CN101884760B

CN101884760B - Chinese medicinal composition for treating diabetes mellitus and preparation method thereof

Info

Publication number: CN101884760B
Application number: CN2010102389853A
Authority: CN
Inventors: 杨贞利
Original assignee: Individual
Current assignee: Individual
Priority date: 2010-07-28
Filing date: 2010-07-28
Publication date: 2011-08-17
Anticipated expiration: 2030-07-28
Also published as: CN101884760A

Abstract

The invention relates to a Chinese medicinal composition for treating diabetes mellitus and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. The Chinese medicinal composition is prepared from red ginseng, mongolian snakegourd root, cinnamomvine, dark plum fruit, couch grass root, gypsum, siberian solomonseal rhizome, kudzuvine root, golden thread, fructus alpiniae oxyphyllae, chicken's gizzard-membrane, Chinese magnoliavine fruit and hawthorn fruit. The Chinese medicinal composition is prepared by immersing the medicaments into clear water for half an hour before administration, stewing the medicaments for 35 to 40 minutes, and taking supernate to prepare decoction, or after stewing the medicaments into the clear water for 5 to 10 minutes, taking the stewed medicaments out for airing and grinding the aired medicaments into powder, putting the powder into an earthen jar, mixing and stirring uniformly, and filling the powder into capsules, or extracting medicinal materials by using a decoction method first, performing high-speed centrifugation on liquid medicine for refining, and after performing evaporation concentration and sealing, and sterilizing by using circulating steam to prepare oral liquid. The Chinese medicinal composition is mainly used for treating the diabetes mellitus, has the effects of tonifying qi and spleen, nourishing kidney and blood, clearing heat and promoting fluid and the like, has the treatment effects of addressing both symptoms and root causes while blood sugar reduction, and has the advantages of low preparation cost, simple and easy preparation method, quick response, high cure rate and no toxic or side effect.

Description

A kind of Chinese medicine composition for the treatment of diabetes and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine composition for the treatment of diabetes and preparation method thereof, belong to the Chinese medicine technical field.

Background technology

Along with the raising of living standards of the people, the sickness rate of diabetes improves, and has become the disease of the 3rd position influence human health after cardiovascular disease and cancer at present.Diabetes are by inherited genetic factors, immunologic function disorder, infected by microbes and toxin thereof, the free radical toxin, the various virulence factors of Nervous and Mental Factors or the like act on body and cause hypoinsulinism, insulin resistant etc. and the sugar that causes, protein, fat, a series of metabolism disorder syndromes such as power and water Xie Zhi, be main feature clinically with the hyperglycemia, polyuria can appear in model case, polydipsia, polyphagia, performance such as become thin, i.e. " three-many-one-little " symptom, Chinese medicine is discussed comparatively detailed to the etiology and pathogenesis of primary disease, it is generally acknowledged it mainly is because the plain body deficiency of YIN, the five internal organs weakness, multiple because of eating and drinking without temperance, the surfeit delicious food, disorder of emotion, labor is desired excessively, and cause deficiency of kidney-YIN, lung dryness of the stomach heat; The pathogenesis emphasis is that the deficiency of YIN is scorching, and is this with the deficiency of YIN, scorchingly is mark; With the passing of time disease prolongs, deficiency of YIN affecting YANG, deficiency in both YIN and YANG; The deficiency of YIN is scorching, and the bright liquid in consumption Tianjin makes blood viscous, the capable not smooth stasis of blood that forms of blood; Deficiency of YIN affecting YANG, the yang deficiency cold coagulation also can cause sun in the blood stasis.

The western medical treatment diabetes cooperate and adopt oral antidiabetic drug and keep on a diet based on insulin injection at present, the treatment diabetes are had effect energetically, but its course of treatment are long, and dosage is big, take easily for a long time and develop immunity to drugs, and side effect is big.Chinese traditional treatment should disease medicine more, but effect is not ideal.

