CN115779025A - Traditional Chinese medicine preparation for treating female acne and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for treating female acne and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal preparation for treating female acne and a preparation method thereof, wherein the medicament is prepared from dandelion, fructus forsythiae, bighead atractylodes rhizome, angelica, poria cocos, ligusticum wallichii, white paeony root, rhizoma alismatis, radix angelicae, almond and platycodon grandiflorum by adding, reducing and cutting: scutellariae radix for patients with rash affecting cheeks; fructus Gardeniae and cortex Phellodendri can be added for treating rash involving chin and mandible; greasy face: adding the three immortals; rhizoma Pinelliae can be added to treat thick greasy tongue coating. The invention has the functions of clearing away heat and toxic material, strengthening spleen and resolving fluid retention, and regulating qi and blood for the female acne with heat toxin accumulated on the upper head, face, chest and back and the pathogenesis basis of phlegm-fluid retention and heat-resolving, namely spleen deficiency fluid retention or qi-blood disharmony. The whole formula combines cold and warm properties and treats both principal and secondary aspects of disease so as to achieve the purpose of removing acne.
Description
Technical Field
The invention relates to the field of medicines, in particular to a traditional Chinese medicine preparation for treating female acne, a preparation method and a preparation method thereof.
Background
Acne Vulgaris (Acne Vulgaris, AV) is a chronic inflammatory skin disease that involves hair follicle-sebaceous gland, and is one of the common dermatosis with lesions, and many patients, especially women, are full of the disease. The pathogenesis of the disease is generally considered to be related to hormone level imbalance, propionibacterium acnes colonization, follicular keratosis, genetic related factors and the like, wherein the hormone level has important influence on the occurrence and development of the disease, and the pathogenesis of the disease is mainly characterized in that the pathogenesis of the disease is that the hyperkeratosis of hair follicle sebaceous glands is promoted, and the hypersecretion of the hair follicle sebaceous glands is stimulated, and the specific mechanism is as follows: 1) By affecting fibroblasts, fibroblast production is promoted, leading to hyperkeratosis of the follicular orifice, accumulation of sebum, and induction of inflammation. 2) Through promoting the generation of a mammalian rapamycin target C1 pathway (mTORC 1), sterol regulatory element binding protein-1 (SREBP-1) is activated so as to promote the synthesis and secretion of lipid.
The inventor finds in clinical practice that female acne patients generally have symptoms of intermingled deficiency and excess and intermingled cold and heat besides the heat-toxicity symptoms, such as: cold limbs, lusterless or pale complexion, loose and tender muscle, quiet and lazy movement, shortness of breath and no desire to speak, lassitude and hypodynamia or dizziness and palpitation, insomnia and dreamful sleep, pale and swollen (slippery) tongue with white or thick greasy coating, deep and thready and weak pulse, and the like, and is often accompanied by thirst and no desire to drink, red face, greasy desquamation, greasy coating and yellow coating, and the rash is manifested as red papule, painful nodule and cyst, pungent food intake and obvious aggravation of skin rash after being decocted overnight. However, the existing medicines and treatment methods for treating the diseases are more, but the treatment effect is not ideal, the disease is easy to relapse, and the disease is difficult to be cured radically.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine compound for treating female acne and a preparation method thereof, and the traditional Chinese medicine compound has an obvious curative effect on female acne caused by heat toxin flaming and skin accumulation (heat toxin accumulation or heat toxin accumulation) accompanied with spleen deficiency fluid retention or accompanied with qi and blood disharmony.
The technical scheme of the invention is as follows:
the traditional Chinese medicine preparation for treating female acne comprises the following medicinal effective components in parts by weight: is prepared from 100-220 parts of dandelion, 100-220 parts of forsythia, 80-200 parts of atractylodes, 40-160 parts of angelica, 80-200 parts of tuckahoe, 40-160 parts of hemlock parsley, 100-450 parts of white peony root, 100-220 parts of alisma orientale, 50-180 parts of angelica dahurica, 50-180 parts of almond and 50-180 parts of platycodon root.
The traditional Chinese medicine preparation for treating female acne comprises the following medicinal effective components in parts by weight: is prepared from dandelion 130-170 parts, forsythia 130-170 parts, white atractylodes rhizome 100-140 parts, chinese angelica root 70-110 parts, poria cocos wolf 100-140 parts, ligusticum wallichii 70-110 parts, root of herbaceous peony 200-400 parts, oriental water plantain rhizome 130-170 parts, dahurian angelica root 80-120 parts, apricot kernel 80-120 parts, root of balloonflower 80-120 parts.
Specifically, the medicinal effective components of the traditional Chinese medicine preparation for treating female acne are calculated according to the weight components: is prepared from 150 parts of dandelion, 150 parts of forsythia, 120 parts of atractylodes, 90 parts of angelica, 120 parts of tuckahoe, 90 parts of hemlock parsley, 300 parts of white peony root, 150 parts of alisma orientale, 100 parts of angelica dahurica, 100 parts of almond and 100 parts of platycodon root.
More specifically, in the traditional Chinese medicine preparation for treating female acne, 100-220 parts of scutellaria baicalensis is added in the formula, wherein the acne patients have rash involving cheeks.
More specifically, in the traditional Chinese medicine preparation for treating female acne, patients with acne mainly have rash affecting chin and lower jaw, and 50-200 parts of cape jasmine fruit and 40-160 parts of salted phellodendron bark are added in the formula.
More specifically, 40-160 parts of rhizoma pinellinae praeparata is added in the traditional Chinese medicine preparation for treating female acne, wherein a thick and greasy fur is provided for acne patients.
More specifically, in the traditional Chinese medicine preparation for treating female acne, the acne patients have greasy faces, and 40-160 parts of malt, 40-160 parts of hawthorn and 40-160 parts of medicinal fermented mass are added in the formula.
According to the preparation method of the traditional Chinese medicine preparation for treating female acne, all medicinal materials in the formula are weighed according to a proportion, processed according to a conventional preparation method, combined with pharmaceutically acceptable pharmaceutic adjuvants and matrixes in the medicine, and prepared into a corresponding oral preparation.
The oral preparation comprises powder, capsule, tablet, pill, granule or soft extract.
The preparation method of the powder comprises the following steps: weighing the medicinal materials according to the proportion, crushing into fine powder, and mixing uniformly to obtain the traditional Chinese medicine.
The preparation method of the capsule comprises the following steps: weighing the medicinal materials according to the proportion of the prescription, adding 6-10 times of water, soaking for 0.5-2h, decocting for 2-3 times, each time for 1-2h, combining the decoctions, mixing uniformly, concentrating to 80% of the original liquid medicine, filtering while hot, concentrating the filtrate to an extract with the relative density of 1.15-1.25 at 70 ℃, drying at 70 ℃ to obtain a dry extract, crushing into fine powder, adding 10% of prepared starch slurry, granulating, drying, finishing granules, and filling into capsules to obtain the traditional Chinese medicine.
The preparation method of the tablet comprises the following steps: weighing the medicinal materials according to the proportion of the prescription, adding 6-10 times of water, soaking for 0.5-2h, decocting for 2-3 times, each time for 1-2h, mixing the decoctions, mixing uniformly, concentrating to 80% of the original liquid medicine, filtering while hot, concentrating the filtrate to an extract with a relative density of 1.20-1.30 at 70 ℃, drying the extract at 70 ℃, and pulverizing into fine powder to obtain a dry extract, taking the dry extract, adding 10% of dextrin, granulating by using 70% of ethanol as a wetting agent, drying, tabletting, and coating with a film to obtain the tablet.
The preparation method of the granules comprises the following steps: weighing the medicinal materials according to the proportion of the formula, adding 6-10 times of water, soaking for 0.5-2h, decocting for 2-3 times, each time for 0.5-2h, combining the decoctions, mixing uniformly, concentrating to 80% of the original liquid, filtering while hot, concentrating the filtrate to an extract with a relative density of 1.20-1.30 at 70 ℃, drying the extract at 70 ℃, and crushing into fine powder to obtain a dry extract, taking 10% of dry sucrose, granulating with 80% of ethanol as a wetting agent, drying at 60 ℃, sieving with a 12-mesh sieve for 1 time, and sieving with a 60-mesh sieve to obtain fine powder to obtain the granules.
