CN112006136A

CN112006136A - Double-ginseng and dendrobium tea for improving abnormal blood sugar and preparation method thereof

Info

Publication number: CN112006136A
Application number: CN202010979129.7A
Authority: CN
Inventors: 傅松涛; 焦宝元
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-09-17
Filing date: 2020-09-17
Publication date: 2020-12-01

Abstract

The invention discloses a dendrobium candidum tea for improving blood sugar abnormality, which comprises 25-1000 parts of tea leaves, 1-100 parts of American ginseng, 1-100 parts of dendrobium, 3-150 parts of astragalus membranaceus, 3-150 parts of radix puerariae, 5-150 parts of wolfberry, 1-50 parts of pollen, 5-50 parts of lily, 5-100 parts of Chinese yam, 5-100 parts of poria cocos, 3-100 parts of dogwood, 5-100 parts of angelica sinensis, 1-50 parts of lucid ganoderma, 3-50 parts of sea buckthorn, 5-200 parts of bitter gourd, 5-100 parts of corn stigma, 5-100 parts of polygonatum, 5-100 parts of rhizoma polygonati, 5-200 parts of mulberry leaves and 0.1-8 parts of chromium picolinate. The invention also discloses a preparation method of the double-ginseng dendrobium tea for improving abnormal blood sugar. The tea disclosed by the invention is added with medicinal and edible components and trace elements such as American ginseng, ginseng and dendrobium, and has the advantages of convenience and pleasure in drinking, safety, effectiveness and the like.

Description

Double-ginseng and dendrobium tea for improving abnormal blood sugar and preparation method thereof

Technical Field

The invention belongs to the technical field of processing of medicinal and edible seasoning tea, and particularly relates to a double-ginseng and dendrobe tea for improving abnormal blood sugar and a preparation method thereof.

Background

Diabetes is a common, frequent, lifelong, but controllable disease.

The diabetes is controlled by comprehensive treatment methods such as diet control, emotion regulation, proper exercise, drug regulation and the like. However, because people are not aware of the conditions of diabetes treatment, and are misled by some unrealistic advertisements, the requirements of some patients on diabetes treatment are too high, so that regular treatment is abandoned, a bias is sought, the disease control is affected, and even the life is threatened.

The traditional Chinese medicine is used for treating diabetes, and emphasizes good indications of developing strong points and avoiding weak points. In terms of the effect of reducing blood sugar, the traditional Chinese medicine is generally not as fast as western medicines, but the traditional Chinese medicine focuses on integral regulation and control, and is obviously superior to the western medicines in the aspect of improving symptoms, so that the traditional Chinese medicine is particularly suitable for non-insulin-dependent patients (namely type II diabetes) or patients with chronic vascular nerve complications.

Researches find that some traditional Chinese medicines have obvious improvement effect on insulin resistance, have no obvious toxic or side effect and have good clinical curative effect. For example, the polysaccharide in the tea can effectively control the rise amplitude of postprandial blood sugar, improve the glucose tolerance and improve the lipid metabolism disorder; extracts of american ginseng have been shown to act on islet beta cells by altering cellular metabolism, increasing insulin secretion, and decreasing apoptosis; the ginseng and the main components thereof can enhance the function of islet cells and weaken the resistance of insulin; polysaccharide and flavonoid carbohydrate contained in the dendrobium officinale have pharmacological activity of reducing blood sugar; the astragalus has the main pharmacological actions of tonifying qi and strengthening exterior, can promote diuresis and has obvious prevention effect on insulin resistance caused by exogenous tumor necrosis factors; radix Puerariae contains flavonoids and polysaccharides, has effects of reducing blood glucose, nourishing body, resisting aging, lowering blood pressure, reducing blood glucose, reducing blood lipid, increasing skin elasticity, caring skin, and promoting secretion of islet beta cell, and has slow and lasting effect.

According to the national supply and marketing headquarters seasoning tea industry standard GH/T1247-2019, the seasoning tea is a product which is prepared by adding a proper amount of other food raw materials and/or food additives into tea serving as a raw material and is drunk by people in a brewing (soaking or boiling) mode. At present, less tea is drunk for daily health care of people with type II diabetes, and the invention aims to develop a seasoning tea product for reducing insulin resistance and improving abnormal blood sugar for people with type II diabetes by applying medicinal and edible components.

Disclosure of Invention

The purpose of the invention is as follows: the invention aims at solving the problems in the prior art, and discloses a Shuangshen dendrobe tea for improving abnormal blood sugar and a preparation method thereof. The invention takes tea as a main body and a carrier, takes extracts of traditional Chinese medicines which are homologous in medicine and food, such as American ginseng, dendrobium, astragalus, kudzu root, medlar, and the like as functional raw materials, and simultaneously adds trace element chromium to improve abnormal blood sugar.

The technical scheme is as follows: the ginseng-dendrobium tea for improving abnormal blood sugar comprises the following components in parts by weight:

25-1000 parts of tea, 1-100 parts of American ginseng, 1-100 parts of dendrobium, 3-150 parts of astragalus membranaceus, 3-150 parts of kudzu vine roots, 5-150 parts of medlar, 1-50 parts of pollen, 5-50 parts of lily, 5-100 parts of Chinese yams, 5-100 parts of poria cocos, 3-100 parts of dogwoods, 5-100 parts of angelica sinensis, 1-50 parts of lucid ganoderma, 3-50 parts of sea-buckthorns, 5-200 parts of bitter gourds, 5-100 parts of corn stigma, 5-100 parts of polygonatum odoratum, 5-100 parts of polygonatum sibiricum, 5-200 parts of mulberries, 5-200 parts of mulberry leaves and 0.1-8 parts of chromium picolinate.

