3 and lipids contents is characterized in that, will be 1., 2., 3., 4. the stand-by dried cream of gained four parts merges, pulverize, behind the mixing, add ancillary drug chromium picolinate or aloe full leaf lyophilized powder again, mixing.
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| CN101053592B (en) * | 2007-05-29 | 2010-06-02 | 中食肽灵（北京）生物科技有限公司 | Medicinal composition for treating impaired glucose tolerance and preparation method thereof |
| CN102058697B (en) * | 2010-12-31 | 2012-01-11 | 广西金海堂药业有限责任公司 | Health product for adjuvant therapy of heart cerebrovascular diseases and preparation method thereof |
| CN102742705B (en) * | 2012-07-25 | 2013-10-30 | 曹树江 | Sealwort sanye tea |
| CN103041118B (en) * | 2013-01-28 | 2014-10-01 | 黑龙江中医药大学 | Composition with effects of reducing blood sugar and reducing blood lipid |
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| CN1404852A (en) * | 2001-08-20 | 2003-03-26 | 刘御广 | Medicine for treating diabetes and its preparation method |
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| CN1404852A (en) * | 2001-08-20 | 2003-03-26 | 刘御广 | Medicine for treating diabetes and its preparation method |
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| Title |
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| 复方苦瓜胶囊治疗非胰岛素依赖型糖尿病 冯桂芹等，中国新药与临床杂志，第19卷第1期 2000 * |
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