CN109498714A - Danggui shaoyao san - Google Patents
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Abstract
The invention discloses a kind of DANGGUI SHAOYAO SAN, the medicinal material including following parts by weight: 0-15 parts of Radix Angelicae Sinensis: 4-19 parts of Chinese herbaceous peony: 4 parts of Poria cocos: 4 parts of Rhizoma Atractylodis Macrocephalae: 8 parts of rhizoma alismatis: 8 parts of Rhizoma Chuanxiong.The beneficial effect of DANGGUI SHAOYAO SAN of the invention is obtained from decoction function and effect, it is suitable for the common formulations such as decoction, pill, powder, paste, sublimed preparation, vina, electuary, oral solutions, capsule, tablet, injection, all kinds of inflammatory pains of oromaxillo-facial region can be effectively treated and be alleviated, while also can treat and alleviating all kinds of inflammatory pains caused by each organ lesion of body.
Description
Technical field
The present invention relates to pharmaceutical technology field more particularly to a kind of DANGGUI SHAOYAO SANs.
Background technique
1, oro-maxillo-facial inflammation pain
Oromaxillo-facial region pain is the general name of (such as tooth) the various property pain such as oral cavity, jaw face, neck tissue organ, is shown as
Two class of Acute Pain and chronic ache.It, will according to the complexity of oromaxillo-facial region anatomical structure, the cause of disease of disease, clinical characters
Mouth Maxillary region pain is divided into inflammatory pain, treatment of traumatic pain, oncological pain, arthralgia, neuropathic pain, iatrogenic pain
With psychological factor pain etc..
Oromaxillo-facial region inflammatory pain, inflammatory pain be by various biological (bacterium, fungi, viruses etc.), physics, chemistry or
Pain caused by immunogenicity inflammation.
In oromaxillo-facial region, the pain as caused by inflammation mainly has pulpitis, periapical inflammation, pericoronitis of the third molar of the mandible, gap sense
Dye, parotitis, glandula submandibularis inflammation, arthritis etc..Toothache is one of most common symptom on clinical oral.Acute pulpitis, urgency
Property periapical inflammation, pericoronitis etc. often show as sharp spontaneous pain.Chronic papillary gingivitis etc. often shows as spontaneous dull pain.Dentine
Allergy, two degree or three degree saprodontias, wedge-shaped defects etc. often show as excitation pain.
Inflammatory pain mechanism is complicated, is regulated and controled by many factors, main mechanism: 1), inflammation exploded metabolism enhancing, inflammation
Medium such as prostaglandin, serotonin, bradykinin etc., tumor necrosis factor-alpha (TNF-α) and algogenic substance etc. stimulate nerve end
The tip causes pain；2), inflammatory seep causes swollen tissue, and tension increases, and compressing or drawing nerve endings cause pain.3), tooth
Pain caused by marrow inflammation, periapical inflammation is to lead to pulp cavity pressure rise by the inflammation of partially or fully dental pulp, and tissue pressure rises
Height, contention effect can make fiber C nerve endings excited, and impulsion, which reaches maincenter, leads to pain.
2, toothache Chinese medicine viewpoint
Motherland's medicine thinks, " tooth being the surplus of the bone ", " Shen controls bone ", stomach of foot Yang Ming through train of thought in gum, so tooth and kidney, gum with
Stomach relationship is the closest.From organic conception, toothache is often lacked of proper care with exopathogen invasion, inflammation, hepatic and renal function and is thinked little of certainly
My health care is related.In general, acute toothache, gum redness person, are mostly controlled from stomach；And chronic toothache, tooth pine, dentalgia it is indistinct, red
It is swollen not notably, preferably controlled from kidney.Chinese medicine is broadly divided into following three kinds having a toothache:
1), acute toothache toothache acutely, breaks out in paroxysmal, breaks out or aggravates to the wind, subtracts bitterly to the cold, is heated and aggravates, and gum is red
Swollen, often there are the symptoms such as aversion to cold, fever, thirsty, rapid pulse in whole body, is more common in acute pulpitis and periapical inflammation initial stage.It controls and preferably dredges
Wind heat-clearing, removing toxicity for detumescence, side is added and subtracted with Yinqiao San.Gastropyretic toothache sharp ache, gum and facial area be red and swollen or gum pyorrhea,
Bleeding gums, sometimes difficulty in opening mouth, while the symptoms such as visible headache, thirsty, halitosis, oliguria, constipation, fever, yellowish fur are more
See pericoronitis, suppurative periapical inflammation.Suitable eliminating stomach-fire, cooling blood and relieving pain are controlled, side is added and subtracted with qingwei powder.Ferritic deficiency of Yin person, can
With yunü decoction plus the root bark of Chinese wolf-berry, radix scrophulariae.
