CN104800600A - Medicine for treating hypertension - Google Patents

Abstract

The invention discloses a medicine for treating hypertension and a preparation method of the medicine. The medicine is prepared from raw materials as follows: common scouring rush herb, uncaria tomentosa, tribulus terrestris, eucommia barks, kernels of durio zibethinus murr, chrysanthemum, radix polygoni multiflori, gastrodia elata, fructus lycii, liquorice, prunella vulgaris, fruits of fiverleaf akebia, kudzuvine roots, fresh apples and eleocharis dulcis. The medicine is a pure traditional Chinese medicine preparation, is safe, has no side effects, can treat symptoms and root causes of liver-kidney yin deficiency type hypertension through kidney tonification, yin nourishment, liver and yang calming and heat clearing and can quickly and effectively reduce blood pressure, effectively relieve uncomfortable symptoms such as dizziness, headache and the like of patients, regulate the body of a patient, and treat hypertension fundamentally according to the pathogeny of hypertension, a preparation method is simple, and effective components in the raw materials can be sufficiently extracted to guarantee medicine efficacy.

Description

One treats hypertensive medicine

Technical field

The present invention relates to one and treat hypertensive medicine, particularly relate to a kind of medicine its preparation method for the treatment of hypertension of deficiency of yin of liver and kidney type, belong to technical field of traditional Chinese medicine preparation.

Background technology

Hypertension is the common a kind of chronic cardiovascular disease of modern society, once morbidity, long-term slight illness will be caused to torment to patient, make to suffer impact in various degree the orthobiosis of patient, even threaten the life of people.The early stage non-evident sympton of hypertension incidence, is easily ignored by people, and the continuity patient along with the course of disease there will be headache, dizzy, uncomfortable in chest, cardio palmus shape more, time serious, obnubilation, tic can occur.In view of bringing out, hypertensive factor is various, and modern medicine study still can not explain its cause of disease completely.Current treatment means many employings Western medicine blood pressure lowering, the Western medicine for blood pressure lowering has hundreds of, and after most of patients takes Western medicine, blood pressure can drop to normal value rapidly.But not for the cause of disease, there is the problem that index is not effected a permanent cure for hypertensive disease in western medicine, make needs of patients Long-term taking medicine, dependency is produced to medicine, and then has to face the untoward reaction of depressor, as lesions of liver and kidney, drug resistance, hyperpotassemia, heart failure etc.Meanwhile, Western medicine effect in the symptoms such as improvement dizziness, headache does not have remarkable result yet, can not alleviate patient suffering timely and effectively.

The traditional Chinese medical science generally believe the formation of hypertension be due to disorder of emotion, eating and drinking without temperance, work and rest excessively, not normal, the expectorant stasis of blood of viscera yin and yang imbalance, disorder of QI and blood, ascending or descending movement of vital Qi hands over resistance and falls ill.Wherein, the hepatic and renal YIN deficiency is hypertensive common pattern of syndrome, is more common in middle and advanced stage hypertension patient, and symptom, for having a dizzy spell, lacks tongue with headache tinnitus, blurring of vision, soreness of the waist and knees, dysphoria with feverish sensation in the chest palms and soles, red tongue.Utilize Chinese medicine preparation to adopt the traditional Chinese medical science to work in coordination with therapy for treating hypertension of deficiency of yin of liver and kidney type, effectively can avoid the side effect of western medicine, while blood pressure lowering, body be regulated comprehensively, reach the effect for the treatment of both the principal and secondary aspects of a disease.

Summary of the invention

The object of the invention is to: provide one to treat hypertensive medicine, this medicine is pure Chinese medicinal preparation, safety has no side effect, adopt the method treating both the principal and secondary aspects of a disease hypertension of deficiency of yin of liver and kidney type of replenishing kidney-YIN, suppressing the hyperactive liver and subsiding YANG, clearing away heat and nourishing YIN, this medicine can effectively blood pressure lowering fast, the malaise symptoms such as effective reduction of patient dizziness headache, regulate patient's body simultaneously, for hypertension pathogeny radical cure hypertension.

To achieve these goals, the invention provides one and treat hypertensive medicine, it is characterized in that: raw material composition and the parts by weight of making this effective ingredient are: Herba Equiseti Hiemalis 3-8 part, Ramulus Uncariae Cum Uncis 10-13 part, Fructus Atriplicis Sibiricae 8-12 part, Cortex Eucommiae 15-20 part, Durio Zibethinus murr pit 8-12 part, Flos Chrysanthemi 15-18 part, Radix Polygoni Multiflori 3-5 part, Rhizoma Gastrodiae 8-12 part, Fructus Lycii 5-8 part, Radix Glycyrrhizae 10-13 part, Spica Prunellae 10-13 part, Fructus Akebiae 2-5 part, Radix Puerariae 2-5 part, fresh apple 15-20 part, Corm Eleocharitis 10-15 part.

