CN105056103A - Steamed buns with assistant effect of reducing blood fat and cholesterol and processing method of steamed buns - Google Patents

Abstract

The invention provides steamed buns with an assistant effect of reducing blood fat and cholesterol. The steamed buns comprise the following raw materials: flour, Chinese medicine additives, water, honey and yeast. The Chinese medicine additives used in the steamed buns comprise the following bulk drugs: cattail pollen, evening primrose, fruit of Cherokee rose, turmeric, hawthorn, fruit of glossy privet, giant knotweed, pseudo-ginseng, radix astragali, cassia seeds, roots of red-rooted salvia, ligusticum wallichii, rheum officinale, rhizoma alismatis, radix paeoniae rubrathe, lotus leaves, waxgourd peel and oriental wormwood. The regimen is far different from a method of taking bitter medicines, the steamed buns are different from the medicines which are difficult to take, patients difficultly persist in taking the medicines, but the steamed buns can be easily accepted by the patients, the patients can eat the steamed buns day by day, and the steamed buns are particularly suitable for conditioning and treating chronic diseases. The cassia seeds in the bulk drugs taste sweet and bitter, are cold in nature, have effects of clearing liver, improving vision, suppressing liver-yang and reducing serum cholesterol, have good curative effect on prevention and treatment of vascular hardening, have a hepatoprotective effect, and can suppress cholesterol increasing and formation of aorta atheromatous plague.

Description

Steamed bread of a kind of auxiliary antilipemic cholesterol reducing and preparation method thereof

Technical field

The present invention relates to the health food containing deriving from plant, animal or raw mineral materials, particularly the steamed bread and preparation method thereof of a kind of auxiliary antilipemic, cholesterol reducing.

Background technology

Along with growth in the living standard, hyperlipidemia and fatty liver have become present epidemic diseases.The main hazard of hyperlipemia causes arteriosclerosis, is the important risk factor of fatal disease as coronary heart disease, apoplexy, myocardial infarction, is also one of factor increasing the weight of the diseases such as hypertension, diabetes, fatty liver, liver cirrhosis, pancreatitis.The infringement of hyperlipemia to health is concealment, gradually, for a long time and general, majority need long-term prescription to treat.If but long-term taking Adjust-blood lipid Western medicine, the healthy of patient can be made again to suffer damage because of side effects of pharmaceutical drugs.And some Chinese herbal medicine has obvious effect to reduction blood fat.

Traditional diet structure of China is very rational, but the more and more westernization of the dietary structure of Chinese.Data shows, 1997 to 2012, in the ten large group foods that China resident consumes, the consumption figure of grain and bean food have dropped 12.6% and 6.8% respectively, carbohydrate food increases 42.1%, and the consumption of plant oil, meat, birds and eggs rises more than 20% all respectively.The appearance of this situation is relevant with problems such as foreign fast food spread unchecked, foreign fast food is food that is fried, that cure processing mostly, meat ratio is very high, the wrong direction of this " eating meat just nutritious " is the major reason causing dietary structure westernization, and in fact, about 60% of fuel value of food carrys out self-carbon water compound, 25% from fat, 12% ~ 15% from protein, is so only desirable meals constituent ratio.The feature of foreign fast food is three-hypers and three low, i.e. high heat, higher fatty acid and high protein, lower mineral, low vitamin and low dietary fiber.Due to nutrition serious unbalance, so international nutrition educational circles claims foreign fast food to be energy bomb and junk food.

Society with fast rhythm lives, the operating pressure of keen competition, serious threat is caused to the physical and mental health of modern, people more than half is made to be in sub-health state, show as: dizzy, nervous, weak, inappetence, hypomnesis, insomnia, indifferent to etc. to thing, in addition, long-term diet is unreasonable, that is: smart grain replaces coarse grain completely, a large amount of three-hypers (high heat, high protein, higher fatty acid), more than three, (antiseptic is many, flavour enhancer is many, hormone is many) pesticide residual in the absorption of food and food, chemical fertilizer stockpiling in vivo, add air, pollution of waterhead and quantity of motion less than normal, go down to make three-hypers disease (hypertension for a long time like this, hyperglycemia, hyperlipidemia), cardiovascular and cerebrovascular disease, cancers etc. so-called " modern civilization diseases " rise rapidly, and constantly rejuvenation, the serious health and lives jeopardizing the mankind.

" three-hypers disease " refers to hypertension, hyperglycemia (diabetes) and hyperlipidemia.Usually along with obesity.They be modern society derive from " affluenza ", can individualism, also may be interrelated.As: diabetes patient is easy to suffer from hypertension or hyperlipidemia simultaneously, and hyperlipidemia is the principal element of arteriosclerosis formation and development, and arteriosclerotic's blood vessel elasticity difference aggravation blood pressure raises, so the later stage all defines " three-hypers disease ".Be what has statistics about three-hypers, in the Chinese ten large causes of death, the mortality rate relevant to metabolic disease is just up to 35.7%, and the death toll relevant to " three-hypers " also accounts for 27% of total death toll.Hyperlipidemia can cause blood vessel embolism; Hypertension can cause cerebral hemorrhage and rupture of blood vessel in brain; Hyperglycemia can cause diabetes.

World Health Organization (WHO) once clearly proposed, and prevented the first line of defence of cardiovascular diseases from reducing " three-hypers " exactly and controlling " three-hypers ".A lot of diabetes patient is with hyperlipemia, and therefore diabetes and hyperlipemia, people call that sister is sick usually, and think that hyperlipidemia is the secondary disease of diabetes.The diabetic of about 40% has disorders of lipid metabolism according to statistics.Be characterized in that triglyceride increases to reduce with high density lipoprotein.When the reason that diabetes cause blood fat to increase is due to diabetes patient's insufficient insulin, body lactonase activity lowers, and therefore easily blood fat increases.Diabetes itself also accompany fat, protein and water, dielectric disorder except carbohydrate metabolism disturbance simultaneously on the other hand.Often there is free fatty to mobilize out from fat depot, triglyceride and FFA concentrations in blood are increased.Type ii diabetes people takes food too much on the one hand again, and motion is few, and impel lipid synthesis in body to increase, this is also the reason causing blood fat to increase.And fat companion's hyperlipidemia person, because Insulin receptor INSR number reduces relatively, thus produce insulin resistant, easy induced Diabetic.Blood fat increased perosn also easily causes the heart, cerebrovascular complication.

Chinese medicine odor is poor, and a lot of people is reluctant long-term taking; Even if take, be medicine three points of poison, allow during people's long-term taking and also produce resisting psychology.How the efficacy exertion of Chinese medicine not being injured human body again to maximum, and obviously improve mouthfeel, people can be accepted, is our problem in the urgent need to address.Containing a large amount of active substance health product safely and effectively inside Chinese medicine, can hypoglycemic greatly, be the key that people expect to deal with problems always.Economize alcohol, hot-tempered matter and soap formula etc. containing fatty acid, Bu Gu in a lot of Chinese medicine, blood fat can be reduced, reduce fat in endovascular deposition, can be used for treating atherosclerosis.Present market in the urgent need to develop a kind of nontoxic, can be absorbed completely by organism, the health food of blood fat reducing.

It has been generally acknowledged that, food is for human body provides the edibility material of growth promoter with the various nutrients needed for healthy existence.That is, food most importantly Nutrition.Actually this is not so, and the traditional Chinese medical science recognizes that food can not only nutrition very early, and can also treat disease and get rid of illness.As doctor's Zhang Xichun in modern age was once pointed out in " Records of Tradition Chinese and Western Medicine in Combination ": food " clothes for patients it, not only treat disease, and can allay one's hunger; Not only allay one's hunger, more can be agreeable to the taste, with suiting the medicine to the illness, disease, from convalesce, is not namely suited the medicine to the illness, and also suffers from without him ".Along with the development of society, people are more and more particular about the way to keep in good health.A lot of food being applicable to health preserving is also promoted thereupon, common are health preserving coarse cereal powder, various grains gruel, medicated diet etc.