The preparation method of the granules comprises the following steps: weighing the medicinal materials according to the proportion of the prescription, adding 6-10 times of water, soaking for 0.5-2h, decocting for 2-3 times, each time for 0.5-2h, combining the decoctions, mixing well, concentrating to 80% of the original liquid, filtering while hot, concentrating the filtrate to an extract with a relative density of 1.20-1.30 at 70 ℃, adding honey, and stirring uniformly to obtain the ointment.
Compared with the prior art, the invention has the following beneficial effects:
the traditional Chinese medicine compound for treating acne is prepared from dandelion, fructus forsythiae, bighead atractylodes rhizome, angelica, poria cocos, ligusticum wallichii, radix paeoniae alba, rhizoma alismatis, radix angelicae, almond and platycodon grandiflorum. Adding Scutellariae radix, fructus Gardeniae, cortex Phellodendri, radix Clematidis (fructus Hordei Germinatus, fructus crataegi, and Massa Medicata Fermentata), and rhizoma Pinelliae Preparata; the properties and the efficacies of the components are as follows: the herba Taraxaci is dried whole plant of Taraxacum mongolicum hand-held of Compositae, taraxacum borealisinsens Kitam, or plants of the same genus; digging and removing when the flower is first opened from spring to autumn; cleaning impurities, and drying in the sun; sweet taste and cold nature; it enters liver and stomach meridians; has effects in clearing away heat and toxic materials, relieving swelling, dispersing pathogen accumulation, and inducing diuresis for treating stranguria; can be used for treating furuncle, swelling, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, pulmonary abscess, intestinal abscess, jaundice due to damp-heat pathogen, and stranguria with astringency and pain due to heat. Fructus forsythiae is dried fruit of Vahl of Forsythia subspensa (Thunb.) of Oleaceae; bitter taste, slightly cold nature; it enters lung, heart and small intestine meridians; has effects of clearing away heat and toxic materials, relieving swelling, dispersing pathogen accumulation, and dispelling pathogenic wind and heat; can be used for treating carbuncle, cellulitis, scrofula, acute mastitis, erysipelas, wind-heat type common cold, early warm disease, high fever, polydipsia, coma, macula, and stranguria caused by heat. The Atractylodis rhizoma is dried rhizome of Atractylodes macrocephala Koidz of Compositae; digging when lower leaves are dry and yellow and upper leaves become brittle in winter, removing silt, drying or sun drying, and removing fibrous roots; bitter and sweet in taste and warm in nature; spleen and stomach meridians entered; has effects of invigorating spleen qi, eliminating dampness, promoting diuresis, arresting sweating, and preventing miscarriage; can be used for treating deficiency-type spleen, anorexia, abdominal distention, diarrhea, phlegm retention, dizziness, palpitation, edema, spontaneous perspiration, and threatened abortion. Radix Angelicae sinensis is dried root of Angelica sinensis (oliv.) Diels of Umbelliferae; digging in late autumn, removing fibrous root and silt, bundling into small bundle after water is slightly evaporated, putting on shed, and slowly smoking with firework; sweet and pungent taste, warm in nature; it enters liver, heart and spleen meridians; has effects in replenishing blood, promoting blood circulation, regulating menstruation, relieving pain, and loosening bowel to relieve constipation; can be used for treating blood deficiency, sallow complexion, giddiness, cardiopalmus, menoxenia, amenorrhea, dysmenorrhea, asthenia cold abdominal pain, rheumatalgia, traumatic injury, superficial infection, pyocutaneous disease, intestinal dryness, and constipation; the wine angelica is used for activating blood and stimulating menstrual flow; can be used for treating amenorrhea, dysmenorrhea, rheumatalgia, and traumatic injury. Poria is dry sclerotium of Wolf of Poria cocos (Schw.) Cos (belonging to Polyporaceae); sweet and light taste, mild in nature; the heart, lung, spleen and kidney meridians are entered; has effects in promoting diuresis, eliminating dampness, invigorating spleen, and calming mind; can be used for treating edema, oliguria, palpitation due to phlegm and fluid retention, spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, palpitation, and insomnia. Rhizoma Ligustici Chuanxiong is dried rhizome of Ligusticum chuanxiong Hort of Umbelliferae; in summer, when the segment disc on the stem is obviously protruded and is slightly purple, the segment disc is dug, silt is removed, the segment disc is dried after being dried, and then fibrous roots are removed; pungent taste and warm nature; it enters liver, gallbladder and pericardium meridians; has effects in promoting blood circulation, activating qi-flowing, dispelling pathogenic wind, and relieving pain; can be used for treating thoracic obstruction, cardialgia, pricking pain in chest and hypochondrium, traumatic injury, menoxenia, amenorrhea, dysmenorrhea, abdominal mass, abdominal pain, headache, and rheumatalgia. Radix Paeoniae alba is dried root of Paeonia lactiflora pall of Ranunculaceae; bitter and sour in taste, slightly cold in nature; it enters liver and spleen meridians; has effects in nourishing blood, regulating menstruation, astringing yin, arresting sweating, nourishing liver, relieving pain, and suppressing liver yang; can be used for treating blood deficiency, sallow complexion, menoxenia, spontaneous perspiration, night sweat, hypochondriac pain, abdominal pain, limb spasm pain, headache, and vertigo. Alismatis rhizoma is dried tuber of Alisma orientale (Sam.) Juzep. Of Alismaceae; picking up stems and leaves in winter when the stems and leaves begin to wither, cleaning, drying, and removing fibrous roots and rough skins; sweet and bland in flavor and cold in nature. Kidney meridian and bladder meridian entered; has effects in promoting diuresis, eliminating dampness, clearing away heat, eliminating turbid pathogen, and reducing blood lipid; can be used for treating dysuria, edema, diarrhea, oliguria, phlegm retention, vertigo, stranguria due to heat-evil, and hyperlipidemia. Radix Angelicae Dahuricae is dried root of Angelica dahurica (Fisch. Ex Hoffm.) Benth.et hook.f. or Angelica dahurica (Fisch. Ex Hoffm.) Benth.et hook.f. var.fortusana (Boiss.) Shan et Yuan; collecting yellow leaves in summer and autumn, removing fibrous root and silt, and sun drying or low temperature drying; pungent taste and warm nature; entering stomach, large intestine and lung meridians; has the effects of relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, dredging nasal orifice, eliminating dampness, stopping leukorrhagia, and relieving swelling and pus discharge; can be used for treating common cold, headache, nose ache, nasal obstruction, allergic rhinitis, nasosinusitis, toothache, leukorrhagia, skin and external diseases, and toxic swelling. Almond is dried mature seed of Prunus armeniaca L. Var. Ansu Maxim, prunus sibirica L. Of Siberian, prunus mandshurica (Maxim.) Koehne or Prunus armeniaca L. Of Rosaceae; collecting mature fruits in summer, removing pulp and nucleocapsid, taking out seeds, and drying in the sun; bitter taste and slightly warm nature; has little toxicity; it enters lung and large intestine meridians; has effects of lowering qi, relieving cough and asthma, and loosening bowel to relieve constipation; can be used for treating cough, asthma, fullness in chest, excessive phlegm, intestinal dryness, and constipation. The Platycodon grandiflorum is dried root of Platycodon grandiflorum (Jacq.) DC of Campanulaceae; bitter and pungent taste, mild in nature; entering lung meridian; has effects in dispersing lung qi, relieving sore throat, eliminating phlegm, and expelling pus; can be used for treating cough with excessive phlegm, chest distress, pharyngalgia, hoarseness, lung carbuncle, and purulent vomiting. The Scutellariae radix is dried root of Scutellaria baicalensis Georgi of Labiatae; digging in spring and autumn, removing fibrous root and silt, drying in the sun, removing coarse skin, and drying in the sun; bitter taste and cold nature; it enters lung, gallbladder, spleen, large intestine and small intestine meridians; has effects in clearing away heat, eliminating dampness, purging pathogenic fire, removing toxic substances, stopping bleeding, and preventing miscarriage; can be used for treating damp-warm syndrome, summer-heat dampness, chest distress, emesis, dampness and heat distention, dysentery, jaundice, cough