CN105878901A

CN105878901A - Traditional Chinese medicine preparation for treating skin flap necrosis after breast cancer operation and preparation method

Info

Publication number: CN105878901A
Application number: CN201610325023.9A
Authority: CN
Inventors: 张洁; 梁云爱
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-05-17
Filing date: 2016-05-17
Publication date: 2016-08-24

Abstract

The invention discloses a traditional Chinese medicine preparation for treating skin flap necrosis after breast cancer operation. The traditional Chinese medicine preparation comprises the following raw materials: radix astragali preparata, codonopsis pilosula, roasted rhizoma atractylodis macrocephalae, poria cocos, angelica sinensis, safflower, salvia miltiorrhiza, roasted peach kernel, radix paeoniae rubra, polygonum multiflorum preparata, fructus amomi, cardamun, rhizoma cyperi, dried orange peel, hedyotis diffusa, fructus lycii, herba epimedii, donkey-hide gelatin, semen cuscutae, flatstem milkvetch seed, raw semen coicis, roasted Chinese yam, sculellaria barbata, lucid ganoderma, herba agrimoniae and radix glycyrrhizae preparata, belonging to the field of traditional Chinese medicine inventions. Based on different characteristics, the traditional Chinese medicines are pretreated by cleaning and dicing and then proportionally mixed and processed by a special method. The traditional Chinese medicine preparation has the functions of nourishing the liver and kidneys, activating blood and dredging channels, dissipating stasis and relieving pain and invigorating the spleen and promoting appetite; the combination and preparation method of the product are unique; and through clinical verification, the medicine has the advantages of remarkable treatment effect, short treatment period, low price and no bad reaction or any toxic/side effect, and has a broad prospect of market application.

Description

A kind of Chinese medicine preparation for treating skin flap necrosis after mammectomy and preparation method

Technical field

The present invention relates to a kind of Chinese medicine preparation, be specifically related to a kind of Chinese medicine preparation for treating skin flap necrosis after mammectomy, the invention still further relates to the preparation method of this Chinese medicine preparation.

Background technology

The reason of skin flap necrosis after mammectomy has multiple, and general common cause has following several, 1, operation technique cause flap circulation obstacle.Being spindle shape otch due to what mammary cancer surgery used, the length (distance of flap the base of a fruit to notching edge) of flap and the ratio 2:1 to be far smaller than of the flap base of a fruit, therefore the base of a fruit's blood fortune deficiency causes may being substantially of flap necrosis non-existent.And the scope that cuts is excessive causes the tension force of flap after stitching big, flap is the thinnest, and destroying subdermal vascular plexus is the main cause causing flap circulation obstacle.2, bandage after operation, compressing is improper causes postoperative skin flap poor arterial inflow.Owing to breast carcinoma postoperative skin flap is thin, tension force is big and blood supply without vertical blood vessel.Flap is inherently in the state of relative ischemia, if dressing wrapping is uneven, local pressure is excessive, it is easy to cause the poor arterial inflow of respective regions and blood supply far-end to cause flap necrosis.3, hypohydrops.Hypohydrops makes flap floating, increases otch tension force, reduces flap circulation, affects wound healing, and easily induce infection, cause or increase the weight of flap necrosis.4, other reasons such as local infection, pyemia, anemia, hypoproteinemia etc..

At present, skin flap necrosis after mammectomy there is no specific short.PGE1 has certain curative effect, but the long-term or short time uses these medicines to treat, hirsutism, acne, edema, Nausea and vomiting, dizziness, constipation etc. series of side effects symptom, and the dependency that hormone is created can be caused, after drug withdrawal, primary affection knock-on increases the weight of the side effect with secondary, patient can be made to produce the biggest misery, therapeutic process again and again, DeGrain, expense is high, causes bigger pressure at heart and ailing pressure to patient.

Summary of the invention

It is an object of the invention to provide a kind of Chinese medicine preparation for treating skin flap necrosis after mammectomy, it is notable that this Chinese medicine preparation has therapeutic effect for treatment skin flap necrosis after mammectomy, healing time is short, cheap, has no adverse reaction and the feature of secondary toxic action.

Inventor is in clinical treatment for many years is put into practice, according to the law of development of this disease, and the combination principle of Chinese medicine, and by substantial amounts of clinical verification, Exploration and conclusion goes out the new formula of the Chinese medicine preparation for treating skin flap necrosis after mammectomy repeatedly.It is notable that the present invention has therapeutic effect, and healing time is short, cheap, has no adverse reaction and the feature of secondary toxic action.

The effect of Chinese medicine of the present invention:

Wherein:

Radix Astragali Preparata: for leguminous plant Radix Astagali Astragalus Membranaceus (Fisch.) Bge. Var. mongholicus (Bge.) Hsiao or Radix Astragali Astragalus The dry root processed product of membranaceus (Fisch.) Bge..The honey Radix Astragali: astragalus mongholicus tablet is added cooked Mel and a little boiled water, mixes thoroughly the most vexed, fry in putting pot to yellow and tack-free time, take out and dry in the air cool (Mel 25 jin that every 100 jin of use are cooked). nature and flavor: sweet, temperature.Return lung, spleen channel.Effect: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and bursts for a long time and does not holds back, and blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst；Chronic nephritis proteinuria, diabetes.