Further, comprising:

600 parts of tea, 50 parts of American ginseng, 20 parts of dendrobium, 100 parts of astragalus membranaceus, 100 parts of kudzu vine root, 100 parts of Chinese wolfberry, 30 parts of pollen, 30 parts of lily, 50 parts of Chinese yam, 50 parts of poria cocos, 50 parts of dogwood, 50 parts of angelica sinensis, 30 parts of lucid ganoderma, 20 parts of sea-buckthorn, 100 parts of bitter gourd, 50 parts of corn stigma, 50 parts of polygonatum odoratum, 50 parts of rhizoma polygonati, 100 parts of mulberry leaf and 7 parts of chromium picolinate.

Furthermore, the tea is prepared by compounding one or more of green tea, white tea, yellow tea, oolong tea, black tea and dark tea.

A preparation method of double-ginseng dendrobium tea for improving abnormal blood sugar comprises the following steps:

(1) preparing a first filtrate:

(11) weighing American ginseng, dendrobium, astragalus, pollen, dogwood and lucid ganoderma according to the formula ratio, selecting, screening and cleaning impurities, and then placing the mixture into an extraction container;

(12) and leaching for the first time:

adding 15-85% V/V ethanol water solution with the volume 5-25 times that of the extraction container, leaching for 4-240 hours at the temperature of 15-75 ℃, filtering, and collecting leaching liquor;

(13) and leaching for the second time:

adding 15-85% V/V ethanol water solution with the volume of 3-20 times that of the extraction container, soaking for 12-96 hours at the temperature of 15-75 ℃, filtering, and collecting leaching liquor;

(14) and leaching for the third time:

(15) combining the leaching liquor obtained in the steps (12) to (14), naturally cooling to normal temperature, standing for 8-96 hours in an environment at 1-10 ℃, collecting supernatant, filtering by using a filter material with a pore size of 0.1-1.0 micron, and collecting filtrate to obtain first filtrate;

(2) preparing a second filtrate

(21) Weighing the kudzu root, the medlar, the lily, the yam, the tuckahoe, the angelica, the balsam pear, the corn stigma, the polygonatum, the rhizoma polygonati, the mulberry leaf and the sea buckthorn according to the formula ratio, selecting, screening and cleaning impurities, and then placing the mixture in an extraction container;

(22) and first decoction:

adding 8-30 times of water into an extraction container, soaking for 0.5-5 hours, heating to boil, decocting for 0.5-4.5 hours, filtering, and collecting filtrate;

(23) and carrying out second decoction:

adding 6-25 times of water into an extraction container, decocting for 0.5-1.5 hours, filtering, and collecting filtrate;

(24) and decocting for the third time:

(25) combining the three filtrates collected in the steps (22) to (24), filtering the three filtrates by using a 30-300-mesh filter screen, centrifuging 300-1200 g of the filtrates to remove fine precipitates, concentrating the supernatant under reduced pressure at 55-95 ℃ and-0.05-0.1 MPa, and concentrating the concentrate into a concentrated solution with the relative density of 1.05-1.25;

(3) adding 90% V/V ethanol water solution with the volume of 1-8 times of that of the concentrated solution obtained in the step (2) at the temperature of 15-65 ℃, fully stirring, naturally cooling to normal temperature, standing for 4-96 hours at the temperature of 1-10 ℃, collecting supernatant, filtering the supernatant through a filter material with the pore diameter of 0.1-1.0 micron, and collecting filtrate;

fourthly, combining the first filtrate obtained in the step (1) and the filtrate obtained in the step (3), fully mixing the two filtrates, concentrating the mixture under reduced pressure at 55-95 ℃ and-0.05-0.1 MPa, and concentrating the filtrate to the volume of a concentrated solution: the feeding amount of the raw materials is 1 (1-4), and a concentrated solution is obtained, wherein:

the volume of the concentrated solution is measured by milliliter, and the feeding amount of the raw materials is measured by gram;

fifthly, weighing the picked tea leaves, flatly paving the tea leaves in a baking pan, wherein the paving thickness is 1-8 cm, and placing the baking pan paved with the tea leaves in a baking oven for ventilation baking at 65-120 ℃ for 0.5-5 hours;

sixthly, fully dissolving chromium picolinate according to the formula amount by using pure water with the volume being 10-500 times of that of the chromium picolinate, adding the dissolved chromium picolinate into the concentrated solution obtained in the step (4), fully stirring and uniformly mixing, spraying the mixture onto tea leaves in a baking pan for 2-20 times, fully stirring to enable liquid medicine to be fully immersed into the tea leaves,

wherein, between two adjacent spraying, the tea is continuously aired and baked for 1-8 hours at 65-120 ℃, and the materials are turned over once every 10-60 minutes;

and (2) after the concentrated solution obtained in the step (4) is completely mixed with tea leaves, fully stirring the mixture to enable the liquid medicine to be completely immersed in the tea leaves, continuously baking the mixture for 1 to 8 hours at 65 to 120 ℃ in a ventilating way, turning the materials once every 10 to 60 minutes until the mixture is dry and slightly pungent in the beginning, grasping the tea leaves to enable the tea leaves to be elastic and conglobate, and slightly touching the tea leaves in the tea ball to enable the tea leaves to be scattered, so that the dendrobium officinale tea for improving the blood sugar abnormality is prepared.

Further, the method also comprises the step (8): and (3) further weighing the double-ginseng dendrobium tea for improving abnormal blood sugar obtained in the step (7), packaging the tea by using a gauze bag, a filter paper bag or an aluminum plastic bag, subpackaging the tea with the specification of 1-5000 g/bag, and preparing the double-ginseng dendrobium tea for improving abnormal blood sugar in an independent package.

Further, in the reduced pressure concentration process of the step (4), ethanol is recovered at the same time.

Further, the tea in the step (5) is prepared by compounding any one or more of green tea, white tea, yellow tea, oolong tea, black tea and black tea.