Summary of the invention

Technical problem to be solved by this invention is, current doctor trained in Western medicine has obtained larger achievement to the research of diabetic hyperlipidemia and treatment, but the hepatic and renal function caused by long-term prescription, symptom of digestive tract, after muscle damage and drug withdrawal, rebound effect is still a difficult problem for treatment.In view of the traditional Chinese medical science has the characteristic of dialectical treatmert, the advantage that Chinese medicine toxic side effect is little, Chinese medicine health-care treatment causes extensive concern.Regimen residence is controlled in food, can not only reach the object of health body-building, disease preventing and treating, and can also give on people's sense organ, spiritual enjoyment, make people among enjoyment food delicious food, unconsciously reach the object of preventing and curing diseases.This naturopathy with take compared with medicine bitter to the taste far different, it is easy to make people detest clothes and be difficult to adhere to unlike medicine, and people are acceptant, can use for a long time, and the conditioning and treating for chronic disease is particularly suitable.

How by the extracts active ingredients of Chinese medicine, then in dietetic therapy, " clothes for patients it, not only treat disease, and can allay one's hunger; Not only allay one's hunger, more can be agreeable to the taste, with suiting the medicine to the illness, disease, from convalesce, is not namely suited the medicine to the illness, and also suffers from without him ".It is the problem that we urgently will solve.

For solving the problems of the technologies described above, the invention provides the steamed bread of a kind of auxiliary antilipemic, cholesterol reducing, it is characterized in that, described steamed bread comprises following raw material: flour, Chinese medicine additive, water, Mel, yeast; Its preparation method is, after raw material mix homogeneously, kneads, and puts into food steamer steam heating 20-30 minute, finished product.

The steamed bread of described auxiliary antilipemic, cholesterol reducing, the raw flour used in steamed bread described in it is for Semen Maydis flour or Fagopyrum esculentum Moench and wheat flour are by 1 _:1 is mixed; The ratio of described Chinese medicine additive and flour is 1: 10.

The steamed bread of described auxiliary antilipemic, cholesterol reducing, the crude drug that the Chinese medicine additive used in steamed bread raw material described in it uses comprises: Pollen Typhae, Radix Oenotherae erythrosepalae, Fructus Rosae Laevigatae, Rhizoma Curcumae Longae, Fructus Crataegi, Fructus Ligustri Lucidi, Rhizoma Polygoni Cuspidati, Radix Notoginseng, the Radix Astragali, Semen Cassiae, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei, Rhizoma Alismatis, Radix Paeoniae Rubra, Folium Nelumbinis, Exocarpium Benincasae, Herba Artemisiae Scopariae.

The steamed bread of described auxiliary antilipemic, cholesterol reducing, the parts by weight of the Chinese medicine additive used in steamed bread raw material described in it can be: Pollen Typhae 10 ~ 20 parts, Radix Oenotherae erythrosepalae 10 ~ 20 parts, Fructus Rosae Laevigatae 10 ~ 20 parts, 10 ~ 20 parts, Rhizoma Curcumae Longae, Fructus Crataegi 10 ~ 20 parts, Fructus Ligustri Lucidi 10 ~ 20 parts, Rhizoma Polygoni Cuspidati 10 ~ 20 parts, Radix Notoginseng 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Semen Cassiae 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, Radix Et Rhizoma Rhei 10 ~ 20 parts, Rhizoma Alismatis 10 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 20 parts, 10 ~ 20 parts, Folium Nelumbinis, Exocarpium Benincasae 10 ~ 20 parts, Herba Artemisiae Scopariae 10 ~ 20 parts.

The steamed bread of described auxiliary antilipemic, cholesterol reducing, the parts by weight of the Chinese medicine additive used in steamed bread raw material described in it can also be: Pollen Typhae 10 ~ 15 parts, Radix Oenotherae erythrosepalae 10 ~ 15 parts, Fructus Rosae Laevigatae 10 ~ 15 parts, 10 ~ 15 parts, Rhizoma Curcumae Longae, Fructus Crataegi 10 ~ 15 parts, Fructus Ligustri Lucidi 10 ~ 15 parts, Rhizoma Polygoni Cuspidati 10 ~ 15 parts, Radix Notoginseng 10 ~ 15 parts, the Radix Astragali 10 ~ 15 parts, Semen Cassiae 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, Radix Et Rhizoma Rhei 10 ~ 20 parts, Rhizoma Alismatis 10 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 20 parts, 10 ~ 20 parts, Folium Nelumbinis, Exocarpium Benincasae 10 ~ 20 parts, Herba Artemisiae Scopariae 10 ~ 20 parts.

Described auxiliary antilipemic, the steamed bread of cholesterol reducing, the parts by weight of the Chinese medicine additive used in steamed bread raw material described in it also can be: Pollen Typhae 10 ~ 20 parts, Radix Oenotherae erythrosepalae 10 ~ 20 parts, Fructus Rosae Laevigatae 10 ~ 20 parts, 10 ~ 20 parts, Rhizoma Curcumae Longae, Fructus Crataegi 10 ~ 20 parts, Fructus Ligustri Lucidi 10 ~ 20 parts, Rhizoma Polygoni Cuspidati 10 ~ 20 parts, Radix Notoginseng 10 ~ 20 parts 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Semen Cassiae 10 ~ 15 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, Rhizoma Chuanxiong 10 ~ 15 parts, Radix Et Rhizoma Rhei 10 ~ 15 parts, Rhizoma Alismatis 10 ~ 15 parts, Radix Paeoniae Rubra 10 ~ 15 parts, 10 ~ 15 parts, Folium Nelumbinis, Exocarpium Benincasae 10 ~ 15 parts, Herba Artemisiae Scopariae 10 ~ 15 parts.

For solving the problems of the technologies described above, the present invention also provides the preparation method of the Chinese medicine additive used in the steamed bread of a kind of auxiliary antilipemic, cholesterol reducing, and described in it, the preparation process of Chinese medicine additive comprises:

A. all crude drug are put into water heating and refluxing extraction 2 times, as component 1;

The medicinal residues of the crude drug b. said extracted crossed again put into ethanol heating and refluxing extraction 2 times, as component 2;

C. by above-mentioned two kinds of extracting solution components 1 and component also 2-in-1, be condensed into extractum, after disinfection, make powder.

In described step a, described crude drug can be put into the water accounting for its quality 10 times amount, 4-6 hour is soaked, heating extraction 2 times, each 1-2 hour in water, merge extractive liquid, remove supernatant after leaving standstill, then 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.25 filtrate, stand for standby use is as component 1.

In described step b, the medicinal residues that above-mentioned steps is extracted can be put into and account for its volume 10 times amount ethanol, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, merge extractive liquid, removes supernatant after leaving standstill, then puts into concentrating under reduced pressure tank, decompression recycling ethanol, being concentrated into liquor strength is 0.1g crude drug/mL, when sucking filtration to the relative density of filtrate is 80 DEG C 1.25 concentrated solution, become component 2.

In described step c, can by component 1 and component 2-in-1 and after, insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 80 DEG C, relative density is the concentrated solution of 1.29, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount; Be condensed into extractum shape, put into oven drying and become powder, then ultraviolet sterilization tinning.