Radix Codonopsis: for Campanulaceae Radix Codonopsis Codonopsis pilosula (Franch.) Nannf., element flower Radix Codonopsis (RADIX CODONOPSIS PILOSULAE from Northwest of China) Codonopsis pilosula Nannf. var. Modesta (Nannf.) L. T. Shen or the dry root of radix codonpsis tangshen Codonopsis tangshen Oliv..Nature and flavor: sweet are flat.Return spleen, lung meridian.Effect: invigorating the spleen and replenishing QI, strengthening spleen and tonifying lung.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency cough, interior-heat is quenched one's thirst.

Rhizoma Atractylodis Macrocephalae (parched): for the processed product of the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz..Nature and flavor: bitter, sweet, temperature.Return spleen, stomach warp.Effect: invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, frequent fetal movement.Described in " herbal classic ": main anemofrigid-damp arthralgia, dead flesh, convulsion, subcutaneous ulcer, hidroschesis, heat extraction helps digestion.

Poria: for the dry sclerotia of On Polyporaceae Poria Poria cocos (Schw.) Wolf.Nature and flavor: sweet, light are flat.GUIXIN, lung, spleen, kidney channel.Effect: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, loose stool has loose bowels, irritability, palpitation with fear insomnia.Described in " property of medicine opinion ": appetizing, preventing or arresting vomiting is inverse, kind tranquilizing mind.Main consumptive lung disease expectorant is stopped up.

Radix Angelicae Sinensis: for the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Nature and flavor: sweet, acrid, warm.Return liver, the heart, spleen channel.Effect: replenishing and activating blood, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizziness cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.Described in " Japan hanako materia medica ": control a wind cutting, all blood, mend all labor, broken stagnant blood, support fresh blood and main addiction.

Flos Carthami: for the dry flower of feverfew Flos Carthami Carthamus tinctorius L..Nature and flavor: pungent, temperature.GUIXIN, Liver Channel.Effect: promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, injury from falling down, skin infection swells and ache." detailed outline ": invigorate blood circulation, moisturizes, pain relieving, dissipates swollen, stimulates the menstrual flow.

Radix Salviae Miltiorrhizae: for the dry root and rhizome of labiate Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bunge..Nature and flavor: bitter, are slightly cold.GUIXIN, Liver Channel.Effect: stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, chest and abdomen twinge, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia；Hepatosplenomegaly, angina pectoris.Described in " the southern regions of the Yunnan Province book on Chinese herbal medicine ": reinforcing the heart sedate, calming heart and tranquilizing mind.Controlling forgetful punching seized with terror, palpitation with fear is insomnia.

Semen Persicae (parched): be the parched medicinal material of Semen Persicae.Semen Persicae: for rosaceous plant Fructus Persicae Prunus persica (L.) Batsch or the dry mature seed of Prunus davidiana Prunus davidiana (Carr.) Franch..Nature and flavor: bitter, sweet, flat.GUIXIN, liver, large intestine channel.Effect: blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation.For amenorrhea, dysmenorrhea, abdominal mass mass in the abdomen, injury from falling down, dryness of the intestine constipation.Described in " herbal classic ": main blood stasis, blood closes lump in the abdomen, pathogen, kills small worm." not Lu ": only cough with dyspnea, disappear hardness in the epigastrium, except soldier hits blood cruelly, broken lump in the abdomen, promote blood circulation, pain relieving.

Radix Paeoniae Rubra: for ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall. or the dry root of river Radix Paeoniae Rubra Paeonia veitchii Lynch.Nature and flavor: bitter, are slightly cold.Return Liver Channel.Effect: clearing away heat and cooling blood, eliminating stasis to stop pain.For maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen stomachache, injury from falling down, carbuncle skin infection.TAO Hong-Jing is said: Radix Paeoniae red person minor benefit, and custom side, with pain relieving, is not subtract Radix Angelicae Sinensis.

Radix Polygoni Multiflori Preparata: for polygonum multiflorum thunb Polygonum The dried root processed product of multiflorum Thunb., its rattan claims " Caulis Polygoni Multiflori ".With the Radix Polygoni Multiflori red the most each one jin, bamboo knife scrapes off rough bark, water from washing rice leaching one night, section, struggles against with Semen sojae atricolor three, every time with three liter of three conjunction three spoonfuls, with paving bean one layer in blister mistake, marmite, the Radix Polygoni Multiflori one layer, to the greatest extent, the bean of steaming is ripe for heavy paving, bean is removed in taking-up, is dried by Radix Polygoni Multiflori, then steams it with bean, and such nine steam nine solarizations, are to use.Nature and flavor: bitter, sweet, puckery, temperature.Return liver, the heart, kidney channel.Effect: removing toxic substances, eliminating carbuncle, loosening bowel to relieve constipation.For scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation；Hyperlipidemia.Described in " book on Chinese herbal medicine is stated ": control apoplexy, headache, migratory arthralgia, the arthroncus of knee, epilepsy syndrome, jaundice.

