CN108704040B - Traditional Chinese medicine composition and application thereof - Google Patents

Abstract

The invention provides a traditional Chinese medicine composition and application thereof, wherein the composition comprises the following components in parts by weight: 95-105 parts of honey-fried licorice root, 33-38 parts of honeysuckle, 33-38 parts of purslane, 33-38 parts of astragalus, 33-38 parts of isatis root, 23-28 parts of raw hawthorn, 23-28 parts of salvia miltiorrhiza, 23-28 parts of saffron crocus, 23-28 parts of red paeony root, 23-28 parts of pseudo-ginseng powder, 23-28 parts of sappan wood, 23-28 parts of sargentgloryvine stem, 18-22 parts of white poria, 18-22 parts of common yam rhizome, 18-22 parts of white paeony root and 18-22 parts of dahurian angelica root; according to the invention, through scientific material selection, reasonable collocation and optimized extraction process, each step of each component is synergistic, and finally, the acne removing product with excellent acne removing effect is obtained, and the acne removing product has wide application prospect and huge market value.

Description

Traditional Chinese medicine composition and application thereof

Technical Field

The invention relates to the field of traditional Chinese medicines, and relates to a traditional Chinese medicine composition and application thereof.

Background

The acne is a chronic inflammatory pathological skin disease of hair follicles and sebaceous glands units related to sebum metabolism, modern medicine considers that the pox is an inertial inflammatory lesion of the hair follicles and the sebaceous glands, is mostly seen in parts with vigorous secretion of cortex such as the face, the chest and the back, and is also commonly called as the acne because the acne is well developed in the adolescence stage, but because the later-stage patient mistakenly extrudes the acne, acne marks, scars and local depressions of the skin are left after the abnormal treatment of a beauty parlor, the skin color is purplish red and dark red, and the patient is not cured for a long time, so that the beauty parlor is very annoying;

although a lot of anti-acne western medicines for acne exist in the market at present, the anti-acne western medicines are basically antibiotics, hormones and the like, such as clindamycin, retinoic acid, ranitidine, metronidazole and the like, most of the products have large side effects, and medicine dependence is easy to generate. Therefore, many patients seek treatment of traditional Chinese medicines, the curative effect of traditional Chinese medicine therapy is relatively obvious, but most traditional Chinese medicine products for treating acnes on the market are products such as ointments, traditional Chinese medicine masks and the like, and almost no liquid products exist, and CN106667852A discloses a traditional Chinese medicine acne removing cream and a preparation method thereof, wherein the traditional Chinese medicine acne removing cream comprises base oil, an emulsifier, a thickener, a polyalcohol humectant, hyaluronic acid, a preservative, a traditional Chinese medicine extracting solution A, a traditional Chinese medicine extracting solution B and water, the traditional Chinese medicine extracting solution A is prepared by extracting traditional Chinese medicines, and the traditional Chinese medicines comprise pseudo-ginseng, safflower, coptis chinensis, scutellaria baicalensis and golden cypress. CN105395717A discloses a traditional Chinese medicine acne removing paste for removing acne and acne marks, which is prepared from the following raw materials, by weight, 5-10 parts of radix scutellariae, 5-10 parts of poria cocos, 5-10 parts of radix sophorae flavescentis, 5-10 parts of rhizoma coptidis, 5-10 parts of bunge corydalis herb, 1-5 parts of salvia officinalis and 1-5 parts of honeysuckle. CN108079270A discloses an acne-removing traditional Chinese medicine composition, which is prepared by adding an ecological nutrient solution into an extracting solution of the following components in parts by weight: 20-50 parts of scutellaria baicalensis, 15-40 parts of rheum officinale, 8-30 parts of sophora flavescens, 5-25 parts of gallnut, 3-10 parts of liquorice and 0-5 parts of dried ginger. The products have the defect of continuously blocking pores, the preparation process is complex, the product effect is general, the acne is lingering and difficult to cure, the physical and mental health of a patient is seriously influenced, the patient easily has social and psychological problems of self-respect, self-confidence damage, embarrassment, depression, tension and the like, and a lot of trouble and pain are brought to the spirit, life and social contact of the patient.

In conclusion, the liquid acne removing product which can not block pores and has the functions of removing oil and whitening is developed, the acne marks of neutral and oily acne-growing skin are effectively removed, and the liquid acne removing product has wide application prospect and great market value.

Disclosure of Invention

Aiming at the defects and actual requirements of the prior art, the invention provides the traditional Chinese medicine composition and the application thereof, the traditional Chinese medicine composition selects a plurality of natural traditional Chinese medicines, reasonably matches the traditional Chinese medicines, optimizes the extraction process, mutually promotes the components, synergizes the effects, and can realize the effects of diminishing inflammation, relieving pain, promoting blood circulation, removing blood stasis and quickly removing acnes.

