CN110946928A

CN110946928A - Natural plant eye spray and preparation method thereof

Info

Publication number: CN110946928A
Application number: CN201911363521.2A
Authority: CN
Inventors: 林泽斌; 黄建香; 朱丹霞; 曾倚琪; 陈敏; 黄雅乐
Original assignee: Guangdong Geeching Biomedical Technology Co ltd
Current assignee: Guangdong Geeching Biomedical Technology Co ltd
Priority date: 2019-12-26
Filing date: 2019-12-26
Publication date: 2020-04-03
Also published as: WO2021128997A1

Abstract

The invention discloses a natural plant eye spray and a preparation method thereof. The eye spray comprises the following components in parts by weight: 50-70 parts of folium artemisiae argyi water, 10-20 parts of green tea leaf water, 10-20 parts of chrysanthemum water, 5-10 parts of roselle water and 0.2-1.0 part of peony root bark extract. The eye spray is free of chemical preservatives, safe, reliable, free of irritation and portable in use, overcomes the defects of most existing eye protection products in the aspects of safety, convenience in use, unobvious effect and the like, can effectively relieve asthenopia, eye interference and the like, can moisten skin around eyes, and has dual effects of brightening eyes and moistening eyes. And the components have strong permeability, can directly reach the basement, and can deeply moisten the eyes and the skin around the eyes. In addition, in the preparation process of the eye spray, the sterilization form of each component adopts the combination of microfiltration membrane filtration, ultrahigh temperature instantaneous sterilization technology and natural plant bacteriostatic agent, thereby ensuring the use safety of the product.

Description

Natural plant eye spray and preparation method thereof

Technical Field

The invention relates to the technical field of eye care daily necessities, in particular to natural plant eye spray and a preparation method thereof.

Background

With the development of the times and the progress of science and technology, the types and the number of electronic technology products are increasing day by day, so that the life and the work of people are more and more kept away from electronic products such as mobile phones, computers and the like. And long-term light radiation directly causes damage to human eyes, causing eye fatigue, dryness, lacrimation, pain and even blurred vision.

Eye protection products on the market generally have the trend of convenient development, such as eye patches, steam eye masks, eyedrops, tear substitutes and the like. However, both eye patches and steam eye masks have space-time limitations; when in use, the eyedrop is in direct contact with eyeballs, has irritation and is easy to damage the structures of the eyeballs; artificial tears are the primary treatment for dry eye, but are short-lived. In addition, chemical additives such as chemical preservatives are mostly added in any form of products, so that toxic and side effects are easily caused to eye tissue cells after long-term use, and safety risks are caused to users.

Disclosure of Invention

The invention aims to provide a natural plant eye spray aiming at the defects or shortcomings in the prior art. The natural plant eye spray disclosed by the invention is free of chemical preservatives, safe, reliable and non-irritant, can make up the defects of most of existing eye protection products in the aspects of safety, convenience in use, unobvious action effect and the like, can effectively relieve the problems of asthenopia, eye interference and the like, can moisten skin around eyes, and has double effects of brightening eyes and moistening eyes.

It is also an object of the present invention to provide a method for preparing said natural plant eye spray.

The purpose of the invention is realized by the following technical scheme.

A natural plant eye spray comprises the following components in parts by weight:

50-70 parts of folium artemisiae argyi water, 10-20 parts of green tea leaf water, 10-20 parts of chrysanthemum water, 5-10 parts of roselle water and 0.2-1.0 part of peony root bark extract.

The natural plant eye spray as a preferred embodiment is prepared by the following steps of:

weighing freshly picked folium Artemisiae Argyi, green tea, flos Chrysanthemi or flos Rosae Rugosae, cleaning, cutting, distilling with water vapor, condensing, and collecting 2-8 times of distillate.

The peony root bark extract is extracted from dried root bark of a peony belonging to Ranunculaceae, and is food grade and water soluble in solubility.

A natural plant eye spray as a preferred embodiment, which is used in conjunction with a spray bottle.