As preferably, raw material composition and the parts by weight of making this effective ingredient are: Herba Equiseti Hiemalis 3 parts, Ramulus Uncariae Cum Uncis 10 parts, Fructus Atriplicis Sibiricae 8 parts, the Cortex Eucommiae 15 parts, Durio Zibethinus murr pit 8 parts, Flos Chrysanthemi 15 parts, Radix Polygoni Multiflori 3 parts, 8 parts, Rhizoma Gastrodiae, Fructus Lycii 5 parts, Radix Glycyrrhizae 10 parts, Spica Prunellae 10 parts, Fructus Akebiae 2 parts, Radix Puerariae 2 parts, fresh apple 15 parts, Corm Eleocharitis 10 parts.

As preferably, raw material composition and the parts by weight of making this effective ingredient are: Herba Equiseti Hiemalis 8 parts, Ramulus Uncariae Cum Uncis 13 parts, Fructus Atriplicis Sibiricae 12 parts, the Cortex Eucommiae 20 parts, Durio Zibethinus murr pit 12 parts, Flos Chrysanthemi 18 parts, Radix Polygoni Multiflori 5 parts, 12 parts, Rhizoma Gastrodiae, Fructus Lycii 8 parts, Radix Glycyrrhizae 13 parts, Spica Prunellae 13 parts, Fructus Akebiae 5 parts, Radix Puerariae 5 parts, fresh apple 20 parts, Corm Eleocharitis 15 parts.

As preferably, raw material composition and the parts by weight of making this effective ingredient are: Herba Equiseti Hiemalis 5 parts, Ramulus Uncariae Cum Uncis 12 parts, Fructus Atriplicis Sibiricae 10 parts, the Cortex Eucommiae 17 parts, Durio Zibethinus murr pit 10 parts, Flos Chrysanthemi 16 parts, Radix Polygoni Multiflori 4 parts, 10 parts, Rhizoma Gastrodiae, Fructus Lycii 7 parts, Radix Glycyrrhizae 12 parts, Spica Prunellae 11 parts, Fructus Akebiae 4 parts, Radix Puerariae 3 parts, fresh apple 17 parts, Corm Eleocharitis 12 parts.

Present invention also offers the preparation method of the hypertensive medicine of described treatment, comprise the following steps:

Step 1: Durio Zibethinus murr pit and Corm Eleocharitis clean peeling, pulverize 80 mesh sieves, and add the distilled water of its gross weight 8 ~ 10 times, slow fire boiling 50 ~ 60 minutes with pulverizer, cross 200 mesh sieve separating filtrate and filtering residues;

Step 2: Fructus Mali pumilae is cleaned, fritter is cut in peeling enucleation, Fructus Mali pumilae block is mixed with step 1 gained filtering residue and puts into-20 DEG C of refrigerator and cooled and freeze 12 hours, vacuum freezing drying oven lyophilization put into by material after freezing, baking temperature is-25 ~-20 DEG C, pressure is-0.09 ~-0.08Mpa, obtains drying composite;

Step 3: Radix Puerariae is cleaned to cut after fritter mixes with step 2 gained drying composite and pulverized with super micron mill, crosses 200 mesh sieves and obtains powder;

Step 4: Herba Equiseti Hiemalis, Ramulus Uncariae Cum Uncis, Fructus Atriplicis Sibiricae, the Cortex Eucommiae, Flos Chrysanthemi, Radix Polygoni Multiflori, Rhizoma Gastrodiae, Fructus Lycii, Radix Glycyrrhizae, Spica Prunellae, Fructus Akebiae mixing are cleaned, add gained filtrate in step 1, slow fire boiling 60 ~ 75 minutes, cross 200 mesh screen after decocting and obtain filtrate, gained filtrate is concentrated into the concentrated solution that relative density is 1.10 ~ 1.15 (60 DEG C), adding ethanol to concentrated solution makes the mass fraction of ethanol reach 65%, stir evenly, leave standstill 15 ~ 18 hours, get after supernatant reclaims ethanol and be concentrated into the thick paste that relative density is 1.30 ~ 1.32 (60 DEG C);

Step 5: powder obtained in step 3 is added in thick paste obtained in step 4, stirring and evenly mixing, granulate, dry, to obtain final product.

The using method of the hypertensive medicine of this treatment: bfore meals, each serving with medicine of the present invention 15 grams, boiling water is taken after mixing it with water, 2 times on the one.