In order to achieve the purpose, the invention adopts the following technical scheme:

in a first aspect, the invention provides a traditional Chinese medicine composition, which comprises the following components in parts by weight: 90-110 parts of honey-fried licorice root, 30-40 parts of honeysuckle, 30-40 parts of purslane, 30-40 parts of astragalus, 30-40 parts of isatis root, 20-30 parts of raw hawthorn, 20-30 parts of salvia miltiorrhiza, 20-30 parts of saffron, 20-30 parts of red paeony root, 20-30 parts of pseudo-ginseng powder, 20-30 parts of sappan wood and 20-30 parts of sargentgloryvine stem.

According to the invention, through long-term research and verification, the inventor selects a plurality of natural traditional Chinese medicines, reasonably matches the traditional Chinese medicines, mutually promotes the components, synergizes the effects, optimizes the extraction process, adds the components and the formula of the medicines in clinical practice, observes the recovery condition of a patient, finally determines the optimal medicine matching, and develops the traditional Chinese medicine acne-removing composition which can realize the effects of diminishing inflammation, relieving pain, promoting blood circulation, removing blood stasis and quickly removing acnes.

The honey-fried licorice root is a leguminous plant, is honey-baked licorice root, is commonly called processing, namely honey is put into a pot to be refined into medium honey, the medium honey is added with slow fire to be uniformly stir-fried, the mixture is taken out of the pot after 3-5min, the mixture is put into a baking room or an oven to be baked at 60 ℃ until the mixture is not sticky, and the mixture is cooled to obtain the honey-fried licorice root, wherein the honey-fried licorice root is a quasi-circular or oval slice, the surface of the honey-fried licorice root is reddish brown or grayish brown, the honey-fried licorice root is slightly glossy, the section of the honey-fried licorice root is yellow to dark yellow, the cambium ring is obvious, and the rays are radial. The honey-fried licorice decoction has the treatment effects of tonifying qi, nourishing yin, activating yang and recovering pulse.

The honeysuckle is named as honeysuckle, and the honeysuckle is named from compendium of materia Medica, and the honeysuckle is named as honeysuckle because the honeysuckle is white at the beginning and then turns yellow. The flos Lonicerae is Lonicera Japonica of Lonicera of Caprifoliaceae and its congeneric plant, and has dried bud or flower with initial blossom; honeysuckle is known as a good medicine for clearing heat and removing toxicity from old times. It is sweet and cold in nature and fragrant, sweet and cold in nature and capable of clearing heat without hurting the stomach, and the fragrance can eliminate pathogenic factors, and the honeysuckle flower can disperse wind heat and also clear and relieve blood toxicity, and is used for various heat diseases, such as fever, eruption, macula, heat toxin sores and carbuncle, sore throat and the like, and has obvious effects.

The herba Portulacae is annual herb, has no hair in the whole plant, flat stem, loose lying on the ground, and light green or dark red branches. The leaves are intergrown, the leaves are flat and thick, are like a crenellated shape, the upper part is dark green, and the lower part is light green or has dark red; the petiole is thick and short. The flower has no peduncle, and blooms in the noon; leaf-shaped; sepals are green and helmet-shaped; yellow petals, inverted egg shape; stamen anthers are yellow; the ovary has no hair, and the capsule has a egg shape; the seeds are fine, inclined spherical, black brown and glossy. The weeds are produced in all parts of China, are fertile and fertile in nature, are drought-resistant and waterlogging-resistant, have strong vitality, grow in vegetable gardens, farmlands and roadside, are common weeds in fields, and are widely distributed in temperate and tropical areas all over the world. The whole herb is used for medicine, and has the functions of clearing heat and promoting diuresis, detoxifying and reducing swelling, diminishing inflammation, quenching thirst and promoting urination; the seeds are used for improving eyesight; can also be used as veterinary drug and pesticide; the tender stem and leaf can be used as vegetable, and is sour in taste, and also is a good feed.

The radix astragali is root of Astragalus membranaceus bge of Leguminosae; digging in spring and autumn, removing soil, fibrous root and root head, drying in the sun to six or seven percent, straightening, bundling and drying in the sun; the main functional indications are as follows: tonify qi, strengthen superficies, expel toxin, expel pus, induce diuresis, and promote granulation. Can be used for treating deficiency of vital energy, asthenia, chronic diarrhea, proctoptosis, spontaneous perspiration, edema, prolapse of nasal mucosa and nasal mucosa, chronic nephritis, albuminuria, diabetes, and unhealed wound.

The radix isatidis is a Chinese medicinal material, is bitter and cold, and has the effects of clearing away heat and toxic materials, cooling blood and relieving sore throat. It is commonly used for epidemic febrile disease, fever, pharyngalgia, epidemic macula, mumps, erysipelas, fever with swollen head, erysipelas, and carbuncle.