Fructus Amomi: for zingiberaceous plant Fructus Amomi Amomum villosum Lour., green shell sand Amomum villosum Lour. var. Xanthioides T. L. Wu et Senjen or SEMEN AMOMI LONGILIGULA Amomum The dry mature fruit of longiligulare T. L. Wu.Nature and flavor: pungent, temperature.Return spleen, stomach, kidney channel.Effect: removing dampness is whetted the appetite, warming spleen and stopping diarrha, regulates the flow of vital energy antiabortive.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is the most hungry, Deficiency and coldness of spleen and stomach, and vomiting is had loose bowels, pregnancy reactions, frequent fetal movement.Described in " Japan hanako materia medica ": control all gas, cramp caused by acute vomiting and diarrhea, cardiac and abdominal pain.

Fructus Amomi Rotundus: for zingiberaceous plant Fructus Amomi Rotundus Amomum kravanh Pierre ex Gagnep.Or the dry mature fruit of amomum compactum Soland ex Maton Amomum compactum Soland ex Maton.Nature and flavor: pungent, temperature.Return lung, spleen, stomach warp.Effect: removing dampness disappears painful abdominal mass, circulation of qi promoting warming middle-JIAO, appetite-stimulating indigestion-relieving.For turbid damp obstructing in middle-JIAO, anorexia, hygropyrexia from the beginning of, uncomfortable in chest the most hungry, cold-damp vomiting, chest and abdomen swelling and pain, food stagnation does not disappears.

Rhizoma Cyperi: for the dry rhizome of sedge dried tuber Cyperus rotundus L..Nature and flavor: hardship pungent, micro-, micro-sweet are flat.Return liver, spleen, tri-jiao channel.Effect: promoting QI circulation for relieving depression, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.Described in " detailed outline ": scattered seasonal epidemic pathogens is trembled with fear epidemic disease, profit three is burnt, solves six kinds of stagnation-syndromes, and the diet that disappears gathers, phlegm retention feeling of fullness, edema of dorsum of the foot, abdominal distention, tinea pedis, only trusted subordinate, limbs, head, mesh, tooth, all pains of ear, ulcer sores, spit blood, hematochezia, hematuria, married woman's bleeding not during menses, wait uncomfortable by the moon, all kinds of diseases and ailments in puerperal before tire.

Pericarpium Citri Reticulatae: for rutaceae orange Citrus Reticulata Blanco and the dry mature skin of variety thereof.Nature and flavor: bitter, pungent, temperature.Return lung, spleen channel.Effect: regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.

Herba Hedyotidis Diffusae: for Rubiaceae plants of Hedyotis Herba Hedyotidis Diffusae Hedyotis diffusa Willd. [Oldenlandia Diffusa (Willd.) Roxb.] herb.Nature and flavor: sweet, light are cool.It is included into stomach, large intestine, small intestine meridian.Effect: heat-clearing and toxic substances removing, inducing diuresis to remove edema, promoting blood circulation and stopping pain.For diseases such as acute appendicitis (appendicitis), furuncle toxic swelling, jaundice due to damp-heat, dysuria；Furuncle carbuncle, venom are controlled in external.Described in " Quanzhou book on Chinese herbal medicine ": heat clearing away dissipating blood stasis, eliminating carbuncle detoxifies.Control ulcer sores, scrofula.Again can lung heat clearing fire, eliminating the pathogens from the lung heat.Control lung-heat dyspnea with rapid and short breath, cough against uncomfortable in chest.

Fructus Lycii: for the dry mature fruit of plant of Solanaceae lycium barbarum Lycium barbarum L..Nature and flavor: sweet are flat.Return liver, kidney channel.Effect: nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat quenches one's thirst, and blood deficiency and yellow complexion, blurred vision is failed to understand.Described in " Treatise on Dietetic Therapy ": hard muscle is resistance to always, except wind, tonification muscles and bones, energy benefit people, remove asthenia.

Herba Epimedii: for Berberidaceae plant Herba Epimedii Epimedium brevicornum Maxim., Epimedium sagittatum Epimedium sagittatum (Sieb.et Zucc.) Maxim. , E. Pubescens Epimedium Pubescens Maxim., Epimedium wushanense Epimedium Wushanense T.S.Ying or Herba Epimedii Epimedium The dry aerial parts of koreanum Nakai.Nature and flavor: acrid, sweet, warm.Return liver, kidney channel.Effect: kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.For impotence and seminal emission, muscles and bones flaccidity is soft, rheumatic arthralgia, numbness contracture；Climacteric hypertension." not Lu ": hard muscles and bones.Disappear scrofula, red carbuncle；Skin ulcer is arranged at bottom, washes, and goes out worm.

Colla Corii Asini: for the skin of equine species donkey Equus Asinus L. through decocting, concentrating the solid gum made.Nature and flavor: sweet are flat.Return lung, liver, kidney channel.Effect: YIN nourishing of enriching blood, moisturizes, hemostasis.For blood deficiency and yellow complexion, dizziness cardiopalmus, flesh flaccidity is unable, dysphoria and insomnia, stirring-up of pathogenic wind in the interior resulting from deficiency, xeropulmonary cough, and chronic cough is spat blood, haematemesis hematuria, metrorrhagia of having blood in stool, vaginal bleeding during pregnancy.Described in " detailed outline is picked up any lost article from the road ": control lumbago caused by internal damage, strength is stretched muscle, is added essence and reinforce the kidney.