The present invention, in order to treat hypertension of deficiency of yin of liver and kidney type, adopts the method for replenishing kidney-YIN, suppressing the hyperactive liver and subsiding YANG, clearing away heat and nourishing YIN, regulates, treating both the principal and secondary aspects of a disease hypertension while blood pressure lowering to body comprehensively.According to Chinese medical theory determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, screen raw material of Chinese medicine by great many of experiments, refining agent method, make each efficacy of drugs produce synergism, thus reach the effect for the treatment of both the principal and secondary aspects of a disease.In the crude drug chosen: Herba Equiseti Hiemalis's sweet in the mouth, hardship, property is put down, nontoxic, has wind and heat dispersing, cooling blood for hemostasis, the effect of improving acuity of vision and removing nebula; Ramulus Uncariae Cum Uncis has calmness, hypotensive effect; Fructus Atriplicis Sibiricae is put down, suppressing the hyperactive liver resolving depression, promoting blood circulation by removing wind, and improving eyesight is antipruritic, dizzy for having a headache, distending pain in the chest and hypochondrium, and breast closes acute mastitis, cataract, rubella pruritus; The Cortex Eucommiae is warm in nature, has blood pressure lowering, diuresis, controls caused by liver and kidney deficiency, instability of kidney QI effect; Herba Taxilli natural disposition is put down, and has blood pressure lowering, diuresis; Durio Zibethinus murr sweet in the mouth temperature, nontoxic, be rich in nutrition, there is effect of spleen invigorating QI invigorating, kidney invigorating and YANG supporting, but Durio Zibethinus murr sarcocarp heat content and sugar higher, hypertension, diabetics should not be eaten more, the property of medicine compared to sarcocarp Durio Zibethinus murr pit is gentleer, can gentle the kidney invigorating, and containing sugar and heat less, can play the effect of kidney and spleen invigorating, more suitable hyperpietic uses simultaneously; Flos Chrysanthemi has heat-clearing and toxic substances removing, effect of detumescence; Radix Polygoni Multiflori sweet in the mouth, temperature, nontoxic, nourishing the blood and yin, loosening bowel to relieve constipation, preventing the attack (or recurrence) of malaria, dispel the wind, removing toxic substances, the soreness of the waist and knees of main blood deficiency Light-headedness, cardiopalmus, insomnia, the hepatic and renal YIN deficiency, early whitening of beard and hair, tinnitus, seminal emission, dryness of the intestine constipation, chronic malaria body void, rubella pruritus, carbuncle sore, scrofula, hemorrhoid; Rhizoma Gastrodiae is put down, energy endogenous wind stopping, and arresting convulsion, can control dizzy pupil, and wind syndrome of head is had a headache; Fructus Lycii is put down, and has the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, blood-enriching tranquillizing, promoting the production of body fluid to quench thirst, nourishing the lung to arrest cough, can control hepatic and renal YIN deficiency, soreness of the waist and knees, dizzy, dizzy; Radix Glycyrrhizae can invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription; Spica Prunellae is cold in nature, has liver heat removing, eliminating stagnation, effect of diuresis; Fructus Akebiae sweet in the mouth, cold, liver-smoothing, qi-regulating, invigorates blood circulation, eliminating stasis to stop pain, relieving restlessness diuresis, and for stomachache due to hyperactive liver-QI attacking the stomach, gastric heat food is slow-witted, excessive thirst; Radix Puerariae is cool in nature, has resolving heat and reducing pathogenic fire, YIN nourishing removing toxic substances, yang invigorating promotes the production of body fluid, effect of stimulating appetite; The acid of Fructus Mali pumilae flat sweet in the mouth, enters the heart, stomach warp, there is reinforcing the heart QI invigorating, promoting the production of body fluid to quench thirst and blood skin moistening, removing toxic substances relieving restlessness, spleen invigorating adjust in, the effect such as blood pressure lowering degrease, be applicable to chronic gastritis, diarrhoea, constipation, hypertension, hyperlipemia etc.; Corm Eleocharitis is cold in nature, there is heat-clearing and toxic substances removing, removing heat from blood promote the production of body fluid, diuresis relieving constipation, Cleering damp and dissolving phlegm, the de-swelling that helps digestion effect, can be used for treating jaundice, dysentery, poliomyelitis, constipation and other diseases, Corm Eleocharitis contains a kind of antimicrobial component, to the certain effect that reduced blood pressure, this material also has preventive and therapeutic effect to cancer.