The raw hawthorn is stone fruit, hard stone, thin pulp, slightly sour and astringent taste, can be eaten raw or used as a preserved fruit cake, can be used as a medicine after being dried, is a Chinese specific medicine and fruit dual-purpose tree species, has the functions of reducing blood fat, blood pressure, strengthening heart, resisting arrhythmia and the like, is also a good medicine for tonifying spleen, stimulating appetite, relieving dyspepsia, promoting blood circulation and reducing phlegm, and has good curative effects on chest, diaphragm and spleen fullness, hernia, blood stasis, amenorrhea and other symptoms; the vitexin is a flavonoid compound in hawthorn, is a drug with strong anticancer effect, and the extract of the vitexin has certain effects on inhibiting the growth, proliferation and infiltration and metastasis of cancer cells in vivo.

The Saviae Miltiorrhizae radix is dried root and rhizome of Salvia miltiorrhiza Bunge of Labiatae. Collected in spring and autumn, removed of silt and dried. The traditional Chinese medicine composition is distributed in most regions in China, has the effects of activating blood circulation to dissipate blood stasis, stimulating the menstrual flow to relieve pain, clearing away the heart fire and relieving restlessness, cooling blood and eliminating carbuncle, and is used for treating thoracic obstruction and heart pain, abdominal and hypochondriac pain, abdominal mass and mass accumulation, heat arthralgia pain, vexation and insomnia, irregular menstruation, dysmenorrheal and amenorrhea and sore and ulcer swelling and pain.

The stigma croci Sativi is dry stigma croci Sativi of Iridaceae, has effects of promoting blood circulation for removing blood stasis, cooling blood, removing toxic substance, resolving stagnation, and tranquilizing, and can be used for treating amenorrhea, obstruction in abdomen, puerperal blood stasis, toxic heat, speckle, depression, stuffiness, palpitation, and mania.

The red paeony root is a dry root of a Ranunculaceae plant red paeony root or a Sichuan red paeony root, is dug in spring and autumn, removes rhizome, fibrous root and silt, is dried in the sun, bitter and slightly cold, enters liver meridian, has the effects of clearing heat, cooling blood, activating blood and removing stasis, is a famous wild genuine traditional Chinese medicinal material, has long application history, large dosage, wide application and relatively rigid demand, and has a considerable number of exports every year.

The pseudo-ginseng powder is a root product of plant pseudo-ginseng, is powder formed by beating main roots of pseudo-ginseng, is named pseudo-ginseng powder and cannot be changed; it is warm in nature, sweet and slightly bitter in taste, entering liver, stomach and large intestine meridians, and is called Bei ren Shen and nan san Qi. Ginseng tonifies qi firstly, and panax notoginseng tonifies blood firstly; the functions of pseudo-ginseng can be summarized by six characters of stopping bleeding, dissipating blood stasis and relieving pain, so that pseudo-ginseng is taken as a medicine for treating incised wound and sore in the past and is rarely taken as a tonic.

The lignum sappan is dried heartwood of lignum sappan of Leguminosae, is more than harvesting in autumn, is dried by removing white sappan, is distributed in Taiwan, Guangxi, Guangdong, Sichuan, Guizhou, Yunnan, etc., has effects of promoting blood circulation, removing blood stasis, relieving swelling and pain, and can be used for treating traumatic injury, fracture and tendon injury, stasis and swelling pain, amenorrhea and dysmenorrhea, puerperal stagnation, thoracico-abdominal pain, and carbuncle and cellulitis swelling pain.

The caulis Sargentodoxae is dry rattan of Sargentodoxa cuneata of Lardizabalaceae. Collected in autumn and winter, removed lateral branches, cut into sections, dried, distributed in yellow river basin, Qinling mountain and southern areas in China, has the effects of clearing away heat and toxic materials, promoting blood circulation, dispelling pathogenic wind and relieving pain, and can be used for treating appendicitis abdominal pain, heat-toxin pyocutaneous disease, amenorrhea, dysmenorrhea, traumatic injury, swelling and pain, and rheumatalgia.

Preferably, the weight parts of the honey-fried licorice root can be 90 parts, 93 parts, 95 parts, 97 parts, 99 parts, 100 parts, 103 parts, 105 parts, 107 parts or 110 parts, and preferably 95-105 parts.

Preferably, the weight portion of the honeysuckle flower can be 30 parts, 33 parts, 35 parts, 38 parts, 39 parts or 40 parts, and is preferably 33-38 parts.

Preferably, the purslane may be present in, for example, 30, 33, 35, 38, 39 or 40 parts by weight, preferably 33-38 parts by weight.

Preferably, the weight portion of the astragalus root can be 30, 33, 35, 38, 39 or 40, preferably 33-38.

Preferably, the parts by weight of the isatis root can be, for example, 30 parts, 33 parts, 35 parts, 38 parts, 39 parts or 40 parts, and preferably 33-38 parts.

Preferably, the weight portion of the raw hawthorn can be 20 parts, 23 parts, 25 parts, 28 parts, 29 parts or 30 parts, and is preferably 23-28 parts.

