CN116585395A - Traditional Chinese medicine composition and traditional Chinese medicine preparation for dispelling wind and relieving itching and preparation method thereof - Google Patents

Traditional Chinese medicine composition and traditional Chinese medicine preparation for dispelling wind and relieving itching and preparation method thereof Download PDF

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Publication number
CN116585395A
CN116585395A CN202310776351.0A CN202310776351A CN116585395A CN 116585395 A CN116585395 A CN 116585395A CN 202310776351 A CN202310776351 A CN 202310776351A CN 116585395 A CN116585395 A CN 116585395A
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China
Prior art keywords
parts
traditional chinese
chinese medicine
relieving itching
dispelling wind
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Pending
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CN202310776351.0A
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Chinese (zh)
Inventor
陈家进
唐颂豪
刘军
林丽丽
柏丽
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NANJING TONGRENTANG PHARMACEUTICAL CO Ltd
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NANJING TONGRENTANG PHARMACEUTICAL CO Ltd
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Priority to CN202310776351.0A priority Critical patent/CN116585395A/en
Publication of CN116585395A publication Critical patent/CN116585395A/en
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    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
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    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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Abstract

The application relates to the technical field of traditional Chinese medicines, and in particular discloses a traditional Chinese medicine composition and a traditional Chinese medicine preparation for dispelling wind and relieving itching and a preparation method thereof. The composition comprises radix Saposhnikoviae, fructus crataegi, periostracum Cicadae, cortex Cuneatae Radicis, cortex Lycii, cordyceps militaris, saccharide additive, fructus forsythiae, semen Lini, radix Angelicae sinensis, rehmanniae radix, caulis Akebiae, herba Schizonepetae, glycyrrhrizae radix, heme iron, bee pollen of fructus Schisandrae chinensis, campsis grandiflora apigenin, flavone, N-acetylneuraminic acid, herba Scutellariae Barbatae extract, octanoyl hydroxamic acid. The components are mixed, boiled and filtered to obtain the traditional Chinese medicine filtrate, and the traditional Chinese medicine filtrate is concentrated to prepare the preparation, so that the traditional Chinese medicine has the effects of dispelling wind, relieving itching, improving mouthfeel, improving immunity and the like, and the effect is remarkable.

Description

Traditional Chinese medicine composition and traditional Chinese medicine preparation for dispelling wind and relieving itching and preparation method thereof
Technical Field
The application relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for dispelling wind and relieving itching, a traditional Chinese medicine preparation and a preparation method thereof.
Background
In most areas, people are prone to various skin diseases with itching due to moist and hot weather. In addition, in some places with poor living environment and sanitary environment, various skin diseases are easy to get and cross-infection is caused, most skin diseases are odd and itchy, the patients are hard to scratch, the illness is aggravated, the patients are painful, and even work, study and rest are affected.
Many anti-inflammatory and antipruritic medicines are sold in the market, and the medicines are traditional Chinese medicines, western medicines, oral medicines and external medicines, but most of the medicines have unsatisfactory anti-inflammatory and antipruritic effects and side effects. Therefore, there is a need for an anti-inflammatory antipruritic drug with good efficacy.
Disclosure of Invention
In order to improve the drug effect, the application provides a traditional Chinese medicine composition for dispelling wind and relieving itching, a traditional Chinese medicine preparation and a preparation method thereof.
In a first aspect, the application provides a traditional Chinese medicine composition for dispelling wind and relieving itching, which adopts the following technical scheme:
a traditional Chinese medicine composition for dispelling wind and relieving itching comprises the following raw materials in parts by weight: 85-97 parts of divaricate saposhnikovia root, 25-40 parts of Chinese hawthorn, 85-95 parts of cicada slough, 22-35 parts of chinaroot greenbrier rhizome, 138-149 parts of cortex lycii radicis, 25-40 parts of cordyceps militaris, 25-40 parts of sugar additive, 102-118 parts of fructus forsythiae, 137-157 parts of flaxseed, 138-153 parts of angelica sinensis, 251-263 parts of rehmannia root, 52-67 parts of akebia stem, 88-96 parts of herba schizonepetae, 34-49 parts of liquorice, 12-33 parts of red ferrite, 13-42 parts of schisandra bee pollen, 9-19 parts of campsis grandiflora apigenin, 2-11 parts of hedyotis flavone, 21-35 parts of N-acetylneuraminic acid, 15-34 parts of herba scutellariae extract and 21-44 parts of octanoyl hydroxamic acid.