In all medicines, the Cortex Eucommiae, Durio Zibethinus murr pit, Fructus Lycii, Radix Puerariae are monarch drug, play the effect of suppressing the hyperactive liver and subsiding YANG, replenishing kidney-YIN, clearing away heat and nourishing YIN; Radix Polygoni Multiflori, Spica Prunellae, Fructus Akebiae, Fructus Mali pumilae, Herba Equiseti Hiemalis, Flos Chrysanthemi, Corm Eleocharitis are ministerial drug, wherein, Radix Polygoni Multiflori, Spica Prunellae, Fructus Akebiae and Fructus Mali pumilae can gain monarch drug suppressing the hyperactive liver and subsiding YANG, replenishing kidney-YIN effect, Herba Equiseti Hiemalis, Flos Chrysanthemi, Corm Eleocharitis can the effect of gain monarch drug Radix Puerariae clearing away heat and nourishing YIN; Fructus Atriplicis Sibiricae, Ramulus Uncariae Cum Uncis, Herba Taxilli are assistant, and Fructus Atriplicis Sibiricae can the disease of dizzy, the headache of principal drug assistance Fructus Lycii and ministerial drug fleece flower root for treating, and Ramulus Uncariae Cum Uncis, Herba Taxilli the principal drug assistance Cortex Eucommiae and ministerial drug Fructus Mali pumilae, Corm Eleocharitis can improve antihypertensive effect; Flos Chrysanthemi, Spica Prunellae, Fructus Akebiae, Radix Puerariae and Corm Eleocharitis mistake impairment of YANG cold in nature, assistant system is with the warm product Cortex Eucommiae, Durio Zibethinus murr pit, Radix Polygoni Multiflori 3 taste, cold impairment of the spleen sun can be avoided to occur stomachache with cool feeling, vomiting clear water, loose stool, again with Radix Glycyrrhizae for making, can better regulate all medicines, Yin Yang balancing, goes after profits and advoids disadvantages, and promotes drug effect.

In preparation process, Durio Zibethinus murr pit and Corm Eleocharitis first decoct by step 1, more better can extract effective ingredient with its filtrate decoction other drug.Content of starch in Corm Eleocharitis and Durio Zibethinus murr is higher, partial starch stripping from raw material in the decoction process of step 1, starch-hydrocolloid is formed in filtrate, the micelle of starch-hydrocolloid has huge specific surface area and surface energy, can active adsorption ion and molecule, in the decoction process of step 4, when contacting with other drug, effectively can adsorb the effective ingredient of drug-eluting, increase the content of the effective ingredient in step 4 gained thick paste, to promote drug effect.Drying composite is prepared after fresh apple stripping and slicing with the filtering residue mixing postlyophilization of step 1 gained in step 2, the nutritional labeling that what cryodesiccated process was best maintain in Fructus Mali pumilae and active substance, the filtering residue lyophilization of step 1 gained can be made full use of in raw material not by the effective ingredient decocted out, in step 3, step 2 gained drying composite pulverizing together with Radix Puerariae is obtained powder, this powder is mixed with step 4 gained thick paste, the cost that can save and add pharmaceutic adjuvant of directly granulating.

Beneficial effect of the present invention is: the invention provides one and treat hypertensive medicine, this medicine is pure Chinese medicinal preparation, safety has no side effect, adopt the method treating both the principal and secondary aspects of a disease hypertension of deficiency of yin of liver and kidney type of replenishing kidney-YIN, suppressing the hyperactive liver and subsiding YANG, clearing away heat and nourishing YIN, this medicine can effectively blood pressure lowering fast, the malaise symptoms such as effective reduction of patient dizziness headache, regulate patient's body simultaneously, for hypertension pathogeny radical cure hypertension, and preparation method is simple, can guarantee drug effect by the effective ingredient fully extracted in raw material.Specifically:

(1) make in the crude drug of this effective elements of the medicine, the Cortex Eucommiae, Durio Zibethinus murr pit, Fructus Lycii, Radix Puerariae are monarch drug, for cause of disease suppressing the hyperactive liver and subsiding YANG, replenishing kidney-YIN, the clearing away heat and nourishing YIN regulation mechanism of hypertension of deficiency of yin of liver and kidney type, be aided with the effect that Radix Polygoni Multiflori, Spica Prunellae, Fructus Akebiae and Fructus Mali pumilae promote monarch drug suppressing the hyperactive liver and subsiding YANG, replenishing kidney-YIN; Being aided with Herba Equiseti Hiemalis, Flos Chrysanthemi and Corm Eleocharitis can the effect of gain monarch drug clearing away heat and nourishing YIN, better regulates patient's body, Yin Yang balancing, simultaneously assistant with Fructus Atriplicis Sibiricae, Ramulus Uncariae Cum Uncis, Herba Taxilli can the disease of dizzy, the headache of principal drug assistance Fructus Lycii treatment, raising antihypertensive effect.