Preferably, the weight portion of the salvia miltiorrhiza is, for example, 20 parts, 23 parts, 25 parts, 28 parts, 29 parts or 30 parts, preferably 23-28 parts.

Preferably, the weight parts of saffron can be, for example, 20 parts, 23 parts, 25 parts, 28 parts, 29 parts or 30 parts, preferably 23-28 parts.

Preferably, the weight portion of the red peony root can be, for example, 20 parts, 23 parts, 25 parts, 28 parts, 29 parts or 30 parts, and is preferably 23 to 28 parts.

Preferably, the part by weight of the pseudo-ginseng powder may be, for example, 20 parts, 23 parts, 25 parts, 28 parts, 29 parts or 30 parts, preferably 23 to 28 parts.

Preferably, the parts by weight of the sappan wood may be, for example, 20 parts, 23 parts, 25 parts, 28 parts, 29 parts or 30 parts, preferably 23 to 28 parts.

Preferably, the parts by weight of the sargentgloryvine stem can be, for example, 20 parts, 23 parts, 25 parts, 28 parts, 29 parts or 30 parts, preferably 23-28 parts.

Preferably, the composition comprises the following components in parts by weight: 95-105 parts of honey-fried licorice root, 33-38 parts of honeysuckle, 33-38 parts of purslane, 33-38 parts of astragalus, 33-38 parts of isatis root, 23-28 parts of raw hawthorn, 23-28 parts of salvia miltiorrhiza, 23-28 parts of saffron crocus, 23-28 parts of red paeony root, 23-28 parts of pseudo-ginseng powder, 23-28 parts of sappan wood and 23-28 parts of sargentgloryvine stem.

Preferably, the composition further comprises 15-25 parts of white poria, 15-25 parts of common yam rhizome, 15-25 parts of white paeony root and 15-25 parts of dahurian angelica root according to parts by weight.

The white poria is a white part of a medicinal material poria cocos block cut with red poria cocos, is usually a traditional Chinese medicine decoction piece, has very wide effect, is compatible with various medicines regardless of four seasons, and can play a unique effect regardless of cold, warm, wind and dampness. The tuckahoe is sweet and light in taste and mild in nature, and has the functions of promoting diuresis and excreting dampness, benefiting spleen and stomach, calming heart and soothing nerves when being used as a medicine; modern medical research: poria has effects of enhancing immunity, and pachyman has obvious effects of resisting tumor and protecting liver, but is contraindicated for patients with deficiency cold and spermatorrhea or qi deficiency sinking.

The dioscorea opposita is a tuber of dioscorea opposita of dioscoreaceae and has the following main functional indications: invigorating spleen, tonifying lung, reinforcing kidney, replenishing essence, and treating diarrhea due to spleen deficiency, chronic dysentery, cough due to asthenia, diabetes, nocturnal emission, leukorrhagia, and frequent micturition. Invigorating spleen and stomach, promoting fluid production, benefiting lung, invigorating kidney, and stopping nocturnal emission, and can be used for treating spleen deficiency, anorexia, chronic diarrhea, lung deficiency, cough and asthma, kidney deficiency, nocturnal emission, leukorrhagia, frequent micturition, asthenia heat, and diabetes.

Wherein the radix Paeoniae alba is dry root of Paeonia lactiflora pall of Ranunculaceae, and is collected in summer and autumn, cleaned, removed head, tail and fine root, boiled in boiling water, peeled or peeled, boiled again, and sun-dried, and has effects of suppressing hyperactive liver, relieving pain, nourishing blood, regulating menstruation, astringing yin, and arresting sweating. Can be used for treating headache, vertigo, hypochondriac pain, abdominal pain, limb spasm and pain, blood deficiency, sallow complexion, menoxenia, spontaneous perspiration, and night sweat.

The radix angelicae is a perennial big herb with the height of 1-2.5 meters, the root of the radix angelicae is cylindrical, the diameter of the base of the stem is 2-5 centimeters, the basal leaves are divided into pinnate parts, the tip of the umbelliform inflorescence is regenerated or lateral, and the fruit is long and round to oval; the root is used as a medicine, and has the functions of dispelling diseases, removing dampness, expelling pus, promoting granulation, promoting blood circulation, relieving pain and the like; can be used for treating wind-cold type common cold, headache, rhinitis, and toothache. The red and white leucorrhea, pain furuncle and pyogenic infections can also be used as spices, some northern provinces are cultivated, are produced by themselves and sold, and a few provinces are regulated, and generally originate in the forest, forest margins, stream sides, shrubs and valley grasslands.

Preferably, the weight portion of the white poria cocos can be 15 parts, 18 parts, 20 parts, 22 parts or 25 parts, and is preferably 18-22 parts.

Preferably, the parts by weight of the common yam rhizome can be 15 parts, 18 parts, 20 parts, 22 parts or 25 parts, and preferably 18-22 parts.