Compatibility: the invention takes tea leaves as a main body and a carrier, takes extracts of medicinal and edible food materials such as American ginseng, dendrobium and the like as auxiliary functional components and flavoring agents, and adds a trace element trivalent chromium (chromium picolinate) to prepare the material-added double-ginseng dendrobium tea for reducing insulin resistance and improving abnormal blood sugar, and the material-added double-ginseng dendrobium tea can be safely drunk for a long time.

Tea leaf: the experimental research finds that the tea has the function of reducing blood sugar. The tea can inhibit the activity of a glucose transporter in small intestinal epithelial cells, and achieves the effect of reducing blood sugar by reducing the intake of glucose in food; it is also shown that the oxidative damage of DNA in lymphocyte is reduced after the diabetic takes tea, i.e. tea can also relieve the diabetic condition by the function of antioxidation. The researches of scholars at home and abroad find that the polysaccharide in the tea can effectively control the postprandial blood sugar rise amplitude, improve the glucose tolerance and improve the lipid metabolism disorder, wherein the soluble polysaccharide is superior to the insoluble polysaccharide. Tea polyphenols in folium Camelliae sinensis can delay the progress of diabetes by resisting oxidation, enhancing the scavenging of active oxygen free radical and hydroxyl free radical, regulating lipid metabolism, and resisting lipid peroxidation. The tea pigment has effects of reducing cholesterol and triglyceride, and increasing high density lipoprotein, so it can be used for preventing and treating diabetes complications such as cardiovascular disease, cerebrovascular disease, and atherosclerosis. In addition, the tea soup also contains the following components for preventing sugar metabolism disturbance: such as vitamin B₁Pantothenic acid, dithiooctanoic acid, etc. are components constituting sugar metabolizing enzyme in body, and have therapeutic effect on preventing sugar metabolism disorder.

American ginseng: has the effects of invigorating qi, nourishing yin, clearing heat, promoting fluid production, and protecting nervous system, cardiovascular system, endocrine system, etc. The research proves that the American ginseng and the prepared American ginseng both have the effects of reducing blood sugar, can obviously improve the blood lipid metabolic disturbance of the type 2 diabetes, can lower the level of inflammatory factors, can relieve the pathological damage of islet beta cells, can promote the secretion of insulin, can enhance the sensitivity of tissues to the insulin, has obvious protective effect on the type 2 diabetes, and also is a dose-dependent process in the whole process. The prepared American ginseng can obviously reduce the fasting blood sugar, the serum total cholesterol, the interleukin-6 and the tumor necrosis factor-alpha content, increase the activities of catalase and glutathione peroxidase of liver tissues and the like, and has the effects of reducing blood sugar, resisting inflammation and resisting oxidation which are superior to the American ginseng.

Ginseng: researches find that the effect of ginseng and the main components thereof on diabetes mainly passes through two ways: one is to enhance the action of islet cells, and the other is to decrease insulin resistance. This led us to believe that ginseng acted in both type two and type one diabetes. The lack of insulin is linked to the decreased production of ATP, while the ginseng extract increases the production of ATP and, in turn, insulin. The ginseng extract reduces the content of mitochondrial UCP-2 protein, which has a negative regulatory effect on insulin secretion, while ATP is increased. In addition to affecting insulin secretion, ginseng extract acts on various glucose receptors and produces an anti-lipolysis effect, thereby lowering blood glucose levels. In conclusion, the ginseng extract can enhance insulin secretion by regulating cell metabolism. In addition, ginseng can prevent oxidative stress, reduce oxidative damage caused by hydrogen peroxide and enhance the protection of catalase and superoxide dismutase in a dose-dependent manner, and thus can be used to remove excess free radicals generated in a diabetic environment. Recent studies have shown that ginseng also has antioxidant properties in specific cells and tissues. Such as islet beta cells, adipose tissue, muscle tissue, and the like. Metabolites of ginseng can reduce insulin resistance in fat and muscle tissues.

Dendrobe: has effects of nourishing yin and clearing heat, and can be used for adjuvant treatment of diabetes. Modern researches prove that the dendrobium officinale contains active ingredients such as polysaccharide, amino acid and alkaloid and has the effects of resisting oxidation, tumors, aging, regulating immunity, reducing blood sugar and the like. Researches show that the extract of the stem and root parts of the dendrobium officinale has the effect of improving the condition of a type II diabetes model mouse, so that certain substances with biological activity in the dendrobium officinale are supposed to be related to the improvement of the sensitivity of a receptor to insulin and the improvement of the pancreatic islet function. The research also finds that polysaccharide, flavonoid carbohydrate and the like contained in the dendrobium officinale have pharmacological activity of reducing blood sugar.

Astragalus root: the main pharmacological actions are ' tonifying qi and consolidating superficial resistance ', promoting diuresis ' and ' expelling toxin and promoting granulation '. Has obvious prevention effect on insulin resistance caused by exogenous tumor necrosis factor, and may be related to reducing blood antagonistic hormone level and increasing tissue glycogen synthesis. The research on the effect of the astragalus extract on the hyperglycemic mice shows that: the blood glucose level of mice in the high-sugar high-fat + astragalus extract group was significantly lower than that in the high-sugar high-fat group (P < 0.05); compared with a normal control group, the sizes of the liver and the kidney of the mice in the high-sugar and high-fat group are slightly increased (P < 0.05); compared with the high-sugar high-fat group, the sizes of the liver and the kidney of the mice in the high-sugar high-fat and astragalus extract group are slightly reduced (P is less than 0.05), which proves that the astragalus extract can obviously reduce the blood sugar level of the mice with hyperglycemia and has a certain influence on the visceral organs of the mice.

Kudzu root: radix Puerariae contains flavonoids and high sugar-containing hypoglycemic substances, and has effects of nourishing body, strengthening body constitution, resisting aging, lowering blood pressure, lowering blood sugar, reducing blood lipid, increasing skin elasticity, and caring skin. Experimental research shows that the puerarin preparation mainly promotes the secretion of islet beta cells, has slow and lasting effect, can improve the blood sugar control condition of type 2 diabetes by intravenous drip, and increases the sensitivity of an organism to insulin.