A method of making a natural plant eye spray as described in any one of the above, comprising the steps of:

(1) weighing folium artemisiae argyi water, green tea leaf water, chrysanthemum water and roselle flower water according to the mass parts, and fully blending and uniformly mixing to obtain eye spray lotion;

(2) filtering, sterilizing and removing impurities from the eye spray dew through an ultrafiltration membrane to obtain pure eye spray dew;

(3) carrying out ultrahigh-temperature instantaneous sterilization on the pure eye spray dew to obtain sterile eye spray dew;

(4) and weighing the peony root-bark extract according to the mass parts, adding the peony root-bark extract into the sterile eye spray dew in a sterile environment, fully and uniformly stirring, and carrying out sterile filling and packaging to obtain the natural plant eye spray.

Preferably, in the step (2), the ultrafiltration membrane is a food-grade folded simple microporous polyethersulfone filter membrane with the pore diameter of 0.22 μm.

Preferably, in the step (2), the ultrafiltration membrane is used for positive pressure filtration, and the filtration pressure difference is less than 0.3 MPa.

Preferably, in the step (3), the ultrahigh-temperature instantaneous sterilization is carried out for 4-6s at the temperature of 130-.

Preferably, in step (3), the aseptic filling includes ozone sterilization of the inner packaging material before filling, ultraviolet space sterilization of the filling chamber, and aseptic operation of the operator.

In the natural plant eye spray, the folium artemisiae argyi water which is the steam distillation extract of the folium artemisiae argyi is contained, the folium artemisiae argyi is rich in phenols and flavonoid components, high scavenging capacity is shown for various free radicals, and the oxidative damage of hydroxyl free radicals to DNA can be effectively reduced or eliminated; folium Artemisiae Argyi water extracted from folium Artemisiae Argyi by distillation has effects of diminishing inflammation, resisting allergy, tranquilizing skin, accelerating skin blood circulation, accelerating cell renewal, removing mottle, reducing wrinkle, improving pouch, and removing black eye, and can be used for wet compress to relieve muscle soreness caused by overuse.

The natural plant eye spray contains green tea leaf water which is a water vapor distillation extract of green tea, and the green tea leaves contain a large amount of natural active substances such as catechin, flavonoid, phenolic acid and the like, so that the natural plant eye spray has strong effects of oxidation resistance, aging resistance, inflammation resistance and the like. The green tea water extracted by distilling green tea not only can prevent the damage of chemical light/ultraviolet light to eyes, but also can improve the dermal elastic fiber lesion caused by photoaging, improve fine lines of eyes and brighten the uniform skin color of eyes through the antioxidation.

The natural plant eye spray contains chrysanthemum water extracted by steam distillation of chrysanthemum. It is recorded in Shen nong Ben Cao Jing (Shen nong's herbal Jing) that Hangzhou white chrysanthemum tea can play the roles of treating dizziness, swelling and pain, eye loss, skin necrosis, aversion to wind-damp arthralgia, promoting qi circulation after long-term use, reducing weight, resisting fatigue and prolonging life. The chrysanthemum contains lutein and various vitamins, has a visual protection effect, has the oxidation resistance to resist the damage of cells and organs caused by free radicals in a human body, effectively prevents cataract, delays the senile vision deterioration, and is clinically used for treating eye diseases caused by liver channel wind heat; in addition, the chrysanthemum total flavonoids can inhibit apoptosis of lacrimal gland acinus and glandular cells, improve basic secretion of tears, maintain stability of tear film, promote corneal injury repair, relieve inflammatory reaction and improve dry eye surface state. In conclusion, the chrysanthemum has good curative effect on dry eyes, fatigue and blurred vision, and is a good product for nourishing eyes and improving eyesight.

The natural plant eye spray of the invention contains the water vapor distillation extract of roselle flower. The roselle flower is a medicine-food dual-purpose plant, contains rich organic acid, vitamin C, various amino acids, flavonoids, anthocyanin and the like, has the functions of eliminating fatigue and resisting oxidation, has the function of protecting electronic radiation, and can effectively relieve the eye fatigue problem caused by the operation of mobile phones, computers and video display terminals. The roselle water extracted by distilling the roselle flowers is used as a powerful humectant, can increase the water retention degree of skin stratum corneum cells, nourish the skin and keep the skin alive.