In the formula, the efficacy of each component is as follows:
the mackerel is the whole herb of the mackerel flower of the plant of the Ranunculaceae, has the effects of dispelling wind, relieving itching, cooling blood, removing toxin, and has better effects on influenza and skin prurigo, and the effects of dispelling wind, relieving itching, cooling blood, removing toxin and the like can be obtained by adding the mackerel into the formula.
Cordyceps militaris is a fungus for both food and medicine, the protein content of the Cordyceps militaris is up to 40.7%, and the contained amino acids necessary for human body are not only complete in variety and sufficient in quantity, but also proper in proportion, and also contain abundant vitamins, minerals and the like, so that the Cordyceps militaris has good nutritional value. In addition, the Cordyceps militaris contains rich cordycepic acid, cordycepin, ergosterol and the like, and has the function of resisting various bacteria. The cordyceps militaris can make the composition obtain abundant nutritional values in the formula, improve the immunity of organisms, and further improve the effects of dispelling wind and relieving itching.
The general Chinese herbal medicine has bitter taste and is difficult to swallow, and the sugar additive is added in the formula of the Chinese herbal medicine composition to reduce the bitter taste and improve the mouthfeel.
The saccharide additive is preferably a mixture of the xylo-oligosaccharide and the L-arabinose, and the xylo-oligosaccharide and the L-arabinose complement each other, so that the bitter taste of the traditional Chinese medicine is covered, the sweet taste is increased, the mouthfeel is improved, the xylo-oligosaccharide and the L-arabinose are not easy to absorb, and the L-arabinose also prevents the xylose from being absorbed, so that the saccharide additive is more suitable for hyperglycemia patients. Through scientific matching of the mixture ratio of the xylooligosaccharide and the L-arabinose, the bitter taste of the traditional Chinese medicine is improved, and the blood sugar is reduced.
Iron is an indispensable component of the body and forms part of hemoglobin, myoglobin, cytochromatin, and histones (cytochrome enzymes, cytochrome oxidases, peroxidases, thixotropic enzymes), etc., thereby imparting oxygen carrying and oxygen consuming functions to them. The heme iron is directly absorbed by intestinal mucosa epithelial cells in the form of porphyrin iron, so that the toxic and side effects and gastrointestinal irritation of chemical iron (such as ferrous sulfate) to human bodies are eliminated, and the iron can be absorbed by the human bodies more efficiently and safely. Therefore, the addition of heme iron promotes blood circulation and improves the absorption of traditional Chinese medicine components by the organism, thereby improving the drug effect.
The campsis grandiflora apigenin has the functions of removing stasis, dredging channels, cooling blood, dispelling wind, treating rubella, tinea, skin itch and the like.
The fructus lycii flavone is a strong antioxidant, can effectively remove oxygen free radicals in a human body, can inhibit full-stage overflow of grease peroxide, has the oxidation preventing capability which is more than ten times that of vitamin E, and can prevent degradation and aging of cells and improve the immunity of the human body. In addition, the fructus Tsaoko flavone can improve blood circulation, promote the absorption of Chinese medicinal components, and improve the medicinal effect.
The heme iron and the hedonia flavone cooperate to promote the absorption and conversion of the traditional Chinese medicine components, thereby improving the efficacy.
Preferably, the nutritional supplement comprises 38.1-54.3 parts of nutritional supplement, wherein the nutritional supplement comprises the following raw materials in parts by weight: 0.1-0.3 part of chitosan, 8-11 parts of grape seed powder, 20-27 parts of erythritol and 10-16 parts of fructo-oligosaccharide.
The nutritional additive comprises chitosan, grape seed powder, erythritol and fructo-oligosaccharide, and has effects of supplementing organism nutrition, promoting absorption, and enhancing immunity.
The fructo-oligosaccharide can obviously improve the microbial population proportion in the intestinal tract, is an activating multiplication factor of bifidobacteria in the intestinal tract, can reduce and inhibit the generation of putrefying substances in the intestinal tract, inhibit the growth of harmful bacteria and regulate the balance in the intestinal tract; can promote the absorption and utilization of trace elements such as iron and calcium so as to prevent osteoporosis; can reduce liver toxin, can generate anticancer organic acid in intestine, and has remarkable anticancer function.