Medlar: the dried Chinese wolfberry fruits contain carotene, amino acids, trace minerals, vitamins, fatty acids, polysaccharides and bioactive components related to health of betaine, and the Chinese wolfberry fruits are reported to have multiple pharmacological functions, such as blood sugar and serum lipid reduction, eye, kidney and liver nourishing, radiation resistance, immunity improvement, aging resistance, cancer resistance, fatigue resistance, hematopoiesis enhancement, male sterility improvement and the like. Research proves that the obvious blood sugar reducing effect and the tendency of improving the serum insulin (Ins) level of the Chinese medicinal wolfberry fruit are realized by repairing islet cells and promoting the regeneration function of islet beta cells. The polysaccharide LBP in the medlar has good hypoglycemic effect, has protective effect on the function of islet cells in early stage of type 2 diabetes, and also has prevention effect on diabetic complications.

Pollen: has effects in clearing away heat, purging pathogenic fire, promoting salivation, quenching thirst, relieving swelling, and expelling pus. The literature reports that the trichosanthes root and the extract thereof have obvious effect on improving various symptoms of diabetes and complications thereof. The agglutinin, protein and alcohol extract have therapeutic effect on diabetes, and are the main antidiabetic active ingredients of radix Trichosanthis. In vitro tests show that the three trichosanthin lectins have insulin-like effects, which indicates that the trichosanthin lectins have insulin-like effects of resisting lipolysis, promoting liposynthesis and the like; the trichosanthin can obviously reduce the severity of the insulin of the NOD mice and obviously reduce the incidence of diabetes.

Chinese yam: the polysaccharide contained in the Chinese yam can obviously reduce the blood sugar of a model-making rat, and the Chinese yam polysaccharide with large dose has more obvious blood sugar reduction, and the blood sugar reduction effect and the dose of the Chinese yam polysaccharide have a certain relation. The mechanism of action may be related to increasing insulin secretion, improving damaged beta cell function of pancreatic islets, and scavenging excessive free radicals. In addition, researches show that the Chinese yam extract can stabilize the blood sugar of patients with diabetic enteropathy and improve the intestinal function. In addition, rhizoma Dioscoreae can reduce blood sugar and blood lipid, and increase glycogen and myocardial glycogen content.

Tuckahoe, poria cocos: sweet, bland and neutral in nature, enter heart, spleen and kidney meridians. The polysaccharides contained in Poria can increase the activity of superoxide dismutase (T-SOD and Cu-SOD) in blood serum and reduce the content of Malondialdehyde (MDA), thereby inhibiting lipid peroxidation activity and resisting oxidation. Experiments show that pachymaran can reduce the rise of blood sugar of rats induced by alloxan, and simultaneously resist lipid peroxidation, which suggests that the blood sugar reducing mechanism of pachymaran may be related to inhibiting the generation of active oxygen free radicals in vivo and reducing the damage of islet beta cells.

Dogwood fruit: the fresh Corni fructus pulp contains monosaccharide, polysaccharide, organic acid, glycosides, iridoids, saponin, flavone, anthraquinone, steroid, triterpene, lactone, etc. Research shows that the dogwood has the functions of regulating immunity, reducing blood sugar, resisting oxidation, resisting cancer and the like. Research shows that the dogwood ethanol extracting solution can reduce the blood sugar level of a rat with non-insulin dependent diabetes mellitus (NIDDM), accelerate the glucose uptake and utilization of peripheral tissues, increase the blood insulin level, and pathological sections show the islet repair hyperplasia. In vitro experiments prove that the alcohol extract of the dogwood has the effect similar to that of insulin on phosphoenolpyruvate carboxykinase, can reduce the expression of gluconeogenic genes of liver, protect pancreas beta cells from being damaged by toxic substances and improve insulin secretion.

Chinese angelica: has effects in promoting blood circulation and relieving pain. Research shows that angelica can reduce the oxidative stress of the kidney of a diabetic rat, improve the renal function of diabetic nephropathy and prevent and inhibit the development of glomerular sclerosis and interstitial fibrosis, thereby delaying the development of diabetic nephropathy. The contained angelica polysaccharide can obviously increase the level of high-density lipoprotein, effectively reduce blood sugar and glycosylated hemoglobin, triglyceride, total cholesterol and low-density lipoprotein, and the blood sugar reduction mechanism of the angelica polysaccharide can be realized by improving the redistribution of blood fat and fatty acid.

Fragrant solomonseal rhizome: has the effects of nourishing yin, moistening dryness, promoting the production of body fluid and quenching thirst. It is said from Ben Cao Zheng Yi that it is effective for treating the symptoms of stomach fire exuberance, dryness and thirst, food consumption, polyphagia and hunger. The modern pharmacological research shows that the polygonatum has the effects of reducing blood sugar, improving immunity, improving cardiovascular system, resisting tumor, resisting aging and the like. The polygonatum odoratum polysaccharide separated from the polygonatum odoratum aqueous extract has an obvious blood sugar reducing effect and is in a good dose-effect relationship; 3 steroidal glycosides compounds (SG-100, SG-280 and SG-460) separated from polygonatum can effectively reduce the blood sugar of diabetic rats, the blood sugar level of an SG-100 administration group is reduced to the maximum extent, and the insulin secretion is not changed while the blood sugar is reduced.

Lily: has the effects of nourishing yin, moistening lung, clearing away heart-fire and tranquilizing mind. Modern pharmacological research shows that lily has the functions of resisting tumor, lowering blood sugar, regulating immunity, resisting fatigue, etc. Research shows that the lily polysaccharide has obvious blood sugar reducing function on diabetes model mice induced by alloxan and is in dose-effect relationship.