The natural plant eye spray contains a water-soluble extract of peony root bark. The peony root bark extract is used as a plant astringent and an antioxidant, has an inhibiting effect on metalloprotease and elastase and an activating effect on cathepsin, shows that the peony root bark extract has skin activating and anti-aging functions, combines excellent oxidation resistance, and can be used for anti-aging cosmetics; moreover, the collagen fiber gel has better contraction effect, shows that the collagen fiber gel has convergence effect on the dermis layer of the skin, and can be used in products for tightening the skin and removing eye bags; in addition, the product has good antibacterial and anti-inflammatory properties, can replace chemical preservatives, and provides quality safety guarantee for the product.

Compared with the prior art, the invention has the following advantages and beneficial effects:

(1) the natural plant eye spray disclosed by the invention is free of chemical preservatives, safe, reliable and non-irritant, overcomes the defects of most existing eye protection products in the aspects of safety, convenience in use, unobvious action effect and the like, can effectively relieve the problems of asthenopia, eye interference and the like, can moisten skin around eyes, has double effects of brightening and moistening eyes, and is particularly suitable for computer people, the old people with dry eyes and itching eyes, drivers, students and other groups who use eyes for a long time.

(2) The components in the natural plant eye spray disclosed by the invention all adopt a form of water vapor distillate, the components all exist in a form of small molecules, the permeability is strong, the components can directly reach the substrate, the eyes and the skin around the eyes can be deeply moistened, the eye injury is reduced, and the effect is lasting.

(3) The natural plant eye spray is matched with the spray bottle for use, is simpler and more portable to use, and is not limited by the use time, space and times.

(4) In the preparation method, the sterilization treatment is carried out by adopting the combined sterilization mode of the microporous membrane filtration, the ultrahigh temperature instantaneous sterilization technology and the natural plant bacteriostatic agent, so that the pollution risk is greatly reduced, and the use safety of the product is ensured.

Detailed Description

The technical solution of the present invention is further described in detail with reference to the following specific examples, but the scope and implementation of the present invention are not limited thereto. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. In the specific examples, unless otherwise specified, the technical means used are in accordance with the conventional means employed by those skilled in the art of the present invention.

In a specific embodiment, the peony root bark extract is extracted from dried root bark of a peony of Ranunculaceae, and the peony root bark extract is food grade and water soluble in solubility.

Example 1

50 parts of folium artemisiae argyi water, 20 parts of green tea leaf water, 20 parts of chrysanthemum water, 9 parts of roselle flower water and 1 part of peony root-bark extract.

Wherein the blumea balsamifera water, the green tea water, the chrysanthemum water and the roselle flower water are prepared by the following methods:

weighing freshly picked folium Artemisiae Argyi, green tea leaf, flos Chrysanthemi or flos Rosae Rugosae, cleaning, cutting into pieces, steam distilling, condensing and collecting 2-8 times of distillate to obtain folium Artemisiae Argyi solution, green tea leaf solution, flos Chrysanthemi solution and flos Rosae Rugosae solution, respectively. In this example, the collected weight of the distillate of the mugwort leaf water is 2 times of the weight of the freshly picked mugwort leaves, the collected weight of the distillate of the green tea leaf water is 4 times of the weight of the freshly picked green tea leaves, the collected weight of the distillate of the chrysanthemum flower water is 8 times of the weight of the freshly picked chrysanthemum flowers, and the collected weight of the distillate of the roselle flower water is 6 times of the weight of the freshly picked roselle flowers.

The natural plant eye spray of this embodiment cooperates the spray bottle to use, uses simple and easy portable, and does not receive the restriction of live time, space and number of times moreover.

The natural plant spray of this example was prepared by the following specific procedure

(1) Weighing folium artemisiae argyi water, green tea leaf water, chrysanthemum water and roselle flower water according to the mass parts, fully blending and uniformly mixing to obtain the eye spray lotion.