due to lung heat, hyperpyrexia, polydipsia, hematemesis, carbuncle, swelling, sore, and threatened abortion. The parched fructus Gardeniae is parched by clear parching method; fructus Gardeniae is dried mature fruit of Gardenia jasminoides Ellis of Rubiaceae; harvesting when the fruits are ripe and reddish yellow for 9-11 months, removing fruit stalks and impurities, steaming to the upper air or slightly scalding in boiling water, taking out and drying; bitter taste and cold nature. The heart, lung and triple energizer meridians entered; has the effects of purging pathogenic fire, relieving restlessness, clearing away heat, promoting diuresis, cooling blood, and removing toxic substances; the external use has the effects of relieving swelling and pain; can be used for treating pyretic vexation, jaundice due to damp-heat pathogen, stranguria, hematemesis, epistaxis, conjunctival congestion, swelling and pain, and pyocutaneous disease due to pathogenic fire; it can be used for treating sprain, contusion and pain. Cortex Phellodendri is dried bark of Phellodenron chinensis Schneid of Rutaceae; bitter taste and cold nature; entering kidney and bladder meridians; has effects in clearing away heat, eliminating dampness, purging pathogenic fire, removing steam, removing toxic materials, and treating sore; can be used for treating damp-heat dysentery, jaundice, dark urine, leukorrhagia, pudendal pruritus, pyretic stranguria, pain, tinea pedis, atrophy 36484, hectic fever, night sweat, spermatorrhea, pyocutaneous disease, toxic swelling, eczema, and eczema. Salted cortex phellodendri is used for nourishing yin and reducing internal heat. Can be used for treating hyperactivity of fire due to yin deficiency, night sweat, and steaming bone. The fructus Hordei Germinatus is processed product of mature fruit of Hordeum vulgare L. of Gramineae by germination and drying; sweet in flavor and mild in nature; spleen and stomach meridians entered; has effects in promoting qi circulation, promoting digestion, invigorating spleen, stimulating appetite, promoting lactation, and relieving flatulence; can be used for treating dyspepsia, abdominal pain, deficiency of spleen-deficiency food, breast milk stagnation, breast pain, breast weaning, hypochondriac pain due to stagnation of liver-qi, and pain of liver and stomach; the raw malt has the functions of strengthening the spleen and stomach, soothing the liver and promoting the circulation of qi; used for treating spleen deficiency, anorexia, milk stasis, and parched fructus Hordei Germinatus have effects of activating qi-flowing, resolving food stagnation, and promoting lactation; can be used for treating indigestion and delactation of women; the parched fructus Hordei Germinatus has functions of resolving food stagnation; can be used for treating abdominal pain and distention due to indigestion. The fructus crataegi is processed product of dried mature fruit of Crataegus pinnatifida Bge.var.major N.E.Br. or Crataegus pinnatifida Bge.of Rosaceae; harvesting in autumn when the fruit is ripe, slicing, drying, parching to brown surface by parching (general rule 0213), and getting parched fructus crataegi; sour and sweet in taste, slightly warm in nature; it enters spleen, stomach and liver meridians; has effects in promoting digestion, invigorating stomach, promoting qi circulation, removing blood stasis, eliminating turbid pathogen, and reducing blood lipid; can be used for treating meat stagnation, gastric cavity distention, dysentery, abdominal pain, blood stasis, amenorrhea, puerperal stagnation, heart and abdominal pain, thoracic obstruction, heart pain, hernia pain, and hyperlipidemia; the digestion promoting and stagnation removing effects of the charred hawthorn are enhanced; can be used for treating food stagnation and diarrhea and dysentery. The medicated leaven is a yellow brown rectangular block, has rough outer surface, yellow brown color, white mold, loose section, yellow brown fragrance and slight taste; has effects in relieving exterior syndrome and regulating stomach function; can be used for treating headache due to cold and heat, dyspepsia, emesis, and distention. Rhizoma Pinelliae Preparata is processed product of rhizoma Pinelliae; the rhizoma Pinelliae is dried tuber of Pinellia Tuber Pinellia ternata (Thunb.) of Araceae; pungent taste and warm nature; spleen, stomach and lung meridians; has effects in eliminating dampness and phlegm; can be used for treating cough and asthma with excessive phlegm, dizziness and palpitation due to phlegm and fluid retention, dizziness and headache due to phlegm syncope.
Square solution:
monarch drug: dandelion and forsythia; radix Scutellariae.
Fructus forsythiae, which belongs to the lung, heart and gallbladder channels, has the functions of clearing away heat and toxic materials, eliminating carbuncle and dissipating stagnation, and dispelling wind and dissipating heat, and is called as "sore house saint medicine" for treating carbuncle, swelling and furuncle caused by heat-toxin and fire-toxin; dandelion, bitter and cold in property, enters liver and stomach meridians, and can clear heat from liver and stomach, resolve swelling and dissipate nodulation, and treat upper energizer like feather but not just light but weak, and is good at clearing heat-toxin in muscle and skin striae due to light and floating texture of Dandelion. Used in combination with forsythia to clear the internal heat of upper jiao and reduce stagnation and relieve swelling; baikal skullcap root, radix Scutellariae, bitter and cold in flavor, with the actions of drying dampness and clearing lung heat, is a principal drug for treating acne caused by wind-heat in lung channel. The dandelion and the forsythia are combined to be monarch drugs, or the dandelion and the forsythia are combined to be monarch drugs with the scutellaria baicalensis, and the monarch drugs and the dandelion and the forsythia are combined to play the roles of clearing heat, detoxifying and dissipating stagnation, or clearing lung heat, detoxifying and dissipating stagnation.
Ministerial drugs: atractylodis rhizoma, poria, and Alismatis rhizoma; angelica, hemlock parsley and white peony root; gardenia and salted phellodendron bark.
(1) Atractylodes, poria, alisma: bighead atractylodes rhizome and tuckahoe are combined, and Bighead atractylodes rhizome is bitter and sweet in taste, warm in nature, enters spleen and stomach channels, is good at tonifying qi to recover spleen transportation, and can also eliminate dampness and promote diuresis to eliminate dampness, so that the white atractylodes rhizome and tuckahoe are the essential medicines for treating spleen deficiency syndromes, and also are good medicines for treating phlegm retention and edema. Poria cocos is sweet and bland, sweet can tonify, and bland can permeate, so as to strengthen body resistance, eliminate pathogenic factors, have the effects of tonifying heart and spleen, promoting diuresis and removing dampness, tonify but not be drastic, benefit but not be violent, and is an essential herb for tonifying spleen and permeating dampness, and also can calm heart and tranquilize mind. Bighead atractylodes rhizome is mainly used for strengthening spleen and eliminating dampness, tuckahoe is mainly used for promoting diuresis and excreting dampness, and when two medicines are used together, one medicine can excrete and the dampness can cause a way, so the spleen can be healthy, damp can be eliminated, swelling can be eliminated, the body can be dissolved, and various kinds of treatment can be eliminated. Rhizoma alismatis is sweet and light in taste and cold in nature, and has the effects of inducing diuresis, excreting dampness, clearing heat and relieving swelling; cold can remove heat, sweet and bland, and excrete dampness, entering kidney and bladder meridians, so it excels in purging kidney fire and excreting dampness of bladder meridian, so it is the herb for inducing diuresis, removing dampness and purging heat; when combined with Bai Zhu and Fu Ling, the herbs have strong spleen qi, good transportation of water dampness, damp-excreting and spleen-qi resolving, turbid yin purgation, self-lifting of clear yang, combined tonics and purgations, mutually supplementing each other, strengthening spleen and removing dampness, so they have very good effect. Therefore, the three medicines are combined to treat the source of dampness and heat caused by spleen deficiency and phlegm retention, and the monarch medicine is taken as the first group of ministerial medicines.