Sea-buckthorn: is warm in nature and sour in taste, and has the effects of relieving cough, eliminating phlegm, promoting digestion, removing food stagnation, promoting blood circulation, removing blood stasis, etc. Modern pharmacological research shows that sea buckthorn has various pharmacological effects of reducing blood sugar, reducing blood fat, resisting tumor, resisting inflammation, regulating immunity and the like. Experiments show that the sea buckthorn extract has the function of reducing the blood sugar of alloxan diabetic mice, and the effect is superior to that of a diabetes-quenching pill control group. In addition, researches show that the seabuckthorn fruit alcohol extract obviously improves various indexes of type II diabetic rats and has a certain dose-effect relationship. The fructus Hippophae extract can reduce blood sugar and improve oxidation resistance. The seabuckthorn flavone can effectively control the blood sugar level of a diabetic rat, correct the substance metabolic disorder of the diabetic rat, and remarkably reduce the blood sugar level and the blood fat level of the diabetic rat caused by streptozotocin.

Bitter gourd: research proves that the momordica saponins have obvious blood sugar reducing effect on diabetic model rabbits, the blood sugar reducing effect is slow and lasting compared with optimal blood sugar reducing effect, the momordica saponins can have the effect similar to insulin, and the momordica saponins are determined as the effective components for reducing the blood sugar of the momordica charantia; khanna discovered in 1974 that insulin-like peptides exist in Momordica charantia, which has blood sugar lowering effect when injected into diabetes patients, and is also effective when orally taken; the balsam pear alcohol extract can obviously increase the content of glycogen of a normal mouse, improve the sugar tolerance of the normal mouse, obviously reduce the blood sugar content of a diabetes model mouse caused by streptozotocin and obviously reduce the blood sugar content of a alloxan diabetes rat; for normal rats fed with glucose, the activity of the balsam pear is lower than that of sulfaphenazole drug tolbutamide, but experiments prove that the balsam pear extract has the function of reducing blood sugar for a recognized diabetes model.

Corn silk: contains various chemical components beneficial to human body, such as saponin, flavone, alkaloid, organic acid, volatile oil, trace elements and vitamins. The saponin in stigma Maydis is the main component for reducing blood sugar of patients with diabetes. The flavonoids in stigma Maydis can reduce free radical generation and remove free radical, has good antioxidant effect, and can be used for preventing diabetic complication. Experiments show that the corn stigma water decoction can obviously reduce the blood sugar of mice with alloxan diabetes. In addition, the corn stigma also contains chromium which is a component of the glucose tolerance factor and can strengthen the function of insulin.

Rhizoma polygonati: it is sweet in nature and neutral in flavor, and enters spleen, lung and kidney meridians. Has effects in invigorating qi, nourishing yin, invigorating spleen, moistening lung, and invigorating kidney. Can be used for treating deficiency of spleen-stomach qi, asthenia, stomach yin deficiency, xerostomia, cough with little appetite, lung deficiency, cough with hemoptysis, essence and blood deficiency, soreness of waist and knees, premature gray hair, and internal heat with thirst quenching effect. Experiments show that: the polygonatum polysaccharide has no obvious influence on the blood sugar level of a normal mouse, but can obviously reduce the blood sugar value of a hyperglycemic mouse induced by epinephrine, and the action mechanism of the polygonatum polysaccharide is closely related to the reduction of the cAMP content in the liver. The rhizoma Polygonati polysaccharide can inhibit the expression of brain tissue glycosylation end product receptor mRNA (RAGE mRNA) of senile diabetic mice, and has protective effect on hyperglycemia and brain tissue injury caused by glycosylation end product (AGE); can obviously reduce the blood sugar and serum glycosylated hemoglobin concentration of experimental diabetic mice and obviously increase the plasma insulin and C peptide levels. Clinical observation of some people using single sealwort to treat type II diabetes also shows obvious curative effect.

And (3) mulberry fruit: has the effects of enriching blood, nourishing yin, promoting the production of body fluid, moistening dryness and the like. The modern pharmacological research shows that mulberry has the effects of reducing blood sugar, reducing blood fat, reducing blood pressure, protecting liver, regulating the immunologic function of organism, promoting the growth of hematopoietic cells and the like. The traditional Chinese medicine liquid medicines such as mulberry, medlar, yam, tuckahoe and the like are reported to be capable of resisting hyperglycemia caused by alloxan and adrenal gland, reducing abnormal serum cholesterol, triglyceride and low-density lipoprotein, and increasing the level of high-density lipoprotein, thereby promoting the catabolism of lipid and playing a role in preventing and treating atherosclerosis.

Mulberry leaf: the mulberry leaves contain blood sugar reducing components and alkaloids such as DNJ, N-Me-DNJ, GALDNJ, Fagomine and the like, and polysaccharides and flavonoids in the mulberry leaves have blood sugar reducing activity, so that the components have low toxicity and are safe to take. Wherein Fagomin can promote insulin release and significantly increase insulin content; the mulberry leaf total polysaccharide can improve the insulin level and play a role in reducing blood sugar by promoting the function of islet B cells; the alcohol extract of the mulberry leaves can inhibit the absorption of sucrose, and the water extract of the mulberry leaves has the inhibiting effect on the activity of maltase and lactase and can inhibit the increase of blood sugar of rats after eating; the alkaloid is also one of the main active ingredients of mulberry leaves, and researches show that the alkaloid of the mulberry leaves can promote the release of insulin, inhibit the activity of alpha-glycosidase, inhibit the absorption of sugar by small intestines and reduce the high peak value of blood sugar after eating.

Ganoderma lucidum: has pharmacological effects of regulating immunity, resisting virus, resisting tumor, reducing blood lipid, protecting heart, etc., and has high safety and less adverse reaction. 431 secondary metabolites are separated from ganoderma lucidum and mainly comprise active ingredients such as ganoderma lucidum polysaccharide, triterpenoids, proteins and the like, wherein the ganoderma lucidum polysaccharide has an obvious blood sugar reducing effect on mice with hyperglycemia caused by alloxan and mice with hyperglycemia caused by norepinephrine, and has small influence on the blood sugar level of normal mice.