2), toothache caused by fire of deficiency type tooth has a dull ache, lesser extent, may aggravate with night in the afternoon, and gum is not mostly red and swollen, often goes out
Show tooth mobility, sting object inability and the pain increased or bleeding gums.Whole body can be with the soreness of waist, dizziness, dry mouth and throat, the red tongue fur of tongue
The symptoms such as white, thready rapid pulse.It is more common in old man's chronic periodontal disease.Suitable nourishing YIN for benefiting the kidney, fall fire analgesic are controlled, side is added with Zhi-Bai-Di-Huang Decotion
Subtract.
3), irascibility toothache toothache traction headache, breaks out when mood swing or aggravates, and whole body is often accompanied by bitter taste, hot eyes, ear
The symptoms such as ring, hypochondriac pain, irritable, red tongue with yellowish fur, rapid pulse be strong.Suitable purging liver and gallbladder, dispersing the depressed liver-qi and alleviating pain, side is gone with Longdan Xiegan Tang
Caulis akebiae adds the coptis, the root bark of tree peony to control it.
3, the traditional Chinese and western medicine viewpoint of dysmenorrhea
Dysmenorrhea is the most common gynecological disease of young woman, refers to before passing through or menstrual period lower abdomen pendant, distending pain occurs, with the soreness of waist
Or other are uncomfortable, severe person directly affects work, life and with symptoms such as coldness of extremities, shiver with cold, Nausea and vomiting, syncopes
It practises.Whether there is or not organic diseases to be divided into two classes: i.e. primary dysmenorrhea and acquired dysmenorrhea according to reproductive organs for dysmenorrhea.Primary pain
It is also referred to as functional dysmenorrhea, most of patients has symptom from after menarche, is mainly shown as that pain on the firstth of passing through is strict
Evil, improves after continuing 2~3d, and symptom disappears after.
Serum prostate cellulose content increases, and causes uterine wall helicine artery and uterine smooth muscle strong contraction while ischemic
Anoxic improves peripheral nerve and causes dysmenorrhea to the sensibility of pain, this theory is known as being the master to form dysmenorrhea by many scholars
Want mechanism.Vasopressing and dysmenorrhea have it is indivisible contact, the hormone by acting on the corresponding receptor on uterus,
Make uterine contraction aggravation and muscular movement, leads to uterus oligemia, cause pain, vasopressing can increase uterus to contracting
The susceptibility of palace drug, this also results in blood flow reduction, causes dysmenorrhea.Endothelin and nitric oxide is out of proportion is also likely to be
Lead to another major reason of dysmenorrhea.
Pathogenesis Chinese medicine thinks that for the old complaint of dysmenorrhea in uterus, " not general rule pain " and " not Rong Ze pain " is main pathogenesis,
Empty person is mainly shown as that qi and blood is weak, and the reasons such as deficiency of the kidney cause uterus that cannot receive the object of this needs, referred to as " not Rong Ze
Bitterly "；Real person is then not lack nutriment in vivo, but since the channel of transport is obstructed, that is, the qi depression to blood stasis, wet often said
Hot stasis blocking or cold blood stasis cause the vim and vigour running in uterus not smooth, referred to as " not general rule pain ".Chinese medical and herbal therapy traditional Chinese medicine
For treating primary dysmenorrhea, effect has obtained clinician and patient's affirmative.