(2) Chinese angelica, ligusticum wallichii, root of herbaceous peony: the angelica has pungent, sweet and warm flavor, enters liver, heart and spleen channels, has the functions of tonifying and warming and dredging, and replenishing blood to regulate qi and activate blood, and is known as holy medicine in blood; when used together with Bai Zhu, it can nourish liver blood and regulate qi and blood to promote circulation, tonify spleen qi and assist spleen yang to promote circulation, and is a common herb pair for regulating qi and blood. White peony root, radix Paeoniae alba is sour and bitter in taste, slightly cold in nature, enters liver and spleen meridians, and has the effects of nourishing blood, astringing yin, regulating nutrient and nourishing liver; the Chinese angelica is used together with the Chinese angelica, the Chinese angelica has the effect of enriching blood and is mainly used for warming yang, the nature of the Chinese angelica is dynamic and mainly walking, the white paeony root has the effect of enriching blood and is mainly used for nourishing yin, the nature of the white paeony root is static and mainly kept, the two medicines are used together with cold and warm, and dynamic and static are combined to play the effects of nourishing yin and enriching blood, harmonizing the spleen with the liver and activating blood circulation to dissipate blood stasis, and the Chinese angelica is mainly used for treating all the diseases of deficiency of qi and blood and incoordination between the liver and the spleen; the rhizoma ligustici wallichii is pungent in flavor and warm in nature, has the effects of promoting qi circulation, relieving depression, dispelling wind, eliminating dampness, promoting blood circulation and relieving pain, can give consideration to both qi system and blood system stasis, and is a key treatment medicine for both qi and blood. The angelica and the white peony root have the effects of tonifying yin by blood and promoting blood circulation by the ligusticum wallichii, and the three medicines are used together to ensure that blood and qi descend, blood vessels are unobstructed and blood stasis is removed. The above three drugs help the monarch drugs to regulate qi and blood, remove toxicity and dissipate stagnation, so it is combined as the second group of ministerial drugs.
(3) Gardenia, salted phellodendron bark: all herbs are bitter, cold and damp-drying, but acne is caused by heat-toxicity originating from triple energizer and phlegm-fluid retention obstructing qi transformation of triple energizer, so Zhi Zi can clear heat and dampness of triple energizer and smooth qi movement, so as to facilitate the monarch drug to clear heat and remove toxicity. Huang Bai is good at nourishing yin and clearing heat because it can clear heat from both sides. In addition, stir-baked fructus Gardeniae and salted cortex Phellodendri can avoid excessive cold and damp heat, and can also guide herbs to enter kidney (lower energizer) to control lower energizer fire. The two herbs are combined to help the monarch drug by clearing heat in lower energizer and triple energizer, and are combined as the third group of ministerial drugs.
Adjuvant drugs: radix Angelicae Dahuricae, semen Armeniacae amarum, and radix Platycodi; hawthorn fruit, malt and Jianqu
Phlegm-fluid retention is caused by dysfunction of the spleen and stomach in transportation and transformation, and failure of the lung to disperse and descend, so it can block the striae and skin and hair, while xing ren is bitter in taste and warm in nature, enters lung and large intestine meridians, and has the action of dispersing lung qi. The bitter, pungent and even platycodon root can disperse lung qi, descend and purge qi, ascend and descend, disperse lung qi, promote chest and diaphragm qi, descend lung qi, dispel phlegm and expel pus, moisten texture and relax bowel. The two medicines are combined, one is descending and the other is dispersing, the functions of dispersing lung qi, relieving sore throat, reducing phlegm and dredging intestines and stomach are achieved, and the three medicines are combined to relieve constipation, so that the pathogenic factors of heat toxin and phlegm dampness are removed, and the pathogenic factors are led out. The radix angelicae dahuricae is pungent and warm, and can assist monarch and minister to perform aromatic dampness-resolving and blood vessel dredging, and also assist monarch and minister to perform bitter diarrhea and injure healthy qi. The hawthorn, the malt and the Jianqu can relieve the food retention of wheaten food, cereal food and meat, promote digestion, prevent the source of phlegm-damp endogenous, and achieve the effects of removing fat and controlling oil. The herbs are warm in nature, so they can be used to monitor the bitter-cold nature of monarch and ministerial herbs to prevent the bitter-cold from damaging the body resistance. Therefore, the almond, the platycodon root, the malt and the medicinal fermented mass are used as adjuvant drugs.
A messenger drug: radix Platycodi and radix Angelicae Dahuricae are led to the upper jiao head and face to make the herbs go up and directly reach the disease, so they are also used as guiding drugs.
In conclusion, the invention has the effects of clearing heat and resolving fluid, strengthening spleen and replenishing qi and harmonizing qi and blood for the female acne with heat toxin accumulated in upper jiao head, face, chest and back and also with the pathogenesis basis of phlegm-fluid retention and heat resolving, namely spleen deficiency and fluid retention and qi and blood disharmony. The whole formula combines cold and warm properties, and treats both principal and secondary aspects of disease to achieve the purpose of removing acne.
Description of the drawings:
FIG. 1: the effective rate of treatment;
FIG. 2: case 1 pre-treatment pictures;
FIG. 3: pictures after treatment of case 1;
FIG. 4 is a schematic view of: case 3 pre-treatment pictures;
FIG. 5 is a schematic view of: case 3 post-treatment pictures.
Detailed Description
The present invention is further illustrated by the following examples, which are not to be construed as limiting the invention.
Example 1:
prescription: 15g of dandelion, 15g of fructus forsythiae, 12g of bighead atractylodes rhizome, 9g of angelica, 12g of poria cocos, 9g of ligusticum wallichii, 30g of radix paeoniae alba, 15g of rhizoma alismatis, 10g of radix angelicae, 10g of almond and 10g of platycodon grandiflorum;
the preparation process comprises the following steps: weighing the medicinal materials according to the proportion, crushing into fine powder, and mixing uniformly to obtain the powder.
The usage and dosage are as follows: one dose is taken every day, and the medicine is taken randomly for 5 days every week, is soaked in 300ml of boiled water, is filtered, is taken 150ml warm in the morning and at night, and is continuously taken for four weeks.
Example 2:
prescription: 10g of dandelion, 10g of fructus forsythiae, 8g of bighead atractylodes rhizome, 4g of angelica, 8g of poria cocos, 4g of ligusticum wallichii, 10g of radix paeoniae alba, 10g of rhizoma alismatis, 5g of radix angelicae, 5g of almond, 5g of platycodon grandiflorum and 10g of scutellaria baicalensis;
the preparation process comprises the following steps: weighing the medicinal materials according to the proportion of the prescription, adding 6 times of water to soak for 0.5h, decocting for 3 times, each time for 2h, combining the three decoctions, mixing uniformly, concentrating to 80% of the original liquid, filtering while hot, concentrating the filtrate to an extract with the relative density of 1.15-1.25 at 70 ℃, drying to a dry extract at 70 ℃, crushing to fine powder, adding 10% of prepared starch slurry to granulate, drying, finishing granules, and filling capsules to obtain the capsule.
The usage and dosage are as follows: it is administered 3 times daily, 2-4g once, and continuously for four weeks.
Example 3:
22g of dandelion, 22g of fructus forsythiae, 20g of bighead atractylodes rhizome, 16g of angelica, 20g of poria cocos, 16g of ligusticum wallichii, 45g of radix paeoniae alba, 22g of rhizoma alismatis, 18g of radix angelicae, 18g of almond, 18g of platycodon grandiflorum, 20g of fructus gardeniae and 16g of salted cortex phellodendri;
the preparation process comprises the following steps: weighing the medicinal materials according to the proportion of the formula, adding 8 times of water to soak for 0.5h, decocting for 2 times, each time for 1h, combining the two decoctions, mixing uniformly, concentrating to 80% of the original liquid, filtering while hot, concentrating the filtrate to an extract with the relative density of 1.20-1.30 at 70 ℃, drying the extract at 70 ℃, and crushing into fine powder to obtain a dry extract, taking the dry extract, adding 10% of dextrin, granulating by using 70% of ethanol as a wetting agent, drying, tabletting, and coating with a film to obtain the tablet.