(2) make in the crude drug of this effective elements of the medicine, Flos Chrysanthemi, Spica Prunellae, Fructus Akebiae, Radix Puerariae and Corm Eleocharitis mistake impairment of YANG cold in nature, assistant system is with the warm product Cortex Eucommiae, Durio Zibethinus murr pit, Radix Polygoni Multiflori 3 taste, cold impairment of the spleen sun can be avoided to occur stomachache with cool feeling, vomiting clear water, loose stool, again with Radix Glycyrrhizae for making, can better regulate all medicines, Yin Yang balancing, go after profits and advoid disadvantages, promote drug effect.

(3) in preparation process, Durio Zibethinus murr pit and Corm Eleocharitis first decoct by step 1, more better can extract effective ingredient with its filtrate decoction other drug.Content of starch in Corm Eleocharitis and Durio Zibethinus murr is higher, in the decoction process of step 1, partial starch stripping from raw material, forms starch-hydrocolloid in filtrate, effectively can adsorb the effective ingredient of drug-eluting, increase the content of the effective ingredient in step 4 gained thick paste, to promote drug effect.

(4) drying composite is prepared after fresh apple stripping and slicing with the filtering residue mixing postlyophilization of step 1 gained in step 2, the nutritional labeling that what cryodesiccated process was best maintain in Fructus Mali pumilae and active substance, the filtering residue lyophilization of step 1 gained can be made full use of in raw material not by the effective ingredient decocted out, in step 3, step 2 gained drying composite pulverizing together with Radix Puerariae is obtained powder, this powder is mixed with step 4 gained thick paste, the cost that can save and add pharmaceutic adjuvant of directly granulating.

Detailed description of the invention

According to following embodiment, the present invention may be better understood.But those skilled in the art will readily understand, concrete material proportion, process conditions and result thereof described by embodiment only should can not limit the present invention described in detail in claims yet for illustration of the present invention.

Embodiment 1

One treats hypertensive medicine, and raw material composition and the parts by weight of making this effective ingredient are: Herba Equiseti Hiemalis 3 grams, Ramulus Uncariae Cum Uncis 10 grams, Fructus Atriplicis Sibiricae 8 grams, the Cortex Eucommiae 15 grams, Durio Zibethinus murr pit 8 grams, Flos Chrysanthemi 15 grams, Radix Polygoni Multiflori 3 grams, 8 grams, Rhizoma Gastrodiae, Fructus Lycii 5 grams, Radix Glycyrrhizae 10 grams, Spica Prunellae 10 grams, Fructus Akebiae 2 grams, Radix Puerariae 2 grams, fresh apple 15 grams, Corm Eleocharitis 10 grams.

The preparation method of the hypertensive medicine of described treatment, comprises the following steps:

Step 1: Durio Zibethinus murr pit and Corm Eleocharitis clean peeling, pulverize 80 mesh sieves, and add the distilled water of its gross weight 8 times, slow fire boiling 50 minutes with pulverizer, cross 200 mesh sieve separating filtrate and filtering residues;

Step 2: Fructus Mali pumilae is cleaned, fritter is cut in peeling enucleation, and mixed with step 1 gained filtering residue by Fructus Mali pumilae block and put into-20 DEG C of refrigerator and cooled and freeze 12 hours, vacuum freezing drying oven lyophilization put into by the material after freezing, baking temperature is-25 DEG C, pressure is-0.09Mpa, obtains drying composite;

Step 3: Radix Puerariae is cleaned to cut after fritter mixes with step 2 gained drying composite and pulverized with super micron mill, crosses 200 mesh sieves and obtains powder;

Step 4: Herba Equiseti Hiemalis, Ramulus Uncariae Cum Uncis, Fructus Atriplicis Sibiricae, the Cortex Eucommiae, Flos Chrysanthemi, Radix Polygoni Multiflori, Rhizoma Gastrodiae, Fructus Lycii, Radix Glycyrrhizae, Spica Prunellae, Fructus Akebiae mixing are cleaned, add gained filtrate in step 1, slow fire boiling 60 minutes, cross 200 mesh screen after decocting and obtain filtrate, gained filtrate is concentrated into the concentrated solution that relative density is 1.10 (60 DEG C), adding ethanol to concentrated solution makes the mass fraction of ethanol reach 65%, stir evenly, leave standstill 15 hours, get after supernatant reclaims ethanol and be concentrated into the thick paste that relative density is 1.30 (60 DEG C);

Step 5: powder obtained in step 3 is added in thick paste obtained in step 4, stirring and evenly mixing, granulate, dry, to obtain final product.

During treatment, ante cibum, boiling water was taken after mixing it with water, each 15 grams, a twice-daily.