4, effect of the DANGGUI SHAOYAO SAN to pain
DANGGUI SHAOYAO SAN come from Eastern Han Dynasty's Zhang Zhongjing " Synopsis Golden Chamber " (married woman bosom is pregnent, abdominal pain, DANGGUI SHAOYAO SAN master it.Radix Angelicae Sinensis
Paeonia Powder side: three liang of Radix Angelicae Sinensis, one jin of Chinese herbaceous peony, four liang of Poria cocos, four liang of Rhizoma Atractylodis Macrocephalae, half jin of rhizoma alismatis, half jin of Rhizoma Chuanxiong.Upper Six-element, pestle be it is scattered,
Take tool for weighing medicine in ancient China, wine and taking medicine three times daily).The medicine was gynaecology's recipe originally, function blood-nourishing tune liver, invigorating spleen to remove dampness, was mainly used to treatment gestation
Abdominal pain.Later age doctor on this basis or has increase and decrease, or adjusts its dosage, but its function is still main are as follows: blood-nourishing, promoting blood circulation, analgesic, benefit
Wet, tune liver, soft liver, for treating vegetative nerve dysfunction, hypoovarianism, threatened abortion, chronic nephritis, hypertension
The diseases such as disease, climacteric syndrome, pelvic inflammatory disease.
However, the research for being used to alleviate all kinds of pain of oromaxillo-facial region for DANGGUI SHAOYAO SAN is actually rare, it is therefore proposed that
DANGGUI SHAOYAO SAN.
Summary of the invention
Technical problems based on background technology, the invention proposes DANGGUI SHAOYAO SANs.
DANGGUI SHAOYAO SAN proposed by the present invention, the medicinal material including following parts by weight: 0-15 parts of Radix Angelicae Sinensis: Chinese herbaceous peony 4-19 parts: Fu
4 parts of Siberian cocklebur: 4 parts of Rhizoma Atractylodis Macrocephalae: 8 parts of rhizoma alismatis: 8 parts of Rhizoma Chuanxiong.
Preferably, the medicinal material including following parts by weight: 0 part of Radix Angelicae Sinensis: 19 parts of Chinese herbaceous peony: 4 parts of Poria cocos: 4 parts of Rhizoma Atractylodis Macrocephalae: 8 parts of rhizoma alismatis:
8 parts of Rhizoma Chuanxiong.
The preparation method of DANGGUI SHAOYAO SAN, comprising the following steps:
S1: Radix Angelicae Sinensis, Chinese herbaceous peony, Poria cocos, Rhizoma Atractylodis Macrocephalae, rhizoma alismatis and the Rhizoma Chuanxiong of high-quality are chosen according to traditional Chinese medicines standard；
S2: Radix Angelicae Sinensis described in S1, Chinese herbaceous peony, Poria cocos, Rhizoma Atractylodis Macrocephalae, rhizoma alismatis and Rhizoma Chuanxiong are mixed in proportion, obtain mixture A；
S3: mixture A described in S2 is put into digester, and the distilled water that certain volume is added is impregnated and decocted, so
After be separated by solid-liquid separation to obtain the first dregs of a decoction B and the first liquid medicine C；
S4: the first dregs of a decoction B described in S3 is put into digester, and the distilled water that certain volume is added is decocted, then into
Row is separated by solid-liquid separation and obtains the second dregs of a decoction D and the second liquid medicine E；
S5: it is condensed into 1g crude drug/ml after the first liquid medicine C described in the second liquid medicine E and S3 described in S4 is mixed, just
The finished product of DANGGUI SHAOYAO SAN is completed, and DANGGUI SHAOYAO SAN finished product is put into 4 DEG C of refrigerators and carries out spare, the used time is heated to temperature
Heat.
Preferably, in the S3, the volume ratio of volume and mixture A that distilled water is added is 8:1.
Preferably, in the S3, soaking time 1h, and decocting time is 2h.
Preferably, in the S4, the volume ratio of volume and the first dregs of a decoction B that distilled water is added is 6:1.
Preferably, in the S4, decocting time 1.5h.