(2) And (3) carrying out positive pressure filtration, impurity removal and sterilization on the eye spray dew through a food-grade folded simple microporous polyethersulfone filter membrane with the aperture of 0.22 mu m, wherein the filtration pressure difference is 0.2MPa, so as to obtain pure eye spray dew.

(3) And (3) carrying out heat preservation and sterilization on the pure eye spray dew at 130 ℃ for 6s, then rapidly cooling to below 40 ℃, and finishing ultrahigh temperature instantaneous sterilization to obtain sterile eye spray dew.

(4) And weighing the peony root-bark extract according to the mass parts, adding the peony root-bark extract into the sterile eye spray distillate in a sterile environment, and fully and uniformly stirring to obtain the eye spray use solution.

(5) And carrying out aseptic filling on the eye spray use solution in an aseptic production workshop, wherein the aseptic filling comprises ozone sterilization of an inner packaging material before filling, ultraviolet space sterilization of a filling chamber and aseptic operation of an operator, and packaging to obtain the natural plant eye spray.

Example 2

70 parts of folium artemisiae argyi water, 14.3 parts of green tea leaf water, 10 parts of chrysanthemum water, 5 parts of roselle water and 0.7 part of peony root-bark extract.

weighing freshly picked folium Artemisiae Argyi, green tea leaf, flos Chrysanthemi or flos Rosae Rugosae, cleaning, cutting into pieces, steam distilling, condensing and collecting 2-8 times of distillate to obtain folium Artemisiae Argyi solution, green tea leaf solution, flos Chrysanthemi solution and flos Rosae Rugosae solution, respectively. In this example, the collected weight of the distillate of the mugwort leaf water is 8 times of the weight of the freshly picked mugwort leaves, the collected weight of the distillate of the green tea leaf water is 2 times of the weight of the freshly picked green tea leaves, the collected weight of the distillate of the chrysanthemum flower water is 6 times of the weight of the freshly picked chrysanthemum flowers, and the collected weight of the distillate of the roselle flower water is 2 times of the weight of the freshly picked roselle flowers.

(3) And (3) carrying out heat preservation and sterilization on the pure eye spray dew at 137 ℃ for 4s, then rapidly cooling to below 40 ℃, and finishing ultrahigh-temperature instantaneous sterilization to obtain sterile eye spray dew.

Example 3

65 parts of folium artemisiae argyi water, 10 parts of green tea leaf water, 14.8 parts of chrysanthemum water, 10 parts of roselle flower water and 0.2 part of peony root-bark extract.

weighing freshly picked folium Artemisiae Argyi, green tea leaf, flos Chrysanthemi or flos Rosae Rugosae, cleaning, cutting into pieces, steam distilling, condensing and collecting 2-8 times of distillate to obtain folium Artemisiae Argyi solution, green tea leaf solution, flos Chrysanthemi solution and flos Rosae Rugosae solution, respectively. In this example, the collected weight of the distillate of the mugwort leaf water is 5 times of the weight of the freshly picked mugwort leaves, the collected weight of the distillate of the green tea leaf water is 8 times of the weight of the freshly picked green tea leaves, the collected weight of the distillate of the chrysanthemum flower water is 2 times of the weight of the freshly picked chrysanthemum flowers, and the collected weight of the distillate of the roselle flower water is 8 times of the weight of the freshly picked roselle flowers.

(2) And (3) carrying out positive pressure filtration, impurity removal and sterilization on the eye spray dew through a food-grade folded simple microporous polyethersulfone filter membrane with the aperture of 0.22 mu m, wherein the filtration pressure difference is 0.25MPa, so as to obtain pure eye spray dew.

(3) And (3) carrying out heat preservation and sterilization on the pure eye spray dew at 135 ℃ for 5s, then rapidly cooling to below 40 ℃, and finishing ultrahigh temperature instantaneous sterilization to obtain sterile eye spray dew.

Animal experiments

To demonstrate the zero eye irritation of the natural plant eye sprays of the present invention to the eye, animal eye irritation experiments were now performed. In the experiment, 4 new zealand rabbits with the same female and the like are selected, the left eye of the animal is a test eye, the right eye of the animal is a blank control eye, the eye spray using solution in the example 2 is used for poisoning the rabbit eye according to the dosage of 0.1 ml/eye, then the eye irritation reaction is observed in 1h, 24h, 48h and 72h respectively, and the experiment result is shown in table 1.