Semen Cuscutae: for the dry mature seed of convolvulus cuscuta plant Cuscuta chinensis Lam..Nature and flavor: sweet, temperature.Return liver,kidney,spleen warp.Effect: nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down；Externally treating leucoderma.Described in " not Lu ": support flesh reinforcing YIN-essence, hard muscles and bones, stem invasion by pathogenic cold, essence, from going out, drowns and has the heeltap, and bitter taste is dry yearningly, and cold blood is long-pending.

Semen Astragali Complanati: for the dry mature seed of leguminous plant astragatus complanatus Astragalus complanatus R.Brown..Nature and flavor: sweet, temperature.Return liver, kidney channel.Effect: temperature compensation Liver and kidney, controlling nocturnal emission with astringent drugs, reducing urination, improving eyesight.For lumbago due to renal deficiency, premature ejaculation of passing out semen, nebulousurine leukorrhagia, dribbling urination, dizziness blurred vision.

Semen Coicis: for grass Semen Coicis Coix lacryma-jobi L. var. The dry mature kernal of ma-yuen (Roman.) Stapf.Nature and flavor: sweet, light are cool.Return spleen, stomach, lung meridian.Effect: spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal, row is dense in heat clearing away.For edema, tinea pedis, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen, lung abscess, acute appendicitis；Verruca plana.Described in " detailed outline ": invigorating spleen and reinforcing stomach, tonifying the lung heat clearing away, remove wind prevailing over dampness.Cook a meal food, control cold air；Decoct drink, diuresis pyretic stranguria.

Rhizoma dioscoreae (parched): for the dry rhizome processed product of Dioscoreaceae plant Rhizoma Dioscoreae Dioscorea opposita Thunb..Nature and flavor: sweet are flat.Return spleen, lung, kidney channel.Effect: spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.For insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung breathes with cough, and emission due to deficiency of the kidney, leukorrhagia, frequent micturition, deficiency-heat is quenched one's thirst.Rhizoma Dioscoreae (parched with bran) spleen reinforcing stomach invigorating.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, leukorrhagia.

Herba Scutellariae Barbatae: for the dry herb of labiate Herba Scutellariae Barbatae Scutellaria barbata Don [S. rivularis Wall].Nature and flavor: pungent, bitter, cold.Return lung, liver, kidney channel.Effect: heat-clearing and toxic substances removing, blood stasis dispelling diuresis.For furuncle swelling toxin, laryngopharynx swelling and pain, venom, fall and flutter the pain of injury, edema, jaundice.Described in " figure will planted by Guangxi medicine ": antiinflammatory, dissipating blood stasis, hemostasis.Control traumatic injury wound, dysentery.

Ganoderma: for On Polyporaceae Ganoderma lucidum (Leyss. Ex Fr.) Karst. Ganoderma Lucidum(Leyss.ex Fr.) Karst. or Ganoderma Ganoderma The dry sporophore of sinense Zhao, Xu et Zhang.Nature and flavor: sweet are flat.GUIXIN, lung, liver, kidney channel.Effect: invigorating QI and tranquilization, relieving cough and asthma.For dizziness sleeplessness, shortness of breath and palpitation, asthenia cough with asthma.

Herba Agrimoniae: for the dry aerial parts of rosaceous plant Radix Agrimoniae Agrimonia pilosa Ledeb..Nature and flavor: bitter, puckery are flat.GUIXIN, Liver Channel.Effect: astringing to arrest bleeding, preventing the attack (or recurrence) of malaria, dysentery relieving, removing toxic substances.For hemoptysis, spit blood, metrostaxis, malaria, dysentery, de-power impairment caused by overstrain, carbuncle sore tumefacting virus, pudendal pruritus leukorrhagia." BAICAO mirror ": the therapeutic method to keep the adverse QI flowing downwards is invigorated blood circulation, manages all kinds of diseases and ailments, dissipates feeling of fullness；Fall and flutter haematemesis, metrorrhagia, dysentery, discharging fresh blood stool.

Radix Glycyrrhizae Preparata: for the Preparation process product of Radix Glycyrrhizae.Nature and flavor: sweet are flat.GUIXIN, lung, spleen, stomach warp.Effect: spleen reinforcing stomach function regulating, Yiqi and vein recovery.For weakness of the spleen and stomach, fatigue and weakness, severe palpitation, irregularly intermittent and regularly intermittent pulse.