Decoction is the conventional dosage forms of the traditional Chinese medical science, and it is convenient with advantages such as disease plus-minuss to have, but decoction decocting, carries, uses inconvenience, and composition is not exclusively fried, and mouthfeel is poor, is not suitable for the Modern human populations medication custom.Because the present invention is mainly used in preventing and treating hyperlipemia, hyperglycemia, this disease belongs to multifactor relevant chronic disease, and the course of disease is longer, needs long-term prescription just can reach good effect, thus should select to take, carry, dietetic therapy easy to use more can improve health-care effect.Current doctor trained in Western medicine has obtained larger achievement, but hepatic and renal function, the symptom of digestive tract caused by long-term prescription to the research of diabetic hyperlipidemia and treatment, and after muscle damage and drug withdrawal, rebound effect is still a difficult problem for treatment.Regimen residence is controlled in food, can not only reach the object of health body-building, disease preventing and treating, and can also give on people's sense organ, spiritual enjoyment, make people among enjoyment food delicious food, unconsciously reach the object of preventing and curing diseases.This naturopathy with take compared with medicine bitter to the taste far different, it is easy to make people detest clothes and be difficult to adhere to unlike medicine, and people are acceptant, can use for a long time, and the conditioning and treating for chronic disease is particularly suitable.By the extracts active ingredients of Chinese medicine, then in dietetic therapy, make its " clothes for patients it, not only treat disease, and can allay one's hunger; Not only allay one's hunger, more can be agreeable to the taste, with suiting the medicine to the illness, disease, from convalesce, is not namely suited the medicine to the illness, and also suffers from without him ".

Detailed description of the invention

In the blood of people, lipid contained in blood plasma is called blood fat, comprise cholesterol, cholesterol ester, triglyceride, phospholipid and not esterified fat acid etc. several.When cholesterol, triglyceride etc. all exceed normal value, be then referred to as hyperlipemia.Hyperlipemia is atherosclerotic Main Etiological Factors.Often cause serious consequence, as coronary heart disease, diabetes, cerebrovas-cularaccident, intractable hypertension and the nephrotic syndrome, pancreatitis, calculosis, fatty liver etc. because invading vitals.Arteriosclerotic generation and development, have close relationship with Hyperlipemia.

Regimen and pharmacotherapy are very different.Food is cured the disease one of most outstanding feature, exactly " ill cure the disease, without treating diseases and making health-care ", to the essentially no toxic and side effects of human body.That is, utilize the biased characteristic of food (paddy flesh fruit dish) nature and flavor aspect, can targetedly for treatment or the auxiliary treatment of some disease, regulating YIN and YANG makes it to tend to balance, contribute to the treatment of disease and the rehabilitation of body and mind, but food is food after all, it contains the various nutrient substance of needed by human, is mainly the continuous consumption making up yang blood and qi.Therefore, even if dialectical inaccurate, food also can not bring too large harm to human body.As well-known doctor's Zhang Xichun said in " Records of Tradition Chinese and Western Medicine in Combination " " dietetic therapy clothes for patients it, not only treat sick and can allay one's hunger, not only allaying one's hunger and more can agreeable to the taste use suit the medicine to the illness, sickly namely not suit the medicine to the illness from convalesce, also suffering from without him ".Therefore, regimen subject range is comparatively extensive, and mainly for sub-health population, next is only patient, as the supplementary means of medicine or other treatment measure, along with diet life is accepted naturally.

Pharmacotherapy mainly uses medicine, and pharmaceutical properties is fiery and forthright, has the title of " poison " from ancient times, and mainly for curing the disease and establishing, therefore pharmacotherapy subject range comparatively limits to, and mainly for patient, is disease therapy and prophylactic important means.If at will dispenser, deficiency syndrome cathartic, excess syndrome tonic, or the medicine of heat syndrome warm nature, the cold syndrome medicine of cold and cool character, not only can not disease therapy, can make original aggravation on the contrary, even worsen.Therefore medication must be very scrupulous.

Regimen residence is controlled in food, can not only reach the object of health body-building, disease preventing and treating, and can also give on people's sense organ, spiritual enjoyment, make people among enjoyment food delicious food, unconsciously reach the object of preventing and curing diseases.This naturopathy with take compared with medicine bitter to the taste far different, it is easy to make people detest clothes and be difficult to adhere to unlike medicine, and people are acceptant, can use for a long time, and the conditioning and treating for chronic disease is particularly suitable.

Chinese medicine is thought that hyperlipidemia, hypercholesterolemia are many and formed by the expectorant blood coagulation stasis of blood, in side, Semen Cassiae sweetness and bitterness is slightly cold, there is liver heat removing and eyesight improving, suppressing liver-YANG effect, and have the effect reducing serum cholesterol, there is good curative effect to treatment of vascular sclerosis, have hepatoprotective effect, the formation of serum cholesterol rising and Aorta atheromatous plague can be suppressed.Fructus Crataegi has promoting digestion and removing stagnation, function of promoting blood circulation to disperse blood clots, and Fructus Crataegi can enter blood system, kind promoting blood circulation to remove blood stasis detumescence, is longer than the meat that disappears and amasss.Rhizoma Curcumae Longae is sweet pungent cool, gastric qi can be inspired up and promoting the production of body fluid to quench thirst, protect the liver, and resists myocardial ischemia and arteriosclerosis and antiplatelet aggregative activity.Pollen Typhae, can depressed liver-energy dispersing and QI regulating, and in reduce phlegm, its gas delicate fragrance and not strong, warm in nature and not high.The arduous temperature of Rhizoma Chuanxiong, armaticity is dry, has good drying damp and strengthening spleen effect, is dampness key medicine, no matter retention of dampness in middle-JIAO, wet all effective at flesh table, damp flowing downward to lower-JIAO, the card controlled, key is domination of damp pathogen.Rhizoma Alismatis is sweet light cold, and its promoting diuresis to eliminate damp pathogen effect is similar to Poria, and the liposoluble part of Rhizoma Alismatis, ethanol extraction and alisol etc. all have significant effect for reducing blood fat, and Rhizoma Alismatis can also be improved the lipid metabolism of liver and have lipotropy.Full side plays the merit of blood fat reducing altogether.

Semen Cassiae is the seed of " Semen Cassiae ", and be conventional Chinese medicine, seed is used as medicine, and has the function of liver heat removing and eyesight improving, relieving constipation.Cure mainly hypertension, headache, dizzy, the disease such as acute conjunctivitis, corneal ulcer, glaucoma, carbuncle furuncle infections.Make tea with its leaf, middle-aged and elderly people long-term drink, can make blood pressure normal, free movement of the bowels.Semen Cassiae is also known as " going back gb 1 ", and Semen Cassiae contains multivitamin and abundant aminoacid, fat, carbohydrate etc., and its health care is subject to people's attention day by day in recent years.Semen Cassiae has the functions such as clearing away liver-fire, wind-damp dispelling, tonifying kidney and improving eyesight, often drinks cassia-tora tea, blood pressure can be made normal, free movement of the bowels, old eye not flower.Clinical trial certificate, drink cassia-tora tea can liver heat removing and eyesight improving, prevent blurred vision, blood pressure lowering, blood fat reducing, minimizing cholesterol etc., for preventing and treating coronary heart disease, hypertension has good curative effect; And Semen Cassiae is rich in vitamin A and zinc, nyctalopia can be prevented and treated and avoid zinc deficiency in children.In addition, the function of cassia-tora tea loosening bowel to relieve constipation also can solve the problem of modern's the intestines and stomach and constipation, can treat constipation due to dry stool, helps smooth defecation.

Rhizoma Alismatis: be longer than promoting diuresis to eliminate damp pathogen, expels the heat-evil, for dysuria, and edema distension, the puckery pain of stranguria with turbid discharge, seminal emission, foot knee joint flaccidity is soft; Fry Rhizoma Alismatis, be partial to and spleen eliminating dampness by diuresis, for phlegm retention, dysentery, the vertigo.Rhizoma Alismatis, Poria, Polyporus; Three all can seep water dampness removing and inducing diuresis to remove edema, and Chang Sanzhe is with using; Right Rhizoma Alismatis is cold in nature, can expel the heat-evil, clearly mutually fire; Poria then can heart-spleen boosting, tranquilizing mind; And Polyporus, can only eliminating dampness by diuresis diuresis.Sweet in the mouth; Light; Cold in nature, return kidney; Urinary bladder channel.Function cures mainly: promoting diuresis to eliminate damp pathogen; Expel the heat-evil treating stranguria.Main dysuria; The puckery pain of pyretic stranguria; Edema distension; Have loose bowels; Dizziness due to fluid-retention; Seminal emission.