Preferably, the white peony root may be 15 parts, 18 parts, 20 parts, 22 parts or 25 parts, preferably 18-22 parts, by weight, for example.

Preferably, the part by weight of the radix angelicae can be 15 parts, 18 parts, 20 parts, 22 parts or 25 parts, and is preferably 18-22 parts.

Preferably, the composition further comprises 18-22 parts of white poria, 18-22 parts of common yam rhizome, 18-22 parts of white paeony root and 18-22 parts of dahurian angelica root according to parts by weight.

Preferably, the composition comprises the following components in parts by weight: 95-105 parts of honey-fried licorice root, 33-38 parts of honeysuckle, 33-38 parts of purslane, 33-38 parts of astragalus, 33-38 parts of isatis root, 23-28 parts of raw hawthorn, 23-28 parts of salvia miltiorrhiza, 23-28 parts of saffron crocus, 23-28 parts of red paeony root, 23-28 parts of pseudo-ginseng powder, 23-28 parts of sappan wood, 23-28 parts of sargentgloryvine stem, 18-22 parts of white poria, 18-22 parts of common yam rhizome, 18-22 parts of white paeony root and 18-22 parts of dahurian angelica root.

In a second aspect, the present invention provides the use of a composition according to the first aspect for the preparation of an anti-acne product.

Preferably, the acne-removing product comprises a medicament and/or a cosmetic.

Preferably, the cosmetic comprises any one of cleansing cream, facial cleanser, face cream, skin oil, essential oil, face washing lotion or skin cleaning water or a combination of at least two of the above.

Preferably, the acne removing product is in a liquid form.

The acne removing product of the liquid is not easy to block pores, further promotes oil discharge, and enhances the acne removing effect.

In a third aspect, the invention provides a method for preparing an acne-removing product, comprising the following steps:

(1) weighing radix Glycyrrhizae Preparata, flos Lonicerae, herba Portulacae, radix astragali, radix Isatidis, fructus crataegi, Saviae Miltiorrhizae radix, stigma croci Sativi, radix Paeoniae Rubra, Notoginseng radix powder, lignum sappan, caulis Sargentodoxae, Poria, rhizoma Dioscoreae, radix Paeoniae alba and radix Angelicae Dahuricae in proportion, and mixing to obtain raw material mixture;

(2) adding an extracting agent into the raw material mixture obtained in the step (1) for soaking and filtering to obtain a leaching solution;

(3) and (3) adding a proper amount of humectant into the leachate obtained in the step (2) to obtain the acne removing product.

Preferably, the ratio in step (1) is: 95-105 parts of honey-fried licorice root, 33-38 parts of honeysuckle, 33-38 parts of purslane, 33-38 parts of astragalus, 33-38 parts of isatis root, 23-28 parts of raw hawthorn, 23-28 parts of salvia miltiorrhiza, 23-28 parts of saffron crocus, 23-28 parts of red paeony root, 23-28 parts of pseudo-ginseng powder, 23-28 parts of sappan wood, 23-28 parts of sargentgloryvine stem, 18-22 parts of white poria, 18-22 parts of common yam rhizome, 18-22 parts of white paeony root and 18-22 parts of dahurian angelica root;

preferably, the extractant in (2) is an organic solvent, preferably an ethanol solution, and more preferably an ethanol solution with a volume concentration of 70-80%.

Preferably, the ethanol solution may have a volume concentration of, for example, 70%, 73%, 75%, 77%, 79%, or 80%.

Preferably, the soaking time in the step (2) is 60-80h, for example, 60h, 65h, 68h, 70h, 72h, 75h, 78h or 80 h.

Preferably, the humectant of step (3) comprises any one or a combination of at least two of collagen, hyaluronic acid or glycerol, preferably glycerol.

As a preferred technical scheme, the method for preparing the acne-removing product specifically comprises the following steps:

(1) weighing 95-105 parts of honey-fried licorice root, 33-38 parts of honeysuckle, 33-38 parts of purslane, 33-38 parts of astragalus, 33-38 parts of isatis root, 23-28 parts of raw hawthorn, 23-28 parts of salvia miltiorrhiza, 23-28 parts of saffron crocus, 23-28 parts of red paeony root, 23-28 parts of pseudo-ginseng powder, 23-28 parts of sappan wood, 23-28 parts of sargentgloryvine stem, 18-22 parts of white poria, 18-22 parts of common yam rhizome, 18-22 parts of white paeony root and 18-22 parts of dahurian angelica root according to parts by weight, and mixing to obtain a raw material mixture;

(2) adding an ethanol solution with the volume concentration of 70-80% into the raw material mixture obtained in the step (1), soaking for 70-80h, and then filtering to obtain a leaching solution;

(3) and (3) adding a proper amount of glycerol into the leachate obtained in the step (2) to obtain the acne removing product.

