CN1404852A - Medicine for treating diabetes and its preparation method - Google Patents
Medicine for treating diabetes and its preparation method Download PDFInfo
- Publication number
- CN1404852A CN1404852A CN 01130687 CN01130687A CN1404852A CN 1404852 A CN1404852 A CN 1404852A CN 01130687 CN01130687 CN 01130687 CN 01130687 A CN01130687 A CN 01130687A CN 1404852 A CN1404852 A CN 1404852A
- Authority
- CN
- China
- Prior art keywords
- medicine
- radix
- capsule
- people
- powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The Chinese medicine for curing diabetes with obvious therapeutic effect is made up by using the Chinese medicinal materials of astragalus root, dried/fresh rehmannia, lonicera flower, melon stalk, cornus fruit and American ginseng as raw material through the processes of pulverizing, disinfecting and drying. Said Chinese medicine can be made into powder preparation, honeyed pill, water-paste pill and capsule, and possesses the functions of reducing blood sugar, glucose in wrine, blood lipid, blood viscosity and improving microcirculation.
Description
Technical field
Of the present inventionly relate to a kind of medicine for the treatment of diabetes, more specifically saying so with the Chinese herbal medicine is Chinese patent medicine of feedstock production and preparation method thereof.
Background technology
Diabetes are one of several big diseases of serious harm human health, and present therapeutic agent is all undesirable, for example, sulfaurea drugs and biguanide drug, curative effect is low, and side effect is big, and for a long time with producing hyperlactacidemia, what have causes fatal hypoglycemia.With infringement liver, kidney and hemocyte, insulin with producing antibody, increases dosage to sulfaurea drugs for a long time, easily impels blood capillary generation pathological changes and increase dosage for a long time.Though the Chinese patent medicine of treatment diabetes is also arranged at present, and curative effect is all not very good.
Summary of the invention
The purpose of this invention is to provide a kind of have blood sugar lowering, glucose in urine, blood fat, blood viscosity, the Chinese herbal treatment agent of the sharp lung of kidney tonifying, QI invigorating tonifying YIN, treatment diabetes without any side effects.
Technical scheme of the present invention is according to motherland's traditional medicine dialectical the executing of diabetes treatment to be administered opinion, make in conjunction with Chinese medicine modern pharmacology and clinic study, by preferred traditional Chinese herbal medicine, clinical development forms for many years, has the nourishing kidney tonifying the lung, QI invigorating tonifying YIN, blood sugar lowering, glucose in urine, blood fat, blood viscosity, strengthen islet function, the effect of microcirculation improvement.
Medicine of the present invention is to make (consumption is parts by weight) by following component:
Radix Astragali 20-40 part, Radix Rehmanniae 15-30 part, Flos Lonicerae 10-30 part,
Fruit base of Fructus Momordicae charantiae 10-20 part, Fructus Corni 5-10 part, Radix Panacis Quinquefolii 5-10 part.
The formula optimization weight portion ratio range of preparation medicine of the present invention is:
Radix Astragali 30-40 part, Radix Rehmanniae 20-30 part, Flos Lonicerae 20-30 part,
Fruit base of Fructus Momordicae charantiae 15-20 part, Fructus Corni 5-10 part, Radix Panacis Quinquefolii 5-10 part.
Above-mentioned each component can be made into powder, honeyed pill, the watered pill, capsule preparations, preferably capsule preparations.Concrete preparation method: may further comprise the steps:
(1) Radix Astragali, the Radix Rehmanniae, Flos Lonicerae, fruit base of Fructus Momordicae charantiae, Fructus Corni, Radix Panacis Quinquefolii are pulverized, crossed 80 mesh sieves, and with the medicated powder mix homogeneously;
(2) medicated powder of step (1) being put into the vacuum disinfection tank sterilizes with alcohol steam;
(3) medicated powder after the sterilization is made the honeyed pill or the watered pill according to a conventional method, medicated powder after perhaps will sterilizing adds an amount of dextrin and ethanol is made unguentum, reentering baking oven heats to 100 ℃ of oven dry, to water content≤1%, make powder then according to a conventional method or get dried cream and put into wobbler and break into the fine particle O that packs into
#Capsule, every capsules 0.4g divides the bottle of packing into to get final product.