Fructus Rosae Laevigatae is the fruit of rosaceous plant Fructus Rosae Laevigatae, also known as Catunaregam spinosa (Thunb.) Tirveng., Fructus Rosae Normalis etc.Fructus Rosae Laevigatae is the famous medicine of the kidney invigorating simply.The traditional Chinese medical science is thought, Fructus Rosae Laevigatae sour in the mouth, and property is put down, and enters kidney, large intestine two warp, has reinforcing the kidney and controlling nocturnal emission, effect of reducing urination and antidiarrheal.Emission and spermatorrhea can be treated, frequent urination and enuresis, leukorrhagia, metrorrhagia, spontaneous perspiration, night sweat, cough due to deficiency of the lung, insufficiency of the spleen dysentery etc.Modern pharmacology research confirms: Fructus Rosae Laevigatae extract can extend the interval between micturition time; Contained tannin has stronger inhibitory action to staphylococcus aureus, escherichia coli, bacillus pyocyaneus etc.Fructus Rosae Laevigatae fruit is oral can promote that gastric secretion helps digest, and intestinal mucosa can be made again to shrink, and secretion reduces and antidiarrheal; Fructus Rosae Laevigatae decocting liquid all has stronger inhibitory action to staphylococcus aureus, escherichia coli, bacillus pyocyaneus, dysentery bacterium and influenza virus.1, controlling nocturnal emission with astringent drugs reducing urination, relieving diarrhea with astringents.Containing a large amount of acidic materials, soap one-tenth etc. in Fructus Rosae Laevigatae, can pass out semen lingering diarrhea, woman's leukorrhagia of man be prevented too much in controlling nocturnal emission with astringent drugs room, again can astringing intestine to stop diarrhea road, prevent the ineffective caused dysentery of insufficiency of the spleen constraint.2, reducing urination for preventing enuresis.Containing a large amount of acidic materials and Saponin in Fructus Rosae Laevigatae, there is restriction wing and take off sphincter, extend interval between micturition, increase each effect of discharging urine volume, can be used for the disease for the treatment of the enuresis and frequent micturition.3, relieving cough and asthma, spasmolytic.The traditional Chinese medical science is thought, breath with cough and how to be caused by abnormal rising of lung-QI, Fructus Rosae Laevigatae sour-puckery flavor, gas of astringing the lung, can relieving cough and asthma.Modern study finds, the composition containing anti-smooth muscle spasm in Fructus Rosae Laevigatae, can prevent the spasm of gastrointestinal and trachea.4, blood fat reducing.Economize alcohol, hot-tempered matter and soap formula etc. containing fatty acid, Bu Gu in Fructus Rosae Laevigatae, blood fat can be reduced, reduce fat in endovascular deposition, can be used for treating atherosclerosis.5, anti-inflammation.Research finds, Fructus Rosae Laevigatae extracting solution can kill staphylococcus aureus and escherichia coli etc., can be used to treat the disease caused because of S. aureus L-forms or coli-infection.

Fructus Crataegi is containing multivitamin, Crataegolic acid, tartaric acid, citric acid, malic acid etc., and also containing the mineral such as flavonoid, lactone, saccharide, protein, fat and calcium, phosphorus, ferrum, contained lipolytic enzyme can promote the digestion of fat food.Promote gastric secretion and increase the functions such as gastric enzyme element.The traditional Chinese medical science is thought, Fructus Crataegi has that removing food stagnancyization is stagnant, convergence effect such as dysentery relieving, activating blood circulation to dissipate blood stasis.Cure mainly the diseases such as eating accumulation, chest and diaphragm feeling of fullness, the amenorrhea of hernia blood stasis.Containing the ingredient such as mountain terpenoid and pyrite class in Fructus Crataegi, there is significant blood vessel dilating and hypotensive effect, there is the function strengthening cardiac muscle, arrhythmia, adjusting blood lipid and cholesterol level, Fructus Crataegi has effect of activating blood circulation to dissipate blood stasis, contribute to removing local congestion state, have auxiliary curative effect to traumatic injury; Flavonoid contained by Fructus Crataegi and the substance such as vitamin C, carotene block and reduce the generation of free radical, and the immunity of energy enhancing body, has anti-aging, anticancer effect; Having in Fructus Crataegi relievings asthma reduces phlegm, the composition of anti-bacteria, treatment abdominal pain diarrhea.

Radix Oenotherae erythrosepalae (formal name used at school: Oenotherabiennis) is the kind of under Oenotheraceae Oenothera.Strong adaptability, acidproof drought-enduring, it is the most important nutrient drug found this century.Can treat various diseases, regulate lipid material in blood, the diseases such as the coronary ligation caused hypercholesterolemia, hyperlipidemia, atherosis and cerebral thrombosis have significant curative effect.Wind-damp dispelling; Bone and muscle strengthening.Main anemofrigid-damp arthralgia; Soreness of bones and muscles, promoting blood circulation to remove obstruction in the collateral; Endogenous wind stopping suppressing the hyperactive liver; Detumescence sore.Main obstruction of qi in the chest and cardialgia; Apoplectic hemiplegia; Stirring-up of pathogenic wind in the interior resulting from deficiency; Children's moves more; Wind dampness rheumatic anesthesia pain; Stomachache is had loose bowels; Dysmenorrhea; Oral-anal-genital ulcer syndrome; Skin infection; Eczema.

Exocarpium Benincasae is used for edema distension, and dysuria, summer-heat is thirsty, oliguria with reddish urine.Compendium of Material Medica: Exocarpium Benincasae (injured, burn grind, wine clothes) control the stasis soreness of waist pain." book on Chinese herbal medicine is new again ": walk skin, dry and chase after wind, spleen reinforcing pathogenic fire purging.

Rhizoma Curcumae Longae removing blood stasis, circulation of qi promoting, stimulates the menstrual flow, pain relieving.Control trusted subordinate's feeling of fullness distending pain, brachialgia, lump in the abdomen, women's blood stasis amenorrhea, puerperal, the stasis of blood stopped stomachache, injury from falling down, carbuncle.Breast for qi depression to blood stasis is suffered from abdominal pain, dysmenorrhea and limbs pain, often joins Rhizoma Corydalis, Rhizoma Cyperi.Tang Materia Medica: main trusted subordinate ties long-pending, and chronic infectious disease is disobedient, the therapeutic method to keep the adverse QI flowing downwards, removing blood stasis, except wind heat, subduing inflammation.Power is strong in Radix Curcumae." Japan hanako materia medica ": control lump in the abdomen clot, carbuncle, logical menstruation, controls to fall and flutters blood stasis, detumescence poison; Only storm wind pain cold air, lower food." Bencao Tujing ": control flatulence and puerperal deteriorated blood make a psychological attack.Energy circulation of qi promoting removing blood stasis with potent drugs, inducing menstruation to relieve menalgia.Cure mainly chest and abdomen swelling and pain, shoulder arm arthralgia pain, unbearably pained, puerperal blood pain, skin ulcer tinea onset, menoxenia, amenorrhea, traumatic injury.Yellow food colour can be extracted again; Contained curcumin can perform an analysis chemical reagent.

Rhizoma Polygoni Cuspidati dampness removing jaundice eliminating, heat-clearing and toxic substances removing, eliminating stasis to stop pain, relieving cough and resolving phlegm.For jaundice due to damp-heat, stranguria with turbid discharge, leukorrhagia, rheumatic arthralgia, carbuncle sore tumefacting virus, burn due to hot liquid or fire, amenorrhea, lump in the abdomen, instep plays damage, cough due to lung-heat.Compendium of Material Medica: grind wine clothes into powder, controls postnatal blood stasis blood pain, and pendant is flutterred confused effectively vexed." Mingyi Bielu ": the main tonneau moon water, broken crux of bleeding.