Erythritol is a natural zero-calorie sweetener, has less effect on blood glucose, and also has antioxidant activity, somatosensory mouthfeel and body immunity.
The chitosan has strong antifungal effect, and can inhibit 32 fungi such as Botrytis, neurospora, and Alternaria. The chitosan concentration is preferably 100. Mu.g/mL or more, and exhibits excellent antifungal properties.
Grape seed powder is grape seed extract containing rich procyanidine, and has effects of resisting oxidation, resisting allergy, delaying skin aging, and inhibiting platelet aggregation and atherosclerosis.
The chitosan, grape seed powder, erythritol and fructo-oligosaccharide cooperate to realize the effects of supplementing nutrition to organisms, promoting absorption and improving immunity.
Preferably, the N-acetylneuraminic acid is 23-32 parts, the barbed skullcap herb extract is 17-31 parts, and octanoyl hydroxamic acid is 25-41 parts.
Preferably, the saccharide additive is a mixture of xylooligosaccharide and L-arabinose.
Preferably, the mass ratio of the xylooligosaccharide to the L-arabinose is (1-2) to (3-5). In the range of the proportion, the L-arabinose prevents xylose from being absorbed while realizing good taste.
Preferably, the medicine further comprises 76-124 parts of absorption promoting composition, wherein the absorption promoting composition comprises 12-19 parts of rhodiola rosea, 9-21 parts of radix puerariae, 13-17 parts of calyx kaki, 7-13 parts of dried orange peel, 11-17 parts of erythrina bark, 21-28 parts of spathi longa and 3-9 parts of jaundice.
Preferably, the rhodiola rosea is 15-18 parts, the kudzu root is 11-17 parts, the persimmon calyx is 14-16 parts and the medicine king stone is 4-8 parts.
The formula of the application also comprises an absorption promoting composition which comprises rhodiola rosea, kudzuvine root, dried persimmon calyx, dried orange peel, erythrina bark, compact flower beans and medicinal royal stones. Wherein, the liquid crystal display device comprises a liquid crystal display device,
rhodiola rosea: has effects in invigorating qi, clearing away lung-heat, astringing, stopping bleeding, dispelling blood stasis, and relieving swelling;
radix Puerariae: has effects in stabilizing blood sugar, stabilizing blood lipid and promoting metabolism;
dried orange peel: has effects of regulating qi-flowing, invigorating spleen, eliminating dampness and eliminating phlegm;
cortex Erythrinae has gray brown bark, pale yellow branch to yellowish brown, gray fuzz, black cone shape thorn, too long tip leaflet width, sharp and blunt tip, near truncated base or broad diamond shape, dark green upper surface, green lower surface, and sparse fuzz on both veins. Erythrina bark is bitter and pungent in flavor and neutral in nature. Has effects in dispelling pathogenic wind and dampness, dredging channels and collaterals, killing parasites, relieving itching, and inhibiting bacteria.
Medicinal Wangshi stone: contains a large amount of mineral elements required by human body, has high content of active magnet, and has health promotion effects of regulating physiological function and renal function of human body.
Meanwhile, rhodiola rosea, kudzuvine root, persimmon calyx and medicinal royal stones in the absorption promoting composition are mutually cooperated, so that the oxygen content in the body is improved, the blood circulation is promoted, and the absorption of active substances of the traditional Chinese medicine is improved. The pericarpium citri reticulatae, erythrina bark and spathic fungus are mutually cooperated to promote blood circulation to remove blood stasis, remove blood stasis in blood, and exclude the body through blood circulation.
Wherein, the medicine Wang Danke activates the inactive cells in the human body so as to increase the active cells, thereby enabling the blood circulation to be smooth and stable. The increase of active cells improves the absorption and metabolism of the medicine by human body.
The iron element of the medicinal royal stone has bivalence and trivalent, has the capability of obtaining electrons and donating electrons, and has stronger oxidation-reduction performance and electron transfer capability. After the active ingredients of the medicine Wangshi enter the human body, the lost electrons are transmitted to acidic substances in blood, so that the acidic substances are reduced to an alkaline state, the process that inactive cells are activated into active cells is completed, and the absorption capacity of the human body is improved. Meanwhile, the active ingredients of the Chinese herbal medicines are excited through the charge transfer of the active magnet, so that the medicine property is enhanced, and the absorption of the human body to nutrition and the metabolism of toxins are enhanced. The rhodiola rosea, the kudzuvine root, the persimmon calyx and the medicinal royal jelly are matched for use, so that the activating effect of the medicinal royal jelly is further enhanced, the oxygen content of cells is increased, the absorption of traditional Chinese medicine essence by the cells is promoted, the metabolism of endotoxin rubbish in blood is promoted, and the activity of the cells is improved.