Preferably, it is each that all kinds of inflammatory pains and body of all kinds of dosage forms for treating and alleviating oromaxillo-facial region are prepared into
All kinds of inflammatory pains caused by organ lesion, these dosage forms include decoction, pill, powder, paste, sublimed preparation, vina, electuary, mouth
Take the common formulations such as liquor, capsule, tablet, injection.
Beneficial effects of the present invention: the beneficial effect of DANGGUI SHAOYAO SAN of the invention is obtained from decoction function and effect,
It is suitable for the common agent such as decoction, pill, powder, paste, sublimed preparation, vina, electuary, oral solutions, capsule, tablet, injection
Type, can effectively treat and alleviate all kinds of inflammatory pains of oromaxillo-facial region, while also can treat and to alleviate body each
All kinds of inflammatory pains caused by organ lesion.
Detailed description of the invention
Fig. 1 is jaw face formalin pain model rat upper lip formalin diffusion region schematic diagram；
Fig. 2 is DANGGUI SHAOYAO SAN prescription as ratio schematic diagram；
Fig. 3 scratches face behavior summary table for each period rat；
Fig. 4 is that rat scratches face number broken line；
Fig. 5 is the variation diagram that different pharmaceutical section between while rat scratches face number；
Fig. 6 is that different pharmaceutical scratches face sum figure to rat.
Specific embodiment
Combined with specific embodiments below the present invention is made further to explain.
1, production DANGGUI SHAOYAO SAN is carried out according to Radix Angelicae Sinensis and the different proportion of Chinese herbaceous peony, specific DANGGUI SHAOYAO SAN prescription becomes
Ratio is as shown in Figure 2.
2, the preparation of DANGGUI SHAOYAO SAN decoction
It includes that Chinese medicine is purchased from medicinal material company, Guangdong Province that DANGGUI SHAOYAO SAN, which has altogether, and ingredient and content are shown in upper figure.Traditional Chinese herbal decoction is decocted
Method is as follows: after Chinese medicine mixes in proportion, adding the distilled water immersion 1h of 8 times of volumes, then decocts 2h, collects liquid medicine；Again into the dregs of a decoction
Add 6 times of volume distilled water, decoct 1.5h, collects liquid medicine；It is condensed into 1g crude drug/ml after the liquid medicine collected twice is mixed, puts 4 DEG C of ice
Case is spare, and the used time is heated to warming.
3, experimental index measuring method
(1), woods causes Orofacial pain model
All Animal adaptabilities are raised 1 week.A few days ago, the daily 30min of animal is continuously accustomed to experimental setup for experiment, cage be it is long ×
The transparent organic glass case of width × height=47 × 25 × 21cm3, in same time interval (morning or afternoon 8:00-11:00) and together
Experiment is completed under the conditions of the illumination and temperature of sample.It is placed within 15 minutes before experimental day, rat injection of formalin transparent
In organic glass case.In all experiments, same assistant gently fixes animal body and head, same experimenter with fabric gloves
With microsyringe quick needle insertion, 2.5% formalin, 50 μ l, blank group injection are injected in subcutaneous tissue of upper lip on the right side of the rat
0.9% physiological saline of equivalent.Injection position pads edge as shown in Figure 1, i.e. skin of upper lip and mucous membrane intersection in upper right lip antenna
Towards antenna pad direction inserting needle injection, the first half of upper lip and antenna pad is distributed in after injecting formalin solution.
(2), behaviouristics measurement experiment method
All smooth rats of formalin injection, which are put at once in observation case, carries out behavior record and assessment.It is single with 3min
Position is observed 45 minutes, and rat uses front/rear pawl to grab and wipes the number of right Maxillary region injection site as animal between recording different groups respectively
The quantitative target of pain, whole process record.While artificial observation timing, ANIMAL PAIN is recorded with high-definition digital HD camera shooting integrated machine
Behavior overall process, convenient for statistical analysis later.
4, grouping and testing index
(1), it is grouped
1), Normal group: normal mice gavages same amount of normal saline.
2), pain model group: formalin cause Orofacial pain model mouse+gavage same amount of normal saline.