Summary of the invention

The present invention is based on prior art, from QI invigorating, and spleen invigorating, the kidney invigorating, beneficial blood, effects such as clearing away heat and promoting production of body fluid are set out and are reached the purpose of treatment diabetes, reach the therapeutic effect for the treatment of both the principal and secondary aspects of a disease in blood sugar lowering.Its cost of manufacture is low, manufacture method is simple, rapid-action, cure rate is high, have no side effect.

For achieving the above object, the crude drug of the Chinese medicine composition of described treatment diabetes composition and weight proportion are:

Radix Ginseng Rubra 40-60 weight portion, Radix Trichosanthis 40-60 weight portion, Rhizoma Dioscoreae 40-60 weight portion, Fructus Mume 90-110 weight portion, Rhizoma Imperatae 40-60 weight portion, Gypsum Fibrosum 40-60 weight portion, Endothelium Corneum Gigeriae Galli 40-60 weight portion, Radix Puerariae 40-60 weight portion, Rhizoma Coptidis 40-60 weight portion, Fructus Alpiniae Oxyphyllae 40-60 weight portion, Rhizoma Polygonati 40-60 weight portion, Fructus Schisandrae Chinensis 40-60 weight portion, Fructus Crataegi 40-60 weight portion

As preferred version, the weight proportion of the crude drug of the Chinese medicine composition of wherein said treatment diabetes is:

Radix Ginseng Rubra 50 weight portions, Radix Trichosanthis 50 weight portions, Rhizoma Dioscoreae 50 weight portions, Fructus Mume 100 weight portions, Rhizoma Imperatae 50 weight portions, Gypsum Fibrosum 50 weight portions, Endothelium Corneum Gigeriae Galli 50 weight portions, Radix Puerariae 50 weight portions, Rhizoma Coptidis 50 weight portions, Fructus Alpiniae Oxyphyllae 50 weight portions, Rhizoma Polygonati 50 weight portions, Fructus Schisandrae Chinensis 50 weight portions, Fructus Crataegi 50 weight portions

As preferred version, wherein said Chinese medicine composition is used for the treatment of diabetes.

As preferred version, wherein said Chinese medicine composition is made any medicament in decoction, capsule or the oral liquid.The preparation method of the Chinese medicine composition of described treatment diabetes by the component that above-mentioned weight ratio is got described Chinese medicine, places clear water to soak half an hour, steaming and decocting 35-40 minute, gets supernatant and makes decoction.

The preparation method of the Chinese medicine composition of described treatment diabetes, by the component that above-mentioned weight ratio is got described Chinese medicine, place clear water steaming and decocting 5-10 minute sterilization after, take out and shine the dry doubling grind into fine powder, put into and pour into into capsule after earthen basin mixes, stirs; As capsule, a dose 6-8 grain as oral liquid, is once taken the 10-20 milliliter, obeys every day three times, and taking medicine before meal is used.

As preferred version, wherein said capsular weight is the 0.8-1.2 gram.

As preferred version, the preparation method of wherein said Chinese medicine composition comprises the steps:

1) lixiviate: adopt decocting method, the component of getting described Chinese medicine by weight was put in the clear water after steaming and decocting 35-40 minute, got supernatant;

2) refining: as to adopt supercentrifugal process that lixiviating solution is carried out purification process, can improve the concentration of effective ingredient, reduce dose, improve stability of formulation;

3) concentrate: select evaporation and concentration for use;

4) packing: the liquid medicine filling after will concentrating is built plug in the easy-open lid bottle of clean dried sterilization, roll the cap seal mouth;

5) sterilization: the steam sterilization that circulates immediately after sealing, make oral liquid.