Chromium picolinate: is a food additive rich in trivalent chromium. At present, trivalent chromium is considered as an active ingredient of Glucose tolerance Factor (Glucose tolerance Factor), which plays a role in alleviating insulin resistance and improving blood Glucose abnormality by enhancing the function of insulin. Trivalent chromium has also been found to activate the disulfide bond between insulin and cell membranes, increasing the binding of insulin to specific receptors, and promoting glucose transport and hepatic glycogen synthesis. In addition, chromium has effects of increasing insulin function of human body, preventing diabetes, controlling coronary heart disease and hypertension, promoting health and preventing myopia.

Has the advantages that: compared with the prior art, the invention has the beneficial effects that: the health-care tea disclosed by the invention is prepared by adding medicinal and edible homologous components and trace elements into the double-ginseng and dendrobium tea, so that a patient can take the health care tea every day, the tea is convenient and quick to drink and has a pleasant taste, no medicinal side effect exists, and the cost is low.

The specific implementation mode is as follows:

the following describes in detail specific embodiments of the present invention.

Detailed description of the preferred embodiment 1

The ginseng-dendrobium tea for improving abnormal blood sugar comprises the following components in parts by weight:

Further, the tea leaves are oolong tea.

(1) preparing a first filtrate:

(12) and leaching for the first time:

adding 15 times of 50% V/V ethanol water solution into the extraction container, leaching at 50 deg.C for 120 hr, filtering, and collecting the leaching solution;

(13) and leaching for the second time:

adding 10 times volume of 50% V/V ethanol water solution into the extraction container, soaking at 50 deg.C for 48 hr, filtering, and collecting the leaching solution;

(14) and leaching for the third time:

(15) combining the leaching liquor obtained in the steps (12) to (14), naturally cooling to normal temperature, standing for 48 hours in an environment of 8 ℃, collecting supernatant, filtering by using a filter material with a pore size of 0.6 micron, and collecting filtrate to obtain first filtrate;

(2) preparing a second filtrate

(22) and first decoction:

adding 20 times of water into an extraction container, soaking for 3 hours, heating to boil, decocting for 3 hours, filtering, and collecting filtrate;

(23) and carrying out second decoction:

adding 15 times of water into an extraction container, decocting for 1 hour, filtering, and collecting filtrate;

(24) and decocting for the third time:

(25) mixing the three filtrates collected in the steps (22) to (24), filtering by a 100-mesh filter screen, centrifuging by 600g to remove fine precipitates, concentrating the supernatant under reduced pressure at 75 ℃ and-0.07 MPa, and concentrating to obtain a concentrated solution with the relative density of 1.15;

(3) adding 90% V/V ethanol aqueous solution with 4 times volume amount into the concentrated solution obtained in the step (2) at 15 ℃, fully stirring, naturally cooling to normal temperature, standing for 48 hours at 5 ℃, collecting supernatant, filtering the supernatant by using a filter material with 0.6 micron pore size, and collecting filtrate;

fourthly, combining the first filtrate obtained in the step (1) and the filtrate obtained in the step (3), fully mixing the two filtrates, concentrating the mixture under reduced pressure at the temperature of 60 ℃ and the pressure of-0.06 MPa, and concentrating the filtrate to the volume of a concentrated solution: the feeding amount of the raw materials is 1:2, and a concentrated solution is obtained, wherein:

fifthly, weighing the picked tea leaves, flatly paving the tea leaves in a baking pan, wherein the paving thickness is 4 cm, and placing the baking pan paved with the tea leaves in a baking oven for 3 hours at 90 ℃ for ventilation baking;

sixthly, fully dissolving chromium picolinate according to the formula amount by using pure water with the volume being 100 times that of the chromium picolinate, adding the dissolved chromium picolinate into the concentrated solution obtained in the step (4), fully stirring and uniformly mixing, spraying the mixture onto tea leaves in a baking pan for 10 times, fully stirring the mixture to enable the liquid medicine to be fully immersed into the tea leaves,

wherein, between two adjacent sprays, the tea is continuously aired and baked for 8 hours at 65 ℃, and the materials are turned over once every 60 minutes;

and (2) after the concentrated solution obtained in the step (4) is completely mixed with the tea leaves, fully stirring the mixture to enable the liquid medicine to be completely immersed in the tea leaves, continuously baking the mixture for 6 hours at 80 ℃ in a ventilating way, turning the materials once every 30 minutes until the mixture is dry and slightly pungent, grasping the tea leaves to enable the tea leaves to be elastic and to form lumps, and slightly touching the tea leaves in the tea lumps with force to enable the tea leaves to be scattered, so that the dendrobium officinale tea for improving the blood sugar abnormality is prepared.

Further, the method also comprises the step (8): and (4) further weighing the double-ginseng dendrobium tea for improving abnormal blood sugar obtained in the step (7), packaging the double-ginseng dendrobium tea by using a gauze bag, subpackaging the products with the specification of 100 g/bag, and preparing the double-ginseng dendrobium tea for improving abnormal blood sugar in an independent package.

Further, the tea leaves in the step (5) are oolong tea.

Specific example 2

25 parts of tea, 3 parts of astragalus membranaceus, 3 parts of kudzu roots, 5 parts of Chinese wolfberry, 1 part of American ginseng, 1 part of dendrobium, 1 part of pollen, 5 parts of lily, 5 parts of Chinese yam, 5 parts of poria cocos, 3 parts of dogwood, 5 parts of angelica sinensis, 1 part of lucid ganoderma, 3 parts of sea-buckthorn, 5 parts of bitter gourd, 5 parts of corn stigma, 5 parts of polygonatum odoratum, 5 parts of rhizoma polygonati, 5 parts of mulberries, 5 parts of mulberry leaves and 0.1 part of chromium picolinate.