In a second aspect, the application provides a traditional Chinese medicine preparation for dispelling wind and relieving itching, which adopts the following technical scheme:
a Chinese medicinal preparation for dispelling pathogenic wind and relieving itching comprises the Chinese medicinal composition.
In a third aspect, the application provides a preparation method of a traditional Chinese medicine composition for dispelling wind and relieving itching, which adopts the following technical scheme:
a preparation method of a traditional Chinese medicine composition for dispelling wind and relieving itching comprises the following steps:
(1) Taking, by weight, 85-97 parts of divaricate saposhnikovia root, 25-40 parts of Chinese hawthorn, 85-95 parts of cicada slough, delphinium, 138-149 parts of cortex lycii radicis, 25-40 parts of cordyceps militaris, 25-40 parts of sugar additives, 102-118 parts of fructus forsythiae, 137-157 parts of flaxseed, 138-153 parts of angelica sinensis, 251-263 parts of rehmannia, 52-67 parts of akebia stem, 88-96 parts of schizonepeta, 34-49 parts of liquorice and 13-42 parts of schisandra bee pollen, and adding water to boil to obtain a first liquid medicine;
(2) Adding 21-35 parts of N-acetylneuraminic acid, 15-34 parts of barbed skullcap herb extract and 21-44 parts of octanoyl hydroxamic acid into the first liquid medicine, and adding water for boiling to obtain a second liquid medicine;
(3) Adding 12-33 parts of red ferrite, 9-19 parts of campsis grandiflora apigenin and 2-11 parts of hedyotis diffusa flavone into the second liquid medicine, boiling, filtering to obtain filtrate, and concentrating the filtrate to obtain a paste preparation.
In summary, the application has the following beneficial effects:
1. the application is preferably prepared by matching herbal medicines, is natural, green, mild and healthy, has synchronous clearing and nourishing, can obviously realize the effects of dispelling wind and relieving itching, can improve immunity and improve taste, and has obvious efficacy.
2. The formula of the application is also added with the mixture of the xylooligosaccharide and the L-arabinose, which improves the taste of the traditional Chinese medicine and is more suitable for patients with hyperglycemia.
3. The formula of the application is added with nutritional components, which consist of chitosan, grape seed powder, erythritol and fructo-oligosaccharide, and has the effects of supplementing organism nutrition, promoting absorption and improving immunity.
4. The formula of the application is added with an absorption promoting composition, and the components of the composition comprise rhodiola rosea, kudzu root, calyx kaki, dried orange peel, erythrina bark, spaghetti and jaundice. The rhodiola rosea, the kudzuvine root, the persimmon calyx and the medicinal royal jelly in the absorption promoting composition are mutually synergistic, so that the oxygen content in the body is improved, the blood circulation is promoted, and the absorption of the active substances of the traditional Chinese medicine is improved. The pericarpium citri reticulatae, erythrina bark and spathic fungus are mutually cooperated to promote blood circulation to remove blood stasis, remove blood stasis in blood, and exclude the body through blood circulation.
Detailed Description
The present application will be described in further detail with reference to examples.
Example 1
The preparation method of the traditional Chinese medicine composition for dispelling wind and relieving itching comprises the following steps:
(1) 97g of divaricate saposhnikovia root, 40g of Chinese hawthorn, 95g of cicada slough, 35g of macula delphinii, 149g of cortex lycii radicis, 40g of cordyceps militaris, 40g of sugar additive, 118g of fructus forsythiae, 157g of flaxseed, 153g of Chinese angelica, 263g of rehmannia root, 67g of akebia stem, 96g of schizonepeta, 49g of liquorice and 42g of schisandra chinensis bee pollen are taken according to the weight ratio, and boiled in water to obtain first liquid medicine;
(2) Adding 35g of N-acetylneuraminic acid, 34g of barbed skullcap herb extract and 44g of octanoyl hydroxamic acid into the first liquid medicine, and adding water for boiling to obtain a second liquid medicine;
(3) Adding 33g of red ferrite, 19g of campsis grandiflora apigenin and 11g of fructus lycii flavone into the second liquid medicine, boiling, filtering to obtain filtrate, and concentrating into ointment.