Diabetes can have multiple factor to cause, as: inherited genetic factors, autoimmune disease, obesity and age etc.The traditional Chinese medical science thinks that diabetes are by the plain body deficiency of YIN, eating and drinking without temperance, and disorder of emotion, the diseases caused by exogenous pathogenic factor six climate exopathogens, the evil infringement of poison causes.Chronic dietary does not save or obesity, makes the fortune function damage of spleen, and is stagnant in the stomach, the intrinsic heat dryness-transformation, impairment of YIN consumption Tianjin YIN fluid being insufficient can change again give birth to scorching, scorching again must impairment of YIN.So vicious cycle and diabetes takes place.And disorder of emotion, depression of liver-QI cause liver to lose bar reaching; The mechanism of qi retardance also can cause lung dryness of the stomach heat, and thirsty polydipsia take place, rapid digestion of food and polyorexia.With the passing of time the deficiency of YIN scorching, must cause deficiency of both QI and YIN.Deficiency of YIN affecting YANG and the deficiency of QI and declination of YANG phenomenon occurs, because lung, stomach, kidney three be through the cloudy deficiency of vital energy, the deficiency of both YIN and YANG disease that yang-energy is held back and occurred.The diseases caused by exogenous pathogenic factor six climate exopathogens are invaded diffusing cream (pancreas) in the dryness-fire wind heat poison heresy, take up internal organs, and the dryness-transformation impairment of body fluid also can be fallen ill.The traditional Chinese medical science is particular about conditioning comprehensively, pays attention to whole regulation and control, is improving symptom, and aspects such as treating both the principal and secondary aspects of a disease obviously are better than doctor trained in Western medicine.

Radix Trichosanthis can clearing away heat-fire among the we, promoting the production of body fluid to quench thirst, and the evacuation of pus detumescence when being used with drugs for nourishing yin, can reach the effect for the treatment of both the principal and secondary aspects of a disease for the treatment diabetes.And Rhizoma Coptidis, all right blood sugar lowering of the use of Radix Puerariae can also promote the regeneration of B cell, and type ii diabetes is had curative effect preferably.Be equipped with Rhizoma Polygonati, Endothelium Corneum Gigeriae Galli, Rhizoma Imperatae, Fructus Mume, Radix Ginseng Rubra, Rhizoma Dioscoreae, medicines such as Fructus Alpiniae Oxyphyllae, get its QI invigorating, YIN nourishing, beneficial blood, promote the production of body fluid, heart tonifying, be good for the stomach, the abirritative effect, very effective in cure for diabetes.Add that Fructus Schisandrae Chinensis can protect the five internal organs, antiinflammatory.Can play the effect for the treatment of both the principal and secondary aspects of a disease to diabetes.

The specific embodiment

Embodiment 1

Get Radix Ginseng Rubra 50 grams, Radix Trichosanthis 50 grams, Rhizoma Dioscoreae 50 grams, Fructus Mume 100 grams, Rhizoma Imperatae 50 grams, Gypsum Fibrosum 50 grams, Rhizoma Polygonati 50 grams, Radix Puerariae 50 grams, Rhizoma Coptidis 50 grams, Fructus Alpiniae Oxyphyllae 50 grams, Endothelium Corneum Gigeriae Galli 50 grams, Fructus Schisandrae Chinensis 50 grams, Fructus Crataegi 50 grams.To in clear water, soak half an hour after the above medicament mixed, steaming and decocting 35-40 minute, to get supernatant and make decoction, service once every day sooner or later, and each dose is 10～20ml.

Clinical test results is after 300 routine patients take this medicine, and cure rate is 90%, and effective percentage is 100%, is a kind of cure rate height, the efficient oral medicine that has no side effect.

Model case:

1. Zhang, man, 44 years old, first visit on October 14 in 2005

Disease: ill ten years glucoses in urine four " ten " number, blood glucose reach 14mmol L, the general power of whole body, absentminded, the appetite surge, weak from head to foot

Clothes we, every day 2 times, sooner or later each once, after continuous 10 days, glucose in urine has reduced two " ten " number, blood glucose becomes nine six.Lack two " ten " number than glucose in urine before the treatment, blood glucose less two four.Afterwards, controlled again about March, when arriving hospital's laboratory examination once more, it is normal that glucose in urine, blood glucose all recover.

The king so-and-so, woman, 65 years old, December in 2005 first visit on the 24th.