3), property control group: formalin causes Orofacial pain model mouse+aspirin 0.1g/KG.
4), 0:19DSS group: formalin causes Orofacial pain model mouse+gavage 0:32DSS 5ml, when every morning 10, even
It is 3 days continuous.
5), 1:9DSS group: formalin causes Orofacial pain model mouse+gavage 1:9DSS 5ml, when every morning 10, continuously
3 days.
6), 1:7DSS group: formalin causes Orofacial pain model mouse+gavage 1:7DSS 5ml, when every morning 10, continuously
3 days.
7), 1:5DSS group: formalin causes Orofacial pain model mouse+gavage 1:5DSS 5ml, when every morning 10, continuously
3 days.
8), 1:3DSS group: formalin causes Orofacial pain model mouse+gavage 1:3DSS 5ml, when every morning 10, continuously
3 days.
9), 1:1DSS group: formalin causes Orofacial pain model mouse+gavage 1:1DSS 5ml, when every morning 10, continuously
3 days.
10), 3:1DSS group: formalin causes Orofacial pain model mouse+gavage 3:1DSS 5ml, when every morning 10, even
It is 3 days continuous.
11), 1:5.33DSS group: formalin cause Orofacial pain model mouse+gavage 1:5.33DSS5ml, every morning 10
When, for three days on end.
12), the taste side Yuan Fangjia group: formalin cause Orofacial pain model mouse+gavage original side plus taste side 5ml, every morning
When 10, for three days on end.
(2), testing index
Record rat pain behavior index.
1) it, grabs the number for wiping right Maxillary region injection site with front/rear pawl as unit rat using 3min, amounts to 45 points of observation
Clock, 15 periods scratch face number.
2), face number is always scratched in rat 1 hour.
5, DANGGUI SHAOYAO SAN prescription ratio relieves pain effect
(1), different pharmaceutical processing formalin causes the influence for scratching face behavior such as Fig. 3, Fig. 4 and Fig. 5 institute of Orofacial pain model mouse
Show.
From scratching face behavior summary table and take out stitches figure difference Radix Angelicae Sinensis and Chinese herbaceous peony ratio recipe group are considerably less than model group, with without working as
Recipe (0:19DSS group) is returned to reduce most obvious.
As shown in fig. 6, can be seen that from face total degree is scratched, different Radix Angelicae Sinensis and Chinese herbaceous peony ratio recipe group are considerably less than model
Group is reduced most bright with no Radix Angelicae Sinensis recipe (0:19DSS group).
(2), conclusion
1) different Radix Angelicae Sinensis and the DANGGUI SHAOYAO SAN prescription of Chinese herbaceous peony ratio can be relieved formalin and cause Orofacial pain effect.
2) Radix Angelicae Sinensis and Chinese herbaceous peony ratio are 0:19, that is, when not having Radix Angelicae Sinensis, alleviate formalin and cause Orofacial pain effect best.
This DANGGUI SHAOYAO SAN can be prepared into all kinds of dosage forms for treating and alleviating all kinds of inflammatory pains of oromaxillo-facial region
And all kinds of inflammatory pains caused by each organ lesion of body, these dosage forms include decoction, pill, powder, paste, sublimed preparation, vina,
The common formulations such as electuary, oral solutions, capsule, tablet, injection.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto,
Anyone skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its
Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.
Claims (8)
1. DANGGUI SHAOYAO SAN, which is characterized in that the medicinal material including following parts by weight: 0-15 parts of Radix Angelicae Sinensis: 4-19 parts of Chinese herbaceous peony: Poria cocos 4
Part: 4 parts of Rhizoma Atractylodis Macrocephalae: 8 parts of rhizoma alismatis: 8 parts of Rhizoma Chuanxiong.
2. DANGGUI SHAOYAO SAN according to claim 1, which is characterized in that the medicinal material including following parts by weight: 0 part of Radix Angelicae Sinensis:
19 parts of Chinese herbaceous peony: 4 parts of Poria cocos: 4 parts of Rhizoma Atractylodis Macrocephalae: 8 parts of rhizoma alismatis: 8 parts of Rhizoma Chuanxiong.