Example 2
The preparation method of the traditional Chinese medicine composition for dispelling wind and relieving itching comprises the following steps:
(1) According to the weight ratio, 85g of divaricate saposhnikovia root, 25g of Chinese hawthorn, 85g of cicada slough, 22g of macula delphinii, 138g of cortex lycii radicis, 25g of cordyceps militaris, 25g of sugar additive, 102g of fructus forsythiae, 137g of flaxseed, 138g of Chinese angelica, 251g of rehmannia, 52g of akebia stem, 88g of schizonepeta, 34g of liquorice and 13g of schisandra chinensis bee pollen are boiled in water to obtain first liquid medicine;
(2) Adding 21g of N-acetylneuraminic acid, 15g of barbed skullcap herb extract and 21g of octanoyl hydroxamic acid into the first liquid medicine, and adding water for boiling to obtain a second liquid medicine;
(3) Adding 12g of red ferrite, 9g of campsis grandiflora apigenin and 2g of fructus lycii flavone into the second liquid medicine, boiling, filtering to obtain filtrate, and concentrating into ointment.
Example 3
The preparation method of the traditional Chinese medicine composition for dispelling wind and relieving itching comprises the following steps:
(1) 89g of divaricate saposhnikovia root, 30g of Chinese hawthorn, 89g of cicada slough, 5g of delphinium grandiflorum, 142g of cortex lycii radicis, 29g of cordyceps militaris, 27g of sugar additive, 109g of fructus forsythiae, 147g of flaxseed, 143g of Chinese angelica, 259g of rehmannia root, 55g of akebia stem, 89g of schizonepeta, 37g of liquorice and 32g of schisandra chinensis bee pollen are taken according to the weight ratio, and boiled in water to obtain first liquid medicine;
(2) Adding 28g of N-acetylneuraminic acid, 24g of barbed skullcap herb extract and 34g of octanoyl hydroxamic acid into the first liquid medicine, and adding water for boiling to obtain a second liquid medicine;
(3) Adding 23g of red ferrite, 12g of campsis grandiflora apigenin and 8g of fructus lycii flavone into the second liquid medicine, boiling, filtering to obtain filtrate, and concentrating into ointment.
Example 4
This embodiment differs from embodiment 1 in that: the nutritional additive comprises the following raw materials in parts by weight: 0.3g of chitosan, 11g of grape seed powder, 27g of erythritol and 16g of fructo-oligosaccharide.
Example 5
This embodiment differs from embodiment 1 in that: the nutritional additive comprises the following raw materials in parts by weight: 0.1g of chitosan, 8g of grape seed powder, 20g of erythritol and 10g of fructo-oligosaccharide.
Example 6
This embodiment differs from embodiment 1 in that: the nutritional additive comprises the following raw materials in parts by weight: 0.2g of chitosan, 9g of grape seed powder, 23g of erythritol and 15g of fructo-oligosaccharide.
Example 7
This embodiment differs from embodiment 1 in that: 32g of N-acetylneuraminic acid, 31g of barbed skullcap herb extract and 41g of octanoyl hydroxamic acid.
Example 8
This embodiment differs from embodiment 1 in that: 23g of N-acetylneuraminic acid, 17g of barbed skullcap herb extract and 25g of octanoyl hydroxamic acid.
Example 9
This embodiment differs from embodiment 1 in that: 25g of N-acetylneuraminic acid, 21g of barbed skullcap herb extract and 31g of octanoyl hydroxamic acid.
Example 10
This embodiment differs from embodiment 1 in that: the saccharide additive is a mixture of xylo-oligosaccharide and L-arabinose, and the mass ratio of the mixture of xylo-oligosaccharide and L-arabinose is 2g to 5g.
Example 11
This embodiment differs from embodiment 1 in that: the saccharide additive is a mixture of xylo-oligosaccharide and L-arabinose, and the mass ratio of the mixture of xylo-oligosaccharide and L-arabinose is 1g to 3g.
Example 12
This embodiment differs from embodiment 1 in that: the saccharide additive is a mixture of xylo-oligosaccharide and L-arabinose, and the mass ratio of the mixture of xylo-oligosaccharide and L-arabinose is 2g to 4g.