The usage and dosage are as follows: it is administered 3 times a day, 2-4g each time, and continuously for four weeks.
Example 4:
15g of dandelion, 18g of fructus forsythiae, 10g of bighead atractylodes rhizome, 9g of angelica, 12g of poria cocos, 14g of ligusticum wallichii, 25g of radix paeoniae alba, 10g of rhizoma alismatis, 11g of radix angelicae, 15g of almond, 5g of platycodon grandiflorum, 9g of malt, 12g of hawthorn and 8g of medicinal fermented mass;
the preparation process comprises the following steps: weighing the medicinal materials according to the proportion of a prescription, adding 10 times of water to soak for 0.5h, decocting for 3 times, each time for 1.5h, combining the three decoctions, mixing uniformly, concentrating to 80% of the original liquid, filtering while hot, concentrating the filtrate to an extract with the relative density of 1.20-1.30 at 70 ℃, drying the extract at 70 ℃, crushing into fine powder to obtain a dry extract, taking 20% of sucrose, granulating by using 80% of ethanol as a wetting agent, drying at 60 ℃, sieving by using a 12-mesh sieve for 1 time, and sieving by using a 60-mesh sieve to obtain the granules.
The usage and dosage are as follows: the preparation is administered 3 times a day, 4-6g each time, and is administered continuously for four weeks.
Example 5:
20g of dandelion, 20g of fructus forsythiae, 16g of bighead atractylodes rhizome, 4g of angelica, 11g of poria cocos, 5g of ligusticum wallichii, 25g of radix paeoniae alba, 12g of rhizoma alismatis, 5g of radix angelicae, 10g of almond, 15g of platycodon grandiflorum and 9g of rhizoma pinellinae praeparata;
the preparation process comprises the following steps: weighing the medicinal materials in the formula according to the proportion, crushing the medicinal materials into fine powder, and uniformly mixing the fine powder to obtain the powder.
The usage and dosage are as follows: one dose is taken every day, and the medicine is taken randomly for 5 days every week, and is soaked by 300ml of boiled water, and is taken 150ml warm respectively in the morning and at the evening for four weeks.
Example 6:
10g of dandelion, 10g of fructus forsythiae, 12g of bighead atractylodes rhizome, 14g of angelica, 16g of poria cocos, 5g of ligusticum wallichii, 20g of radix paeoniae alba, 15g of rhizoma alismatis, 15g of radix angelicae, 6g of almond, 8g of platycodon grandiflorum, 15g of scutellaria baicalensis, 12g of gardenia and 8g of salted cortex phellodendri;
the preparation process comprises the following steps: weighing the medicinal materials according to the proportion of the prescription, adding 6 times of water to soak for 0.5h, decocting for 3 times, each time for 2h, combining the three decoctions, mixing uniformly, concentrating to 80% of the original liquid, filtering while hot, concentrating the filtrate to an extract with the relative density of 1.15-1.25 at 70 ℃, drying to a dry extract at 70 ℃, crushing to fine powder, adding 10% of prepared starch slurry to granulate, drying, finishing granules, and filling capsules to obtain the capsule.
The usage and dosage are as follows: it is administered 3 times daily, 2-4g once, and continuously for four weeks.
Example 7:
prescription: 15g of dandelion, 15g of fructus forsythiae, 12g of bighead atractylodes rhizome, 9g of angelica, 12g of poria cocos, 9g of ligusticum wallichii, 30g of radix paeoniae alba, 15g of rhizoma alismatis, 10g of radix angelicae, 10g of almond, 10g of platycodon grandiflorum, 15g of scutellaria baicalensis, 10g of gardenia, 9g of salted cortex phellodendri, 9g of malt, 9g of hawthorn, 9g of medicinal fermented mass and 9g of rhizoma pinellinae praeparata;
the preparation process comprises the following steps: weighing the medicinal materials according to the proportion of the prescription, adding 8 times of water to soak for 0.5h, decocting for 2 times, each time for 1h, combining the two decoctions, mixing uniformly, concentrating to 80% of the original liquid, filtering while hot, concentrating the filtrate to an extract with the relative density of 1.20-1.30 at 70 ℃, adding honey, and stirring uniformly to prepare the ointment.
The usage and dosage are as follows: it is administered 3 times a day, 2-4g each time, and continuously for four weeks.
In order to verify the beneficial effects of the invention, the inventor carries out relevant clinical tests and experimental researches, and the experimental process and the results are as follows:
1 clinical test
1.1 sources of cases
The cases were from female acne patients who were seen at the first subsidiary hospital of Guizhou TCM university (also known as the Guizhou province Hospital) at 04-2021 to 01-2022, and the serum control group was healthy women read by Guizhou TCM university during the study. The final test group included 35 patients, 5 patients were dropped and culled, 30 patients were completed, and 10 serum control groups were completed. The two groups of subjects were tested for statistically insignificant differences in age distribution (P > 0.05).
1.2 diagnostic criteria
1.2.1 Western diagnostic standards
The diagnostic standard of Western medicine refers to the diagnostic standard of AV in "clinical dermatology" written by Zhao Zhang, which is better developed in teenagers and is mainly characterized by comedones and leucodocks and inflammatory papular pustules. Severity of acne was scored using a 12-point ranking by Cunliffe.
1.2.2 Chinese medicine dialectical typing Standard
The standard of syndrome differentiation and typing is made by referring to clinical experience and combining with literature progress: (1) spleen deficiency with fluid retention, and/or with disharmony between qi and blood: lusterless or sallow complexion, pleasure and laziness to movement, loose muscle and tender meat, cold body and limbs, chest distress and anorexia, poor appetite and thin stools, thirst and no desire for drinking, greasy face and thin and white leucorrhea. Swollen tongue with teeth marks on the edge and smooth tongue surface. Pale or dull tongue. A thick or greasy tongue coating. Deep, thready, wiry or slippery pulse; pale complexion, dizziness, palpitation, dreaminess, warm feeling in the extremities, dry and astringent skin, irregular menstruation (low menstruation, dysmenorrhea, amenorrhea). Pale or dull tongue. Deep and thready and weak pulse. (2) Accumulation of toxic heat in the skin: acne with papules red in color; or painful nodules, or with multiple pustules, even cysts; it can be accompanied with thirst, pungent and thick taste after eating or skin rash aggravated after staying up overnight, red tongue tip and yellow tongue coating. The syndrome can be distinguished as the principal syndrome by having the syndrome (1) and (2) simultaneously.
1.3 inclusion criteria
(1) The medicine meets the diagnosis standard of common acne in Western medicine, and is graded into the first 7 patients by a Cunliffe grading method;
(2) those who meet the above-mentioned diagnostic criteria of spleen deficiency, fluid retention, qi-blood disharmony and skin-heat toxin accumulation in traditional Chinese medicine;
(3) age 18-45 years, female;
(4) the patient voluntarily joins the clinical test, obeys the test requirements, and can complete the medication according to the medical advice to finish the test;
(5) each subject needs to take a picture before treatment, fill in a traditional Chinese medicine syndrome evaluation table in a coordinated manner, and sign an informed consent.
1.4 exclusion criteria
(1) Pregnant women in lactation;
(2) acne caused by application of chemicals or drugs;
(3) patients with serious primary diseases and mental diseases such as cardiovascular diseases, cerebrovascular diseases, liver diseases, kidney diseases, hemopoietic system diseases and the like are combined;
(4) the medicine for treating acne (such as retinoids, spironolactone, tanshinone, traditional Chinese medicine, etc.) is taken in the last month;
(5) other facial diseases that affect the observation of efficacy.