Compared with the prior art, the invention has the following beneficial effects:

the traditional Chinese medicine composition provided by the invention is scientific in material selection, reasonable in formula and simple and efficient in preparation process, the prepared acne removing product has the effects of diminishing inflammation, relieving pain, promoting blood circulation to remove blood stasis, quickly removing acne marks, removing oil and whitening, is particularly suitable for neutral and oily acne-growing skin, has a treatment rate of more than 90% according to skin damage count, is quick in effect taking, does not irritate the skin, does not leave pigment deposits and acne marks, and has a wide application prospect and a huge market value.

Drawings

FIG. 1 is a view of a patient's face prior to treatment according to the present invention;

figure 2 is a view of a patient's face after treatment according to the present invention.

Detailed Description

To further illustrate the technical means and effects of the present invention, the following further describes the technical solutions of the present invention by way of specific embodiments with reference to the drawings, but the present invention is not limited to the scope of the embodiments.

Example 1

(1) Weighing 100g of honey-fried licorice root, 35g of honeysuckle, 35g of purslane, 35g of astragalus, 35g of isatis root, 25g of raw hawthorn, 25g of salvia miltiorrhiza, 25g of saffron, 25g of red paeony root, 25g of pseudo-ginseng powder, 25g of sappan wood, 25g of sargentgloryvine stem, 20g of white poria, 20g of common yam rhizome, 20g of white paeony root and 20g of dahurian angelica root according to the parts by weight, and mixing to obtain a raw material mixture;

(2) adding an ethanol solution with the volume concentration of 75% into the raw material mixture obtained in the step (1), soaking for 72 hours, and then filtering to obtain a leaching solution;

(3) and (3) adding 100 ml of glycerol into the leachate obtained in the step (2) to obtain the acne removing product.

Example 2

(1) Weighing 90g of honey-fried licorice root, 30g of honeysuckle, 30g of purslane, 30g of astragalus, 30g of isatis root, 20g of raw hawthorn, 20g of salvia miltiorrhiza, 20g of saffron, 20g of red paeony root, 20g of pseudo-ginseng powder, 20g of sappan wood, 20g of sargentgloryvine stem, 15g of white poria, 15g of common yam rhizome, 15g of white paeony root and 15g of dahurian angelica root according to the parts by weight, and mixing to obtain a raw material mixture;

(2) adding an ethanol solution with the volume concentration of 70% into the raw material mixture obtained in the step (1), soaking for 70 hours, and then filtering to obtain a leaching solution;

(3) and (3) adding 80 ml of glycerol into the leachate obtained in the step (2) to obtain the acne removing product.

Example 3

(1) Weighing 110g of honey-fried licorice root, 40g of honeysuckle, 40g of purslane, 40g of astragalus, 40g of isatis root, 30g of raw hawthorn, 30g of salvia miltiorrhiza, 30g of saffron, 30g of red paeony root, 30g of pseudo-ginseng powder, 30g of sappan wood, 30g of sargentgloryvine stem, 25g of white poria, 25g of common yam rhizome, 25g of white paeony root and 25g of dahurian angelica root according to the parts by weight, and mixing to obtain a raw material mixture;

(2) adding an ethanol solution with the volume concentration of 80% into the raw material mixture obtained in the step (1), soaking for 80 hours, and then filtering to obtain a leaching solution;

(3) and (3) adding 120 ml of glycerol into the leachate obtained in the step (2) to obtain the acne removing product.

Example 4

(1) Weighing 95g of honey-fried licorice root, 33g of honeysuckle, 33g of purslane, 33g of astragalus, 33g of isatis root, 23g of raw hawthorn, 23g of salvia miltiorrhiza, 23g of saffron, 23g of red paeony root, 23g of pseudo-ginseng powder, 23g of sappan wood, 23g of sargentgloryvine stem, 18g of white poria, 18g of common yam rhizome, 18g of white paeony root and 18g of dahurian angelica root according to the parts by weight, and mixing to obtain a raw material mixture;

(2) adding an ethanol solution with the volume concentration of 78% into the raw material mixture obtained in the step (1), soaking for 78 hours, and then filtering to obtain a leaching solution;

(3) and (3) adding 100 ml of glycerol into the leachate obtained in the step (2) to obtain the acne removing product.

Example 5

(1) Weighing 105g of honey-fried licorice root, 38g of honeysuckle, 38g of purslane, 38g of astragalus, 38g of isatis root, 28g of raw hawthorn, 28g of salvia miltiorrhiza, 28g of saffron crocus, 28g of red paeony root, 28g of pseudo-ginseng powder, 28g of sappan wood, 28g of sargentgloryvine stem, 22g of white poria, 22g of common yam rhizome, 22g of white paeony root and 22g of dahurian angelica root according to the parts by weight, and mixing to obtain a raw material mixture;

(2) adding an ethanol solution with the volume concentration of 75% into the raw material mixture obtained in the step (1), soaking for 72 hours, and then filtering to obtain a leaching solution;

(3) and (3) adding 100 ml of glycerol into the leachate obtained in the step (2) to obtain the acne removing product.