Embodiment 2 prepares the hypertensive instant particles as Chinese medicine for the treatment of

One treats hypertensive medicine, and raw material composition and the parts by weight of making this effective ingredient are: Herba Equiseti Hiemalis 8 grams, Ramulus Uncariae Cum Uncis 13 grams, Fructus Atriplicis Sibiricae 12 grams, the Cortex Eucommiae 20 grams, Durio Zibethinus murr pit 12 grams, Flos Chrysanthemi 18 grams, Radix Polygoni Multiflori 5 grams, 12 grams, Rhizoma Gastrodiae, Fructus Lycii 8 grams, Radix Glycyrrhizae 13 grams, Spica Prunellae 13 grams, Fructus Akebiae 5 grams, Radix Puerariae 5 grams, fresh apple 20 grams, Corm Eleocharitis 15 grams.

The preparation method of this medicine is similar to embodiment 1, and difference is: add the water that Durio Zibethinus murr pit and Corm Eleocharitis gross weight multiple are 10 times in step 1, slow fire boiling 60 minutes; In step 2, baking temperature is-20 DEG C, pressure is-0.08Mpa; Slow fire boiling 75 minutes in step 4, cross 200 mesh screen after decocting and obtain filtrate, gained filtrate is concentrated into the concentrated solution that relative density is 1.15 (60 DEG C), adding ethanol to concentrated solution makes the mass fraction of ethanol reach 65%, stir evenly, leave standstill 18 hours, get after supernatant reclaims ethanol and be concentrated into the thick paste that relative density is 1.32 (60 DEG C).

During treatment, ante cibum, boiling water was taken after mixing it with water, each 15 grams, a twice-daily.

Embodiment 3

One treats hypertensive medicine, and raw material composition and the parts by weight of making this effective ingredient are: Herba Equiseti Hiemalis 5 grams, Ramulus Uncariae Cum Uncis 12 grams, Fructus Atriplicis Sibiricae 10 grams, the Cortex Eucommiae 17 grams, Durio Zibethinus murr pit 10 grams, Flos Chrysanthemi 16 grams, Radix Polygoni Multiflori 4 grams, 10 grams, Rhizoma Gastrodiae, Fructus Lycii 7 grams, Radix Glycyrrhizae 12 grams, Spica Prunellae 11 grams, Fructus Akebiae 4 grams, Radix Puerariae 3 grams, fresh apple 17 grams, Corm Eleocharitis 12 grams.

The preparation method of this medicine is similar to embodiment 1, and difference is: add the water that Durio Zibethinus murr pit and Corm Eleocharitis gross weight multiple are 9 times in step 1, slow fire boiling 55 minutes; In step 2, baking temperature is-23 DEG C, pressure is-0.08Mpa; Slow fire boiling 70 minutes in step 4, cross 200 mesh screen after decocting and obtain filtrate, gained filtrate is concentrated into the concentrated solution that relative density is 1.12 (60 DEG C), adding ethanol to concentrated solution makes the mass fraction of ethanol reach 65%, stir evenly, leave standstill 16 hours, get after supernatant reclaims ethanol and be concentrated into the thick paste that relative density is 1.31 (60 DEG C).

During treatment, ante cibum, boiling water was taken after mixing it with water, each 15 grams, a twice-daily.

Embodiment 4 acute oral toxicity test:

The hypertensive medicine of this treatment is by Ministry of Public Health " cosmetics health specification " (2007 editions) " acute oral toxicity once limit the quantity test method(s) " experiment, choose healthy adult mice, body weight 18-22g, 30, male and female half and half, must not exceed 10% of average weight with sex mice mesosome heavy phase difference.Experiment starts fasting in front 16h, then 3 groups are equally divided into arbitrarily with the administration of per os administration by gavage to adult mice, give the medicine of embodiment 1 to 3 respectively, gavage metering is with 5000mg/Kg weighing machine, then fasting 3 days is continued, test mice overall health of patients, diet, drinking-water, body weight increase all normal, do not occur trembling, twitch, sialorrhea, diarrhoea, obviously intoxicating phenomenon and the phenomena of mortality such as drowsiness, stupor, place's post mortem Non Apparent Abnormality, judges that this medicine is to the nontoxic level in the true border of adult mice acute oral toxicity.

Embodiment 5 clinical experimental study

Give the medicine of any one of the embodiment of the present invention 1 to 3, during treatment, ante cibum, boiling water was taken after mixing it with water, each 15 grams, a twice-daily, and 30 was 1 course for the treatment of, observe the curative effect after serveing on 3 courses for the treatment of.