The square solution of the present invention is: Radix Astragali Preparata invigorating QI to consolidate the body surface resistance, expelling pus and promoting granulation, Radix Codonopsis invigorating the spleen and replenishing QI, strengthening spleen and tonifying lung, Fructus Lycii nourishing the liver and kidney, replenishing vital essence to improve eyesight, Herba Epimedii the kidney invigorating bone strengthening, expelling wind and removing dampness, Colla Corii Asini nourishing blood YIN nourishing, moisturize hemostasis, Semen Cuscutae nourishing the liver and kidney, improving eyesight antidiarrheal, Semen Astragali Complanati temperature compensation Liver and kidney, controlling nocturnal emission with astringent drugs improving eyesight, Ganoderma invigorating QI and tranquilization, relieving cough and asthma, above eight taste medicines are as monarch drug in side, all return kidney channel, there is nourishing the liver and kidney, the effect of QI invigorating of invigorating blood circulation.Chinese medicine is thought, primary disease is because body vital essence is not enough, causes pathogen invasion to cause body breast lesion, and then carries out the postoperative sequela that excision causes.So nourishing the liver and kidney, QI invigorating of invigorating blood circulation be treatment skin flap necrosis after mammectomy basis, above eight taste medicines as monarch drug, the most fundamentally nourishing the liver and kidney, QI invigorating of invigorating blood circulation, make disease obtain basic control.Chinese angelica blood supplementing is invigorated blood circulation, loosening bowel to relieve constipation, Flos Carthami promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain, Radix Salviae Miltiorrhizae stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, Semen Persicae (parched) blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, Radix Paeoniae Rubra clearing away heat and cooling blood, eliminating stasis to stop pain, Radix Polygoni Multiflori Preparata heat-clearing and toxic substances removing, loosening bowel to relieve constipation, Rhizoma Cyperi promoting QI circulation for relieving depression, menstruction regulating and pain relieving, Herba Hedyotidis Diffusae heat-clearing and toxic substances removing, inducing diuresis to remove edema, Herba Scutellariae Barbatae heat-clearing and toxic substances removing, blood stasis dispelling diuresis, Herba Agrimoniae astringing to arrest bleeding, dysentery relieving detoxify, ministerial drug in the above ten taste medicine sides of being, returns Liver Channel, the traditional Chinese medical science to say that The liver and the kidney have a common source, congenital, Liver and kidney the common origin is in essential substance for reproduction；In the day after tomorrow, supplementing nutrition of the essence that the first day after tomorrow that Liver and kidney is hidden by kidney jointly is comprehensive.Ministerial drug on the one hand auxiliary monarch drug nourishing the liver and kidney, effect of QI invigorating of invigorating blood circulation in side；On the other hand there is effect of promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain as ministerial drug.Rhizoma Atractylodis Macrocephalae (parched) invigorating the spleen and benefiting QI, dampness diuretic, Poria promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming, Fructus Amomi removing dampness is whetted the appetite, warming spleen and stopping diarrha, Fructus Amomi Rotundus removing dampness disappears painful abdominal mass, circulation of qi promoting warming middle-JIAO, Pericarpium Citri Reticulatae regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm, Semen Coicis spleen invigorating eliminating dampness by diuresis, row is dense in heat clearing away, Rhizoma dioscoreae (parched) spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, above seven flavor medicine is as adjuvant drug, return spleen, stomach warp, the day after tomorrow is changed grain rice and generates the vital essence of people, back feeding Liver and kidney operates, from pathology, treatment causes the inducement of skin flap necrosis after mammectomy, the nourishing the liver and kidney of the monarch and his subjects two medicine can be promoted as adjuvant drug, the effect of QI invigorating of invigorating blood circulation, body promoting blood circulation to restore menstrual flow can be promoted by using corrigent the monarch and his subjects two medicine again, the effect of eliminating stasis to stop pain.Simultaneously as the effect with spleen benefiting and stimulating the appetite.Radix Glycyrrhizae Preparata, as making medicine in side, has coordinating the actions of various ingredients in a prescription, the effect of mediation flavour of a drug, and all medicines of this side share, and the monarch and his subjects pull together, and assistant makes the most auxiliary, has effect of nourishing the liver and kidney, promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain, spleen benefiting and stimulating the appetite, it is possible to effectively treat skin flap necrosis after mammectomy.

Another important feature of the present invention is that this Chinese medicine preparation contains abundant nutritional labeling, more than 17 kinds are had rich in aminoacid, wherein essential amino acid has threonine, valine, methionine, isoleucine, leucine, lysine and phenylalanine, trace element containing needed by human has ferrum, chromium, copper, boron, manganese, strontium and zinc, another calcic, potassium, magnesium, phosphorus several human body macroelement.Above nutritional labeling is all needed by human material, can effectively strengthen body immunity.

nullMedicine material consumption of the present invention is groped to sum up to draw through inventor in a large number，Each raw material dosage is for all having a preferable curative effect in following weight parts scope: Radix Astragali Preparata 58-62 part、Radix Codonopsis 28-32 part、Rhizoma Atractylodis Macrocephalae (parched) 28-32 part、Poria 18-22 part、Radix Angelicae Sinensis 13-17 part、Flos Carthami 8-12 part、Radix Salviae Miltiorrhizae 18-22 part、Semen Persicae (parched) 10-14 part、Radix Paeoniae Rubra 10-14 part、Radix Polygoni Multiflori Preparata 18-22 part、Fructus Amomi 4-8 part、Fructus Amomi Rotundus 7-11 part、Rhizoma Cyperi 13-17 part、Pericarpium Citri Reticulatae 10-14 part、Herba Hedyotidis Diffusae 22-26 part、Fructus Lycii 18-22 part、Herba Epimedii 13-17 part、Colla Corii Asini 4-8 part、Semen Cuscutae 18-22 part、Semen Astragali Complanati 13-17 part、Semen Coicis 18-22 part、Rhizoma dioscoreae (parched) 16-20 part、Herba Scutellariae Barbatae 22-26 part、Ganoderma 18-22 part、Herba Agrimoniae 28-32 part、Radix Glycyrrhizae Preparata 4-8 part.