Radix Notoginseng is used as medicine with its root, and it is warm in nature, acrid in the mouth, has significant blood circulation promoting and blood stasis dispelling, subduing swelling and relieving pain effect, has the good reputation of " Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) ", " southern part of the country SHENCAO ".Excavating in season in winter in spring two because being everlasting, being divided into again " spring seven " and " winter seven ".Record in Qing Dynasty's pharmaceutical texts supplementary Amplifications of the Compendium of Materia Medica: " ginseng qi-tonifying the first, Radix Notoginseng enriches blood the first, taste with and merit also etc., therefore claiming Panax pseudoginseng, is the most precious person in Chinese medicine." become famous Chinese patent medicine " YUNNAN BAIYAO " at home and abroad and " Pien Tze Huang ", be namely that primary raw material is made with Radix Notoginseng.Cure mainly spitting of blood, spit blood, epistaxis, has blood in stool, metrorrhagia, traumatic hemorrhage, breast ventral spine pain, tumbling and swelling.

Radix Et Rhizoma Rhei is the medical herbs that " Chinese Pharmacopoeia " includes, and medicinal source is the dry root and rhizome of polygonum rheum palmatum RheumpalmatumL., Rheum tanguticum RheumtanguticumMaxim.exBalf. or Rheum officinale RheumofficinaleBaill..Autumn Mo in the stem and leaf withered or secondary spring excavates before germinateing, and removing radicula, scrapes off crust, valve cutting or section, and rope wears bunchiness drying or convection drying.Chinese rhubarb is mainly done medicinal, and Chinese herb rhubarb has attacks the effects such as stagnant, clearing away damp-heat, pathogenic fire purging, removing heat from blood, blood stasis dispelling, removing toxic substances.Europe and the Radix Et Rhizoma Rhei in the Middle East mainly refer to the Rheum kind that several work is edible, and stem is red, gas delicate fragrance, bitter in the mouth and micro-puckery, and that chews sticks to one's teeth, and has sand feeling.Belong to purgatives medicine, raw comparatively strong with discharge function, ripe use then discharge function is comparatively delayed and is longer than eliminating fire and detoxication, eliminating damp-heat; Processed with wine merit is arrogated to oneself and is invigorated blood circulation, and kind clear part of the body cavity above the diaphragm housing the heart and lungs blood system is ripe; Parch to black is usually used in cooling blood for hemostasis.

Herba Artemisiae Scopariae is used for jaundice oliguria, hygropyrexia heat-damp in summer, eczema pruritus." Bencao Jingshu ": Herba Artemisiae Scopariae, the raw heat of its main air, pathogen accumulation of heat, jaundice, the whole body jaundice, dysuria and feverish sensation in the head, all damp and hot bright at sun, lunar disease of viscera connecting with this channel also.Bitter cold energy dampness heat extraction, damp and hotly goes, then all diseases are from moving back.The key medicine of dehumidifying heat radiation knot also.

Folium Nelumbinis dietary function: pungent micro-puckery, the cool in nature nature and flavor of Folium Nelumbinis bitter in the mouth are cold and cool, imapirment of the spleen and stomach, must add a little trembling with fear temperature must relax cold and cool property., GUIXIN, liver, spleen channel. and delicate fragrance rises loose; There is summer heat relieving and dampness eliminating, spleen invigorating yang invigorating, effect of dissipating blood stasis hemostasis. cure mainly summer-heat excessive thirst, have a headache dizzy, edema, lack of appetite abdominal distention, dysentery, leucorrhea, proctoptosis, spit blood, epistaxis, spitting of blood, has blood in stool, metrorrhagia, post partum longtime lochia, traumatic blood stasis.

Rhizoma Chuanxiong (formal name used at school: Ligusticumchuanxionghort), cultivated plant, main product in Sichuan (Guanxian county), in Yunnan, Guizhou, the ground such as Guangxi, be grown on gentle climatic environment.Be a kind of Chinese medicinal plant, be usually used in blood-activating and qi-promoting, wind-expelling pain-stopping, the pungent temperature of Rhizoma Chuanxiong is fragrant dry, walks and does not keep, can go loose, and the up mountain peak that reaches is pushed up; Enter blood system again, descendingly reach the sea of blood.Blood circulation promoting and blood stasis dispelling effect is extensive, the suitable various disease of stagnation of blood stasis; Wind-expelling pain-stopping, effectiveness is excellent, can control the diseases such as wind syndrome of head headache, rheumatic arthralgia.It is gas medicine in blood that former times people calls Rhizoma Chuanxiong, the functions such as pungent loose, the resolving depression of its residence of dangerous speech, sensible, pain relieving.

Fructus Ligustri Lucidi is used for the poor vision of the hepatic and renal YIN deficiency, visual deterioration, early whitening of beard and hair, soreness of waist tinnitus and fever due to yin deficiency etc.This product energy tonifying liver kidney yin, but the efficacy of a drug is gentle, slowly must get effect.Control poor vision, often join Radix Rehmanniae Preparata, Fructus Lycii is equal to use, controls early whitening of beard and hair, and often join the same use of Fructus Mori, fever due to yin deficiency, often joins Cortex Lycii.The hepatic and renal YIN deficiency, Light-headedness, seminal emission tinnitus, soreness of the waist and knees, early whitening of beard and hair, coronary heart disease, hyperlipemia, hypertension, chronic hepatitis.The protective effect research of liver is thought, Fructus Ligustri Lucidi contains oleanolic acid, to rat skin lower injection, serum glutamic pyruvic transminase can be reduced, there is obvious protective effect to the hepatic injury of Carbon Tetrachloride Induced, and can liver cell regeneration be promoted. oleanolic acid also can make triglyceride accumulation minimizing in liver, hepatocellular degeneration necrosis obviously alleviates, glycogen accumulation increases, serum γglobulin declines; Ultrastructure visible hepatocyte mitochondrial swelling and endosomal vesicle degeneration alleviate, hepatic tissue interstitial inflammation habituation

Radix Salviae Miltiorrhizae is bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen lumps, and skin infection swells and ache, and tumbling down is grieved, menoxenia, amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect." detailed outline " carries: Radix Salviae Miltiorrhizae, and by " the sensible opinion of married woman " cloud, SIWU TANG controls gynecopathy, pays no attention to antenatal puerperal, how many through water, all can be general, and only taste Radix Salviae Miltiorrhizae falls apart, and cures mainly identical with it.Lid Radix Salviae Miltiorrhizae can break stagnated blood, and mend fresh blood, peaceful tire, fall stillborn fetus, only metrorrhagia dysentery, regulating menstruation arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae TANSHINONES has blood vessel dilating, improves circulation, removes the effects such as intravascular coagulation, has effect of invigorating blood circulation trace, and can promote that liver blood circulates, be beneficial to liver cell regeneration.

The Radix Astragali has the effects such as invigorating QI to consolidate the body surface resistance, diuretic detumescent, expelling pus and toxin by strengthening QI, granulation promoting.The history of medicinal existing more than 2000 year so far of the Radix Astragali, modern study, the Radix Astragali is containing the various trace elements such as Saponin, sucrose, polysaccharide, several amino acids, folic acid and selenium, zinc, copper.Have enhancing human body immunity function, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.But table excess pathogen is contained, retention of dampness due to stagnation of QI, and food stagnation is stagnated, carbuncle from the beginning of or the excess syndrome such as pyretic toxicity Shang Sheng after bursting.The Radix Astragali has invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, effect of expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst." herbal classic " is recorded: " main carbuncle, loses skin ulcer for a long time, evacuation of pus pain relieving.Tonify deficiency, children's's all kinds of diseases and ailments." " Japan hanako materia medica " record: " help gas strengthening bone and muscle, put on flesh and enrich blood.”