The hypertension of deficiency of yin of liver and kidney type patient that random selecting 100 is made a definite diagnosis, patient's arteries and veins disease is stringy and thready pulse or counts accurately, patient all meets 2 grades of Evaluation of Diagnostic Criteria of Hypertension (160-179/100-109mmHg), patient age 50-70 year, average 60 years old, symptom, for having a dizzy spell, lacks tongue with headache tinnitus, blurring of vision, soreness of the waist and knees, dysphoria with feverish sensation in the chest palms and soles, red tongue.After 3 courses for the treatment of, assess this medicine effect, evaluation criteria is: effectively: patient's diastolic pressure comparatively treats front more than decline 10mmHg, or patient's systolic pressure comparatively treats front decline 30mmHg, or patient clinical symptom takes a turn for the better to some extent, three possesses wherein one or more; Invalid: diastolic pressure and systolic pressure are all without obviously reducing or raising to some extent, and clinical symptoms is not improved or increases the weight of.Through statistics, the effective percentage of the hypertensive medicine for the treatment of of the present invention reaches 97%.

Clinical exemplary embodiments:

1, Jiang, 60 years old, female, suffer from hypertension of deficiency of yin of liver and kidney type, often dizziness headache, soreness of the waist and knees, blurring of vision, feverish sensation in the palms and soles, xerostomia pharyngalgia, examination in hospital low pressure 105, high pressure 165, after taking Western medicine blood pressure lowering, low pressure 96, high pressure 145, unstable blood pressure is fixed, time height time low, take the hypertensive medicine for the treatment of of embodiment 1 after 10 days, dizziness headache, soreness of the waist and knees, blurring of vision, feverish sensation in the palms and soles, xerostomia pharyngalgia symptom is alleviated to some extent, after 3 courses for the treatment of, dizziness headache symptom is eliminated, blood pressure stabilization, low pressure 90, high pressure 135, after again through the treatment of 4 courses for the treatment of, blood markers recovers normal, clinical symptom disappearance, drug withdrawal was not recurred in 2 years.

2, king so-and-so, 50 years old, man, suffer from hypertension of deficiency of yin of liver and kidney type, often have a dizzy spell, blurring of vision, xerostomia pharyngalgia, the few tongue of red tongue, lower limb pain is numb, examination in hospital, low pressure 108, high pressure 179, take western medicine of depressurization for many years, poor effect, low during height during blood pressure, headache and dizzy situation can not get alleviating, take the hypertensive medicine for the treatment of of embodiment 3 after 30 days, have a dizzy spell, blurring of vision, xerostomia pharyngalgia, the few tongue of red tongue, lower limb pain pain and numbness is alleviated to some extent, after 3 courses for the treatment of, blood pressure stabilization, low pressure 95, high pressure 135, headache and dizzy symptom disappears, after again through the treatment of 6 courses for the treatment of, blood markers recovers normal, reduce dose and change 1 into once, one time 15 grams, blood pressure stabilization in SM 1 year, discontinue medication and do not recur for 1 year.

3, bent certain, 65 years old, female, suffer from hypertension of deficiency of yin of liver and kidney type, often have a dizzy spell, headache tinnitus, soreness of the waist and knees, blurring of vision, feverish sensation in the palms and soles, examination in hospital low pressure 102, high pressure 160, take Western medicine blood pressure lowering, poor effect, and have asthma, the untoward reaction of edema, take the hypertensive medicine for the treatment of of embodiment 2 after 15 days, have a dizzy spell, headache tinnitus, soreness of the waist and knees, blurring of vision, feverish sensation in the palms and soles symptom is alleviated to some extent, after 3 courses for the treatment of, dizziness headache symptom is eliminated, blood pressure stabilization low pressure 90, high pressure 125, after again through the treatment of 6 courses for the treatment of, blood markers recovers normal, discontinue medication and do not recur for 1 year.

Result shows, the hypertensive medicine for the treatment of of the present invention, evident in efficacy in the treatment of hypertension of deficiency of yin of liver and kidney type, can stablize blood pressure lowering, conditioning human body, improves patients ' life quality, takes safe and effective, and healing is without recurrence.

Above embodiment is only for illustrating technical conceive of the present invention and feature; its object is to allow person skilled in the art understand content of the present invention and to be implemented; can not limit the scope of the invention with this; all equivalences done according to spirit of the present invention change or modify, and all should be encompassed in protection scope of the present invention.

Claims (5)

1. treat a hypertensive medicine, it is characterized in that: raw material composition and the parts by weight of making this effective ingredient are: Herba Equiseti Hiemalis 3-8 part, Ramulus Uncariae Cum Uncis 10-13 part, Fructus Atriplicis Sibiricae 8-12 part, Cortex Eucommiae 15-20 part, Durio Zibethinus murr pit 8-12 part, Flos Chrysanthemi 15-18 part, Radix Polygoni Multiflori 3-5 part, Rhizoma Gastrodiae 8-12 part, Fructus Lycii 5-8 part, Radix Glycyrrhizae 10-13 part, Spica Prunellae 10-13 part, Fructus Akebiae 2-5 part, Radix Puerariae 2-5 part, fresh apple 15-20 part, Corm Eleocharitis 10-15 part.