Also can directly add medical starch behind above-mentioned steps (2) the medicated powder mix homogeneously and ethanol is made unguentum, reentering baking oven heats to 100 ℃ of oven dry, to water content≤1%, getting dried cream puts into wobbler and breaks into fine particle, and with on its lay case, thickness is 1cm, and with ultraviolet radiation sterilization in 1 hour, O packs into
#Capsule, the heavy 0.4g of every capsules divides the bottle of packing into to get final product.
Capsule instructions of taking of the present invention: every day 3 times, each 2-3 grain, take 20 minutes ante cibum.
Advantage of the present invention:
The traditional Chinese medical science is thought, the generation of diabetes is owing to due to the deficiency of both QI and YIN, production of dryness-heat in the interior, control suitable supplementing QI and nourishing YIN and be this.The Radix Rehmanniae, mountain cornel YIN nourishing nourishing YIN in the present invention's prescription, kidney tonifying is supporing yang; The Radix Astragali, Radix Panacis Quinquefolii yin nourishing QI invigorating, Yi Wei moisturize; Fruit base of Fructus Momordicae charantiae, Flos Lonicerae remove pathogenic heat, separate insidious, blood fat reducing.The same usefulness of Six-element, reasonable compatibility supplements and complements each other, and plays the effect of nourishing kidney tonifying the lung, QI invigorating tonifying YIN altogether.
Medicine of the present invention is by 5 years nearly ten thousand patients' the clinical observation and the checking of several families hospital expert, and the treatment diabetes curative effect is remarkable, has blood sugar lowering, glucose in urine, blood fat, blood viscosity, improves the effect of little ring, and untoward reaction do not occur.In addition, clinically also observe, medicine of the present invention recovers the effect of non-obese diabetic people's insulin secretion function in addition, but the also various complication that cause of prophylactic treatment diabetes, and can be used as the adjuvant therapy medicaments of type i diabetes.
The clinical observation result situation is as follows:
One. clinical data
1. physical data
Selected patient all meets the diagnosis of diabetes standard of The World Health Organization's proposition in 1980, among the 347 routine patients, and male 168 examples, women 179 examples; Age 12-89 year (average 50.8 ± 10.0), the course of disease 1 month-29 years (average 7.78 ± 3.9).Noninsulindependent diabetes (NIDDM) 300 examples, sick (IDDM) 47 examples of insulin-dependent sugar.Contrast level 67 examples, man's 29 examples, woman's 38 examples, age 34-82 year (51.4 ± 10.5), the course of disease 3 months (7.1 ± 3.9 years), all patient is divided into 3 groups by treatment situation before going to a doctor: 1. just send out and take capsule for treating group 152 examples of the present invention, be morbidity example just, do not accept any blood sugar lowering treatment, took capsule for treating of the present invention merely; 2. self-controlled group 148 examples, past attempts clothes other medicines treatment curative effect is bad and change and take capsule for treating of the present invention; 3. insulinize group 47 people, the patient of insulinize does not reach the ideal control index, takes capsule for treating of the present invention and change; 4. matched group 67 people: select glyburide, diamicron conventional therapy for use, before the treatment patient is carried out Diabetes Mellitus Knowledge education, and the sugar of having a blood test, glucose in urine, carbohydrate tolerance, blood fat, cholesterol, insulin release test, carbamide ammonia, biochemical analysis such as liver function.
2. Therapeutic Method
Obey capsule 4-12 grain of the present invention every day according to the state of an illness, divide and take for three times, decrement gradually after blood glucose is normal.
Two. the result
1. curative effect determinate standard
Three grades of curative effect determinate standards, 1. produce effects adopting Ministry of Public Health to formulate: fasting glucose, 2 hours after the meal blood glucose, twenty-four-hour urine sugar quantitatively descend more than 30% before the treatment, relevant transference cure, and complication is controlled.2. effective: the quantitatively treatment of fasting glucose, 2 hours after the meal blood glucose, twenty-four-hour urine sugar, preceding decline 10-29%, relevant symptom disappears substantially, the complication treatment of still needing.3. invalid: do not reach These parameters, clinical symptoms does not have obvious change.
