CN1274677C - 一种利美尼定的制备方法 - Google Patents
一种利美尼定的制备方法 Download PDFInfo
- Publication number
- CN1274677C CN1274677C CN 200410054136 CN200410054136A CN1274677C CN 1274677 C CN1274677 C CN 1274677C CN 200410054136 CN200410054136 CN 200410054136 CN 200410054136 A CN200410054136 A CN 200410054136A CN 1274677 C CN1274677 C CN 1274677C
- Authority
- CN
- China
- Prior art keywords
- preparation
- rilmenidine
- bicyclo
- grams
- toluene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title claims 2
- 238000002360 preparation method Methods 0.000 claims abstract 13
- CQXADFVORZEARL-UHFFFAOYSA-N Rilmenidine Chemical compound C1CC1C(C1CC1)NC1=NCCO1 CQXADFVORZEARL-UHFFFAOYSA-N 0.000 claims abstract 11
- 229960000764 rilmenidine Drugs 0.000 claims abstract 11
- 238000006482 condensation reaction Methods 0.000 claims abstract 3
- 238000006243 chemical reaction Methods 0.000 claims abstract 2
- 238000002425 crystallisation Methods 0.000 claims abstract 2
- 230000008025 crystallization Effects 0.000 claims abstract 2
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 9
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 8
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 4
- IMSODMZESSGVBE-UHFFFAOYSA-N 2-Oxazoline Chemical compound C1CN=CO1 IMSODMZESSGVBE-UHFFFAOYSA-N 0.000 claims 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 3
- PGPFRBIKUWKSTJ-UHFFFAOYSA-N cyclopropylcyclopropane Chemical group C1CC1C1CC1 PGPFRBIKUWKSTJ-UHFFFAOYSA-N 0.000 claims 3
- BAVYZALUXZFZLV-UHFFFAOYSA-N mono-methylamine Natural products NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 claims 3
- 239000003960 organic solvent Substances 0.000 claims 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims 2
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 claims 2
- 239000012046 mixed solvent Substances 0.000 claims 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 2
- ZBOGUDPFEVIZIQ-UHFFFAOYSA-N toluene;dihydrochloride Chemical compound Cl.Cl.CC1=CC=CC=C1 ZBOGUDPFEVIZIQ-UHFFFAOYSA-N 0.000 claims 2
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 abstract 3
- 239000002994 raw material Substances 0.000 abstract 2
- GDGUATCKWWKTLM-UHFFFAOYSA-N dicyclopropylmethanamine Chemical compound C1CC1C(N)C1CC1 GDGUATCKWWKTLM-UHFFFAOYSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000008020 evaporation Effects 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 238000005057 refrigeration Methods 0.000 abstract 1
Images
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- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Description
Claims (9)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 200410054136 CN1274677C (zh) | 2004-08-31 | 2004-08-31 | 一种利美尼定的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 200410054136 CN1274677C (zh) | 2004-08-31 | 2004-08-31 | 一种利美尼定的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1629144A CN1629144A (zh) | 2005-06-22 |
CN1274677C true CN1274677C (zh) | 2006-09-13 |
Family
ID=34846176
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 200410054136 Expired - Lifetime CN1274677C (zh) | 2004-08-31 | 2004-08-31 | 一种利美尼定的制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1274677C (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102351710B (zh) * | 2011-10-21 | 2013-11-27 | 合肥工业大学 | 一种医药中间体双环丙基甲胺的制备方法 |
-
2004
- 2004-08-31 CN CN 200410054136 patent/CN1274677C/zh not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CN1629144A (zh) | 2005-06-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C56 | Change in the name or address of the patentee |
Owner name: REALSUN CHEMICAL GROUP CO.,LTD. Free format text: FORMER NAME: ZHEJIANG LIANSHENG CHEMICAL INDUSTRY CO., LTD. |
|
CP01 | Change in the name or title of a patent holder |
Address after: Zhejiang Jia Zhi Jiaojiang District of Taizhou City, Zhejiang province 318013 Sanshan Industrial Zone Liansheng Chemical Industry Co Ltd Patentee after: Liansheng Chemical Group Co Ltd Address before: Zhejiang Jia Zhi Jiaojiang District of Taizhou City, Zhejiang province 318013 Sanshan Industrial Zone Liansheng Chemical Industry Co Ltd Patentee before: Zhejiang Realsun Chemical Industry Co., Ltd. |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20160401 Address after: 317016 Zhejiang City, Zhejiang Province, Taizhou City, Anhui Province, chemical raw material base, Waterfront Park Patentee after: Linhai Liansheng Chemical Co., Ltd. Address before: Zhejiang Jia Zhi Jiaojiang District of Taizhou City, Zhejiang province 318013 Sanshan Industrial Zone Liansheng Chemical Industry Co Ltd Patentee before: Liansheng Chemical Group Co Ltd |
|
C56 | Change in the name or address of the patentee | ||
CP03 | Change of name, title or address |
Address after: No. 9 Taizhou 317016 Zhejiang 317000 Toumen Port District East Third Avenue near the sea Patentee after: Zhejiang Liansheng chemical Limited by Share Ltd Address before: 317016 Zhejiang City, Zhejiang Province, Taizhou City, Anhui Province, chemical raw material base, Waterfront Park Patentee before: Linhai Liansheng Chemical Co., Ltd. |