1.5 shedding and rejection criteria
(1) Those who fail to complete the course of treatment or do not cooperate with the treatment;
(2) the test subjects were stopped due to severe adverse reactions with the drug;
(3) the patients who do not follow the medical advice during the treatment process.
1.6 methods
Subjects meeting the standard were divided into two groups a and B (group a was the test group and group B was the serum control group) group a, and the follow-up measures were performed on the basis of the basic treatment, while group B was the serum control alone and no other intervention was performed:
(1) Group a (test group):
1) Decoction for removing phlegm and removing blood stasis (the original name of the recipe, abbreviated as "clear pox decoction")
The formula is as follows:
15g of dandelion, 15g of fructus forsythiae, 12g of bighead atractylodes rhizome, 9g of angelica, 12g of poria cocos, 9g of ligusticum wallichii, 30g of radix paeoniae alba, 15g of rhizoma alismatis, 10g of radix angelicae, 10g of almond and 10g of platycodon grandiflorum;
adding and reducing cutting: 15g of scutellaria baicalensis is added for people with rash affecting cheeks; fructus Gardeniae 10g and cortex Phellodendri 9g for patients with rash involving chin and mandible; greasy face: adding 9g of each of the three immortals (malt, hawthorn and medicated leaven); pinellia tuber 9g is added when the tongue coating is thick and greasy.
(1) The usage and dosage are as follows: one dose is taken every day, 5 days are taken randomly every week, and 150ml is taken warm in the morning and evening after being mixed with 300ml of boiled water for four weeks continuously.
2) Basic treatment (all clinical professional guidelines/expert consensus recommended conventional treatment regimens):
(1) externally applied modified inverse powder with proportion optimized through research of our department
Consists of the following components: the rhubarb and the sulfur in a ratio of 1 are crushed (powder preparation) by an SF-400 type high-speed crusher (type I)
The usage and dosage are as follows: after cleaning the face before sleeping, taking out a proper amount of the reversed medicine powder, placing the medicine powder into a cup, heating boiled water (the ratio of the medicine powder to the boiled water is 1.5), fully and uniformly mixing the medicine powder into paste (the medicine powder and the boiled water are not dripped when the medicine powder is applied to the back of a hand), cooling the medicine powder, externally applying the medicine powder to a skin damage area with the thickness of about 2-3mm, scraping the medicine after 25 minutes, and cleaning the face with clean water once every night.
(2) Pricking therapy for acupuncture needles
For example, if the patient has skin lesions such as acne and pustule, acne and inflammatory secretion can be removed by disinfecting with acne needle.
(2) Group B (serum control group)
The serum control group was intended to select 30 healthy women who did not suffer from acne and to test hormone levels by drawing blood during 2-4 days of the menstrual period.
1.7 Observation index
(1) Test groups: patient age, course of disease, severity of skin lesions; scoring the traditional Chinese medicine symptoms and skin lesions; serum hormone levels: DHEA, DHEA-S, IGF-1.
(2) Serum control group: age and levels of DHEA, DHEA-S, IGF-1 hormones.
1.8 therapeutic efficacy evaluation criteria
Reference is made to Zhengxian cornus 'guiding principle treatment for clinical research of new Chinese medicine' formulated in 2002.
(1) Calculating the formula:
efficacy index (%) = [ (pre-treatment integral-post-treatment integral)/pre-treatment integral ] × 100%.
Total effective rate (%) = [ (recovery + significant effect + effective)/total number of cases ] × 100%.
(2) Skin lesion therapeutic effect judgment standard
(1) Recovery, namely, the rash is completely removed, and only the pigmentation and the scar are left.
(2) The medicine has obvious effect that the rash is regressed by more than 70 percent or the severity degree is reduced by more than 2 degrees.
(3) Effective, 70% or more than 30% of rash subsides, or the severity degree is reduced by more than 1 degree, and new skin damage still appears.
(4) Ineffective, with <30% regression of the rash, or increased in weight.
1.9 statistical methods
The statistical method of the research adopts SPSS25.0 statistical software to carry out statistical analysis, and hormone levels, skin damage scores and traditional Chinese medicine syndrome scores before and after treatment of patients in a test group adopt paired t test or coincidence rank and test; t test or rank sum test of independent samples is adopted during comparison among groups; two classification logistic regression analyses are adopted for the positive events of the research of the influence factors of the curative effect.
2 results
2.1 statistics of treatment effectiveness
The total effective rate of the test group is 90%, the average curative effect index is 55.42%, and the significant effect rate is 33.33%, which is shown in figure 1.
2.2 analysis of the levels of hormones in the first two groups before treatment
TABLE 1 analysis of DHEA and DHEAS levels in the test and serum control groups before treatment
TABLE 2 analysis of IGF-1 levels in the test group before treatment and in the serum control group
According to tables 1, 2: the comparison of the levels of DHEA, DHEA-S and IGF-1 in the blank control group in the test group has statistical significance (P is less than 0.05), and the levels of three hormones in the test group are higher than those in normal people.
2.3 analysis of DHEA, IGF-1, DHEA-S before and after treatment and Chinese medicine syndrome, skin damage score analysis
TABLE 3 analysis of DHEA before and after treatment in the test groups
TABLE 4 analysis of IGF-1, DHEA-S, chinese medicine syndrome score, skin lesion score before and after treatment in the test group
According to the test groups shown in tables 3 and 4, the comparison of the levels of DHEA, DHEA-S and IGF-1 before and after treatment, the traditional Chinese medicine syndrome score and the skin damage score analysis level has statistical significance (P is less than 0.05), and the hormone levels, the skin damage score and the traditional Chinese medicine syndrome score of the patient after treatment are all reduced compared with the levels before treatment.
Discussion of 3
The common acne is a common clinical impairment disease, and the inventor discovers that female acne patients commonly have symptoms of deficiency-excess inclusion and cold-heat complex through clinical symptoms for more than ten years, and coagulates spleen deficiency fluid retention, qi-blood disharmony and heat-toxin skin accumulation according to a series of symptoms; at present, emaciation is regarded as beauty, diet is controlled, mental fatigue and hypodynamia, abdominal pain are persistent, loose stool are caused after spleen qi deficiency is caused for a long time, spleen yang is involved for a long time, food essence is not dispersed due to spleen yang deficiency, qi and blood are supplemented passively, and pale and lusterless complexion, dizziness and hypodynamia, insomnia and dreamful sleep, scanty menstruation and the like are caused. Yang deficiency does not transport dampness, dampness accumulates to transform into heat for a long time, and acne is caused when the damp-heat fumigates the head and face. Syndrome differentiation is caused by spleen deficiency, fluid retention, qi and blood disharmony, and heat-toxin accumulation in the skin, so that the treatment is performed by the decoction for transforming fluid retention and the decoction for treating acne with blood serum (the original name of the prescription is called as acne clearing decoction for short). In the formula, the white atractylodes rhizome is sweet and warm in taste, is an essential medicine for strengthening the spleen, has the effects of tonifying qi and strengthening the spleen, eliminating dampness and promoting diuresis, and the Chinese angelica is a holy medicine for tonifying blood and regulating blood and menstruation and is used together with the white atractylodes rhizome, and the qi and blood are concordant and the spleen tonifying and the blood are monarch medicines; in order to strengthen the effect of enriching the blood and prevent the stagnation of qi and blood caused by too much tonifying, the white paeony root and the Szechuan lovage rhizome are added as ministers, the white paeony root has the functions of nourishing the blood, astringing yin, softening the liver, and harmonizing qi and blood by taking the effects of promoting qi circulation and activating blood as a blood-qi-flowing medicine, namely the Szechuan lovage rhizome, so as to achieve the effect of tonifying without stagnation; because the disease has the effects of spleen and stomach damp-heat accumulation in the interior and stomach heat flaming up on the surface and the heat surpasses the flesh and becomes pus, fructus forsythiae is used for dispelling wind and heat, clearing heat and removing toxicity, dandelion is used for clearing heat and removing toxicity, detumescence and pus discharge, poria cocos is used for diuresis and excreting dampness, spleen and rhizoma alismatis are used for clearing heat and excreting dampness in combination, damp-heat evil is discharged from the lower part, dampness has a way, spleen can be healthy, dampness can be removed, and drinking can be eliminated, and the four medicines are used as adjuvant and adjuvant medicines for assisting the effects of spleen strengthening, transforming and excreting water of monarch and minister medicines and simultaneously dispersing exterior pathogens; the disease is caused by the steaming of the face due to stomach heat, the disease is located at the upper part and is due to yangming of the foot, and the dahurian angelica root is due to the stomach meridian of yangming of the foot, so the effect of guiding the meridian is obtained and the functions of relieving swelling and expelling pus are also achieved; the platycodon root and the almond disperse lung qi to make the exterior excess pathogens come out from the skin and hair and lead the herbs to go upward and directly reach the focus, and the three herbs are mainly used for leading the meridians and carrying the herbs to go upward. The medicines have the effects of invigorating spleen, resolving fluid retention, regulating qi and blood, and clearing away heat and toxic materials. The results of this study also suggest a clear therapeutic effect of the recipe for this type of patient.