Disease: year multiple antidiabetic drug of clothes surplus the trouble diabetes 20, thirsty desire for hot drinks, clear urine in large amounts, the acid of waist knee joint is cold, limbs fatigue, indigestion and loss of appetite abdominal distention, complexion is impractical, two lower limbs edema, fasting glucose 13mmol L, glucose in urine +++, it is tender to look into corpulent tongue, pale tongue, and there is indentation on the limit, and tongue is greasy in vain, deep-slow pulse.

This disease is a deficiency of spleen-YANG and kidneyYANG, can not steam the liquid of refining and cause diabetes, controls suitable warming and recuperating the spleen and kidney, and diuretic is let out turbid, activating QI to generate body fluid, the clothes we, every day 2 times, sooner or later respectively once, and after 10 days, sx, take hundred doses by this side's plus-minus, transference cure to hospital's blood test, is urinated all normal.

3. Lee, woman, 56 years old, first visit on February 5 in 2006.

Disease: year, blood glucose 11mmol L, symptom at present before the meal surplus the trouble diabetes 10: it is weak to become thin, sweating while acting, and deficiency of QI with disinclination to talk, Mental fatigue, dry mouth and tougue, dysphoria with feverish sensation in the chest palms and soles, shortness of breath and palpitation, insomnia, corpulent tongue has the tooth seal, and body of the tongue is light red, white and thin fur, deep-thready pulse.

This diabetes, the course of disease are gradually of a specified duration, scorchingly do not remove, and vital QI cannot conquer pathogen, vigour is hindered, causes deficiency of both QI and YIN.Clothes we sx after month continues to take bad sensation complete obiteration after 3 months, and various inspections are all normal.

Claims

1. a Chinese medicine composition is used for the treatment of diabetes, it is characterized in that, the crude drug of described Chinese medicine composition is formed and weight proportion is:

Radix Ginseng Rubra 40-60 weight portion, Radix Trichosanthis 40-60 weight portion, Rhizoma Dioscoreae 40-60 weight portion, Fructus Mume 90-110 weight portion,

Rhizoma Imperatae 40-60 weight portion, Gypsum Fibrosum 40-60 weight portion, Endothelium Corneum Gigeriae Galli 40-60 weight portion, Radix Puerariae 40-60 weight portion,

Rhizoma Coptidis 40-60 weight portion, Fructus Alpiniae Oxyphyllae 40-60 weight portion, Rhizoma Polygonati 40-60 weight portion, Fructus Schisandrae Chinensis 40-60 weight portion,

Fructus Crataegi 40-60 weight portion.

2. Chinese medicine composition as claimed in claim 1 is characterized in that, the crude drug of described Chinese medicine is formed and weight proportion is:

Radix Ginseng Rubra 50 weight portions, Radix Trichosanthis 50 weight portions, Rhizoma Dioscoreae 50 weight portions, Fructus Mume 100 weight portions,

Rhizoma Imperatae 50 weight portions, Gypsum Fibrosum 50 weight portions, Endothelium Corneum Gigeriae Galli 50 weight portions, Radix Puerariae 50 weight portions,

Rhizoma Coptidis 50 weight portions, Fructus Alpiniae Oxyphyllae 50 weight portions, Rhizoma Polygonati 50 weight portions, Fructus Schisandrae Chinensis 50 weight portions,

Fructus Crataegi 50 weight portions.

3. Chinese medicine composition as claimed in claim 1 or 2 is characterized in that, described Chinese medicine composition is made any medicament in decoction, capsule or the oral liquid.

4. the preparation method of Chinese medicine composition as claimed in claim 1 or 2 is characterized in that, gets described Chinese medicinal composition by above-mentioned weight ratio, places clear water to soak half an hour, after steaming and decocting 35-40 minute, gets supernatant and makes decoction.

5. preparation method of Chinese medicine composition as claimed in claim 1 or 2, it is characterized in that, get described Chinese medicinal composition by above-mentioned weight ratio, placed the clear water steaming and decocting 5-10 minute, after the sterilization, take out and shine the dry doubling grind into fine powder, put into and pour into into capsule after earthen basin mixes, stirs.

6. preparation method as claimed in claim 5 is characterized in that, described capsular weight is the 0.8-1.2 gram.