Therapeutic outcome see Table 2, table 3
Find out by table 2, table 3: 1. first hair medication therapy groups 152 people of the present invention, produce effects 129 people, effective 21 people, invalid 2 people; Obvious effective rate 85.00%, total effective rate 98.60%, inefficiency 1.40%; 2. self-controlled group 148 people, produce effects 118 people, effective 23 people, invalid 7 people, obvious effective rate 79.00%, total effective rate are 95.00%, inefficiency is 5%; 3. insulinize group 47 people (the Proinsulin consumption is constant) produce effects 43 people, effective 3 people, invalid 1 people, obvious effective rate 93%, total effective rate 97%, inefficiency 2.2%; 4. matched group 67 people, produce effects 46 people, effective 15 people, invalid 6 people, obvious effective rate is 68%, and total effective rate is 76%, and inefficiency is 24%.
Clinical observation proves that the curative effect of Drug therapy of the present invention obviously is better than matched group, also is better than self-controlled group.Take first II type obesity of Drug therapy of the present invention or islet function preferably patient by keep on a diet, the Da Shengli weight standard, took 30% patient Ke Da clinical cure (only need diet control, do not need Drug therapy) medicine 5-8 of the present invention month.
Insulinize group (Proinsulin dosage is constant) adds Drug therapy of the present invention, wherein 5 people stop insulinize and only obey maintenance drug therapy of the present invention, 18 people reduce insulin dosage 12 units every day, 16 insulin humans original every days change secondary every day into three times, capsule of the present invention is the ideal adjuvant therapy medicaments of type i diabetes.
Capsule of the present invention confirms by clinical practice, can promote the beta Cell of islet excreting insulin, promotes the periphery utilization of insulin, can also suppress the glycogen heteroplasia, promotes glycolysis, thereby blood glucose is descended, and makes β cell regeneration.Also have microcirculation improvement, blood fat reducing in addition, fall the effect of blood viscosity.
In Drug therapy of the present invention, we have done the long period work of following up a case by regular visits in (June-3 year do not wait) to patient, except that regular detection bran urine diease occurrence index, also internal organs such as, the heart, liver, kidney have been carried out comprehensively making regular check on of system, check liver function, blood urea nitrogen, myocardial enzymes etc. are not found the infringement of internal organs such as the heart, liver, kidney.
Medicine of the present invention is close on ten thousand example clothes patients through 5 and is taken observation, and few side effects and slight has except that individual patients the symptoms of digestive tract such as abdominal distention, appetite slightly subtract, constipation, diarrhoea, does not find other untoward reaction.
Specific embodiment
Example 1
The used raw material weight umber of this example sees Table 1.Concrete preparation method: herbal raw material is pulverized, crossed 80 mesh sieves, mix homogeneously by the sterilization of vacuum disinfection tank, adds an amount of dextrin and ethanol and makes unguentum, in baking oven, dry to water content be 1%, break into powdery with wobbler then, O packs into
#Capsule by the heavy 0.4g of every capsules, gets final product in the bottle of packing into.
Example 2
Example 2-3 produces capsule by table 1 raw material weight umber proportioning, and preparation method is with example 1.