Example 13
This embodiment differs from embodiment 1 in that: the medicine also comprises an absorption promoting composition, wherein the absorption promoting composition comprises 19g of rhodiola rosea, 21g of kudzuvine root, 17g of persimmon calyx, 13g of dried orange peel, 17g of erythrina bark, 28g of spaghetti and 9g of medicine king stone.
Example 14
This embodiment differs from embodiment 1 in that: the medicine also comprises an absorption promoting composition, wherein the absorption promoting composition comprises 12g of rhodiola rosea, 9g of kudzuvine root, 13g of persimmon calyx, 7g of dried orange peel, 11g of erythrina bark, 21g of spaghetti and 3g of medicine king stone.
Example 15
This embodiment differs from embodiment 1 in that: the medicine also comprises an absorption promoting composition, wherein the absorption promoting composition comprises 15g of rhodiola rosea, 11g of kudzuvine root, 14g of persimmon calyx, 9g of dried orange peel, 16g of erythrina bark, 25g of spaghetti and 4g of medicine king stone.
Example 16
This embodiment differs from embodiment 15 in that: the filtrate is not concentrated, and the rhodiola rosea is 18g, the kudzuvine root is 17g, the persimmon calyx is 16g and the medicine Wangshi is 8 g.
Example 17
This embodiment differs from embodiment 15 in that: the filtrate is not concentrated, and the rhodiola rosea 15g, the kudzuvine root 11g, the persimmon calyx 14g and the medicine Wangshi 4g are prepared.
Example 18
This embodiment differs from embodiment 15 in that: 16g of rhodiola rosea, 15g of kudzuvine root, 15g of persimmon calyx and 6g of medicine Wangshi, and the filtrate is not concentrated.
Comparative example 1
The difference from example 10 is that no saccharide additive was added.
Comparative example 2
The difference from example 16 is that rhodiola root is not included.
Comparative example 3
The difference from example 16 is that kudzuvine root is not included.
Comparative example 4
The difference from example 16 is that the calyx kaki is not included.
Comparative example 5
The difference from example 16 is that the medicinal royal jelly is not included.
Performance and efficacy testing:
1. experiment of drug efficacy
Case one
Li Mou female, 40 years old. The itching is the most serious at night after two years of facial eczema, bleeding and pain occur when the itching is grasped by hands, the mometasone furoate emulsifiable paste has no effect during the period, and the ointment of the embodiment 1 of the traditional Chinese medicine is applied for curing after 5 days.
Case two
Wang Mou female, 38 years old. The itching is most serious at night when the facial eczema is suffered from one year and half, the itching is scratched by hands, bleeding and pain occur, the mometasone furoate cream is not effective in the period, the ointment of the embodiment 2 of the traditional Chinese medicine is applied, and the skin is cured after 5 days.
Case three
Li Mou Male, 32 years old. The itching is the most serious at night after two years of facial eczema, bleeding and pain occur when the itching is grasped by hands, the mometasone furoate emulsifiable paste is not effective in the period, and the ointment of the embodiment 3 of the traditional Chinese medicine is applied for curing after 5 days.
Case four
Li Mou female, 40 years old. The ointment of the embodiment 4 of the traditional Chinese medicine is applied for 4 days, and the facial eczema is cured, and the face is ruddy, good in gas color and good in mental state.
Case five
Zhou Mou Male, 29 years old. The ointment of the example 5 of the traditional Chinese medicine is applied for 3 days, and the facial eczema heals, and the face is ruddy, good in gas color and good in mental state.
Case six
Li Mou female, 33 years old. The ointment of the example 6 is applied for 2 days, and the facial eczema is cured, and the face is ruddy, good in gas color and good in mental state.
Case seven
Dai Mou Male, 41 years old. The ointment of the example 7 of the traditional Chinese medicine is applied for 3 days, and the facial eczema is cured, and the face is ruddy and has good gas color.
Case eight
Li Mou female, 40 years old. The ointment of the example 8 of the traditional Chinese medicine is applied for 3 days, and the facial eczema is cured, and the face is ruddy and has good gas color.
Case nine
He Mou Male, 29 years old. The itching is most serious at night after the face eczema is suffered from year, the itching is scratched by hands, bleeding and pain occur, the mometasone furoate cream is not effective during the period, the ointment of the embodiment 9 of the traditional Chinese medicine is applied, the face eczema is healed after 2 days, the face is ruddy, and the qi color is good.