Wherein it is preferably: Radix Astragali Preparata 60 parts, Radix Codonopsis 30 parts, Rhizoma Atractylodis Macrocephalae (parched) 30 parts, 20 parts of Poria, Radix Angelicae Sinensis 15 parts, 10 parts of Flos Carthami, Radix Salviae Miltiorrhizae 20 parts, Semen Persicae (parched) 12 parts, Radix Paeoniae Rubra 12 parts, Radix Polygoni Multiflori Preparata 20 parts, Fructus Amomi 6 parts, 9 parts of Fructus Amomi Rotundus, Rhizoma Cyperi 15 parts, Pericarpium Citri Reticulatae 12 parts, Herba Hedyotidis Diffusae 24 parts, Fructus Lycii 20 parts, Herba Epimedii 15 parts, 6 parts of Colla Corii Asini, Semen Cuscutae 20 parts, Semen Astragali Complanati 15 parts, Semen Coicis 20 parts, Rhizoma dioscoreae (parched) 18 parts, Herba Scutellariae Barbatae 24 parts, Ganoderma 20 parts, Herba Agrimoniae 30 parts, Radix Glycyrrhizae Preparata 6 parts.

The preparation method of a kind of Chinese medicine preparation for treating skin flap necrosis after mammectomy is as follows:

Step one: by weight of the present invention, takes Radix Astragali Preparata, Rhizoma Atractylodis Macrocephalae (parched), Semen Persicae (parched), Rhizoma dioscoreae (parched), pulverizes, and crosses 200 mesh sieves, standby；

Step 2: by weight of the present invention, takes Radix Polygoni Multiflori Preparata, Ganoderma medical material is placed in marmite, adds the water of 3 times of volumes, intense fire infusion 20-30 minute, fire infusion 30-40 minute of larding speech with literary allusions, and filter liquor, repeatedly infusion three times merge three filtrates, standby；

Step 3: by weight of the present invention, takes Colla Corii Asini, pulverizes pulverizing, crosses 200 mesh sieves, standby；

Step 4: by weight proportion of the present invention, take Radix Codonopsis, Poria, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Rhizoma Cyperi, Pericarpium Citri Reticulatae medical material are placed in marmite, add the water of 8 times of volumes, after intense fire infusion 20-30 minute, add Radix Angelicae Sinensis, Flos Carthami, Fructus Amomi Rotundus, Herba Hedyotidis Diffusae, Fructus Lycii, Herba Epimedii, Herba Scutellariae Barbatae, Herba Agrimoniae, Radix Glycyrrhizae Preparata and the Semen Coicis tied with bundle respectively, Semen Cuscutae, Semen Astragali Complanati, Fructus Amomi, intense fire infusion 10-20 minute, fire infusion of larding speech with literary allusions obtains filtrate in 30 ~ 40 minutes, infusion merges gained filtrate for three times repeatedly, standby；

Step 5: combining step two, step 4 gained filtrate are taken after mixing it with water step one, three gained powder while hot, mixing, stir evenly, both the decoction for the treatment of skin flap necrosis after mammectomy of the present invention.

Using method of the present invention: take decoction, take in meal one hour after, three times a day.

Medicine of the present invention has the effect of nourishing the liver and kidney, promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain, spleen benefiting and stimulating the appetite, and good analgesic effect, cheap, having no side effect, easy to use, the mode that this Chinese medicine preparation uses treats the injury that can reduce Western medicine to patient body, alleviate the slight illness of patient, according to clinical 240 example patient view statistics, use medicine of the present invention the total effective rate course for the treatment of 82.5%, two the course for the treatment of total effective rate 95%.

Detailed description of the invention

Embodiment one: Radix Astragali Preparata 60 parts, Radix Codonopsis 30 parts, Rhizoma Atractylodis Macrocephalae (parched) 30 parts, 20 parts of Poria, Radix Angelicae Sinensis 15 parts, 10 parts of Flos Carthami, Radix Salviae Miltiorrhizae 20 parts, Semen Persicae (parched) 12 parts, Radix Paeoniae Rubra 12 parts, Radix Polygoni Multiflori Preparata 20 parts, Fructus Amomi 6 parts, 9 parts of Fructus Amomi Rotundus, Rhizoma Cyperi 15 parts, Pericarpium Citri Reticulatae 12 parts, Herba Hedyotidis Diffusae 24 parts, Fructus Lycii 20 parts, Herba Epimedii 15 parts, 6 parts of Colla Corii Asini, Semen Cuscutae 20 parts, Semen Astragali Complanati 15 parts, Semen Coicis 20 parts, Rhizoma dioscoreae (parched) 18 parts, Herba Scutellariae Barbatae 24 parts, Ganoderma 20 parts, Herba Agrimoniae 30 parts, Radix Glycyrrhizae Preparata 6 parts.