Aiming at the research of hormone level on acne occurrence, at present, androgen is considered to influence sebaceous gland secretion and the keratinization process of hair follicle sebaceous glands mainly through a main mechanism, and a specific mechanism is reported that the androgen promotes lipid synthesis mainly through the fact that after the androgen is combined with AR receptors in the sebaceous glands, the phosphorylation level of mTOR is increased, so that the generation of a mammalian rapamycin target C1 pathway (mTORC 1) is promoted, and sterol regulatory element binding protein-1 (SREBP-1) is activated, so that the synthesis and secretion of lipid are promoted. The androgen can also induce the differentiation of sebaceous gland cells by regulating the Wnt/beta-catenin pathway, and the differentiated sebaceous gland cells can show high-level AR so as to promote the accumulation of lipid. In addition to the effects of T and DHT on the disease, studies have shown that DHEA and DHEA-S are also involved in the pathogenesis of acne, as both can be converted to T and DHT as androgen precursors. Therefore, the levels of DHEA and DHEA-S have definite influence on the levels of T and DHT in sebocytes, and application of DHEA medicines is reported to have definite side effects on acne abroad. In women, kling CM et al suggest that peripheral metabolism of DHEA is a major contributor to its circulating hormone levels, and that 40% -75% of testosterone levels in premenopausal women are converted from DHEA, from which it is surmised that DHEA and DHEA-S levels are significant for acne in women, and studies have demonstrated this. A recent Meta analysis by Schering et al of the effect of DHEA on human insulin growth factor-1 (IGF-I) suggests that supplementation with DHEA may increase serum IGF-I levels, particularly in female subjects. IGF-I is also an important factor in the development of inflammation in acne. Researches show that a sleep-deficient person can cause insulin resistance, so that insulin secretion is increased, and the promoting effect of the sleep-deficient person on androgen is enhanced, insulin also has a definite effect of promoting IGF-1 generation, and IGF-1 has the effects of promoting skin keratinocyte proliferation and androgen generation; wherein the androgenic mechanism inhibits T to E2 by inhibiting androgen receptor signaling, indirectly resulting in increased DHT; in addition, it can stimulate sebaceous gland cell proliferation, promote sebum synthesis and inflammatory factor production. The clinical application of the recipe shows that the curative effect is particularly good for female patients, and the various medicines in the recipe have definite hormone-like effects, so the observation of the influence of the recipe on the hormone levels of DHEA, IGF-1 and DHEA-S is expanded.
The results suggest that the recipe may have a mechanism for regulating the levels of hormones IGF-1, DHEA and DHEA-S, so as to indirectly regulate sebum secretion, keratinization of hair follicle ducts and inhibit the release of inflammatory factors to achieve the purpose of treatment, and particularly which pathway and target point need to be further explored through regulation.
4 clinical cases
Case 1:
wangzhi, female, 25 years old, repeated skin rash on the face with pain for 5 years, aggravation of half a month, multiple red papules, acnes and nodules on the face, a few cysts, pustules on the tops of part of papules, obvious tenderness, obvious pus and pustule powder spills after extrusion, and as shown in figure 2;
the etiology of the patient is as follows: in 5 years, the front part of the patient gradually appears mostly in papules, is red and is accompanied by tenderness, powdery and fat substances overflow when the patient is squeezed by hands, and part of the powdery and fat substances are rice-grain-shaped semitransparent particles, so that the patient can be diagnosed by multiple parties, the patient can be temporarily improved after receiving WiA acid cream external rubbing, adapalene gel external rubbing, fusidic acid external rubbing and the like, but the skin rash always exists and is aggravated repeatedly, a small amount of pustules are accompanied, and the curative effect of oral minocycline and doxycycline is still not obvious. Before half a month, the rash gradually increased, the rash was bright red, some of the tops appeared to be pustules, and the pus overflowed by squeezing with hands with obvious pain, cold hands and feet, and bitter mouth. Pinsu menoxenia, scanty menstruation, aversion to cold, poor appetite, loose stool, dizziness, palpitation, insomnia, pale tongue, swollen tongue, tongue marginal and tooth marks, slippery tongue surface, white and greasy coating, deep and thready pulse, and superficial and rapid pulse in cun;
family history: the father had severe acne, leaving many pits and scars on the face.
And (3) diagnosis:
traditional Chinese medicine diagnosis: acne [ syndrome of retention of heat-toxin (skin retention), spleen deficiency and fluid retention ]. Western medicine diagnosis: acne vulgaris.
Prescription:
the traditional Chinese medicine is taken orally: 18g of dandelion, 20g of fructus forsythiae, 12g of bighead atractylodes rhizome, 9g of angelica, 18g of poria cocos, 9g of ligusticum wallichii, 30g of radix paeoniae alba, 15g of rhizoma alismatis, 10g of radix angelicae, 10g of almond and 10g of platycodon grandiflorum;
the using method comprises the following steps: decocting with water for oral administration, one dose per day (three times for oral administration);
and (3) return visit: after the medicine is continuously taken for 10 days, the diagnosis is carried out, the rash is obviously improved, the pustules are faded, and the pain is obviously relieved. Palpitation and insomnia disappear, the hands and feet get warm earlier, and the bitter taste of the mouth disappears.
Prescription for further diagnosis: the traditional Chinese medicine is taken orally: 18g of dandelion, 20g of fructus forsythiae, 12g of bighead atractylodes rhizome, 9g of angelica, 18g of poria cocos, 9g of ligusticum wallichii, 30g of radix paeoniae alba, 15g of rhizoma alismatis, 10g of radix angelicae, 10g of almond and 10g of platycodon grandiflorum;
the using method comprises the following steps: orally taking one dose per day (three times per day);
and the re-diagnosis is carried out after continuously taking the medicine for 10 days: papules, nodules, cysts and pustules are completely disappeared without pain, face only has acne marks and pigmentation, palpitation and insomnia disappear, hands and feet are warm earlier, and bitter taste disappears, as shown in figure 3.
Case 2:
in a certain course, women are 20 years old, the facial inflammatory papules and pustules are repeated for 1+ year, the patients have sallow complexion, adverse rising of the four limbs, poor appetite and loose stools, greasy face, swollen tongue, tooth marks on the sides, smooth tongue surface, pale tongue, thick and greasy fur, deep and smooth pulse, perioral inflammatory papules, pustules, brown crusts, partial fusion, acne marks and pigmentation on the cheeks;
the etiology of the patient is as follows: 1+ year ago, due to pimples and pustules on the face in the night and menstrual period, the pain around the mouth is particularly caused, the external medicine is purchased by oneself, the skin damage is relieved after the use, but the repeated attack is caused, the systemic diagnosis and treatment are not carried out, and the pain is aggravated in the night or menstrual period;
and (3) diagnosis:
traditional Chinese medicine diagnosis: acne [ syndrome of retained heat-toxin and spleen deficiency and fluid retention ], western diagnosis of acne;
prescription: the traditional Chinese medicine is taken orally: 10g of dandelion, 20g of fructus forsythiae, 10g of angelica, 20g of white peony root, 20g of poria cocos, 10g of bighead atractylodes rhizome, 10g of rhizoma alismatis, 12g of ligusticum wallichii, 10g of platycodon grandiflorum, 6g of radix angelicae, 10g of almond, 20g of gardenia, 12g of salted cortex phellodendri, 18g of scutellaria baicalensis, 10g of malt, 10g of medicinal fermented mass, 10g of hawthorn and 10g of rhizoma pinellinae praeparata;
the using method comprises the following steps: orally taking one dose per day (three times per day);
after continuously taking the medicine for 10 days, the doctor can make a return visit, the inflammatory papules on the face are removed, the perioral papules and pustules are obviously improved, and more acne marks, pigmentation and dysmenorrheal are relieved.