Radix Paeoniae Rubra, clots absorbing, pain relieving, removing heat from blood, detumescence.Cure mainly: control the stagnant amenorrhea of the stasis of blood, hernia abdominal mass is gathered, suffer from abdominal pain, hypochondriac pain, epistaxis, dysentery, discharging fresh blood stool, conjunctival congestion, carbuncle, injury from falling down.Radix Paeoniae Rubra can purify the blood a point excess-heat, and dissipating blood stasis blood is detained.This product function is close with Cortex Moutan, therefore normal and Cortex Moutan mutual reinforcement between is for use.But the effect of Cortex Moutan clearing away heat and cooling blood is better, can purify the blood a point excess-heat, can control fever due to yin deficiency again; And Radix Paeoniae Rubra can only be used for blood system excess-heat, be good at promoting blood circulation to remove blood stasis." herbal classic ": main pathogen stomachache, except arthralgia due to stagnation of blood, broken hard long-pending, cold and heat hernia abdominal mass, pain relieving, diuresis, QI invigorating.

The specific embodiment of the invention

Specific embodiment 1: by flour, Chinese medicine additive, water, Mel, yeast, mix in proportion, fermentation, then compressing, put into baking oven baking, cooling, packaging, finished product.

Specific embodiment 2: choose 1: 1 corn flour and Semen Tritici aestivi flour mix even after, add and account for its Chinese medicine additive powder of 1/10th, three is stirred; Add appropriate yeast, water, Mel, stir, ferment after 1-2 hour, question handler is waken up, and starts compression molding, puts into baking oven baking, cooling, packaging, finished product.

Specific embodiment 3:

Choose 1: 1 Buckwheat flour and Semen Tritici aestivi flour mix even after, add and account for its Chinese medicine additive powder of 1/10th, three is stirred; Add appropriate yeast, water, Mel, stir, ferment after 1-2 hour, question handler is waken up, and starts compression molding, puts into baking oven baking, cooling, packaging, finished product

Specific embodiment 4:

Get 500g wheat flour and 500g Semen Maydis flour is mixed even, then add the Chinese medicine additive of 100g, add appropriate yeast, Mel, add water and start to knead, become after a dough until it, be placed on airtight container fermentation 2-3 hour, then make steamed bread, upper food steamer steams 20-30 minute, and take the dish out of the pot molding.

The preparation of Chinese medicine additive:

Embodiment 1: get Pollen Typhae 1000g, Radix Oenotherae erythrosepalae 1000g, Fructus Rosae Laevigatae 1000g, Rhizoma Curcumae Longae 1000g, Fructus Crataegi 1000g, Fructus Ligustri Lucidi 1000g, Rhizoma Polygoni Cuspidati 1000g, Radix Notoginseng 1000g, Radix Astragali 1000g, Semen Cassiae 1000g, Radix Salviae Miltiorrhizae 1000g, Rhizoma Chuanxiong 1000g, Radix Et Rhizoma Rhei 1000g, Rhizoma Alismatis 1000g, Radix Paeoniae Rubra 1000g, Folium Nelumbinis 1000g, Exocarpium Benincasae 1000g, Herba Artemisiae Scopariae 1000g.Crude drug is steeped 2-4 hour in the water accounting for its quality 10 times amount, then put into extraction pot heated and boiled 1 hour, filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 45 minutes, filters, then by stand for standby use after twice filtrate mixing, as component 1.

The medicinal residues again said extracted crossed, put into 10 times amount ethanol, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, merge extractive liquid, removes supernatant after leaving standstill, then puts into concentrating under reduced pressure tank, decompression recycling ethanol, being concentrated into liquor strength is 0.1g crude drug/mL, when sucking filtration to the relative density of filtrate is 20 DEG C 1.06 concentrated solution, become component 2.

By component 1 and component 2-in-1 and after insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.25, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount; Baking oven put into by extractum after concentrated, powdered bottling after ultraviolet ray sterilization bactericidal.

Embodiment 2: get Pollen Typhae 1200g, Radix Oenotherae erythrosepalae 1100g, Fructus Rosae Laevigatae 1200g, Rhizoma Curcumae Longae 1100g, Fructus Crataegi 1100g, Fructus Ligustri Lucidi 1200g, Rhizoma Polygoni Cuspidati 1100g, Radix Notoginseng 1100g, Radix Astragali 1200g, Semen Cassiae 1200g, Radix Salviae Miltiorrhizae 1200g, Rhizoma Chuanxiong 1100g, Radix Et Rhizoma Rhei 1200g, Rhizoma Alismatis 1200g, Radix Paeoniae Rubra 1200g, Folium Nelumbinis 1200g, Exocarpium Benincasae 1200g, Herba Artemisiae Scopariae 1100g.Steep in the water accounting for its quality 10 times amount, by soaked crude drug heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.06 extractum, heating be concentrated into paste, stand for standby use is as component 1.Again the medicinal residues that above-mentioned steps is extracted are put into 10 times amount ethanol, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, merge extractive liquid, supernatant is removed after leaving standstill, then put into concentrating under reduced pressure tank, decompression recycling ethanol, being concentrated into liquor strength is 0.1g crude drug/mL, when sucking filtration to the relative density of filtrate is 20 DEG C 1.06 extractum, become component 2.By component 1 and component 2-in-1 and after insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the extractum of 1.25, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount; After unguentum ultraviolet ray sterilization bactericidal after concentrated, make powder bottling.

Chinese medicine additive animal acute toxicity test of the present invention

One, test material

(1) animal mouse NIH kind male and female half and half, body weight 20-22g, are provided by Shandong medical college Animal Lab..

(2) test medicine: the powder that the present invention is made, is diluted with distilled water into suspension.

Two, test method and result:

Mice maximum tolerance determination: get healthy mice 32, male and female half and half, divided three groups within 24 hours, and only, gross weight 1.8ml, is equivalent to crude drug in whole 4.0g to each 0.6ml/ of gavage intestinal, i.e. 100g crude drug/kg/d, is equivalent to 857 times of clinical 65 kilograms of people.After mice administration routinely feedstuff within 12 days, have no animal dead and do not go out, existing toxic reaction.Therefore prove, medicine of the present invention has no side effect, and clinical practice is safe and reliable.

The long-term toxicity test for animals of pharmaceutical composition of the present invention

One, test material and method

(1) test medicine: the powder that the embodiment of the present invention is made, is diluted with distilled water into suspension.

(2) laboratory animal, healthy rat Wistar, body weight 100-130g, 140 male and female half and half, by sex and body weight random packet, four groups, often organize 35.1, take test medicine for 2,3 groups, dosage is respectively 9.6/kg/d, 6.4/kg/d, 3.2/kg/d.4 groups contrast to the distilled water of respective volume amount, the equal gavage enteral administration of rat, often organize and be once used in conjunction 6 months, put to death half, and all death in 12 days is observed in remaining 1/2 drug withdrawal.

Two, test index

(1) general status comprises body weight, diet, emotion, movable energy.

(2) hemogram checking: red blood cell count(RBC), numeration of leukocyte, platelet count, hemogram etc., quantitative hemoglobin counts.

(3) biochemical analysis, serum albumin quantitatively, cholesterol, blood sugar quantitative.

(4) pathologic diagnosis: get half animal after experimental result and weigh, sacrificed by decapitation, gets blood, solution is treated others for earnest simultaneously, liver, kidney, lung, brain, spleen, gastrointestinal, bladder, adrenal gland do pathologic diagnosis.

Three, result of the test: show through rat chronic toxicity test, with the heavy dose of coloclysis of the present invention six months, increases the growth of rat, body weight, all has no side effect to brain, Liver and kidney function.Do not find that infringement changes to each histoorgan of rat, blood circulation, medication group compares no significant difference with matched group.

Chinese medicine additive Ergonomy of the present invention research:

Hyperlipoidemia method (preventative to given the test agent): rat feeding normal feedstuff is observed 5 ~ 10 days under experimental situation, then tail blood is got, measure serum total cholesterol (TC), triglyceride (TG), HDL-C (HDLC) level.According to serum total cholesterol (TC) level, carry out random packet, while giving high lipid food, give the given the test agent of various dose, regularly weigh in, terminate fasting 16 hours in experiment, survey serum TC, TG, HDL-C level.