Table 1
Table 1
| Project | Example 1 | Example 2 | Example 3 |
| The Radix Astragali, umber | ????22 | ????40 | ????30 |
| The Radix Rehmanniae, umber | ????16 | ????30 | ????22 |
| Flos Lonicerae, umber | ????15 | ????30 | ????20 |
| Fruit base of Fructus Momordicae charantiae, umber | ????12 | ????20 | ????15 |
| Fructus Corni, umber | ????7 | ????10 | ????8 |
| Radix Panacis Quinquefolii, umber | ????6 | ????10 | ????8 |
Respectively organize blood glucose, glucose in urine variation before and after table 2 treatment
| Group | Fasting glucose (mmol/L) | 2 hours after the meal blood glucose (mmol/L) | Glycosuria gram (mg/L, 24 hours) | |||
| Before the treatment | After the treatment | Before the treatment | After the treatment | Before the treatment | After the treatment | |
| Just send out medication therapy groups 152 people of the present invention | ??15.27±5.37 | ??8.24±0.42 | ??20.1±8.19 | ??9.37±0.51 | ??108.2±36.31 | ??19.36±15.44 |
| Self-controlled group 148 people | ??11.97±4.20 | ??9.23±2.16 | ??11.90±2.16 | ??9.90±0.32 | ??99.37±32.62 | ??22.18±18.15 |
| Insulinize group 47 people | ??11.76±2.19 | ??8.98±3.12 | ??18.87±7.81 | ??9.52±0.39 | ??78.76±21.66 | ??56.92±22.11 |
| 67 people are organized in confrontation | ??14.16±4.12 | ??9.87±3.62 | ??19.86±9.24 | ??10.52±0.87 | ??108.97±58.71 | ??61.13±16.03 |
Each group is treated result of determination before and after table 3 treatment
| Group | Produce effects | Effectively | Invalid | Obvious effective rate | Total effective rate | Inefficiency |
| First Fa Benmingfa medication therapy groups 152 people | ??129 | ??21 | ??2 | ??85％ | ??98.6％ | ??1.4％ |
| Self-controlled group 148 people | ??118 | ??23 | ??7 | ??79％ | ??95％ | ??5％ |
| Insulinize group 47 people | ??43 | ??3 | ??1 | ??93％ | ??97％ | ??2.2％ |
| Matched group 67 people | ??46 | ??15 | ??6 | ??68％ | ??76％ | ??24％ |
Claims (5)
1. medicine for the treatment of diabetes is characterized in that the medicament of being made by the following weight proportion raw material:
Radix Astragali 20-30 part, Radix Rehmanniae 15-30 part, Flos Lonicerae 10-30 part,
Fruit base of Fructus Momordicae charantiae 10-20 part, Fructus Corni 5-10 part, Radix Panacis Quinquefolii 5-10 part.
2. according to the medicine of the described treatment glycosuria of claim 1, the weight proportion of each raw material wherein:
Radix Astragali 30-40 part, Radix Rehmanniae 20-30 part, Flos Lonicerae 20-30 part,
Fruit base of Fructus Momordicae charantiae 15-20 part, Fructus Corni 5-10 part, Radix Panacis Quinquefolii 5-10 part.
3. according to the medicine of the described treatment glycosuria of claim 1, it is characterized in that described medicament comprises powder, honeyed pill, the watered pill, capsule.
4. according to the preparation method of the medicine of the described treatment glycosuria of claim 3, it is characterized in that may further comprise the steps:
(1) Radix Astragali, the Radix Rehmanniae, Flos Lonicerae, fruit base of Fructus Momordicae charantiae, Fructus Corni, Radix Panacis Quinquefolii are pulverized, crossed 80 mesh sieves, and with the medicated powder mix homogeneously;
(2) medicated powder of step (1) being put into the vacuum disinfection tank sterilizes with alcohol steam;
(3) medicated powder after the sterilization is made the honeyed pill or the watered pill, medicated powder after perhaps will sterilizing adds an amount of dextrin and ethanol is made unguentum, reenter baking oven and heat,, make powder then or get dried cream and put into wobbler and break into the fine particle O that packs into to water content≤1% to 100 ℃ of oven dry
#Capsule, every capsules 0.4g divides the bottle of packing into to get final product.