TABLE 1 results of animal eye irritation experiments

As can be seen from the results shown in table 1, the natural plant eye spray of example 2 did not show any adverse symptoms after being applied to the eyes of new zealand rabbits, suggesting that the natural plant eye spray of the present invention is not irritating to the eyes.

To further consider the safety of the natural eye spray of the present invention to the periocular skin, several skin irritation experiments were performed. Selecting 4 female equal-weight New Zealand rabbits in the experiment, removing hairs on two sides of a dorsal column of the rabbits 24h before the experiment by using a razor, taking 3cm x 3cm on the left and the right respectively as a test area and a control area, taking 0.5ml of the natural plant eye spray in the embodiment 2, and applying the natural plant eye spray on the test area for 1 time every day for 14 days continuously; and the skin of the test and control areas was observed and scored 1h before each application, starting on day 2, with the results shown in table 2.

TABLE 2 results of the animal eye skin safety test

As can be seen from the results shown in table 2, the natural plant eye spray of example 2 was continuously applied to the skin of new zealand rabbits without any adverse symptoms or abnormalities, suggesting that the natural plant eye spray of the present invention was not irritating to the skin.

Effects of use

The natural plant eye spray finished product in example 2 was used for market trial investigation of 30 office workers for 4-6 times per day for a trial period of 1 week. When in use, the spray is ensured to sweep across eyes for 2-3 times, and eyes are blinked lightly to be absorbed naturally.

According to statistics, 80% of people feedback that eyes feel comfortable after use, and the eye fatigue phenomenon can be relieved immediately; 40% of the test subjects feed back the preparation, so that the phenomena of dry eyes and acid swelling caused by careless rest after long-time watching of a computer screen can be obviously improved; in addition, 2% of the subjects showed that the eyes were perceived as brighter after use.

In conclusion, the natural plant eye spray provided by the invention has the effects of relieving asthenopia, dry eye and blurred vision caused by overuse of eyes, and achieves better effects on improving and protecting eyes and protecting eyesight.

The above embodiments are merely preferred embodiments of the present invention, and are provided only for describing the technical solutions of the present invention in further detail to help understanding the principles of the technical solutions of the present invention. Meanwhile, for those skilled in the art, according to the technical solutions of the present invention, there may be variations in the specific embodiments and applications, and in summary, any changes, combinations, deletions, substitutions or modifications that do not depart from the spirit and scope of the present invention are included in the protection scope of the present invention.

Claims

1. The natural plant eye spray is characterized by comprising the following components in parts by weight:

2. The natural plant eye spray of claim 1, wherein the mugwort leaf water, green tea leaf water, chrysanthemum water and roselle flower water are prepared by the following method:

3. The natural plant eye spray of claim 1, wherein the peony root bark extract is extracted from the dried root bark of a peony belonging to the family Ranunculaceae, and is food grade and water soluble in solubility.

4. A natural plant eye spray according to any one of claims 1 to 3, wherein said natural plant eye spray is used in conjunction with a spray bottle.

5. A method of preparing a natural plant eye spray according to any one of claims 1 to 4, comprising the steps of:

6. The preparation method according to claim 5, wherein in the step (2), the ultrafiltration membrane is a food-grade folded simple microporous polyethersulfone filter membrane with the pore size of 0.22 μm, and the fine pore size has the filtration and sterilization effects.

7. The method according to claim 5, wherein in the step (2), the ultrafiltration membrane is subjected to positive pressure filtration, and the filtration pressure difference is less than 0.3 MPa.

8. The preparation method according to claim 5, wherein in the step (3), the ultrahigh temperature instantaneous sterilization is performed by rapidly cooling to below 40 ℃ after heat preservation sterilization at 130 ℃ and 140 ℃ for 4-6 s.

9. The method according to claim 5, wherein the aseptic filling in step (3) includes ozone sterilization of the inner wrapper before filling, ultraviolet space sterilization of the filling chamber, and aseptic operation by an operator.