Hyperlipoidemia method (therapeutic is to given the test agent): rat feeding normal feedstuff is observed 5 ~ 10 days under experimental situation, then tail blood is got, measure serum total cholesterol (TC), triglyceride (TG), HDL-C (HDLC) level.Start each treated animal from formal experiment and use high lipid food feed instead 7 ~ 10 days, get tail blood, then measure serum TC, TG, HDL-C level, with before feed high lipid food than to determine whether to form hyperlipemia model.Again according to TC level, carry out random packet, given the test agent per os gavage, high fat matched group, to the solvent of same volume, continues to give high lipid food, and regularly weighs in, and terminates rear fasting 16 hours in experiment, measures serum TC, TG, HDL-C level.

Result judges: serum total cholesterol and the triglyceride binomial index positive in serum total cholesterol, triglyceride, HDL-C three Indexs measure, can judge that auxiliary lipid-lowering function results of animal of the present invention is positive.

Pharmacodynamic experiment:

The cholesterol reducing effect for reducing fat of present zoopery to hyperlipemia is tested, and verifies effect of the present invention.

1 materials and methods

1.1 laboratory animals, rearing conditions and feedstuff

SPF level SD male rat 55, body weight 150 ~ 230g, is provided by Affiliated Hospital of Qingdao University Experimental Animal Center, raises at Qingdao hospital experimental center SPF level Animal Lab..Keep the room temperature of 23 DEG C ± 1 DEG C in animal housing, humidity 60% ± 10%, freely drinks water, takes food, and adopts the alternately illumination of 12h light and shade, changes weekly 3 water, change 2 bedding and padding.Rat chow diet, is derived from Center for Disease Control (CDC) of Shandong Province.High lipid food: 61% chow diet, 5% fructose, 12% yolk powder, 22% Adeps Sus domestica, fully grinds to form strip after mixing, originates from Center for Disease Control (CDC) of Shandong Province.

1.2 reagent

Vessel used to hold grain at the imperial sacrifice urea assistant rhzomorph (streptozotocin, STZ) injectable powder: Sigma company produces, and is made into the application liquid of 3mg/ml, mixes 5min with agitator during experiment with ice-cold pH4.50.1mmol/L citrate buffer solution, after dissolving mixing completely, inject immediately.

1.3 method

SPF level SD male rat 55, body weight 150 ~ 230g, after adaptability raises 1 week, separates 10 rats at random as Normal group, feeds with full nutrition feed, does not do any process.All the other 45 rats high lipid food feeds fasting 12h after 1 month, gives disposable celiac injection STZ30mg/kg.After 72h, tail vein measures blood glucose, blood fat, liver function.Random blood sugar the rat of 18mmol/L be modeling success.Finally become mould 36, be divided into 3 groups at random according to blood glucose height: the present invention 1 group, the present invention 2 groups and Western medicine group.Give the present invention 1 group (3ml/kg) respectively, the present invention 2 groups (9ml/mg, beneficial fat health), Western medicine group (metformin hydrochloride 2ml/kg+ fenofibrate 3ml/kg) gavage is treated, 1 time/d.Period gives high glucose and high fat forage feed always.Normal group gives normal saline.Fasting glucose (fastingbloodglucose is checked after February, FBG), T-CHOL (totalcholesterol, TC), triacylglycerol (triglyceride, TG), alanine aminotransferase (alanineaminotransferase, ALT), observe the curative effect.

1.4 statistical procedures

Data mean ± standard deviation (-x ± s) represents, adopts SPSS13.0 statistical software, and own control adopts independent t test, and enumeration data adopts x2 inspection.P < 0.05 has statistical significance.

2 results

Before and after the present invention 1 group, the present invention 2 groups, the treatment of Western medicine group, indices contrast is visible: FBG, TC, TG of 3 groups all has obvious reduction, and difference has statistical significance (t=4.891, P < 0.01).All decreased by the visible 3 groups of liver function ALT of table 1, difference has statistical significance (t=3.062, P < 0.01).It is more visible that wherein the present invention 1 group, the present invention 2 groups and Western medicine group treat rear indices: FBG, TC all have reduction, but not statistically significant (P > 0.05), the reduction of the present invention 1 group and the present invention 2 groups of TG is obviously better than Western medicine group, there is statistical significance (t=2.449, P < 0.05), and the recovery of liver function ALT is better than Western medicine group, there is statistical significance (t=6.518, P < 0.01).

After 3 groups of treatments, indices contrasts visible with matched group: FBG, TG of 3 groups for the treatment of groups more all have rising with matched group, but not statistically significant (P > 0.05), and TC declines obviously, there is statistical significance (t=2.566, P < 0.01), the liver function of 3 groups for the treatment of groups all has infringement, the index of ALT more all has rising with matched group, there is statistical significance (t=2.798, P < 0.01), in table 1.

Table 1 respectively organizes FBG, TC, TG, ALT level (mmol/L ,-x ± s) before and after treating

Note: compare before and after each group treatment, #P < 0.05, ##P < 0.01; Compare with Western medicine group, * P < 0.05, * * P < 0.01; Compare with matched group, $ P < 0.05, $ $ P < 0.01.

In recent years, along with improving constantly of people's living standard, the disease incidence such as diabetes, coronary heart disease increases day by day.In the blood of people, lipid contained in blood plasma is called blood fat, comprise cholesterol, cholesterol ester, triglyceride, phospholipid and not esterified fat acid etc. several.When cholesterol, triglyceride etc. all exceed normal value, be then referred to as hyperlipemia.Hyperlipemia is atherosclerotic Main Etiological Factors.Often cause serious consequence, as coronary heart disease, diabetes, cerebrovas-cularaccident, intractable hypertension and the nephrotic syndrome, pancreatitis, calculosis, fatty liver etc. because invading vitals.Arteriosclerotic generation and development, have close relationship with Hyperlipemia.Chinese herbal medicine effect is stablized, few side effects, and research has the Chinese herbal medicine of hypoglycemic lipid-lowering effect, can provide more method for clinical treatment diabetes, hyperlipemia.

Chinese tradition meals be particular about balance, propose " grain rice are preferably foster, lose bean then bad; Five poultrys are fitted as benefit, cross then harmful non-shallow; Five dishes are often for filling, fresh greenish-yellow red; Five fruits when for helping, being made every effort to less and counting " meals principle.Describing by modern languages is exactly will keep the bio-diversity of food source, based on cereal; Veterinary antibiotics and potato class will be eaten more; Every day will take in enough beans and goods thereof; The animal foods such as fish, fowl, meat, egg, milk want appropriate.

In fact, when some compatriots hanker after diet westernization, the east diet structure being representative with Chinese tradition dietary structure, but more and more by common people are attracted attention.It has been generally acknowledged that, food is for human body provides the edibility material of growth promoter with the various nutrients needed for healthy existence.That is, food most importantly Nutrition.Actually this is not so, and the traditional Chinese medical science recognizes that food can not only nutrition very early, and can also treat disease and get rid of illness.As doctor's Zhang Xichun in modern age was once pointed out in " Records of Tradition Chinese and Western Medicine in Combination ": food " clothes for patients it, not only treat disease, and can allay one's hunger; Not only allay one's hunger, more can be agreeable to the taste, with suiting the medicine to the illness, disease, from convalesce, is not namely suited the medicine to the illness, and also suffers from without him ".Along with the development of society, people are more and more particular about the way to keep in good health.A lot of food being applicable to health preserving is also promoted thereupon, common are health preserving coarse cereal powder, various grains gruel, medicated diet etc.