3. the preparation method of DANGGUI SHAOYAO SAN according to claim 1 or 2, which comprises the following steps:
S1: Radix Angelicae Sinensis, Chinese herbaceous peony, Poria cocos, Rhizoma Atractylodis Macrocephalae, rhizoma alismatis and the Rhizoma Chuanxiong of high-quality are chosen according to traditional Chinese medicines standard；
S2: Radix Angelicae Sinensis described in S1, Chinese herbaceous peony, Poria cocos, Rhizoma Atractylodis Macrocephalae, rhizoma alismatis and Rhizoma Chuanxiong are mixed in proportion, obtain mixture A；
S3: mixture A described in S2 is put into digester, and the distilled water that certain volume is added is impregnated and decocted, so
After be separated by solid-liquid separation to obtain the first dregs of a decoction B and the first liquid medicine C；
S4: the first dregs of a decoction B described in S3 is put into digester, and the distilled water that certain volume is added is decocted, then into
Row is separated by solid-liquid separation and obtains the second dregs of a decoction D and the second liquid medicine E；
S5: it is condensed into 1g crude drug/ml after the first liquid medicine C described in the second liquid medicine E and S3 described in S4 is mixed, just
The finished product of DANGGUI SHAOYAO SAN is completed, and DANGGUI SHAOYAO SAN finished product is put into 4 DEG C of refrigerators and carries out spare, the used time is heated to temperature
Heat.
4. the preparation method of DANGGUI SHAOYAO SAN according to claim 2, which is characterized in that in the S3, distilled water is added
Volume and mixture A volume ratio be 8:1.
5. the preparation method of DANGGUI SHAOYAO SAN according to claim 2, which is characterized in that in the S3, soaking time is
1h, and decocting time is 2h.
6. the preparation method of DANGGUI SHAOYAO SAN according to claim 2, which is characterized in that in the S4, distilled water is added
Volume and the first dregs of a decoction B volume ratio be 6:1.
7. the preparation method of DANGGUI SHAOYAO SAN according to claim 2, which is characterized in that in the S4, decocting time is
1.5h。
8. DANGGUI SHAOYAO SAN feature according to claim 1 or 2 and formula are prepared into all kinds of dosage forms for treating and alleviating
All kinds of inflammatory pains caused by all kinds of inflammatory pains and each organ lesion of body of oromaxillo-facial region, these dosage forms include soup
The common formulations such as agent, pill, powder, paste, sublimed preparation, vina, electuary, oral solutions, capsule, tablet, injection.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115779025A (en) * | 2022-12-09 | 2023-03-14 | 贵州中医药大学第一附属医院 | Traditional Chinese medicine preparation for treating female acne and preparation method thereof |
| CN116920030A (en) * | 2023-05-16 | 2023-10-24 | 海南医学院第二附属医院 | Traditional Chinese medicine composition for treating diabetic peripheral neuropathy qi deficiency and blood stasis |
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| CN101167901A (en) * | 2006-10-26 | 2008-04-30 | 中国人民解放军军事医学科学院毒物药物研究所 | Chinese angelica and peony formula extraction, preparation and medical use thereof |
| CN102846878A (en) * | 2011-06-30 | 2013-01-02 | 苏州知微堂生物科技有限公司 | Preparation technology and production method for an integrated new formulation of angelica peony wine |
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Cited By (3)
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|---|---|---|---|---|
| CN115779025A (en) * | 2022-12-09 | 2023-03-14 | 贵州中医药大学第一附属医院 | Traditional Chinese medicine preparation for treating female acne and preparation method thereof |
| CN115779025B (en) * | 2022-12-09 | 2024-02-23 | 贵州中医药大学第一附属医院 | Traditional Chinese medicine preparation for treating female acne and preparation method thereof |
| CN116920030A (en) * | 2023-05-16 | 2023-10-24 | 海南医学院第二附属医院 | Traditional Chinese medicine composition for treating diabetic peripheral neuropathy qi deficiency and blood stasis |
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