Embodiment two: Radix Astragali Preparata 61 parts, Radix Codonopsis 31 parts, Rhizoma Atractylodis Macrocephalae (parched) 31 parts, 21 parts of Poria, Radix Angelicae Sinensis 15 parts, 10 parts of Flos Carthami, Radix Salviae Miltiorrhizae 21 parts, Semen Persicae (parched) 11 parts, Radix Paeoniae Rubra 12 parts, Radix Polygoni Multiflori Preparata 20 parts, Fructus Amomi 7 parts, 9 parts of Fructus Amomi Rotundus, Rhizoma Cyperi 15 parts, Pericarpium Citri Reticulatae 12 parts, Herba Hedyotidis Diffusae 23 parts, Fructus Lycii 21 parts, Herba Epimedii 14 parts, 7 parts of Colla Corii Asini, Semen Cuscutae 21 parts, Semen Astragali Complanati 16 parts, Semen Coicis 21 parts, Rhizoma dioscoreae (parched) 17 parts, Herba Scutellariae Barbatae 23 parts, Ganoderma 21 parts, Herba Agrimoniae 31 parts, Radix Glycyrrhizae Preparata 7 parts.

Embodiment three: Radix Astragali Preparata 59 parts, Radix Codonopsis 29 parts, Rhizoma Atractylodis Macrocephalae (parched) 28 parts, 18 parts of Poria, Radix Angelicae Sinensis 15 parts, 11 parts of Flos Carthami, Radix Salviae Miltiorrhizae 21 parts, Semen Persicae (parched) 11 parts, Radix Paeoniae Rubra 11 parts, Radix Polygoni Multiflori Preparata 21 parts, Fructus Amomi 8 parts, 7 parts of Fructus Amomi Rotundus, Rhizoma Cyperi 14 parts, Pericarpium Citri Reticulatae 13 parts, Herba Hedyotidis Diffusae 24 parts, Fructus Lycii 20 parts, Herba Epimedii 15 parts, 6 parts of Colla Corii Asini, Semen Cuscutae 19 parts, Semen Astragali Complanati 15 parts, Semen Coicis 21 parts, Rhizoma dioscoreae (parched) 19 parts, Herba Scutellariae Barbatae 22 parts, Ganoderma 19 parts, Herba Agrimoniae 32 parts, Radix Glycyrrhizae Preparata 8 parts.

Patient is presented herein below and uses the clinical statistics data of medicine of the present invention:

One, physical data

Accept out-patient 240 example for medical treatment, patient is randomly divided into observation group and each 120 examples of matched group, wherein male 10 example, women 230 example, M-F 1:23, max age 60 years old, minimal ages 36 years old, course of disease some months to several years.Every basic documents such as two groups of patient ages, sex, courses of disease are essentially identical, no significant difference (P ＞ 0.05).

Two, diagnostic criteria

Patient with breast cancer carries out the skin that Post operation ischemia occurs in 24 hours and loses color and progressively present livid purple color edema surface and have vesicle, and after 3 ~ 7 days, the boundary of necrotic zone progressively understands the skin gradually hard crust shape in black.

Three, Therapeutic Method:

1, observation group is treated by invention implementation according to Medications Example one of the present invention, weighting raw materials, takes decoction, take, three times a day in meal one hour after.It within 7 days, it is a course for the treatment of.

2, matched group uses conventional western medicine Prostaglandin E 1 Treatment, within 7 days, is a course for the treatment of.

Four, efficacy assessment standard:

1, cure: postoperative wound healing is good, without large area flap necrosis and hypohydrops, does not leave any sequela, all takes out stitches and can carry out next step chemotherapy.

2, take a turn for the better: postoperative wound heals substantially, has little area flap necrosis and hypohydrops, does not leave any sequela, all takes out stitches and carries out next step chemotherapy.

3, invalid: through treating more than 1 week, symptom is not all felt any better person.

Five, therapeutic outcome statistics:

Matched group result is added up

Use the Comparison of therapeutic situation of this Chinese medicine preparation two courses for the treatment of of two groups of patients

Wherein: total effective rate=cure rate+improvement rate

By contrasting the treatment total effective rate of two groups of patients it appeared that observation group is apparently higher than matched group, thus illustrate, Chinese medicine of the present invention has good clinical effectiveness on treatment skin flap necrosis after mammectomy, the cure rate for the treatment of can be effectively improved, effect is notable, cheap, have no adverse reaction and any toxic and side effects, there is wide market application foreground.

Model case and curative effect:

Case one, patient Wang, female, 56 years old, people from Qingdao City, comes here and goes to a doctor on May 20th, 2014.Main suit: suffer from breast carcinoma, after carrying out excision, occurs the skin of ischemia to lose color progressively presenting livid purple color edema surface have vesicle after 48 hours, remove examination in hospital and do biopsy and be diagnosed as skin flap necrosis after mammectomy.Through treatment pain relief, but do not cure.Then here treatment, uses made preparation in the embodiment of the present invention one, and selected preparation method, and symptom goes down, and after medication 5 days, pain disappears, and affected part recovers good, continues medication 6 days, thoroughly cures, and Effect of follow-up visit by telephone does not recurs half a year.