Case ten
Zhang Mou female, 35 years old. The ointment of the example 13 is applied for 2 days, and the facial eczema is cured, and the face is ruddy and has good gas color.
Case eleven
Wu Mou female, 37 years old. The itching is the most serious at night after two years of facial eczema, bleeding and pain occur when the itching is grasped by hands, the mometasone furoate emulsifiable paste is not effective in the period, the ointment of the embodiment 14 of the traditional Chinese medicine is applied for 2 days and a half of the time, the facial eczema is healed, the face is ruddy, and the gas color is good.
Twelve cases of cases
Lin Mou Male, 29 years old. The itching is the most serious at night after two years of facial eczema, bleeding and pain occur when the itching is grasped by hands, the mometasone furoate emulsifiable paste is not effective in the period, the ointment of the embodiment 14 of the traditional Chinese medicine is applied for 2 days and a half of the time, the facial eczema is healed, the face is ruddy, and the gas color is good.
The experiment shows that the traditional Chinese medicine has good effects of dispelling wind and relieving itching, and can improve nutrition and improve health and mental state. The results of the cases ten, eleven and twelve show that the addition of the absorption promoting composition is beneficial to the absorption of the traditional Chinese medicine components and the realization of the drug effect.
2. Interaction experiment of rhodiola rosea, kudzuvine root, persimmon calyx and medicine king stone:
experiment design: 27 patients suffering from transient cerebral ischemia (9 groups of 3 persons each) were given the traditional Chinese medicines prepared in examples 16, 17, 18 and comparative examples 2, 3, 4, 52 times a day, 10mL each time, and after 30 days of administration, parameters of blood were measured and the average value was found, and the results are shown in table 1.
TABLE 1
As can be seen from the results in the table, the patients in the examples 15, 16, 17 and 18 show a significantly reduced viscosity and red blood cell electrophoresis time compared with the blood in the example 1 after taking the traditional Chinese medicine liquid in the patent, and the round platelet content is significantly increased, which indicates that the absorption promoting composition has a better effect of promoting blood circulation and improving the absorption of the active substances of the traditional Chinese medicine. Compared with example 15, the patients in example 16, example 17 and example 18 have obviously reduced or decreased round platelet content, which indicates that the proportion of rhodiola rosea, kudzu root, calyx kaki and medicinal king stone has influence on the effect. The example 16, the example 17 and the example 18 all show larger reduction or decrease amplitude and larger increase amplitude of the round platelet content compared with the comparative example 2, the comparative example 3, the comparative example 4 and the comparative example 5, which indicates that the rhodiola rosea, the kudzuvine root, the persimmon calyx and the medicine king stone are mutually cooperated, and the improvement of the medicine effect is promoted.
3. Sensory testing
The oral liquid prepared in example 10, example 11, example 12 and comparative example 1 was taken for 3 patients with hyperglycemia containing eczema, respectively, and taken for 2 times a week, 10mL each time, and the tasting results are shown in Table 2 below.
TABLE 2
As can be seen from the results in the table, the traditional Chinese medicine liquid of the example 10, the example 11 and the example 12 have sweet taste, no bitter and astringent taste and good taste compared with the traditional Chinese medicine liquid of the comparative example 2. Meanwhile, the blood sugar levels of examples 10, 11 and 12 were lower than those of example 1, indicating that the mixture of xylooligosaccharide and L-arabinose was not absorbed by the body, but rather had a decreasing effect.
The present embodiment is only for explanation of the present application and is not to be construed as limiting the present application, and modifications to the present embodiment, which may not creatively contribute to the present application as required by those skilled in the art after reading the present specification, are all protected by patent laws within the scope of claims of the present application.

Claims (9)

1. A traditional Chinese medicine composition for dispelling wind and relieving itching is characterized in that: the material comprises the following raw materials in parts by weight: 85-97 parts of divaricate saposhnikovia root, 25-40 parts of Chinese hawthorn, 85-95 parts of cicada slough, 22-35 parts of chinaroot greenbrier rhizome, 138-149 parts of cortex lycii radicis, 25-40 parts of cordyceps militaris, 25-40 parts of sugar additive, 102-118 parts of fructus forsythiae, 137-157 parts of flaxseed, 138-153 parts of angelica sinensis, 251-263 parts of rehmannia root, 52-67 parts of akebia stem, 88-96 parts of herba schizonepetae, 34-49 parts of liquorice, 12-33 parts of red ferrite, 13-42 parts of schisandra bee pollen, 9-19 parts of campsis grandiflora apigenin, 2-11 parts of hedyotis flavone, 21-35 parts of N-acetylneuraminic acid, 15-34 parts of herba scutellariae extract and 21-44 parts of octanoyl hydroxamic acid.