Comparative example 1

The conditions were the same as in example 1 except that honey-fried licorice root was not added, compared with example 1.

Comparative example 2

The conditions were the same as in example 1 except that the amount of honey-fried licorice root added was changed to 150g as compared with example 1.

Comparative example 3

Compared with example 1, the conditions were the same as example 1 except that honeysuckle, astragalus, isatis root and purslane were not added.

Comparative example 4

Compared with example 1, the conditions were the same as example 1 except that the addition amounts of honeysuckle, astragalus, isatis root and purslane were changed to 50 g.

Comparative example 5

Compared with example 1, the conditions were the same as example 1 except that raw hawthorn, salvia miltiorrhiza, saffron, red peony root, pseudo-ginseng powder, sapanwood and sargentgloryvine stem were not added.

Comparative example 6

Compared with the example 1, the conditions are the same as the example 1 except that the addition amounts of the raw hawthorn, the salvia miltiorrhiza, the saffron, the red paeony root, the pseudo-ginseng powder, the sappan wood and the sargentgloryvine stem are all changed to 40 g.

Comparative example 7

Compared with example 1, the conditions are the same as example 1 except that the white poria, the common yam rhizome, the white paeony root and the dahurian angelica root are not added.

Comparative example 8

Compared with the example 1, the conditions are the same as the example 1 except that the addition amounts of the white poria, the common yam rhizome, the white paeony root and the dahurian angelica root are all changed to 30 g.

Comparative example 9

The same conditions as in example 1 were used except that the ethanol solution was changed to water, as compared with example 1.

Comparative example 10

The conditions were the same as in example 1 except that the soaking time was changed to 50 hours, compared to example 1.

And (3) experimental detection:

selecting 150 experimental subjects, namely half of men and women, wherein the average age of the experimental subjects is 20-30 years old, and moderate and severe skin acne patients with obvious papules, pustules and acne marks on the face are randomly divided into 15 groups, 10 people in each group record the skin damage count of the experimental subjects before treatment, the experimental method is that the experimental subjects respectively use the acne removal products of examples and comparative examples every night, the use period is 4 weeks, the skin damage number is counted after four weeks, the treatment rate is calculated according to the following formula ((before treatment skin damage count-after treatment skin damage count)/before treatment skin damage count multiplied by 100%, and the pigmentation and acne mark conditions of the face of the experimental subjects are observed, and the results are shown in table 1;

TABLE 1

As can be seen from table 1, the acne-removing products prepared according to the technical schemes provided by the invention in examples 1-5 have excellent treatment rates, all of which are greater than 90%, and have no pigmentation and acne marks, wherein the treatment rate is 95.6% with the best effect in example 1, while the formulas of comparative examples 1-8 are not according to the technical schemes of the invention, lack of components or excessive addition of components, and comparative example 9 and comparative example 10 do not adopt the extraction process provided by the invention, so that the treatment rate of the finally extracted acne-removing products is obviously reduced, and the acne-removing products have pigmentation and acne marks.

And (3) drug sensitivity test:

test subjects: examples 1-5 prepared anti-acne products.

The test population: 50 people, half of men and women, age 15-35 years, are randomly divided into five groups;

health condition: the subject has no allergic history of skin diseases and accords with the volunteer selection standard of the subject;

the spot pasting method comprises the following steps: selecting a qualified spot tester, putting a proper amount of acne-removing products into the spot tester in a closed spot-sticking experiment mode, externally sticking a special adhesive tape on the back of a testee, removing a tested substance after 12 hours, respectively observing skin reactions for 24 hours after removal, and recording results according to skin reaction grading standards in cosmetic hygiene standards.

The result of the human body skin patch test shows that: 50 subjects observe skin reactions in 24 hours through a patch test of the acne removing product, wherein 0 case has adverse skin reactions, and the experimental subjects do not show any reaction and have no adverse reactions in the experimental process, such as erythema, burning sensation or pruritus and other symptoms, which indicates that the acne removing traditional Chinese medicine composition has no irritation to the skin, wherein a result chart before treatment of a certain female experimental subject of the experimental group of the embodiment 1 is shown in a figure 1, and a result chart after treatment is shown in a figure 2;

as can be seen from the figure 1 and the figure 2, the traditional Chinese medicine composition provided by the invention has an obvious treatment effect, acne marks obviously disappear after four weeks, and pigmentation is avoided.

In conclusion, the traditional Chinese medicine composition provided by the invention is scientific in material selection, reasonable in formula and simple and efficient in preparation process, the prepared acne removing product has the effects of diminishing inflammation, relieving pain, promoting blood circulation to remove blood stasis, quickly removing acne marks, removing oil and whitening, is particularly suitable for neutral and oily acne-growing skin, takes effect quickly, does not irritate the skin, does not leave pigment deposits and acne marks, and has wide application prospect and huge market value.

The applicant states that the present invention is illustrated in detail by the above examples, but the present invention is not limited to the above detailed methods, i.e. it is not meant that the present invention must rely on the above detailed methods for its implementation. It should be understood by those skilled in the art that any modification of the present invention, equivalent substitutions of the raw materials of the product of the present invention, addition of auxiliary components, selection of specific modes, etc., are within the scope and disclosure of the present invention.

Claims (5)

1. The acne removing product is characterized by being prepared from the following components: 95-105 parts of honey-fried licorice root, 33-38 parts of honeysuckle, 33-38 parts of purslane, 33-38 parts of astragalus, 33-38 parts of isatis root, 23-28 parts of raw hawthorn, 23-28 parts of salvia miltiorrhiza, 23-28 parts of saffron crocus, 23-28 parts of red paeony root, 23-28 parts of pseudo-ginseng powder, 23-28 parts of sappan wood, 23-28 parts of sargentgloryvine stem, 18-22 parts of white poria, 18-22 parts of common yam rhizome, 18-22 parts of white paeony root and 18-22 parts of dahurian angelica root;

the method for preparing the acne-removing product comprises the following steps:

(1) weighing radix Glycyrrhizae Preparata, flos Lonicerae, herba Portulacae, radix astragali, radix Isatidis, fructus crataegi, Saviae Miltiorrhizae radix, stigma croci Sativi, radix Paeoniae Rubra, Notoginseng radix powder, lignum sappan, caulis Sargentodoxae, Poria, rhizoma Dioscoreae, radix Paeoniae alba and radix Angelicae Dahuricae in proportion, and mixing to obtain raw material mixture;

(2) adding ethanol solution with volume concentration of 70-80% into the raw material mixture obtained in the step (1), soaking for 70-80h, and filtering to obtain leachate;

(3) and (3) adding a proper amount of humectant into the leachate obtained in the step (2) to obtain the acne removing product.

2. The acne treatment product according to claim 1, wherein the acne treatment product comprises a drug and/or a cosmetic;

the cosmetic comprises any one or combination of at least two of cleaning cream, face cream and skin moistening oil.

3. The acne treatment product according to claim 2, wherein the form of the acne treatment product is a liquid form.

4. A method for preparing an acne-removing product according to any of claims 1-3, comprising the steps of:

(1) weighing radix Glycyrrhizae Preparata, flos Lonicerae, herba Portulacae, radix astragali, radix Isatidis, fructus crataegi, Saviae Miltiorrhizae radix, stigma croci Sativi, radix Paeoniae Rubra, Notoginseng radix powder, lignum sappan, caulis Sargentodoxae, Poria, rhizoma Dioscoreae, radix Paeoniae alba and radix Angelicae Dahuricae in proportion, and mixing to obtain raw material mixture;

(2) adding ethanol solution with volume concentration of 70-80% into the raw material mixture obtained in the step (1), soaking for 70-80h, and filtering to obtain leachate;

(3) adding a proper amount of humectant into the leachate obtained in the step (2) to obtain the acne removing product;

the proportion of the step (1) is as follows: 95-105 parts of honey-fried licorice root, 33-38 parts of honeysuckle, 33-38 parts of purslane, 33-38 parts of astragalus, 33-38 parts of isatis root, 23-28 parts of raw hawthorn, 23-28 parts of salvia miltiorrhiza, 23-28 parts of saffron crocus, 23-28 parts of red paeony root, 23-28 parts of pseudo-ginseng powder, 23-28 parts of sappan wood, 23-28 parts of sargentgloryvine stem, 18-22 parts of white poria, 18-22 parts of common yam rhizome, 18-22 parts of white paeony root and 18-22 parts of dahurian angelica root;

the humectant in the step (3) comprises any one or a combination of at least two of collagen, hyaluronic acid or glycerol.

5. The method according to claim 4, characterized in that it comprises in particular the steps of:

(1) weighing 95-105 parts of honey-fried licorice root, 33-38 parts of honeysuckle, 33-38 parts of purslane, 33-38 parts of astragalus, 33-38 parts of isatis root, 23-28 parts of raw hawthorn, 23-28 parts of salvia miltiorrhiza, 23-28 parts of saffron crocus, 23-28 parts of red paeony root, 23-28 parts of pseudo-ginseng powder, 23-28 parts of sappan wood, 23-28 parts of sargentgloryvine stem, 18-22 parts of white poria, 18-22 parts of common yam rhizome, 18-22 parts of white paeony root and 18-22 parts of dahurian angelica root according to parts by weight, and mixing to obtain a raw material mixture;

(2) adding an ethanol solution with the volume concentration of 70-80% into the raw material mixture obtained in the step (1), soaking for 70-80h, and then filtering to obtain a leaching solution;

(3) and (3) adding a proper amount of glycerol into the leachate obtained in the step (2) to obtain the acne removing product.

Images