Case two, patient Lee, female, 42 years old, people from Linyi, Shandong.Come here on January 14th, 2015 to go to a doctor, symptom is as follows after diagnosing: patient carries out the skin that Post operation ischemia occurs in 36 hours and loses color and progressively present livid purple color edema surface and have vesicle, after 3 days, the boundary of necrotic zone progressively understands the skin gradually hard crust shape in black, is diagnosed as skin flap necrosis after mammectomy.Using made preparation in the embodiment of the present invention one, and selected preparation method, symptom goes down, and pain slightly alleviates, and after medication 7 days, pain disappears, and affected part recovers good, continues medication 5 days, thoroughly cures, and Effect of follow-up visit by telephone does not recurs half a year.

Claims

null1. the Chinese medicine preparation being used for treating skin flap necrosis after mammectomy，It is characterized in that，This Chinese medicine preparation is made up of the medicine of following weight portion: Radix Astragali Preparata 58-62 part、Radix Codonopsis 28-32 part、Rhizoma Atractylodis Macrocephalae (parched) 28-32 part、Poria 18-22 part、Radix Angelicae Sinensis 13-17 part、Flos Carthami 8-12 part、Radix Salviae Miltiorrhizae 18-22 part、Semen Persicae (parched) 10-14 part、Radix Paeoniae Rubra 10-14 part、Radix Polygoni Multiflori Preparata 18-22 part、Fructus Amomi 4-8 part、Fructus Amomi Rotundus 7-11 part、Rhizoma Cyperi 13-17 part、Pericarpium Citri Reticulatae 10-14 part、Herba Hedyotidis Diffusae 22-26 part、Fructus Lycii 18-22 part、Herba Epimedii 13-17 part、Colla Corii Asini 4-8 part、Semen Cuscutae 18-22 part、Semen Astragali Complanati 13-17 part、Semen Coicis 18-22 part、Rhizoma dioscoreae (parched) 16-20 part、Herba Scutellariae Barbatae 22-26 part、Ganoderma 18-22 part、Herba Agrimoniae 28-32 part、Radix Glycyrrhizae Preparata 4-8 part.
Chinese medicine preparation for treating skin flap necrosis after mammectomy the most according to claim 1, it is characterized in that, it is made up of the medicine of following weight portion: Radix Astragali Preparata 60 parts, Radix Codonopsis 30 parts, Rhizoma Atractylodis Macrocephalae (parched) 30 parts, 20 parts of Poria, Radix Angelicae Sinensis 15 parts, 10 parts of Flos Carthami, Radix Salviae Miltiorrhizae 20 parts, Semen Persicae (parched) 12 parts, Radix Paeoniae Rubra 12 parts, Radix Polygoni Multiflori Preparata 20 parts, Fructus Amomi 6 parts, 9 parts of Fructus Amomi Rotundus, Rhizoma Cyperi 15 parts, Pericarpium Citri Reticulatae 12 parts, Herba Hedyotidis Diffusae 24 parts, Fructus Lycii 20 parts, Herba Epimedii 15 parts, 6 parts of Colla Corii Asini, Semen Cuscutae 20 parts, Semen Astragali Complanati 15 parts, Semen Coicis 20 parts, Rhizoma dioscoreae (parched) 18 parts, Herba Scutellariae Barbatae 24 parts, Ganoderma 20 parts, Herba Agrimoniae 30 parts, Radix Glycyrrhizae Preparata 6 parts.
Chinese medicine preparation for treating skin flap necrosis after mammectomy the most according to claim 1 and 2, it is characterised in that: described Chinese medicine preparation is decoction.
4. the preparation method being used for treating the Chinese medicine preparation of skin flap necrosis after mammectomy, it is characterised in that preparation method is as follows: step one: by weight of the present invention, takes Radix Astragali Preparata, Rhizoma Atractylodis Macrocephalae (parched), Semen Persicae (parched), Rhizoma dioscoreae (parched), pulverizes, crosses 200 mesh sieves, standby；Step 2: by weight of the present invention, takes Radix Polygoni Multiflori Preparata, Ganoderma medical material is placed in marmite, adds the water of 3 times of volumes, intense fire infusion 20-30 minute, fire infusion 30-40 minute of larding speech with literary allusions, and filter liquor, repeatedly infusion three times merge three filtrates, standby；Step 3: by weight of the present invention, takes Colla Corii Asini, pulverizes pulverizing, crosses 200 mesh sieves, standby；Step 4: by weight proportion of the present invention, take Radix Codonopsis, Poria, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Rhizoma Cyperi, Pericarpium Citri Reticulatae medical material are placed in marmite, add the water of 8 times of volumes, after intense fire infusion 20-30 minute, add Radix Angelicae Sinensis, Flos Carthami, Fructus Amomi Rotundus, Herba Hedyotidis Diffusae, Fructus Lycii, Herba Epimedii, Herba Scutellariae Barbatae, Herba Agrimoniae, Radix Glycyrrhizae Preparata and the Semen Coicis tied with bundle respectively, Semen Cuscutae, Semen Astragali Complanati, Fructus Amomi, intense fire infusion 10-20 minute, fire infusion of larding speech with literary allusions obtains filtrate in 30 ~ 40 minutes, infusion merges gained filtrate for three times repeatedly, standby；Step 5: combining step two, step 4 gained filtrate are taken after mixing it with water step one, three gained powder while hot, mixing, stir evenly, both the decoction for the treatment of skin flap necrosis after mammectomy of the present invention.