2. The traditional Chinese medicine composition for dispelling wind and relieving itching according to claim 1, which is characterized in that: also comprises 38.1-54.3 parts of nutrition additive.
3. The traditional Chinese medicine composition for dispelling wind and relieving itching according to claim 2, which is characterized in that: the nutrition additive comprises the following raw materials in parts by weight: 0.1-0.3 part of chitosan, 8-11 parts of grape seed powder, 20-27 parts of erythritol and 10-16 parts of fructo-oligosaccharide.
4. The traditional Chinese medicine composition for dispelling wind and relieving itching according to claim 1, which is characterized in that: the saccharide additive is a mixture of xylooligosaccharide and L-arabinose.
5. The traditional Chinese medicine composition for dispelling wind and relieving itching according to claim 4, wherein the traditional Chinese medicine composition is characterized in that: the mass ratio of the xylooligosaccharide to the L-arabinose is (1-2) to (3-5).
6. The traditional Chinese medicine composition for dispelling wind and relieving itching according to claim 1, which is characterized in that: 76-124 parts of absorption-promoting composition are also included.
7. The traditional Chinese medicine composition for dispelling wind and relieving itching according to claim 6, wherein the traditional Chinese medicine composition is characterized in that: the promoting composition comprises 12-19 parts of rhodiola rosea, 9-21 parts of radix puerariae, 13-17 parts of calyx kaki, 7-13 parts of dried orange peel, 11-17 parts of erythrina bark, 21-28 parts of spaghetti and 3-9 parts of medicinal royal jelly.
8. A traditional Chinese medicine preparation for dispelling wind and relieving itching is characterized in that: comprising the Chinese medicinal composition of any one of claims 1-7.
9. The method for preparing the traditional Chinese medicine composition for eliminating wind and relieving itching according to any one of claims 1 to 7, which is characterized in that: the method comprises the following steps:
(1) Taking, by weight, 85-97 parts of divaricate saposhnikovia root, 25-40 parts of Chinese hawthorn, 85-95 parts of cicada slough, 22-35 parts of delphinium grandiflorum, 138-149 parts of cortex lycii radicis, 25-40 parts of cordyceps militaris, 25-40 parts of sugar additives, 102-118 parts of fructus forsythiae, 137-157 parts of flaxseed, 138-153 parts of Chinese angelica, 251-263 parts of rehmannia root, 52-67 parts of akebia stem, 88-96 parts of schizonepeta, 34-49 parts of liquorice and 13-42 parts of schisandra chinensis bee pollen, and boiling the mixture with water to obtain a first liquid medicine;
(2) Adding 21-35 parts of N-acetylneuraminic acid, 15-34 parts of barbed skullcap herb extract and 21-44 parts of octanoyl hydroxamic acid into the first liquid medicine, and adding water for boiling to obtain a second liquid medicine;
(3) Adding 12-33 parts of red ferrite, 9-19 parts of campsis grandiflora apigenin and 2-11 parts of hedyotis diffusa flavone into the second liquid medicine, boiling, and filtering to obtain a filtrate.
CN202310776351.0A 2023-06-28 2023-06-28 Traditional Chinese medicine composition and traditional Chinese medicine preparation for dispelling wind and relieving itching and preparation method thereof Pending CN116585395A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101822747A (en) * 2009-09-02 2010-09-08 烟台大洋制药有限公司 Sugar-free wind-eliminating and itching-relieving granule
CN115487268A (en) * 2022-09-30 2022-12-20 广州聚缘堂丹道药业科技有限公司 A composition for promoting blood circulation and toxin metabolism, and its preparation method

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101822747A (en) * 2009-09-02 2010-09-08 烟台大洋制药有限公司 Sugar-free wind-eliminating and itching-relieving granule
CN115487268A (en) * 2022-09-30 2022-12-20 广州聚缘堂丹道药业科技有限公司 A composition for promoting blood circulation and toxin metabolism, and its preparation method

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