5. in accordance with the method for claim 4, directly add medical starch and ethanol behind its Chinese medicine powder mix homogeneously and make unguentum, reentering baking oven heats to 100 ℃ of oven dry, to water content≤1%, get dried cream and put into wobbler and break into fine particle, and with on its lay case, thickness is 1cm, with ultraviolet radiation sterilization in 1 hour, O packs into
#Capsule, the heavy 0.4g of every capsules divides the bottle of packing into to get final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011306874A CN1169547C (en) | 2001-08-20 | 2001-08-20 | Medicine for treating diabetes and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011306874A CN1169547C (en) | 2001-08-20 | 2001-08-20 | Medicine for treating diabetes and its preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1404852A true CN1404852A (en) | 2003-03-26 |
| CN1169547C CN1169547C (en) | 2004-10-06 |
Family
ID=4670065
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB011306874A Expired - Fee Related CN1169547C (en) | 2001-08-20 | 2001-08-20 | Medicine for treating diabetes and its preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1169547C (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1330353C (en) * | 2005-06-24 | 2007-08-08 | 焦家良 | Chinese traditional medicine for adjusting contents of blood sugar and blood fat, and preparation method |
| CN103656647A (en) * | 2013-10-11 | 2014-03-26 | 黄培光 | Effective prescription for radically treating diabetes |
| CN103652193A (en) * | 2013-12-11 | 2014-03-26 | 山东中大药业有限公司 | Health-care tea for diabetics |
| CN105663772A (en) * | 2016-02-29 | 2016-06-15 | 杨成 | Drug for treating diabetes mellitus |
-
2001
- 2001-08-20 CN CNB011306874A patent/CN1169547C/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1330353C (en) * | 2005-06-24 | 2007-08-08 | 焦家良 | Chinese traditional medicine for adjusting contents of blood sugar and blood fat, and preparation method |
| CN103656647A (en) * | 2013-10-11 | 2014-03-26 | 黄培光 | Effective prescription for radically treating diabetes |
| CN103652193A (en) * | 2013-12-11 | 2014-03-26 | 山东中大药业有限公司 | Health-care tea for diabetics |
| CN103652193B (en) * | 2013-12-11 | 2015-06-03 | 衣艳 | Health-care tea for diabetics |
| CN105663772A (en) * | 2016-02-29 | 2016-06-15 | 杨成 | Drug for treating diabetes mellitus |
| CN105663772B (en) * | 2016-02-29 | 2019-03-08 | 杨成 | A kind of drug for treating diabetes |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1169547C (en) | 2004-10-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101554362A (en) | Composition of natural product and preparation thereof | |
| CN102631595B (en) | Medicament for treating II-type diabetes mellitus and preparation method thereof | |
| CN1169547C (en) | Medicine for treating diabetes and its preparation method | |
| CN1401365A (en) | Chinese health medicine | |
| CN1108159C (en) | Traditional Chinese medicine for curing diabetes and kidney deficiency | |
| CN1052419C (en) | Herb medicine for treating diabetes mellitus | |
| CN101077360B (en) | Medicinal composition for treating sugar diabetes skin ulcer and preparation method thereof | |
| CN101204554B (en) | Medicaments composite for stomach illness and preparation method thereof | |
| CN1939494A (en) | Purge capsules for old person and production thereof | |
| CN1131051C (en) | medicine for treating cervical spondylosis and preparation method thereof | |
| CN1943691A (en) | A Chinese traditional medicinal composition for treatment of osteoporosis and its preparation method | |
| CN1895504A (en) | Chinese medicine for treating osteoporosis and its preparation | |
| CN100339119C (en) | Traditional Chinese medicine prepns. for treating diabete | |
| CN1748771A (en) | Chinese medicine composition for treating diabetes and its preparing method and use | |
| CN100345575C (en) | Chinese-medicinal preparation for treating gastropathy and its making method | |
| CN1269518C (en) | Compound medicine for treating tuberculosis and its preparing method | |
| CN114377063B (en) | Traditional Chinese medicine composition for treating delayed fracture healing | |
| CN102579801B (en) | Traditional Chinese medicine preparation for treating diabetic syndrome and preparation method of same | |
| CN1318042C (en) | Application of barbat skullcap in preparing medication for treating diabetes | |
| CN101347483A (en) | Chinese herbal medicinal composition for treating enterogastric disease and preparation method and use | |
| CN1233394C (en) | Reumatic arthritis treating medicine | |
| CN1306830A (en) | Medicine for treating type II diabetes | |
| CN1122524C (en) | Chinese medicine for treating diabetes and its preparing process | |
| CN1097333A (en) | A kind of pure plant health preparation glycolipid disappears and method for making | |
| CN1686365A (en) | Medicinal composition for treating diabetes and its preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |