CN115487268B - Composition for promoting blood circulation and toxin metabolism and preparation method thereof - Google Patents

Composition for promoting blood circulation and toxin metabolism and preparation method thereof Download PDF

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CN115487268B
CN115487268B CN202211211323.6A CN202211211323A CN115487268B CN 115487268 B CN115487268 B CN 115487268B CN 202211211323 A CN202211211323 A CN 202211211323A CN 115487268 B CN115487268 B CN 115487268B
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composition
toxin
blood
blood circulation
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CN115487268A (en
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王红霞
李慧
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Guangzhou Juyuantang Dandao Pharmaceutical Technology Co ltd
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Abstract

The invention discloses a composition for promoting blood circulation and toxin metabolism and a preparation method thereof, belonging to the technical field of traditional Chinese medicines; the composition comprises the following raw materials in parts by weight: 0.06 part of medicinal Wangshi, 6 parts of rhodiola rosea, 1.5-1.8 parts of sedum aizoon, 1.2-1.5 parts of liquorice, 1.8 parts of lophatherum gracile, 1.2-1.5 parts of lotus leaf, 0.9-1.5 parts of kudzuvine root, 0.9-1.2 parts of chrysanthemum, 1.5-1.8 parts of dried orange peel and 1.2-1.5 parts of rose; soaking the herbal composition for three times by adopting a three-steaming and three-soaking process, distilling for three times, and drying to obtain a finished product; the composition can promote the toxin deposited on the wall of the blood vessel to flow into the blood, and the toxin enters the intestinal tract along with the blood circulation and is discharged out of the body, so that the problem of toxin accumulation in the blood of the human body is solved.

Description

Composition for promoting blood circulation and toxin metabolism and preparation method thereof
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and relates to a composition for promoting blood circulation and toxin metabolism and a preparation method thereof.
Background
In the current society, people have irregular diet, high life and study pressure, serious air pollution, excessive intake of garbage food, frequent stay up and the like, so that blood endotoxin cannot be metabolized in time, and the blood endotoxin becomes one of the main problems affecting human health, such as common hypertension, hyperlipidemia and hyperviscosity, which are diseases formed by the retention of typical blood toxins in the body. It is well known that fresh blood is a basic guarantee for maintaining human health, and when toxins stay in blood, not only some hematopathy is formed, but also the toxins have direct influence on viscera of a human body along with the circulation of blood. Modern medicine also proves that blood in the population suffering from three highs is relatively viscous, and toxins such as blood sugar, triglyceride, cholesterol and the like in the blood are retained in the body and cannot be metabolized in time. In addition, most modern people have vigorous deficiency fire, and the toxin in the body is corroded continuously, so that the normal metabolism of the human body is blocked. Because human daily metabolism can all produce new toxin, and in addition the toxin that has not in time been metabolized away before, blood endotoxin can pile up year by year, and this can directly lead to blood circulation speed to slow down on the one hand, aggravate the circumstances that metabolism is blocked on the other hand can cause the toxin to deposit on the vascular wall, and then arouse the vascular stenosis, if toxin piles up further to increase, can cause the blood vessel to block up in a certain part directly, appears more dangerous situation. More important, the current three-high problem (hypertension, hyperlipidemia and hyperviscosity) is younger year by year. Therefore, improving the blood metabolism ability in human blood, assisting the perennial precipitation of toxins which cannot flow freely on the blood vessel wall, metabolizing and discharging out of the body along with the blood circulation, is an urgent need for health in the present day.
The medicine king stone has the important effects of promoting blood circulation and expelling toxin on human health, and has the unique magnetic characteristics, good promoting effect on human blood circulation, high gain and activating effect on the medicine property of Chinese herbal medicine and inactive cells of human body. The medicine king stone, also called Tibetan jade, is a kind of dark green jade from the Tibetan forest glossy ganoderma area, and the treatment of diseases by the folk application medicine king stone in China has been 1700 years old, and the well-known ancient medical books of Shennong's herbal medicine channels, ben Cao gang mu and the like are recorded in detail. The medicine Wang Danzhong is rich in biotite, actinolite, calcite and active magnet, and contains various microelements such as calcium, magnesium, iron, zinc, selenium and the like beneficial to human body. The medicine king stone is combined with the activation of the traditional Chinese medicine and the inactive cells in blood, so that the herbal formula is developed in a targeted way, the blood circulation in blood vessels of a human body is smooth, the blood circulation speed is accelerated, the metabolism of blood toxins is further improved, and meanwhile, the blood environment of the human body is restored to an alkaline or alkalescent health state from acidity, so that the medicine king stone has positive influence on relieving or solving the blood problems of people at present.
Disclosure of Invention
The invention overcomes the defects of the prior art and provides a composition for promoting blood circulation and toxin metabolism and a preparation method thereof. So as to relieve the problem of human blood toxin accumulation.
In order to achieve the above purpose, the present invention is realized by the following technical scheme.
A composition for promoting blood circulation and toxin metabolism comprises the following raw materials in parts by weight: 0.06 part of medicinal Wangshi, 6 parts of rhodiola rosea, 1.5-1.8 parts of sedum aizoon, 1.2-1.5 parts of liquorice, 1.8 parts of lophatherum gracile, 1.2-1.5 parts of lotus leaf, 0.9-1.5 parts of kudzuvine root, 0.9-1.2 parts of chrysanthemum, 1.5-1.8 parts of dried orange peel and 1.2-1.5 parts of rose.
Preferably, the material comprises the following raw materials in parts by weight: 0.06 part of medicinal Wangshi, 6 parts of rhodiola rosea, 1.5 parts of seville orange flower, 1.2 parts of liquorice, 1.8 parts of lophatherum gracile, 1.2 parts of lotus leaf, 0.9 part of kudzuvine root, 0.9 part of chrysanthemum, 1.5 parts of dried orange peel and 1.2 parts of rose.
Preferably, the jobstone contains the following mineral components: al (Al) 2 O 3 ,BaO,CaO,Cr 2 O 3 ,TFe 2 O 3 ,K 2 O,MgO,MnO, Na 2 O,P 2 O 5 ,SiO 2 ,SO 3 ,SrO,TiO 2
A method of preparing a composition for promoting blood circulation and toxin metabolism comprising the steps of:
1) Soaking all the raw materials in water for 4-6 hours, and then dividing the raw materials into three parts;
2) Stirring and heating the three soaked raw materials to 85-90 ℃ respectively, and then distilling for 45-50 minutes to sequentially obtain a distillate A component, a distillate B component and a distillate C component; mixing A, B, C components, adding into plant residues obtained after distillation of the component C, and uniformly stirring;
3) Boiling the obtained plant residue mixed with the distillate to completely evaporate water to obtain a mixture;
4) Air drying the mixture, and oven drying at 50-60deg.C for 10-15min.
Preferably, the decoction is performed by adopting slow fire.
Preferably, the materials are dried by an oven and then ground into solid powder, and the solid powder is packaged.
The preparation method adopts a preparation process of three steaming and three soaking, and three parts of plant herbal essences are fused into one part of food material, so that the tonifying function of the medicinal royal jelly and the clearing and nourishing efficacy of the herbal are fused.
Pharmacological analysis:
the efficacy of the herbal medicines is as follows:
rhodiola rosea: has effects in invigorating qi, clearing away lung-heat, improving intelligence, nourishing heart, astringing, stopping bleeding, dispelling blood stasis, and relieving swelling;
substitution flower: has effects of dispersing stagnated liver qi, and relieving heart pressure;
licorice root: has effects of invigorating qi, invigorating spleen and stomach, improving spleen and stomach weakness, relieving fatigue, palpitation, and short breath;
lophatherum gracile: has effects in relieving dryness and restlessness, and treating upper region of heart fire;
lotus leaf: has effects of reducing blood lipid, loosening bowel to relieve constipation;
radix Puerariae: has effects in stabilizing blood sugar, stabilizing blood lipid and promoting metabolism;
and (3) chrysanthemum: has effects in lowering blood pressure, improving eyesight, and refreshing brain;
dried orange peel: has effects of regulating qi-flowing, invigorating spleen, eliminating dampness and eliminating phlegm;
and (3) rose: has effects of dispelling blood stasis, dredging collaterals, invigorating qi and replenishing blood;
medicinal Wangshi stone: contains a large amount of mineral elements required by human body, has high content of active magnet, and has health promotion effects of regulating physiological function and renal function of human body.
The principle of the formula is as follows:
in the formula of the invention, the monarch drugs are rhodiola rosea, seville orange flower and liquorice. The rhodiola rosea has high oxygen content, takes the effect of soothing liver and regulating qi by substituting flowers, has the effect of tonifying qi and supplementing middle-jiao by liquorice, supplements oxygen required by human body, and has the effects of improving oxygen content of human body by cooperation of the three, and promoting blood circulation by stimulating nerve circulation; the ministerial drugs of the formula are lophatherum gracile, lotus leaves, kudzuvine roots, chrysanthemum, dried orange peels and roses, which have the effects of activating blood and dissolving stasis, and can dissolve blood stasis in blood and enter a human toxin expelling channel along with blood circulation; the adjuvant drug of the formula is the medicinal royal stones, the magnetism of the medicinal royal stones enhances the property of the medicines in the herbal formula, on the one hand, inactive cells in a human body are activated, the absorption and metabolism capacity of the human body on the medicines are enhanced by the increase of the active cells, and under the activation of the medicinal royal stones, more active cells in the human blood are subjected to the action of a natural magnetic field to perform benign circulation, so that the blood circulation is smooth and stable, and the natural and healthy state is achieved.
The iron element of the active magnet in the medicine king stone has valence of +2 and +3, the iron element with valence of +2 loses electrons and oxidizes into iron with valence of +3, and the iron element with valence of +3 obtains electrons and reduces into iron with valence of +2, so the medicine king stone has electron obtaining capability and electron donating capability, and shows strong oxidation-reduction performance and electron transfer capability. After the medicine king stone enters a human body, electrons are lost through +2 valent iron ions to convert +3 valent iron ions, the lost electrons are transmitted to acidic substances in blood, the acidic substances are reduced to an alkaline state, the process that inactive cells are activated to active cells is completed, and the capability of the human body for absorbing herbal essence in the health preserving bag is improved. The active magnet in the medicinal royal jelly also has a gain effect on herbal essence, and the active ingredients of the Chinese herbal medicines are excited through charge transfer of the active magnet, so that the medicinal property is enhanced. Enhancing the property of herbal essence and improving the capability of human body to absorb the herbal essence, so that the absorption of nutrition and the metabolism of toxin by human body are enhanced. The rhodiola rosea, the medicinal royal stones and the herbal essence are matched for use, so that the activating effect of the medicinal royal stones is further enhanced, the oxygen content of cells is increased, the absorption of the herbal essence by the cells is promoted, the blood circulation is accelerated, and the metabolism of endotoxin rubbish in blood is promoted.
Compared with the prior art, the invention has the following beneficial effects:
(1) The invention selects natural herbal medicines for compatibility, does not contain any additive, is natural and green, is healthy and mild, and is synchronous in clearing and nourishing; (2) The medicine king stone component is added in the invention, and the medicine king stone component contains abundant mineral elements of human body, can promote toxin deposited on the vascular wall to flow into blood, and can discharge the toxin out of the body along with the blood circulation of the toxin entering the intestinal tract, thereby solving the problem of toxin accumulation of human body blood.
Detailed Description
In order to make the technical problems, technical schemes and beneficial effects to be solved more clear, the invention is further described in detail by combining the embodiments. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention. The following describes the technical scheme of the present invention in detail with reference to examples, but the scope of protection is not limited thereto.
Example 1
Wang Danshi combined health preserving bag with medicine for promoting blood circulation and toxin metabolism
1. Weighing three raw materials, wherein each raw material comprises 0.02g of medicinal royal stone, 2g of rhodiola rosea, 0.5g of substituted flowers, 0.4g of liquorice, 0.6g of lophatherum gracile, 0.4g of lotus leaves, 0.3g of kudzuvine root, 0.3g of chrysanthemum, 0.5g of dried orange peel and 0.4g of rose; the traditional Chinese medicine Wangshi is selected from the Tibetan area Yalu Tibetan river basin with extremely high collection difficulty and rare stock.
Taking one part of the raw materials for soaking for 4 hours;
2. distilling the soaked composition at high temperature, regulating the distillation temperature to 80 ℃, distilling at high temperature for 45 minutes, extracting plant essence, and pouring out plant residues;
3. taking a second part of raw materials, soaking for 4 hours, regulating the temperature to 80 ℃, continuously distilling at high temperature for 45 minutes, extracting plant essence, and pouring out plant residues;
4. taking a third part of raw materials, soaking for 4 hours, regulating the temperature to 80 ℃, distilling at a high temperature for 45 minutes, extracting plant essence, and keeping plant residues;
5. uniformly mixing the plant essence extracted by three times of distillation and the plant residue which remains, and decocting slowly with slow fire until the water is completely evaporated;
6. air-drying the evaporated mixture in a shade, and placing the air-dried mixture into a drying box for drying for 15 minutes at the temperature of 45 ℃; grinding the dried herbal mixture into solid powder, and bagging, wherein the weight of each bag is 6 g.
Example 2
Wang Danshi combined health preserving bag with medicine for promoting blood circulation and toxin metabolism
1. Weighing three raw materials, wherein each raw material comprises 0.02g of medicinal royal stone, 2g of rhodiola rosea, 0.6g of substituted flowers, 0.5g of liquorice, 0.6g of lophatherum gracile, 0.5g of lotus leaves, 0.4g of kudzuvine root, 0.4g of chrysanthemum, 0.6g of dried orange peel and 0.5g of rose, and taking one of the raw materials for soaking for 6 hours;
2. distilling the soaked composition at high temperature to 85 ℃, distilling at high temperature for 45 minutes, extracting plant essence, and pouring out plant residues;
3. taking a second part of raw materials, soaking for 6 hours, regulating the temperature to 85 ℃, continuously distilling at high temperature for 45 minutes, extracting plant essence, and pouring out plant residues;
4. taking a third part of raw materials, soaking for 6 hours, regulating the temperature to 85 ℃, distilling at a high temperature for 45 minutes, extracting plant essence, and keeping plant residues;
5. uniformly mixing the plant essence extracted by three times of distillation and the plant residue which remains, and decocting slowly with slow fire until the water is completely evaporated;
6. air-drying the evaporated mixture in a shade, and placing the air-dried mixture into a drying box for drying for 15 minutes at 50 ℃ under control; grinding the dried herbal mixture into solid powder, and bagging, wherein the weight of each bag is 6 g.
Example 3
The preparation method of the medicine Wang Danshi material combination health preserving bag for promoting blood circulation and toxin metabolism comprises the following steps:
1. weighing three raw materials, wherein each raw material comprises 0.03g of medicinal royal stone, 2g of rhodiola rosea, 0.6g of substituted flowers, 0.5g of liquorice, 0.6g of lophatherum gracile, 0.5g of lotus leaves, 0.3g of kudzuvine root, 0.5g of chrysanthemum, 0.5g of dried orange peel and 0.6g of rose; taking one part of the raw materials for soaking for 6 hours;
2. distilling the soaked composition at high temperature, controlling the distillation temperature to 90 ℃, distilling at high temperature for 50 minutes, extracting plant essence, and pouring out plant residues;
3. soaking the second raw material for 6 hours, regulating the temperature to 90 ℃, continuously distilling at high temperature for 50 minutes, extracting plant essence, and pouring out plant residues;
4. soaking the third raw material for 6 hours, regulating the temperature to 90 ℃, distilling at high temperature for 50 minutes, extracting plant essence, and keeping plant residues;
5. uniformly mixing the plant essence extracted by three times of distillation and the plant residue which remains, and decocting slowly with slow fire until the water is completely evaporated;
6. air-drying the evaporated mixture in a shade, and placing the air-dried mixture into a drying box for drying for 15 minutes at 50 ℃ under control; grinding the dried herbal mixture into solid powder, and bagging, wherein the weight of each bag is 6 g.
The administration method comprises the following steps: the herbal essence can be taken 1 time in the morning and afternoon each time, 2 bags each time are soaked in boiled water at 90-100 ℃ for 5-10 minutes and then taken, the soaking in boiled water is repeated for 3 times, and the herbal essence can be fully exerted after the soaking, so that the herbal essence has an effect for 1 week.
Test example:
the invention carries out an animal acute toxicity test, and the result shows that the invention has no obvious toxic reaction or other abnormality; the effect verification of blood glucose toxin metabolism is carried out, and the result shows that the invention can obviously promote the metabolism of blood glucose in blood.
1. Acute toxicity test of mice by intragastric administration
The purpose is as follows: three gavage dosing acute toxicity tests were performed with SPF grade kunming mice over 24 hours. The acute toxic reaction and death condition of the mice are observed, and experimental basis is provided for the safety of the mice.
The method comprises the following steps: mice were divided into 2 groups of 20 mice, and the three distilled herbal essences of example 3 of the present invention were administered by three times of gastric lavage at doses of 6g, 10g, 14g, 10 mice per group. After the animals are fasted and not forbidden for 12 hours, the corresponding test products are administrated by stomach irrigation for three times within 24 hours, the acute toxic reaction and death condition of the animals are observed, and then the animals are observed for 1 time every day and continuously observed for 14 days; weighing the body weight at 3 rd, 7 th and 14 th days of administration; animals were sacrificed until the end of 14d, and the animal organs were observed in a general anatomic manner, and the volume, color, texture, etc. of the organs were markedly abnormal.
Results: the mice are continuously observed for 4 hours after being subjected to gastric lavage, and no toxic reaction such as diarrhea, convulsion, hair erection, prone position and the like is found. Animals in the group of the invention do not die from the administration to the end of the test, the maximum administration amount of the mice by lavage is 30g, and the weights of the animals in the group of the invention are not obviously different from each other after the administration for 3, 7 and 14 days; after the test, the cervical dislocation is killed, the animal is roughly observed by naked eyes after dissection, and the volume, color, texture and the like of the organ tissues and organs of the animal are not abnormal.
Conclusion: under the test conditions, the maximum gastric lavage dosage of the mice provided by the invention is 36g, which is 6 times of the dosage of adults. After dissection, no obvious abnormality was found in the major viscera of the animals of the group of the invention.
2. Efficacy verification test of blood glucose metabolism in blood
Through an effect test of blood glucose metabolism in blood, the effect of the Wang Danshi material combination health preserving bag for promoting blood circulation and toxin metabolism, prepared in the above examples 1-3, is verified.
Inclusion criteria: age 30-70 years old, PG is more than or equal to 11.1mmol/L after 80g glucose is orally taken for 2 hours; the subject was informed and signed informed consent. Exclusion criteria: there are diseases caused by non-diabetes; women in gestation or lactation.
Test grouping and test method: a total of 80 persons (confirmed by hospitals as diabetics) are taken into the test, and are randomly and averagely divided into 4 groups, and 20 persons in each group (the average value of PG after oral administration of 80g of common sugar for 2 hours measured before the test is carried out is not significantly different among the groups); a first group took the medicine Wang Danshi material combination health preserving bag (2 times a day, 2 bags each) prepared in example 1; a second group took the medicine Wang Danshi material combination health preserving bag prepared in example 2 (2 times a day, 2 bags each); a third group took the medicine Wang Danshi material combination health preserving bag prepared in example 3 (2 times a day, 2 bags each); the fourth group was taken with metformin (500 mg each time, 1 time a day); the average value of each group before the start of the test was recorded and 1 time every 15 days was measured, and the test was continued for 2 months (data statistics were performed based on the average value of PG after 2 hours of oral administration of 80g of glucose, respectively).
The results of the OGTT test are shown in table 1 below:
TABLE 1
As shown in table 1, the OGTT can be maintained at a normal level within 2 months when the blood glucose in the blood is cleaned by adopting the medicine Wang Danshi material combination health preserving bag for promoting blood circulation and toxin metabolism; the Wang Danshi material combination health preserving bag prepared in the embodiment 1 has a remarkable and better treatment effect, can basically maintain the normal OGTT level in 1 month, and is beneficial to shortening the treatment course. The effect of the medicine Wang Danshi material combined health preserving bag for clearing blood sugar is also obviously superior to that of metformin.
The subjects were each given a periodic return visit (1 return visit per month, and a continuous return visit within 1 year) after the test was completed, and during the test and return visit, the administration of the drug Wang Danshi material combination health care package of examples 1-3 did not show significant adverse reactions, indicating that the safety of the drug Wang Danshi material combination health care package for promoting blood circulation and toxin metabolism of the present invention was good.
The foregoing description of the preferred embodiments of the invention is not intended to be limiting, but rather is intended to cover all modifications, equivalents, alternatives, and improvements that fall within the spirit and scope of the invention.
Typical cases:
(1) Case 1
Pay a certain woman, 50 years old. The obtained hypertension has high pressure of 160mmHg and low pressure of 100mmHg, and is usually dizziness, emaciation, weakness and weakness, and the traditional Chinese medicine diagnosis is yin-fluid deficiency and dryness-heat excess. The Wang Danshi material combined health preserving bag prepared by the invention is taken for 2 bags each time, 2 times a day, and divided into two courses of treatment, 1 month, and three courses of treatment. After the back consultation, the blood pressure is basically recovered to be normal, the high pressure is 130mmHg, the low pressure is 80mmHg, and the symptoms of dizziness and weakness are obviously relieved. According to the self-description of patients, the symptoms of the disease are reduced, and the spirit is good; after the administration, the patients continue to take the medicine for 6 courses of treatment for consolidation, so that the blood pressure is stable and no recurrence exists.
(2) Case 2
Some women, 68 years old. The obtained diabetes has the advantages of years of weakness, no force, urination, xerosis cutis, leg arterial thrombosis, edema, numbness, and fasting blood glucose value of 21-22mmol/L, and insulin is always injected for treatment. The Wang Danshi material combination health preserving bag prepared by the invention is taken for 2 times a day, and 1 month and one treatment course. After 3 courses of treatment, symptoms are relieved, leg edema disappears, insulin injection is not needed, and fasting blood glucose reaches 10-11mmol/L. And after the administration is continued for half a year, symptoms such as weakness, lack of strength, urination, xerosis cutis, leg artery thrombosis and the like are basically eliminated, and the blood sugar value is restored to 7-8 mmol/L. Until now blood sugar has been stable.
(3) Case 3
Luqi, male, 65 years old. Has cerebral infarction sequela, craniocerebral CT examination and diagnosis of bilateral basal ganglia lacunar infarction, severe headache and inability to sleep, the upper eyelid of the right eye is weak, the upper eyelid cannot be opened, one leg is weak, walking needs walking stick assistance, and the memory is poor. The Wang Danshi material combination health preserving bag prepared by the invention is taken for 2 bags each time, 1 day and 2 times, and is taken separately in the morning and afternoon for 1 month and one treatment course. After taking 3 courses of treatment, the headache is relieved, the sleep is improved, the upper eyelid of the right eye is half open, the legs are obviously powerful, and the memory is enhanced. After the administration is continued for half a year, the symptoms basically disappear, the sleep quality is good, the upper eyelid of the right eye is completely recovered, and the walking is separated from the crutch.
While the invention has been described in detail in connection with specific preferred embodiments thereof, it is not to be construed as limited thereto, but rather as a result of a simple deduction or substitution by a person having ordinary skill in the art to which the invention pertains without departing from the scope of the invention defined by the appended claims.

Claims (5)

1. The composition for promoting blood circulation and toxin metabolism is characterized by comprising the following raw materials in parts by weight: 0.06 part of medicinal Wangshi, 6 parts of rhodiola rosea, 1.5 parts of seville orange flower, 1.2 parts of liquorice, 1.8 parts of lophatherum gracile, 1.2 parts of lotus leaf, 0.9 part of kudzuvine root, 0.9 part of chrysanthemum, 1.5 parts of dried orange peel and 1.2 parts of rose.
2. A composition for promoting blood circulation and toxin metabolism according to claim 1, wherein the yaowan stone contains the following mineral components: al (Al) 2 O 3 ,BaO,CaO,Cr 2 O 3 ,TFe 2 O 3 ,K 2 O,MgO,MnO,Na 2 O,P 2 O 5 ,SiO 2 ,SO 3 ,SrO,TiO 2
3. A method for preparing a composition for promoting blood circulation and toxin metabolism according to claim 1 or 2, comprising the steps of:
1) Soaking all the raw materials in water for 4-6 hours, and then dividing the raw materials into three parts;
2) Stirring and heating the three soaked raw materials to 85-90 ℃ respectively, and then distilling for 45-50 minutes to sequentially obtain a distillate A component, a distillate B component and a distillate C component; mixing A, B, C components, adding into plant residues obtained after distillation of the component C, and uniformly stirring;
3) Boiling the obtained plant residue mixed with the distillate to completely evaporate water to obtain a mixture;
4) Air drying the mixture, and oven drying at 50-60deg.C for 10-15min.
4. The method of claim 3, wherein the decocting is performed with slow fire.
5. A method of preparing a composition for promoting blood circulation and toxin metabolism according to claim 3, wherein the composition is prepared by oven-drying and grinding into solid powder, and bagging.
CN202211211323.6A 2022-09-30 2022-09-30 Composition for promoting blood circulation and toxin metabolism and preparation method thereof Active CN115487268B (en)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102451363A (en) * 2010-10-28 2012-05-16 罗朝雯 Chinese herbal medicinal weight-reducing tea
CN103110718A (en) * 2013-02-03 2013-05-22 威海博力生物工程有限公司 Preparation for regulating metabolism, protecting liver as well as preventing and treating cardiovascular and cerebrovascular diseases
CN106215012A (en) * 2016-08-29 2016-12-14 广西康宝海美三高生态茶有限公司 Prevention and treatment hypertension, hyperlipidemia, the teabag of hyperglycemia and processing method
CN107050349A (en) * 2017-05-04 2017-08-18 南京苏新智慧社区服务有限公司 A kind of cream taste of toxin expelling promoting blood circulation and its preparation method and application
CN108125091A (en) * 2018-01-22 2018-06-08 斯汏克(北京)生物科技有限公司 A kind of preparation method for improving cardiovascular and cerebrovascular Chinese herbal medicine composite enzyme drink

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102451363A (en) * 2010-10-28 2012-05-16 罗朝雯 Chinese herbal medicinal weight-reducing tea
CN103110718A (en) * 2013-02-03 2013-05-22 威海博力生物工程有限公司 Preparation for regulating metabolism, protecting liver as well as preventing and treating cardiovascular and cerebrovascular diseases
CN106215012A (en) * 2016-08-29 2016-12-14 广西康宝海美三高生态茶有限公司 Prevention and treatment hypertension, hyperlipidemia, the teabag of hyperglycemia and processing method
CN107050349A (en) * 2017-05-04 2017-08-18 南京苏新智慧社区服务有限公司 A kind of cream taste of toxin expelling promoting blood circulation and its preparation method and application
CN108125091A (en) * 2018-01-22 2018-06-08 斯汏克(北京)生物科技有限公司 A kind of preparation method for improving cardiovascular and cerebrovascular Chinese herbal medicine composite enzyme drink

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
脂糖泰胶囊降血糖实验研究;邢连喜;徐增康;蔺小平;常锋;刘建书;;陕西中医;-;第33卷(第12期);1685-1687 *

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