Further, the tea leaves are green tea.

(1) preparing a first filtrate:

(12) and leaching for the first time:

adding 15% V/V ethanol water solution with volume 5 times of the extraction container, leaching at 15 deg.C for 240 hr, filtering, and collecting leaching solution;

(13) and leaching for the second time:

adding 85% V/V ethanol water solution with volume 3 times of the extraction container, soaking at 15 deg.C for 96 hr, filtering, and collecting the leaching solution;

(14) and leaching for the third time:

adding 15% V/V ethanol water solution with volume 3 times of the extraction container, soaking at 15 deg.C for 96 hr, filtering, and collecting the leaching solution;

(15) combining the leaching liquor obtained in the steps (12) to (14), naturally cooling to normal temperature, standing for 96 hours in an environment at 1 ℃, collecting supernatant, filtering by using a filter material with a pore size of 0.1 micrometer, and collecting filtrate to obtain first filtrate;

(2) preparing a second filtrate

(22) and first decoction:

adding 8 times of water into an extraction container, soaking for 0.5 hour, heating to boil, decocting for 0.5 hour, filtering, and collecting filtrate;

(23) and carrying out second decoction:

adding 6 times of water into the extraction container, decocting for 0.5 hr, filtering, and collecting filtrate;

(24) and decocting for the third time:

(25) mixing the three filtrates collected in the steps (22) to (24), filtering by a 30-mesh filter screen, centrifuging by 300g to remove fine precipitates, concentrating the supernatant under reduced pressure at 55 ℃ and-0.1 MPa, and concentrating to obtain a concentrated solution with the relative density of 1.05;

(3) adding 90% V/V ethanol aqueous solution with the volume of 1 times of that of the concentrated solution obtained in the step (2) into the concentrated solution at the temperature of 45 ℃, fully stirring the mixture, naturally cooling the mixture to the normal temperature, standing the mixture for 96 hours at the temperature of 1 ℃, collecting supernatant, filtering the supernatant by using a filter material with the pore diameter of 0.1 micron, and collecting filtrate;

fourthly, combining the first filtrate obtained in the step (1) and the filtrate obtained in the step (3), fully mixing the two filtrates, concentrating the mixture under reduced pressure at 55 ℃ and-0.1 MPa, and concentrating the filtrate to the volume of a concentrated solution: the feeding amount of the raw materials is 1:1, and a concentrated solution is obtained, wherein:

fifthly, weighing the picked tea leaves, flatly paving the tea leaves in a baking pan with the paving thickness of 1 cm, and placing the baking pan paved with the tea leaves in a baking oven for ventilation baking at 65 ℃ for 0.5 hour;

sixthly, fully dissolving chromium picolinate according to the formula amount by using pure water with the volume being 10 times that of the chromium picolinate, adding the dissolved chromium picolinate into the concentrated solution obtained in the step (4), fully stirring and uniformly mixing, spraying the mixture onto tea leaves in a baking pan for 2 times, fully stirring the mixture to enable the liquid medicine to be fully immersed into the tea leaves,

wherein, between two adjacent sprays, the tea is continuously baked for 4 hours at 100 ℃ in a ventilation way, and the materials are turned over once every 30 minutes;

and (2) after the concentrated solution obtained in the step (4) is completely mixed with the tea leaves, fully stirring the mixture to enable the liquid medicine to be completely immersed in the tea leaves, continuously baking the mixture for 8 hours at 65 ℃ in a ventilating way, turning the materials once every 60 minutes until the mixture is dry and slightly pungent, grasping the tea leaves to enable the tea leaves to be elastic and to form lumps, and slightly touching the tea leaves in the tea lumps with force to enable the tea leaves to be scattered, so that the dendrobium officinale tea for improving the blood sugar abnormality is prepared.

Further, the method also comprises the step (8): and (4) further weighing the double-ginseng dendrobium tea for improving abnormal blood sugar obtained in the step (7), packaging the tea by using filter paper bags, and subpackaging the tea with the specification of 1 g/bag to prepare the double-ginseng dendrobium tea for improving abnormal blood sugar in an independent package.

Further, the tea leaves in the step (5) are green tea.

Specific example 3

1000 parts of tea, 100 parts of American ginseng, 100 parts of dendrobium, 150 parts of astragalus membranaceus, 150 parts of radix puerariae, 150 parts of medlar, 50 parts of pollen, 50 parts of lily, 100 parts of Chinese yam, 100 parts of poria cocos, 100 parts of dogwood, 100 parts of angelica sinensis, 50 parts of lucid ganoderma, 50 parts of sea-buckthorn, 200 parts of bitter gourd, 100 parts of corn stigma, 100 parts of polygonatum odoratum, 100 parts of rhizoma polygonati, 200 parts of mulberry leaves and 8 parts of chromium picolinate.

Further, the tea leaves are white tea.

(1) preparing a first filtrate:

(12) and leaching for the first time:

adding a 25-time volume of 85% V/V ethanol aqueous solution into the extraction container, leaching for 4 hours at 75 ℃, filtering, and collecting a leaching solution;

(13) and leaching for the second time:

adding 15% V/V ethanol water solution with volume 20 times of the extraction container, soaking at 75 deg.C for 12 hr, filtering, and collecting the leaching solution;

(14) and leaching for the third time:

adding 85% V/V ethanol water solution with 20 times volume into the extraction container, soaking at 75 deg.C for 12 hr, filtering, and collecting the leaching solution;

(15) combining the leaching liquor obtained in the steps (12) to (14), naturally cooling to normal temperature, standing for 8 hours in an environment of 10 ℃, collecting supernatant, filtering by using a filter material with a pore size of 1.0 micron, and collecting filtrate to obtain first filtrate;

(2) preparing a second filtrate

(22) and first decoction:

adding 30 times of water into an extraction container, soaking for 5 hours, heating to boil, decocting for 4.5 hours, filtering, and collecting filtrate;