Clinical trial:

The result of clinical trial of the present invention: test objective: observe more than 45 years old person in middle and old age's hyperglycemia hyperlipidemia high-risk group and take the present invention and Probucol respectively, its modal untoward reaction is gastrointestinal upset, the incidence rate of diarrhoea is approximately 10%, also has flatulence, stomachache, nausea and vomiting.Adult usual amounts be each 0.5g, every day 2 times, early, dinner time take.

Method: by hyperglycemia hyperlipidemia population at risk between 120 routine 45-55, hypercholesterolemia, hyperlipidemia patient are divided into of the present invention group of (every day normal breakfast, lunch and dinner at random, all with steamed bread of the present invention for staple food, one 2-3, every day breakfast, lunch and dinner, coordinate the dish of low fat, low oily low sugar, refuse to obey any Western medicine).Probucol treatment group 1g/d; The Blood Lipid level before and after its treatment is measured respectively treatment more than 8 weeks or 8 weeks; Each group is divided into two groups according to degree of danger again, and namely dangerous group and atheromatosis or diabetic groups observe its therapeutic effect.

Result: the cholesterol (TC) before and after the treatment of Probucol treatment group, triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) level have obvious decline (P < 0.05), HDL-C level raises to some extent, but diversity is not significantly (P > 0.05); Cholesterol (TC) before and after treatment group treatment of the present invention, triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) level all have clearly decline (P < 0.01), and HDL-C level is increased significantly (P < 0.05).In 120 examples, total compliance rate is 69.89%, wherein dangerous group compliance rate is 74.56%, atheromatosis or diabetic groups compliance rate are 64.21%, Probucol treatment is up to standard more difficult for diabetics blood fat reducing in secondary prevention, and total blood fat compliance rate of the present invention is 83.12%, apparently higher than 44.62% (P < 0.05) of Probucol group.

Claims (10)

1. a steamed bread for auxiliary antilipemic cholesterol reducing, is characterized in that, described steamed bread comprises following raw material: flour, Chinese medicine additive, water, Mel, yeast; Its preparation method is, after raw material mix homogeneously, kneads, and puts into food steamer steam heating 20-30 minute, finished product.

2. the steamed bread of auxiliary antilipemic, cholesterol reducing according to claim 1, is characterized in that, the raw flour used in described steamed bread is mixed by 1: 1 for Semen Maydis flour or Fagopyrum esculentum Moench and wheat flour; The parts by weight ratio of described Chinese medicine additive and flour is 1: 10 ~ 20.

3. the steamed bread of auxiliary antilipemic cholesterol reducing according to claim 1, it is characterized in that, the crude drug that described Chinese medicine additive uses comprises: Pollen Typhae, Radix Oenotherae erythrosepalae, Fructus Rosae Laevigatae, Rhizoma Curcumae Longae, Fructus Crataegi, Fructus Ligustri Lucidi, Rhizoma Polygoni Cuspidati, Radix Notoginseng, the Radix Astragali, Semen Cassiae, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei, Rhizoma Alismatis, Radix Paeoniae Rubra, Folium Nelumbinis, Exocarpium Benincasae, Herba Artemisiae Scopariae.

4. the steamed bread of auxiliary antilipemic cholesterol reducing according to claim 1, it is characterized in that, the parts by weight of the Chinese medicine additive used in described steamed bread raw material comprise: Pollen Typhae 10 ~ 20 parts, Radix Oenotherae erythrosepalae 10 ~ 20 parts, Fructus Rosae Laevigatae 10 ~ 20 parts, 10 ~ 20 parts, Rhizoma Curcumae Longae, Fructus Crataegi 10 ~ 20 parts, Fructus Ligustri Lucidi 10 ~ 20 parts, Rhizoma Polygoni Cuspidati 10 ~ 20 parts, Radix Notoginseng 10 ~ 20 parts 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Semen Cassiae 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, Radix Et Rhizoma Rhei 10 ~ 20 parts, Rhizoma Alismatis 10 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 20 parts, 10 ~ 20 parts, Folium Nelumbinis, Exocarpium Benincasae 10 ~ 20 parts, Herba Artemisiae Scopariae 10 ~ 20 parts.

5. the steamed bread of auxiliary antilipemic cholesterol reducing according to claim 1, it is characterized in that, the parts by weight of the Chinese medicine additive used in described steamed bread raw material comprise: Pollen Typhae 10 ~ 15 parts, Radix Oenotherae erythrosepalae 10 ~ 15 parts, Fructus Rosae Laevigatae 10 ~ 15 parts, 10 ~ 15 parts, Rhizoma Curcumae Longae, Fructus Crataegi 10 ~ 15 parts, Fructus Ligustri Lucidi 10 ~ 15 parts, Rhizoma Polygoni Cuspidati 10 ~ 15 parts, Radix Notoginseng 10 ~ 15 parts, the Radix Astragali 10 ~ 15 parts, Semen Cassiae 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, Radix Et Rhizoma Rhei 10 ~ 20 parts, Rhizoma Alismatis 10 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 20 parts, 10 ~ 20 parts, Folium Nelumbinis, Exocarpium Benincasae 10 ~ 20 parts, Herba Artemisiae Scopariae 10 ~ 20 parts.

6. the steamed bread of auxiliary antilipemic cholesterol reducing according to claim 1, it is characterized in that, the parts by weight of the Chinese medicine additive used in described steamed bread raw material comprise: Pollen Typhae 10 ~ 20 parts, Radix Oenotherae erythrosepalae 10 ~ 20 parts, Fructus Rosae Laevigatae 10 ~ 20 parts, 10 ~ 20 parts, Rhizoma Curcumae Longae, Fructus Crataegi 10 ~ 20 parts, Fructus Ligustri Lucidi 10 ~ 20 parts, Rhizoma Polygoni Cuspidati 10 ~ 20 parts, Radix Notoginseng 10 ~ 20 parts 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Semen Cassiae 10 ~ 15 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, Rhizoma Chuanxiong 10 ~ 15 parts, Radix Et Rhizoma Rhei 10 ~ 15 parts, Rhizoma Alismatis 10 ~ 15 parts, Radix Paeoniae Rubra 10 ~ 15 parts, 10 ~ 15 parts, Folium Nelumbinis, Exocarpium Benincasae 10 ~ 15 parts, Herba Artemisiae Scopariae 10 ~ 15 parts.

7. according to any one of claim 1 ~ 6 auxiliary antilipemic cholesterol reducing steamed bread in the preparation method of Chinese medicine additive that uses, it is characterized in that, the preparation process of described Chinese medicine additive comprises:

A. all crude drug are put into water heating and refluxing extraction 2 times, as component 1;

The medicinal residues of the crude drug b. said extracted crossed again put into ethanol heating and refluxing extraction 2 times, as component 2;

C. by above-mentioned two kinds of extracting solution components 1 and component also 2-in-1, be condensed into extractum, after disinfection, make powder.

8. the preparation method of Chinese medicine additive according to claim 7, is characterized in that, in described step a, described crude drug is put into the water accounting for its quality 10 times amount, 4-6 hour is soaked, heating extraction 2 times, each 1-2 hour in water, merge extractive liquid, remove supernatant after leaving standstill, then 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.25 filtrate, stand for standby use is as component 1.

9. the preparation method of Chinese medicine additive according to claim 7, is characterized in that, in described step b, the medicinal residues that above-mentioned steps is extracted are put into and accounts for its volume 10 times amount ethanol, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, merge extractive liquid, removes supernatant after leaving standstill, then puts into concentrating under reduced pressure tank, decompression recycling ethanol, being concentrated into liquor strength is 0.1g crude drug/mL, when sucking filtration to the relative density of filtrate is 80 DEG C 1.25 concentrated solution, become component 2.

10. the preparation method of Chinese medicine additive according to claim 7, is characterized in that, in described step c, by component 1 and component 2-in-1 and after, insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 80 DEG C, relative density is the concentrated solution of 1.29, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount; Be condensed into extractum shape, put into oven drying and become powder, then ultraviolet sterilization tinning.