2. the hypertensive medicine for the treatment of as claimed in claim 1, is characterized in that: raw material composition and the parts by weight of making this effective ingredient are: Herba Equiseti Hiemalis 3 parts, Ramulus Uncariae Cum Uncis 10 parts, Fructus Atriplicis Sibiricae 8 parts, the Cortex Eucommiae 15 parts, Durio Zibethinus murr pit 8 parts, Flos Chrysanthemi 15 parts, Radix Polygoni Multiflori 3 parts, 8 parts, Rhizoma Gastrodiae, Fructus Lycii 5 parts, Radix Glycyrrhizae 10 parts, Spica Prunellae 10 parts, Fructus Akebiae 2 parts, Radix Puerariae 2 parts, fresh apple 15 parts, Corm Eleocharitis 10 parts.

3. the hypertensive medicine for the treatment of as claimed in claim 1, is characterized in that: raw material composition and the parts by weight of making this effective ingredient are: Herba Equiseti Hiemalis 8 parts, Ramulus Uncariae Cum Uncis 13 parts, Fructus Atriplicis Sibiricae 12 parts, the Cortex Eucommiae 20 parts, Durio Zibethinus murr pit 12 parts, Flos Chrysanthemi 18 parts, Radix Polygoni Multiflori 5 parts, 12 parts, Rhizoma Gastrodiae, Fructus Lycii 8 parts, Radix Glycyrrhizae 13 parts, Spica Prunellae 13 parts, Fructus Akebiae 5 parts, Radix Puerariae 5 parts, fresh apple 20 parts, Corm Eleocharitis 15 parts.

4. the hypertensive medicine for the treatment of as claimed in claim 1, is characterized in that: raw material composition and the parts by weight of making this effective ingredient are: Herba Equiseti Hiemalis 5 parts, Ramulus Uncariae Cum Uncis 12 parts, Fructus Atriplicis Sibiricae 10 parts, the Cortex Eucommiae 17 parts, Durio Zibethinus murr pit 10 parts, Flos Chrysanthemi 16 parts, Radix Polygoni Multiflori 4 parts, 10 parts, Rhizoma Gastrodiae, Fructus Lycii 7 parts, Radix Glycyrrhizae 12 parts, Spica Prunellae 11 parts, Fructus Akebiae 4 parts, Radix Puerariae 3 parts, fresh apple 17 parts, Corm Eleocharitis 12 parts.

5. the preparation method of the hypertensive medicine for the treatment of according to claim 1, is characterized in that: comprise the following steps:

Step 1: Durio Zibethinus murr pit and Corm Eleocharitis clean peeling, pulverize 80 mesh sieves, and add the distilled water of its gross weight 8 ~ 10 times, slow fire boiling 50 ~ 60 minutes with pulverizer, cross 200 mesh sieve separating filtrate and filtering residues;

Step 2: Fructus Mali pumilae is cleaned, fritter is cut in peeling enucleation, Fructus Mali pumilae block is mixed with step 1 gained filtering residue and puts into-20 DEG C of refrigerator and cooled and freeze 12 hours, vacuum freezing drying oven lyophilization put into by material after freezing, baking temperature is-25 ~-20 DEG C, pressure is-0.09 ~-0.08Mpa, obtains drying composite;

Step 3: Radix Puerariae is cleaned to cut after fritter mixes with step 2 gained drying composite and pulverized with super micron mill, crosses 200 mesh sieves and obtains powder;

Step 4: Herba Equiseti Hiemalis, Ramulus Uncariae Cum Uncis, Fructus Tribuli, the Cortex Eucommiae, Flos Chrysanthemi, Radix Polygoni Multiflori, Rhizoma Gastrodiae, Fructus Lycii, Radix Glycyrrhizae, Spica Prunellae, Fructus Akebiae mixing are cleaned, add gained filtrate in step 1, decoct 60 ~ 75 minutes, cross 200 mesh screen after decocting and obtain filtrate, gained filtrate is concentrated into the concentrated solution that relative density is 1.10 ~ 1.15 (60 DEG C), adding ethanol to concentrated solution makes the mass fraction of ethanol reach 65%, stir evenly, leave standstill 15 ~ 18 hours, get after supernatant reclaims ethanol and be concentrated into the thick paste that relative density is 1.30 ~ 1.32 (60 DEG C);

Step 5: powder obtained in step 3 is added in thick paste obtained in step 4, stirring and evenly mixing, granulate, dry, to obtain final product.