Prescription for further consultation: the traditional Chinese medicine is taken orally: 20g of dandelion, 20g of fructus forsythiae, 10g of angelica, 30g of white peony root, 10g of poria cocos, 20g of rhizoma alismatis, 6g of ligusticum wallichii, 10g of bighead atractylodes rhizome, 20g of cape jasmine, 12g of salted cortex phellodendri, 18g of scutellaria baicalensis, 10g of medicinal fermented mass, 10g of malt, 10g of hawthorn, 10g of platycodon grandiflorum, 10g of almond and 6g of radix angelicae;
the using method comprises the following steps: orally administered one dose per day (three times per day);
after continuously taking the medicine for 10 days, the doctor can make a return visit, and then the inflammatory papules on the face are removed, the perioral papules and pustules are removed, and the face has acne marks, pigmentation and no dysmenorrheal.
Case 3:
yang is certain, women are 23 years old, the pimple on the face is repeated for 1+ year, the patients have sallow complexion, cold body and limbs, greasy skin, anorexia, good sleep, pale red tongue body, greasy tongue coating, smooth tongue surface, slippery pulse, red pimple on the face, acne mark and pigmentation;
the etiology of the patient is as follows: 1+ year ago, red pimples appear on the face without obvious inducement, pus spots and pain caused by touching, the fusidic acid cream is purchased by oneself for external use, the rash is improved during use, the improvement of the rash is not obvious after long-term use, and the rash is aggravated every night, under high pressure or in menstrual period, as shown in figure 4;
and (3) diagnosis: traditional Chinese medicine diagnosis: acne [ syndrome of retention of heat-toxin in the body, spleen deficiency and fluid retention ]. And (3) Western diagnosis: acne is caused.
Prescription: the traditional Chinese medicine is taken orally: 20g of dandelion, 15g of fructus forsythiae, 10g of angelica, 10g of radix paeoniae alba, 10g of poria cocos, 10g of bighead atractylodes rhizome, 10g of rhizoma alismatis, 10g of ligusticum wallichii, 18g of radix scutellariae tablets, 12g of salted cortex phellodendri, 10g of hawthorn, 10g of medicinal fermented mass, 10g of malt, 12g of platycodon grandiflorum, 10g of almond, 10g of radix angelicae, 9g of fructus gardeniae and 9g of rhizoma pinellinae praeparata;
the using method comprises the following steps: orally administered one dose per day (three times per day);
after continuously taking the medicine for 10 days, the patient is diagnosed again, the inflammatory papules on the face are obviously improved, the face is scattered on the papules with red color, the diet is better, the face color is light yellow, the patient can sleep well, the T-shaped area of the skin is greasy, the patient can feel both greasy and greasy, the tongue is fat and large, the teeth marks are formed on the edges, the tongue surface is smooth, the tongue is light, the fur is slightly greasy, and the pulse is smooth.
Prescription for further diagnosis: the traditional Chinese medicine is taken orally: 20g of dandelion, 12g of fructus forsythiae, 10g of angelica, 10g of white peony root, 10g of poria cocos, 10g of bighead atractylodes rhizome, 10g of rhizoma alismatis, 12g of salted cortex phellodendri, 10g of malt, 10g of ligusticum wallichii, 18g of scutellaria baicalensis slices, 10g of hawthorn, 10g of medicinal fermented mass, 12g of platycodon grandiflorum, 10g of radix angelicae, 10g of almond and 10g of cape jasmine;
the using method comprises the following steps: orally administered one dose per day (three times per day);
after continuously taking the medicine for 10 days, the re-diagnosis is carried out, the inflammatory papules on the face are removed, and a small amount of acne marks and shallow pigmentation are formed on the face, which is shown in figure 5.
Claims (10)
1. A traditional Chinese medicine preparation for treating female acne is characterized in that: the medicinal active ingredients comprise the following components in parts by weight: is prepared from 100-220 parts of dandelion, 100-220 parts of forsythia, 80-200 parts of bighead atractylodes rhizome, 40-160 parts of angelica, 80-200 parts of poria cocos, 40-160 parts of ligusticum wallichii, 100-450 parts of white peony root, 100-220 parts of rhizoma alismatis, 50-180 parts of radix angelicae, 50-180 parts of almond and 50-180 parts of platycodon grandiflorum.
2. The Chinese medicinal preparation for treating female acne as claimed in claim 1, wherein: the medicinal active ingredients comprise the following components in parts by weight: is prepared from dandelion 130-170 parts, forsythia 130-170 parts, white atractylodes rhizome 100-140 parts, chinese angelica root 70-110 parts, poria cocos wolf 100-140 parts, ligusticum wallichii 70-110 parts, root of herbaceous peony 200-400 parts, oriental water plantain rhizome 130-170 parts, dahurian angelica root 80-120 parts, apricot kernel 80-120 parts, root of balloonflower 80-120 parts.
3. The traditional Chinese medicine preparation for treating female acne as claimed in claim 2, characterized in that: the medicinal active ingredients comprise the following components in parts by weight: is prepared from dandelion 150 parts, forsythia 150 parts, atractylodes rhizome 120 parts, chinese angelica 90 parts, poria cocos wolf 120 parts, ligusticum wallichii 90 parts, root of herbaceous peony 300 parts, oriental water plantain rhizome 150 parts, dahurian angelica root 100 parts, apricot kernel 100 parts and orange peduncle 100 parts.
4. The traditional Chinese medicine preparation for treating female acne according to any one of claims 1 to 3, characterized in that: the prescription for acne patients with rash involving cheeks is added with 100-220 parts of scutellaria baicalensis.
5. The traditional Chinese medicine preparation for treating female acne according to any one of claims 1 to 3, characterized in that: the acne sufferer mainly has rash involving chin and lower jaw, and 50-200 parts of cape jasmine fruit and 40-160 parts of salt phellodendron bark are added in the formula.
6. The traditional Chinese medicine preparation for treating female acne according to any one of claims 1 to 3, characterized in that: the weight of the acne patients with thick and greasy fur is increased by 40-160 parts of rhizoma pinellinae praeparata.
7. The Chinese medicinal preparation for treating female acne according to any one of claims 1 to 3, wherein: the acne patients have greasy face, and 40-160 parts of malt, 40-160 parts of hawthorn and 40-160 parts of medicinal fermented mass are added in the formula.
8. A method of preparing a Chinese medicinal preparation for the treatment of female acne as claimed in any of claims 1 to 7, wherein: all the medicinal materials in the prescription are weighed according to the proportion, processed according to the conventional preparation method, combined with the acceptable pharmaceutic adjuvant and the matrix in the medicine and prepared into the corresponding oral preparation.
9. The method for preparing a Chinese herbal compound for treating female acne according to claim 8, characterized in that: the oral preparation comprises powder, capsules, tablets, pills, granules or soft extract.
10. The preparation method of the compound traditional Chinese medicine for treating female acne as claimed in claim 9, is characterized in that: the preparation method of the powder comprises the following steps: weighing the medicinal materials in the formula according to the proportion, crushing the medicinal materials into fine powder, and uniformly mixing the fine powder to obtain the traditional Chinese medicine.
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