(23) and carrying out second decoction:

adding 25 times of water into the extraction container, decocting for 1.5 hours, filtering, and collecting filtrate;

(24) and decocting for the third time:

(25) combining the three filtrates collected in the steps (22) to (24), filtering by a 300-mesh filter screen, centrifuging 1200g to remove fine precipitates, concentrating the supernatant under reduced pressure at 95 ℃ and-0.05 MPa, and concentrating to obtain a concentrated solution with the relative density of 1.25;

(3) adding 90% V/V ethanol aqueous solution with volume of 8 times of that of the concentrated solution obtained in the step (2) at 65 ℃, fully stirring, naturally cooling to normal temperature, standing for 4 hours at 10 ℃, collecting supernatant, filtering the supernatant by using a filter material with pore diameter of 1.0 micron, and collecting filtrate;

fourthly, combining the first filtrate obtained in the step (1) and the filtrate obtained in the step (3), fully mixing the two filtrates, concentrating the mixture under reduced pressure at the temperature of 95 ℃ and the pressure of-0.05 MPa, and concentrating the filtrate to the volume of a concentrated solution: the feeding amount of the raw materials is 1:4, and a concentrated solution is obtained, wherein:

fifthly, weighing the picked tea leaves, flatly paving the tea leaves in a baking pan, wherein the paving thickness is 8 cm, and placing the baking pan paved with the tea leaves in a baking oven for ventilation baking at 120 ℃ for 5 hours;

sixthly, fully dissolving chromium picolinate according to the formula amount by using pure water with the volume 500 times that of the chromium picolinate, adding the dissolved chromium picolinate into the concentrated solution obtained in the step (4), fully stirring and uniformly mixing, spraying the mixture onto tea leaves in a baking pan for 20 times, fully stirring to enable the liquid medicine to be fully immersed into the tea leaves,

wherein, between two adjacent sprays, the tea is continuously baked for 1 hour at 120 ℃ in a ventilation way, and the materials are turned over once every 10 minutes;

and (2) after the concentrated solution obtained in the step (4) is completely mixed with the tea leaves, fully stirring the mixture to enable the liquid medicine to be completely immersed in the tea leaves, continuously baking the mixture for 1 hour at 120 ℃ in a ventilated mode, turning the materials once every 10 minutes until the mixture is dry and slightly pungent, grasping the tea leaves, enabling the tea leaves to be elastic and conglobate, and enabling tea leaf particles in the tea leaf conglobate to be scattered by slightly touching the tea leaf particles, so that the dendrobium officinale tea for improving the blood sugar abnormality is prepared.

Further, the method also comprises the step (8): and (4) further weighing the double-ginseng dendrobium tea for improving abnormal blood sugar obtained in the step (7), packaging the double-ginseng dendrobium tea by using an aluminum plastic bag, and subpackaging the products with the specification of 5000 g/bag to prepare the double-ginseng dendrobium tea for improving abnormal blood sugar which is packaged independently.

Further, the tea leaves in the step (5) are white tea.

Specific examples 4 to 8

The same as in example 1, except that the tea leaves are different in kind:

the embodiments of the present invention have been described in detail. However, the present invention is not limited to the above-described embodiments, and various changes can be made within the knowledge of those skilled in the art without departing from the spirit of the present invention.

Claims

1. The ginseng-dendrobium tea for improving abnormal blood sugar is characterized by comprising the following components in parts by weight:

2. The ginseng and dendrobium officinale tea for improving abnormal blood sugar of claim 1, comprising:

3. The tea for improving abnormal blood sugar of claim 2, wherein the tea is one or more selected from green tea, white tea, yellow tea, oolong tea, black tea and black tea.

4. The preparation method of the dendrobium candidum tea for improving the blood sugar abnormality according to any one of claims 1 to 3, which is characterized by comprising the following steps:

(1) preparing a first filtrate:

(12) and leaching for the first time:

(13) and leaching for the second time:

(14) and leaching for the third time:

(15) combining the leaching liquor obtained in the steps (12) to (14), naturally cooling to normal temperature, standing for 8-96 hours in an environment at 1-10 ℃, collecting supernatant, filtering by using a filter material with a pore size of 0.1-1.0 micron, and collecting filtrate to obtain first filtrate; (2) preparing a second filtrate

(22) and first decoction:

(23) and carrying out second decoction:

(24) and decocting for the third time:

sixthly, fully dissolving chromium picolinate according to the formula amount by using pure water with the volume being 10-500 times of that of the chromium picolinate, adding the dissolved chromium picolinate into the concentrated solution obtained in the step (4), fully stirring and uniformly mixing, spraying the mixed solution onto tea leaves in a baking pan for 2-20 times, and fully stirring to enable the liquid medicine to be completely immersed into the tea leaves, wherein:

between two adjacent spraying, continuously baking the tea leaves for 1-8 hours at 65-120 ℃ in a ventilating way, and turning over the materials once every 10-60 minutes;

5. The preparation method of the double-ginseng dendrobium tea for improving abnormal blood sugar as claimed in claim 4, further comprising the step (8): and (3) further weighing the double-ginseng dendrobium tea for improving abnormal blood sugar obtained in the step (7), packaging the tea by using a gauze bag, a filter paper bag or an aluminum plastic bag, subpackaging the tea with the specification of 1-5000 g/bag, and preparing the double-ginseng dendrobium tea for improving abnormal blood sugar in an independent package.

6. The preparation method of the double-ginseng dendrobium tea for improving the abnormal blood sugar as claimed in claim 4, wherein the ethanol is recovered during the reduced pressure concentration process in the step (4).

7. The method for preparing the double-ginseng dendrobium tea for improving the abnormal blood sugar as claimed in claim 4, wherein the tea leaves in the step (5) are any one or more of green tea, white tea, yellow tea, oolong tea, black tea and black tea.